Frequency-domain diffuse optical spectroscopy with real-time data visualization for monitoring of breast neoplasms

Diffuse optical methods have demonstrated significant potential to monitor breast cancer treatment response. Unfortunately, many diffuse optical tools involve lengthy acquisition, slow data processing, or both, limiting their clinical utility. Here, we present a new frequency domain diffuse optical device capable of providing real-time tissue oxygenation maps. This device is made possible through the integration of three enabling technologies: real-time 3D probe tracking, rapid translation of raw data to optical properties, and new high-speed acquisition electronics. We have demonstrated the ability of this instrument to identify inclusions in phantoms as well as to make proof-of-concept measurements in breast tissue.