Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication.

[1]  Donald E. Ingber,et al.  Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies? , 2020, Advanced science.

[2]  C. Mummery,et al.  Organs-on-chips: into the next decade , 2020, Nature Reviews Drug Discovery.

[3]  J. Leijten,et al.  Monolithic microfluidic platform for exerting gradients of compression on cell-laden hydrogels, and application to a model of the articular cartilage , 2020, Sensors and Actuators B: Chemical.

[4]  R. Schasfoort,et al.  Cancer-ID: Toward Identification of Cancer by Tumor-Derived Extracellular Vesicles in Blood , 2020, Frontiers in Oncology.

[5]  Hao Sun,et al.  Combining additive manufacturing with microfluidics: an emerging method for developing novel organs-on-chips , 2020 .

[6]  Sónia Gonçalves Patrício,et al.  Freeform 3D printing using a continuous viscoelastic supporting matrix , 2020, Biofabrication.

[7]  Bing Zhang,et al.  Efficient Drug Screening and Nephrotoxicity Assessment on Co-culture Microfluidic Kidney Chip , 2020, Scientific Reports.

[8]  H. S. Rho,et al.  A 3D Polydimethylsiloxane Microhourglass-Shaped Channel Array Made by Reflowing Photoresist Structures for Engineering a Blood Capillary Network. , 2020, Methods.

[9]  Samuel S Hinman,et al.  Microphysiological System Design: Simplicity Is Elegance. , 2020, Current opinion in biomedical engineering.

[10]  C. Bishop,et al.  Drug compound screening in single and integrated multi-organoid body-on-a-chip systems , 2020, Biofabrication.

[11]  C. Bishop,et al.  Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform. , 2020, Acta biomaterialia.

[12]  Gerwin Osnabrugge,et al.  Model-based wavefront shaping microscopy. , 2020, Optics letters.

[13]  A. Hierlemann,et al.  In Vitro Platform for Studying Human Insulin Release Dynamics of Single Pancreatic Islet Microtissues at High Resolution , 2020, Advanced biosystems.

[14]  Richard Novak,et al.  Robotic fluidic coupling and interrogation of multiple vascularized organ chips , 2020, Nature Biomedical Engineering.

[15]  Richard Novak,et al.  Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips , 2020, Nature Biomedical Engineering.

[16]  Carlos F. Ng,et al.  On-chip recapitulation of clinical bone-marrow toxicities and patient-specific pathophysiology , 2019, Nature Biomedical Engineering.

[17]  S. Gandhi,et al.  Imaging the dynamic recruitment of monocytes to the blood–brain barrier and specific brain regions during Toxoplasma gondii infection , 2019, Proceedings of the National Academy of Sciences.

[18]  Jeong-Yeol Yoon,et al.  Methods of Delivering Mechanical Stimuli to Organ-on-a-Chip , 2019, Micromachines.

[19]  Lucia Boeri,et al.  Advanced Organ-on-a-Chip Devices to Investigate Liver Multi-Organ Communication: Focus on Gut, Microbiota and Brain , 2019, Bioengineering.

[20]  U. Marx,et al.  Autologous induced pluripotent stem cell-derived four-organ-chip , 2019, Future science OA.

[21]  Katja Schenke-Layland,et al.  Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform , 2019, eLife.

[22]  Linda G. Griffith,et al.  Gut-Liver physiomimetics reveal paradoxical modulation of IBD-related inflammation by short-chain fatty acids , 2019, bioRxiv.

[23]  Ali Khademhosseini,et al.  The emergence of 3D bioprinting in organ-on-chip systems , 2019, Progress in Biomedical Engineering.

[24]  R. Ismagilov,et al.  Human-gut-microbiome on a chip , 2019, Nature Biomedical Engineering.

[25]  Huan Li,et al.  Self-aligning Tetris-Like (TILE) modular microfluidic platform for mimicking multi-organ interactions. , 2019, Lab on a chip.

[26]  Sean P. Palecek,et al.  Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies , 2019, Nature Communications.

[27]  A. Barbero,et al.  Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model , 2019, Nature Biomedical Engineering.

[28]  Deepak Choudhury,et al.  Microfluidic bioprinting for organ-on-a-chip models. , 2019, Drug discovery today.

[29]  S. Wölfl,et al.  In vitro metabolic activation of vitamin D3 by using a multi-compartment microfluidic liver-kidney organ on chip platform , 2019, Scientific Reports.

[30]  J. Munson,et al.  Two-way communication between ex vivo tissues on a microfluidic chip: application to tumor-lymph node interaction. , 2019, Lab on a chip.

[31]  Massimo Mastrangeli,et al.  Organ-on-chip in development: Towards a roadmap for organs-on-chip. , 2019, ALTEX.

[32]  Yi Zhao,et al.  Multi-Organs-on-Chips: Towards Long-Term Biomedical Investigations , 2019, Molecules.

[33]  Arrate Muñoz-Barrutia,et al.  Applications of Light-Sheet Microscopy in Microdevices , 2019, Front. Neuroanat..

[34]  A. Skardal,et al.  A multi-site metastasis-on-a-chip microphysiological system for assessing metastatic preference of cancer cells. , 2018, Biotechnology and bioengineering.

[35]  Julia Hoeng,et al.  A lung/liver-on-a-chip platform for acute and chronic toxicity studies. , 2018, Lab on a chip.

[36]  LembongJosephine,et al.  A Fluidic Culture Platform for Spatially Patterned Cell Growth, Differentiation, and Cocultures. , 2018 .

[37]  Jong Hwan Sung,et al.  Recent Advances in Body-on-a-Chip Systems. , 2018, Analytical chemistry.

[38]  Jiacheng He,et al.  An integrated adipose-tissue-on-chip nanoplasmonic biosensing platform for investigating obesity-associated inflammation. , 2018, Lab on a chip.

[39]  M. Speicher,et al.  Current and future perspectives of liquid biopsies in genomics-driven oncology , 2018, Nature Reviews Genetics.

[40]  Luke A Schwerdtfeger,et al.  From organotypic culture to body‐on‐a‐chip: A neuroendocrine perspective , 2018, Journal of neuroendocrinology.

[41]  W. Cui,et al.  Development of a biomimetic liver tumor-on-a-chip model based on decellularized liver matrix for toxicity testing. , 2018, Lab on a chip.

[42]  A. Redaelli,et al.  A microscale biomimetic platform for generation and electro-mechanical stimulation of 3D cardiac microtissues , 2018, APL bioengineering.

[43]  Y. Toh,et al.  A liver-immune coculture array for predicting systemic drug-induced skin sensitization. , 2018, Lab on a chip.

[44]  H. S. Rho,et al.  An oviduct-on-a-chip provides an enhanced in vitro environment for zygote genome reprogramming , 2018, Nature Communications.

[45]  M. Radisic,et al.  Curvature facilitates podocyte culture in a biomimetic platform. , 2018, Lab on a chip.

[46]  T. Steger-Hartmann,et al.  Simultaneous evaluation of anti-EGFR-induced tumour and adverse skin effects in a microfluidic human 3D co-culture model , 2018, Scientific Reports.

[47]  Jerry C. Hu,et al.  A Guide for Using Mechanical Stimulation to Enhance Tissue-Engineered Articular Cartilage Properties. , 2018, Tissue engineering. Part B, Reviews.

[48]  T. Puzyn,et al.  Implementation of a dynamic intestinal gut-on-a-chip barrier model for transport studies of lipophilic dioxin congeners , 2018, RSC advances.

[49]  Sean P Sheehy,et al.  A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells , 2018, Nature Biotechnology.

[50]  Anne Riu,et al.  Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system. , 2018, Biomaterials.

[51]  Michael L Shuler,et al.  A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells. , 2018, Lab on a chip.

[52]  T. Gaborski,et al.  Use of porous membranes in tissue barrier and co-culture models. , 2018, Lab on a chip.

[53]  Uwe Marx,et al.  Bioengineering of a Full-Thickness Skin Equivalent in a 96-Well Insert Format for Substance Permeation Studies and Organ-On-A-Chip Applications , 2018, Bioengineering.

[54]  Charles S Henry,et al.  Powering ex vivo tissue models in microfluidic systems. , 2018, Lab on a chip.

[55]  G. Mosayebi,et al.  Mesenchymal Stem Cells Differentiate to Endothelial Cells Using Recombinant Vascular Endothelial Growth Factor -A. , 2018, Reports of biochemistry & molecular biology.

[56]  Francesca Stradolini,et al.  Organs-on-chip monitoring: sensors and other strategies , 2018 .

[57]  James W. MacDonald,et al.  Human Organ-Specific Endothelial Cell Heterogeneity , 2018, iScience.

[58]  Murat Cirit,et al.  Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies , 2018, Scientific Reports.

[59]  Gordana Vunjak-Novakovic,et al.  Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development. , 2018, Cell stem cell.

[60]  Ryan T. Halvorson,et al.  Automated fabrication of photopatterned gelatin hydrogels for organ-on-chips applications , 2018, Biofabrication.

[61]  P. Dittrich,et al.  Microfluidics to Mimic Blood Flow in Health and Disease , 2018 .

[62]  T. Andersson,et al.  Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model , 2017, Scientific Reports.

[63]  Xavier Gidrol,et al.  Deciphering Cell Intrinsic Properties: A Key Issue for Robust Organoid Production. , 2017, Trends in biotechnology.

[64]  Matthias P Lutolf,et al.  Synthesis and characterization of well-defined hydrogel matrices and their application to intestinal stem cell and organoid culture , 2017, Nature Protocols.

[65]  Ali Khademhosseini,et al.  Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform , 2017, Scientific Reports.

[66]  K. Agladze,et al.  Biocontractile microfluidic channels for peristaltic pumping , 2017, Biomedical Microdevices.

[67]  Yu Shrike Zhang,et al.  Modular multi-organ-on-chips platform with physicochemical sensor integration , 2017, 2017 IEEE 60th International Midwest Symposium on Circuits and Systems (MWSCAS).

[68]  Emmanuel Roy,et al.  Thermoplastic elastomer with advanced hydrophilization and bonding performances for rapid (30 s) and easy molding of microfluidic devices. , 2017, Lab on a chip.

[69]  Murat Cirit,et al.  Integrated gut/liver microphysiological systems elucidates inflammatory inter‐tissue crosstalk , 2017, Biotechnology and bioengineering.

[70]  Murat Cirit,et al.  Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies , 2017, The AAPS Journal.

[71]  Hidetoshi Kotera,et al.  Integrating perfusable vascular networks with a three-dimensional tissue in a microfluidic device. , 2017, Integrative biology : quantitative biosciences from nano to macro.

[72]  Nancy L Allbritton,et al.  A microengineered collagen scaffold for generating a polarized crypt-villus architecture of human small intestinal epithelium. , 2017, Biomaterials.

[73]  L. Bergers,et al.  Progress and Future Prospectives in Skin-on-Chip Development with Emphasis on the use of Different Cell Types and Technical Challenges , 2017, Stem Cell Reviews and Reports.

[74]  David J Hughes,et al.  Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems , 2017, Experimental biology and medicine.

[75]  T. Hope,et al.  A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle , 2017, Nature Communications.

[76]  Sean P Sheehy,et al.  Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes , 2017, Experimental biology and medicine.

[77]  Ning Hu,et al.  Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors , 2017, Proceedings of the National Academy of Sciences.

[78]  A. Polilov,et al.  The scaling and allometry of organ size associated with miniaturization in insects: A case study for Coleoptera and Hymenoptera , 2017, Scientific Reports.

[79]  Steven C George,et al.  A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications. , 2017, Lab on a chip.

[80]  Dong-Woo Cho,et al.  3D Printing of Organs-On-Chips , 2017, Bioengineering.

[81]  C. Hsia Comparative analysis of the mechanical signals in lung development and compensatory growth , 2017, Cell and Tissue Research.

[82]  Renaud Renault,et al.  Transient microfluidic compartmentalization using actionable microfilaments for biochemical assays, cell culture and organs-on-chip. , 2016, Lab on a chip.

[83]  Hans Clevers,et al.  Designer matrices for intestinal stem cell and organoid culture , 2016, Nature.

[84]  Huanjun Chen,et al.  Sulfated fucoidan FP08S2 inhibits lung cancer cell growth in vivo by disrupting angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling. , 2016, Cancer letters.

[85]  Sung-Jin Park,et al.  Instrumented cardiac microphysiological devices via multi-material 3D printing , 2016, Nature materials.

[86]  Xiancheng Li,et al.  Design and Construction of a Multi-Organ Microfluidic Chip Mimicking the in vivo Microenvironment of Lung Cancer Metastasis. , 2016, ACS applied materials & interfaces.

[87]  Xavier Gidrol,et al.  A 3D Toolbox to Enhance Physiological Relevance of Human Tissue Models. , 2016, Trends in biotechnology.

[88]  S. Soker,et al.  A reductionist metastasis‐on‐a‐chip platform for in vitro tumor progression modeling and drug screening , 2016, Biotechnology and bioengineering.

[89]  Feng Xu,et al.  4D Bioprinting for Biomedical Applications. , 2016, Trends in biotechnology.

[90]  Mandy B. Esch,et al.  Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue. , 2016, Lab on a chip.

[91]  Pasqualina M. Sarro,et al.  Cytostretch, an Organ-on-Chip Platform , 2016, Micromachines.

[92]  Ali Khademhosseini,et al.  Cardiovascular Organ-on-a-Chip Platforms for Drug Discovery and Development. , 2016, Applied in vitro toxicology.

[93]  Xiaojie Li,et al.  A novel microfluidic model can mimic organ-specific metastasis of circulating tumor cells , 2016, Oncotarget.

[94]  Stephan Herminghaus,et al.  Self-Driven Jamming in Growing Microbial Populations , 2016, Nature Physics.

[95]  William McLamb,et al.  Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs , 2016, Scientific Reports.

[96]  Frederic Yves Bois,et al.  Investigation of ifosfamide and chloroacetaldehyde renal toxicity through integration of in vitro liver–kidney microfluidic data and pharmacokinetic‐system biology models , 2016, Journal of applied toxicology : JAT.

[97]  Jennifer L West,et al.  Studying the influence of angiogenesis in in vitro cancer model systems. , 2016, Advanced drug delivery reviews.

[98]  Zimple Matharu,et al.  Liver injury-on-a-chip: microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury. , 2015, Lab on a chip.

[99]  Kevin E. Healy,et al.  μOrgano: A Lego®-Like Plug & Play System for Modular Multi-Organ-Chips , 2015, PloS one.

[100]  DA Lauffenburger,et al.  Physiome-on-a-Chip: The Challenge of “Scaling” in Design, Operation, and Translation of Microphysiological Systems , 2015, CPT: pharmacometrics & systems pharmacology.

[101]  Uwe Marx,et al.  A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing. , 2015, Journal of biotechnology.

[102]  A. Hierlemann,et al.  3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis. , 2015, Journal of biotechnology.

[103]  F. Sonntag,et al.  A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents. , 2015, Lab on a chip.

[104]  Andreas Hierlemann,et al.  96-Well Format-Based Microfluidic Platform for Parallel Interconnection of Multiple Multicellular Spheroids , 2015, Journal of laboratory automation.

[105]  Teruo Fujii,et al.  An On-Chip Small Intestine–Liver Model for Pharmacokinetic Studies , 2015, Journal of laboratory automation.

[106]  Ronan M. T. Fleming,et al.  Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture. , 2015, Lab on a chip.

[107]  Michael L Shuler,et al.  Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling. , 2015, Integrative biology : quantitative biosciences from nano to macro.

[108]  N Verdonschot,et al.  A medium throughput device to study the effects of combinations of surface strains and fluid-flow shear stresses on cells. , 2015, Lab on a chip.

[109]  Christopher Moraes,et al.  On being the right size: scaling effects in designing a human-on-a-chip. , 2013, Integrative biology : quantitative biosciences from nano to macro.

[110]  Uwe Marx,et al.  Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion. , 2013, Lab on a chip.

[111]  Jie Shen,et al.  admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties , 2012, J. Chem. Inf. Model..

[112]  D. Ingber,et al.  A human breathing lung‐on‐a‐chip , 2010, Annals of the American Thoracic Society.

[113]  Wolfgang Eberle,et al.  Building blocks for a European Organ-on-Chip roadmap. , 2019, ALTEX.

[114]  A. Jemal,et al.  Cancer statistics, 2019 , 2019, CA: a cancer journal for clinicians.

[115]  DoYeun Park,et al.  Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation. , 2019, Trends in biotechnology.

[116]  S. Sugiura,et al.  A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform. , 2017, Lab on a chip.

[117]  J R Coppeta,et al.  A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control. , 2016, Lab on a chip.