A point process approach for analyzing gait variability dynamics

We present a novel statistical paradigm for modeling and analysis of gait variability which captures the natural point process structure of gait intervals and allows for definition of new measures instantaneous mean and standard deviation. We validate our model using two existing data sets from physionet.org. Results show an excellent model fit and yield insights into the underlying statistical structure behind human gait. Statistical analyses further corroborate previous findings of increased variability in gait at different speeds, both self-paced and metronome-paced, and reveal a significant increase in gait variability in Parkinson's subjects, as compared to young and elderly healthy subjects. These results indicate the validity of a point process approach to the analysis of gait, and the potential utility of incorporating instantaneous measures of gait into diagnostic or patient monitoring applications.

[1]  J. Jankovic,et al.  Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results , 2008, Movement disorders : official journal of the Movement Disorder Society.

[2]  Emery N. Brown,et al.  Analysis of heartbeat dynamics by point process adaptive filtering , 2006, IEEE Transactions on Biomedical Engineering.

[3]  Emery N. Brown,et al.  The Time-Rescaling Theorem and Its Application to Neural Spike Train Data Analysis , 2002, Neural Computation.

[4]  Jeffrey M. Hausdorff,et al.  Is walking a random walk? Evidence for long-range correlations in stride interval of human gait. , 1995, Journal of applied physiology.

[5]  Sheldon M. Ross Introduction to Probability Models. , 1995 .

[6]  Jeffrey M. Hausdorff,et al.  Gait variability and basal ganglia disorders: Stride‐to‐stride variations of gait cycle timing in parkinson's disease and Huntington's disease , 1998, Movement disorders : official journal of the Movement Disorder Society.

[7]  T Chau,et al.  A review of analytical techniques for gait data. Part 2: neural network and wavelet methods. , 2001, Gait & posture.

[8]  Jeffrey M. Hausdorff,et al.  Physionet: Components of a New Research Resource for Complex Physiologic Signals". Circu-lation Vol , 2000 .

[9]  Sheldon M. Ross,et al.  Introduction to Probability Models, Eighth Edition , 1972 .

[10]  Emery N. Brown,et al.  Brain correlates of autonomic modulation: Combining heart rate variability with fMRI , 2008, NeuroImage.

[11]  Meg E Morris,et al.  Locomotor Training in People With Parkinson Disease , 2006, Physical Therapy.

[12]  Jeffrey M. Hausdorff Gait dynamics in Parkinson's disease: common and distinct behavior among stride length, gait variability, and fractal-like scaling. , 2009, Chaos.

[13]  Jeffrey M. Hausdorff,et al.  Fractal dynamics of human gait: stability of long-range correlations in stride interval fluctuations. , 1996, Journal of applied physiology.

[14]  R. Walker,et al.  Incidence and prediction of falls in Parkinson's disease: a prospective multidisciplinary study , 2002, Journal of neurology, neurosurgery, and psychiatry.

[15]  D. Brooks Functional imaging studies on dopamine and motor control , 2001, Journal of Neural Transmission.

[16]  Jeffrey M. Hausdorff Gait variability: methods, modeling and meaning , 2005, Journal of NeuroEngineering and Rehabilitation.

[17]  Jeffrey M. Hausdorff,et al.  Wearable Assistant for Parkinson’s Disease Patients With the Freezing of Gait Symptom , 2010, IEEE Transactions on Information Technology in Biomedicine.

[18]  Jeffrey M. Hausdorff,et al.  Altered fractal dynamics of gait: reduced stride-interval correlations with aging and Huntington's disease. , 1997, Journal of applied physiology.

[19]  T Chau,et al.  A review of analytical techniques for gait data. Part 1: Fuzzy, statistical and fractal methods. , 2001, Gait & posture.

[20]  E. Brown,et al.  A point-process model of human heartbeat intervals: new definitions of heart rate and heart rate variability. , 2005, American journal of physiology. Heart and circulatory physiology.

[21]  Emery N. Brown,et al.  Characterizing nonlinear heartbeat dynamics within a point process framework , 2010, 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.