Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo

Objectives: This guideline provides evidence-based recommendations on managing benign paroxysmal positional vertigo (BPPV), which is the most common vestibular disorder in adults, with a lifetime prevalence of 2.4 percent. The guideline targets patients aged 18 years or older with a potential diagnosis of BPPV, evaluated in any setting in which an adult with BPPV would be identified, monitored, or managed. This guideline is intended for all clinicians who are likely to diagnose and manage adults with BPPV. Purpose: The primary purposes of this guideline are to improve quality of care and outcomes for BPPV by improving the accurate and efficient diagnosis of BPPV, reducing the inappropriate use of vestibular suppressant medications, decreasing the inappropriate use of ancillary tests such as radiographic imaging and vestibular testing, and to promote the use of effective repositioning maneuvers for treatment. In creating this guideline, the American Academy of Otolaryngology—Head and Neck Surgery Foundation selected a panel representing the fields of audiology, chiropractic medicine, emergency medicine, family medicine, geriatric medicine, internal medicine, neurology, nursing, otolaryngology–head and neck surgery, physical therapy, and physical medicine and rehabilitation. Results The panel made strong recommendations that 1) clinicians should diagnose posterior semicircular canal BPPV when vertigo associated with nystagmus is provoked by the Dix-Hallpike maneuver. The panel made recommendations against 1) radiographic imaging, vestibular testing, or both in patients diagnosed with BPPV, unless the diagnosis is uncertain or there are additional symptoms or signs unrelated to BPPV that warrant testing; and 2) routinely treating BPPV with vestibular suppressant medications such as antihistamines or benzodiazepines. The panel made recommendations that 1) if the patient has a history compatible with BPPV and the Dix-Hallpike test is negative, clinicians should perform a supine roll test to assess for lateral semicircular canal BPPV; 2) clinicians should differentiate BPPV from other causes of imbalance, dizziness, and vertigo; 3) clinicians should question patients with BPPV for factors that modify management including impaired mobility or balance, CNS disorders, lack of home support, and increased risk for falling; 4) clinicians should treat patients with posterior canal BPPV with a particle repositioning maneuver (PRM); 5) clinicians should reassess patients within 1 month after an initial period of observation or treatment to confirm symptom resolution; 6) clinicians should evaluate patients with BPPV who are initial treatment failures for persistent BPPV or underlying peripheral vestibular or CNS disorders; and 7) clinicians should counsel patients regarding the impact of BPPV on their safety, the potential for disease recurrence, and the importance of follow-up. The panel offered as options that 1) clinicians may offer vestibular rehabilitation, either self-administered or with a clinician, for the initial treatment of BPPV and 2) clinicians may offer observation as initial management for patients with BPPV and with assurance of follow-up. The panel made no recommendation concerning audiometric testing in patients diagnosed with BPPV. Disclaimer: This clinical practice guideline is not intended as a sole source of guidance in managing benign paroxysmal positional vertigo. Rather, it is designed to assist clinicians by providing an evidence-based framework for decision-making strategies. The guideline is not intended to replace clinical judgement or establish a protocol for all individuals with this condition, and may not provide the only appropriate approach to diagnosing and managing this problem. ® 2008 American Academy of Otolaryngology–Head and Neck Surgery Foundation. All rights reserved.

[1]  Ji Soo Kim,et al.  Nystagmus while recumbent in horizontal canal benign paroxysmal positional vertigo , 2006, Neurology.

[2]  John C. Li Mastoid Oscillation: A Critical Factor for Success in the Canalith Repositioning Procedure , 1995, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[3]  D. Baguley,et al.  Recurrence of symptoms following treatment of posterior semicircular canal benign positional paroxysmal vertigo with a particle repositioning manoeuvre. , 2000, The Journal of otolaryngology.

[4]  M. Hill,et al.  A randomized clinical trial to assess the efficacy of the Epley maneuver in the treatment of acute benign positional vertigo. , 2004, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[5]  S. Whitney,et al.  Multisensory Impairment in Older Adults: Evaluation and Intervention , 2006 .

[6]  J. Lopez-Escamez,et al.  Anterior semicircular canal benign paroxysmal positional vertigo and positional downbeating nystagmus. , 2006, American journal of otolaryngology.

[7]  C. Gordon,et al.  Benign paroxysmal positional vertigo as the cause of dizziness in patients after severe traumatic brain injury: diagnosis and treatment , 2005, Brain injury.

[8]  A. Cesarani,et al.  The treatment of acute vertigo , 2004, Neurological Sciences.

[9]  T. Brandt,et al.  VIIIth nerve vascular compression syndrome: vestibular paroxysmia. , 1994, Bailliere's clinical neurology.

[10]  M. Gizzi,et al.  The diagnostic value of imaging the patient with dizziness. A Bayesian approach. , 1996, Archives of neurology.

[11]  M. Ruckenstein Therapeutic Efficacy of the Epley Canalith Repositioning Maneuver , 2001, The Laryngoscope.

[12]  D. Ireland,et al.  Post-treatment instructions in the nonsurgical management of benign paroxysmal positional vertigo. , 1996, The Journal of otolaryngology.

[13]  A. Katsarkas,et al.  Benign paroxysmal positional vertigo (BPPV): idiopathic versus post-traumatic. , 1999, Acta oto-laryngologica.

[14]  M. Perracini,et al.  Clinical evaluation of elderly people with chronic vestibular disorder , 2006, Brazilian journal of otorhinolaryngology.

[15]  Richard N. Shiffman,et al.  Bmc Medical Informatics and Decision Making the Guideline Implementability Appraisal (glia): Development of an Instrument to Identify Obstacles to Guideline Implementation , 2022 .

[16]  R. Tusa,et al.  Complications of the canalith repositioning procedure. , 1996, Archives of otolaryngology--head & neck surgery.

[17]  G. B. Colvin,et al.  Benign paroxysmal positional vertigo and canalith repositioning: clinical correlations. , 2000, The American journal of otology.

[18]  C. Gordon,et al.  Is posttraumatic benign paroxysmal positional vertigo different from the idiopathic form? , 2004, Archives of neurology.

[19]  David E Newman-Toker,et al.  Spectrum of dizziness visits to US emergency departments: cross-sectional analysis from a nationally representative sample. , 2008, Mayo Clinic proceedings.

[20]  P. Kramer,et al.  Benign paroxysmal positioning vertigo in multiple sclerosis: diagnosis, pathophysiology and therapeutic techniques , 2003, Multiple sclerosis.

[21]  E. Smouha,et al.  Atypical Forms of Paroxysmal Positional Nystagmus , 1995, Ear, nose, & throat journal.

[22]  A. Bronstein,et al.  Three hundred sixty-degree rotation of the posterior semicircular canal for treatment of benign positional vertigo: A placebo-controlled trial , 1997, Neurology.

[23]  R. Baloh,et al.  Differentiating between peripheral and central causes of vertigo , 2004, Journal of the Neurological Sciences.

[24]  C. Pane,et al.  [Semont maneuver and vestibular rehabilitation exercises in the treatment of benign paroxysmal postural vertigo. A comparative study]. , 2000, Neurologia.

[25]  G. M. Halmágyi,et al.  What inner ear diseases cause benign paroxysmal positional vertigo? , 2000, Acta oto-laryngologica.

[26]  S. Schappert National Ambulatory Medical Care Survey: 1989 summary. , 1992, Vital and health statistics. Series 13, Data from the National Health Survey.

[27]  L. Caballero,et al.  Benign paroxysmal vertigo: a comparative prospective study of the efficacy of Brandt and Daroff exercises, Semont and Epley maneuver. , 2001, Revue de laryngologie - otologie - rhinologie.

[28]  U Büttner,et al.  Diagnostic criteria for central versus peripheral positioning nystagmus and vertigo: a review. , 1999, Acta oto-laryngologica.

[29]  Martti Juhola,et al.  Production of Diagnostic Rules from a Neurotologic Database with Decision Trees , 2000, The Annals of otology, rhinology, and laryngology.

[30]  Ji Soo Kim,et al.  Clinical Characteristics of Benign Paroxysmal Positional Vertigo in Korea: A Multicenter Study , 2006, Journal of Korean medical science.

[31]  M. Bance,et al.  The AAO-HNS Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Menière's disease: have they been applied in the published literature of the last decade? , 2003, Clinical otolaryngology and allied sciences.

[32]  S. Graham,et al.  Traumatic myositis ossificans of the levator scapulae muscle. , 1998, American journal of otolaryngology.

[33]  R. Daroff,et al.  Therapy for benign paroxysmal positioning vertigo, revisited , 1994, Neurology.

[34]  S. Whitney,et al.  Efficacy of vestibular rehabilitation. , 2000, Otolaryngologic clinics of North America.

[35]  D. Balatsouras,et al.  Diagnostic, Pathophysiologic, and Therapeutic Aspects of Benign Paroxysmal Positional Vertigo , 2004, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[36]  Y. Melamed,et al.  Nonspecific vertigo with normal otoneurological examination. The role of vestibular laboratory tests , 1996, The Journal of Laryngology & Otology.

[37]  John C. Li,et al.  Cost-Effective Management of bEnign Positional Vertigo Using Canalith Repositioning , 2000, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[38]  J. Lopez-Escamez,et al.  Long-term outcome and health-related quality of life in benign paroxysmal positional vertigo , 2005, European Archives of Oto-Rhino-Laryngology and Head & Neck.

[39]  E Kentala,et al.  Characteristics of six otologic diseases involving vertigo. , 1996, The American journal of otology.

[40]  R. McGlinchey,et al.  The anticholinergic risk scale and anticholinergic adverse effects in older persons. , 2008, Archives of internal medicine.

[41]  Samy Suissa,et al.  Benzodiazepines and elderly drivers: a comparison of pharmacoepidemiological study designs , 2007, Pharmacoepidemiology and drug safety.

[42]  W. Krueger,et al.  Anterior Canal Benign Paroxysmal Positional Vertigo: An Underappreciated Entity , 2007, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[43]  Neil Cherian,et al.  Canalith Repositioning for Benign Paroxysmal Positional Vertigo , 2005, Otology and Neurotology.

[44]  J. Goebel,et al.  Migraine-associated Dizziness: Patient Characteristics and Management Options , 2002, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[45]  M. Russolo,et al.  360-Degree Canalith Repositioning Procedure for the Horizontal Canal , 2004, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[46]  Juliana Maria Gazzola,et al.  Circunstâncias e consequências de quedas em idosos com vestibulopatia crônica , 2006 .

[47]  H. Cohen Side-Lying as an Alternative to the Dix-Hallpike Test of the Posterior Canal , 2004, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[48]  M. Tinetti,et al.  Fall risk index for elderly patients based on number of chronic disabilities. , 1986, The American journal of medicine.

[49]  G. Magliulo,et al.  Benign paroxysmal positional vertigo and post-treatment quality of life , 2005, European Archives of Oto-Rhino-Laryngology and Head & Neck.

[50]  S. Cass,et al.  Short- and long-term outcomes of canalith repositioning for benign paroxysmal positional vertigo , 2000, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[51]  H. Ishinaga,et al.  Long-term outcome of benign paroxysmal positional vertigo , 2003, Neurology.

[52]  S. Génieys Troubles de l'équilibre chez le sujet âgé , 2007 .

[53]  H. Neuhauser Epidemiology of vertigo , 2007, Current opinion in neurology.

[54]  H. Neuhauser,et al.  Epidemiology of vertigo, migraine and vestibular migraine , 2009, Journal of Neurology.

[55]  L. J. Teixeira,et al.  Maneuvers for the treatment of benign positional paroxysmal vertigo: a systematic review , 2015, Brazilian journal of otorhinolaryngology.

[56]  J. Goebel,et al.  The Meaning of the Word “Vertigo” , 2001, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[57]  F. O. Black,et al.  Postural Disturbance in Patients with Benign Paroxysmal Positional Nystagmus , 1984, The Annals of otology, rhinology, and laryngology.

[58]  A. Uneri Migraine and Benign Paroxysmal Positional Vertigo: An Outcome Study of 476 Patients , 2004, Ear, nose, & throat journal.

[59]  D. Vibert,et al.  Benign Paroxysmal Positional Vertigo in Older Women May be Related to Osteoporosis and Osteopenia , 2003, The Annals of otology, rhinology, and laryngology.

[60]  S. W. Denholm,et al.  Benign paroxysmal positional vertigo. , 1993, BMJ.

[61]  T. Frohman,et al.  Vertigo in MS: Utility of positional and particle repositioning maneuvers , 2000, Neurology.

[62]  S. Marzo,et al.  Diagnosis and Management of Post‐Traumatic Vertigo , 2004, The Laryngoscope.

[63]  A. Detsky Sources of bias for authors of clinical practice guidelines , 2006, Canadian Medical Association Journal.

[64]  R. Baloh,et al.  Vertigo of vascular origin. Clinical and electronystagmographic features in 84 cases. , 1989, Archives of neurology.

[65]  S. Herdman Advances in the treatment of vestibular disorders. , 1997, Physical therapy.

[66]  G. Garaventa,et al.  Effect of repetition of Semont's manoeuvre on benign paroxysmal positional vertigo of posterior semicircular canal. , 2003, Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale.

[67]  A. Beckers,et al.  Benign Paroxysmal Positional Vertigo in the Elderly: Treatment by Habituation Exercises , 1988, Journal of the American Geriatrics Society.

[68]  J A McClure,et al.  Free‐Floating endolymph particles: A new operative finding during posterior semicircular canal occlusion , 1992, The Laryngoscope.

[69]  F. Barbone,et al.  Association of road-traffic accidents with benzodiazepine use , 1998, The Lancet.

[70]  J. Bergenius,et al.  Vestibular neuritis: a follow-up study. , 1999, Acta oto-laryngologica.

[71]  U S Nayak,et al.  Balance in elderly patients: the "get-up and go" test. , 1986, Archives of physical medicine and rehabilitation.

[72]  Yea-Ru Yang,et al.  Balance Ability in Patients with Benign Paroxysmal Positional Vertigo , 2006, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[73]  R. Baloh,et al.  The Dix‐Hallpike Test and The Canalith Repositioning Maneuver , 2005, The Laryngoscope.

[74]  Saumil N Merchant,et al.  Clinical, Experimental, and Theoretical Investigations of the Effect of Superior Semicircular Canal Dehiscence on Hearing Mechanisms , 2004, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[75]  E Vitte,et al.  Curing the BPPV with a liberatory maneuver. , 1988, Advances in oto-rhino-laryngology.

[76]  N. Shepard,et al.  Programmatic Vestibular Rehabilitation , 1995, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[77]  O. Guntinas-Lichius Acute vestibular syndrome. , 1999, The New England journal of medicine.

[78]  E. Skargren,et al.  Effects of home training and additional physical therapy on recovery after acute unilateral vestibular loss- a randomized study , 2005, Clinical rehabilitation.

[79]  A. Vinik,et al.  Clinical manifestations and current treatment options for diabetic neuropathies. , 2007, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[80]  S. Angeli,et al.  Systematic Approach to Benign Paroxysmal Positional Vertigo in the Elderly , 2003, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[81]  D. Pinder,et al.  The Epley (canalith repositioning) manoeuvre for benign paroxysmal positional vertigo. , 2002, The Cochrane database of systematic reviews.

[82]  H. Neuhauser,et al.  Epidemiology of benign paroxysmal positional vertigo: a population based study , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[83]  Thomas Brandt,et al.  Phobic Postural Vertigo , 1996, Neurology.

[84]  B. Cakır,et al.  Efficacy of postural restriction in treating benign paroxysmal positional vertigo. , 2006, Archives of otolaryngology--head & neck surgery.

[85]  G. Caruso,et al.  Epidemiological Data from 2270 PPV Patients , 2005 .

[86]  Gaye W. Cronin,et al.  Effectiveness of Treatment Techniques in 923 Cases of Benign Paroxysmal Positional Vertigo , 2005, The Laryngoscope.

[87]  R. Baloh,et al.  Isolated dizziness in vertebrobasilar insufficiency: Clinical features, angiography, and follow-up. , 1994, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[88]  L. Crevits A liberatory maneuver for the treatment of horizontal canal paroxysmal positional vertigo. , 2002, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[89]  I. Sayin,et al.  What Is the True Incidence of Horizontal Semicircular Canal Benign Paroxysmal Positional Vertigo? , 2006, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[90]  R. Baloh Clinical practice. Vestibular neuritis. , 2003, The New England journal of medicine.

[91]  M. Hoffer,et al.  Characterizing and Treating Dizziness after Mild Head Trauma , 2004, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[92]  J. D. Hood,et al.  Neuro-otological manifestations of migraine. , 1984, Brain : a journal of neurology.

[93]  S. Massingale,et al.  Variables Affecting Treatment in Benign Paroxysmal Positional Vertigo , 2000, The Laryngoscope.

[94]  L. Rubenstein Falls in older people: epidemiology, risk factors and strategies for prevention. , 2006, Age and ageing.

[95]  R. Tusa,et al.  Practice Parameter: Therapies for benign paroxysmal positional vertigo (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of NeurologySYMBOLSYMBOLSYMBOL , 2008, Neurology.

[96]  S. Herdman,et al.  Vestibular rehabilitation of patients with vestibular hypofunction or with benign paroxysmal positional vertigo. , 2000, Current opinion in neurology.

[97]  Richard N Shiffman,et al.  Clinical Practice Guidelines: A Manual for Developing Evidence-Based Guidelines to Facilitate Performance Measurement and Quality Improvement , 2006, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[98]  P. Fransson,et al.  Passive sustained turning of the head induces asymmetric gain of the vestibulo-ocular reflex in healthy subjects. , 1998, Acta oto-laryngologica.

[99]  D. Sherman,et al.  Treatment outcomes of benign paroxysmal positional vertigo. , 2001, The Journal of otolaryngology.

[100]  J E DeLozier,et al.  National Ambulatory Medical Care Survey: 1989 summary. , 1991, Advance data.

[101]  M. Heinrichs,et al.  Neuroendocrine mechanisms of stress and social interaction: implications for mental disorders , 2007, Current opinion in psychiatry.

[102]  T. Hain,et al.  Pharmacological Treatment of Vertigo , 2003, CNS drugs.

[103]  G. Paludetti,et al.  Postural control in benign paroxysmal positional vertigo before and after recovery. , 1998, Acta oto-laryngologica.

[104]  H. Cohen,et al.  Effectiveness of Treatments for Benign Paroxysmal Positional Vertigo of the Posterior Canal , 2005, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[105]  R. Tusa,et al.  Assessment: Vestibular testing techniques in adults and children , 2000, Neurology.

[106]  Gaye W. Cronin,et al.  Comparison of the Canalith Repositioning Procedure and Vestibular Habituation Training in Forty Patients with Benign Paroxysmal Positional Vertigo , 1996, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[107]  H. Jenkins,et al.  Cost‐Effectiveness of the Diagnostic Evaluation of Vertigo , 1999, The Laryngoscope.

[108]  H. Cohen,et al.  Treatment variations on the Epley maneuver for benign paroxysmal positional vertigo. , 2004, American journal of otolaryngology.

[109]  S. Cass,et al.  Short- and Long-Term Outcomes of Canalith Repositioning for Benign Paroxysmal Positional Vertigo , 2000 .

[110]  N. Panda,et al.  Efficacy of particle repositioning maneuver in BPPV: a prospective study. , 2003, American journal of otolaryngology.

[111]  M. Bance,et al.  Experience from a multidisciplinary "dizzy" clinic. , 2000, The American journal of otology.

[112]  L. Luxon,et al.  Dizziness following head injury: A neuro-otological study , 1995, Journal of Neurology.

[113]  F. Salvinelli,et al.  Benign paroxysmal positional vertigo: a comparative prospective study on the efficacy of Semont's maneuver and no treatment strategy. , 2003, La Clinica terapeutica.

[114]  S. Lord,et al.  Atypical Antipsychotic Medications and Risk of Falls in Residents of Aged Care Facilities , 2005, Journal of the American Geriatrics Society.

[115]  N. Shepard,et al.  Update on vestibular rehabilitation therapy. , 1996, Otolaryngologic clinics of North America.

[116]  Yea-Ru Yang,et al.  Balance improvement in patients with benign paroxysmal positional vertigo , 2008, Clinical rehabilitation.

[117]  Ronald H Labuguen,et al.  Initial evaluation of vertigo. , 2006, American family physician.

[118]  L. Minor,et al.  Symptoms and Signs in Superior Canal Dehiscence Syndrome , 2001, Annals of the New York Academy of Sciences.

[119]  M. Gagliardi,et al.  Repositioning Maneuver for the Treatment of the Apogeotropic Variant of Horizontal Canal Benign Paroxysmal Positional Vertigo , 2005, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[120]  R. Baloh,et al.  Paroxysmal positional vertigo syndrome. , 1999, The American journal of otology.

[121]  David A. Froehling,et al.  The canalith repositioning procedure for the treatment of benign paroxysmal positional vertigo: a randomized controlled trial. , 2000, Mayo Clinic proceedings.

[122]  P. Pagnini,et al.  Treatment of horizontal semicircular canal benign paroxysmal positional vertigo. , 1997, Journal of vestibular research : equilibrium & orientation.

[123]  M. Cesari,et al.  Anticholinergic Drugs and Physical Function Among Frail Elderly Population , 2007, Clinical pharmacology and therapeutics.

[124]  P. Westerhuis,et al.  The International Classification of Headache Disorders (2nd ed.) , 2004 .

[125]  J. Richardson Factors Associated With Falls in Older Patients With Diffuse Polyneuropathy , 2002, Journal of the American Geriatrics Society.

[126]  C. Hollenbeak,et al.  Mastoid Oscillation in Canalith Repositioning for Paroxysmal Positional Vertigo , 2001, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[127]  T. Hain,et al.  Pharmacologic treatment of persons with dizziness. , 2005, Neurologic clinics.

[128]  N. Takeda,et al.  Natural course of the remission of vertigo in patients with benign paroxysmal positional vertigo , 2005, Neurology.

[129]  David M. Eddy,et al.  A Manual for Assessing Health Practices & Designing Practice Policies: The Explicit Approach , 1992 .

[130]  J. Furman,et al.  Panic, agoraphobia, and vestibular dysfunction. , 1996, The American journal of psychiatry.

[131]  T. Murofushi,et al.  The outcome of the canalith repositioning procedure for benign paroxysmal positional vertigo: are there any characteristic features of treatment failure cases? , 2001, Acta oto-laryngologica. Supplementum.

[132]  T. Fife Recognition and management of horizontal canal benign positional vertigo. , 1998, The American journal of otology.

[133]  R. Baloh,et al.  Cerebellar infarction presenting isolated vertigo , 2006, Neurology.

[134]  R. Baloh,et al.  Horizontal semicircular canal variant of benign positional vertigo , 1993, Neurology.

[135]  C. Millikan,et al.  Vertigo of vascular origin. , 1990, Archives of neurology.

[136]  L. Pollak,et al.  Effectiveness of the Particle Repositioning Maneuver in Benign Paroxysmal Positional Vertigo with and without Additional Vestibular Pathology , 2002, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[137]  G. Asprella Libonati Diagnostic and treatment strategy of lateral semicircular canal canalolithiasis. , 2005, Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale.

[138]  J. Kronenberg,et al.  Epley's manoeuvre for benign paroxysmal positional vertigo: a prospective study. , 1999, Clinical otolaryngology and allied sciences.

[139]  H. Neuhauser,et al.  Short-term efficacy of Epley’s manoeuvre: a double-blind randomised trial , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[140]  J. Newton,et al.  Benign paroxysmal positional vertigo: clinical characteristics of dizzy patients referred to a Falls and Syncope Unit. , 2005, QJM : monthly journal of the Association of Physicians.

[141]  J. Lopez-Escamez,et al.  [Meta-analysis of the treatment of benign paroxysmal positional vertigo by Epley and Semont maneuvers]. , 1999, Acta otorrinolaringologica espanola.

[142]  T. MacDonald,et al.  Association of road-traffic accidents with benzodiazepine use , 1998, The Lancet.

[143]  F. Charbel,et al.  The Chiari I Malformation and the Neurotologist , 2002, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[144]  H. Jenkins,et al.  Unrecognized Benign Paroxysmal Positional Vertigo in Elderly Patients , 2000, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[145]  P. Catalano,et al.  Diagnosis and Management of Lateral Semicircular Canal Benign Paroxysmal Positional Vertigo , 2005, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[146]  Juliana Maria Gazzola,et al.  Caracterização clínica de idosos com disfunção vestibular crônica , 2006 .

[147]  R. Bernabei,et al.  Treatment of Benign Positional Vertigo in the Elderly: A Randomized Trial , 2004, The Laryngoscope.

[148]  V. Honrubia Self-treatment of benign paroxysmal positional vertigo: Semont maneuver vs Epley procedure , 2005, Neurology.

[149]  Beynon Gj,et al.  Recurrence of symptoms following treatment of posterior semicircular canal benign positional paroxysmal vertigo with a particle repositioning manoeuvre. , 2000 .

[150]  R. Tusa,et al.  The effect of the canalith repositioning maneuver on resolving postural instability in patients with benign paroxysmal positional vertigo. , 2000, The American journal of otology.

[151]  Robert J. Brey,et al.  Randomized Trial of the Canalith Repositioning Procedure , 1995, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[152]  Hui-ling Lee,et al.  A Single Therapy for All Subtypes of Horizontal Canal Positional Vertigo , 2005, The Laryngoscope.

[153]  J. Koo,et al.  Nystagmus during neck flexion in the pitch plane in benign paroxysmal positional vertigo involving the horizontal canal , 2007, Journal of the Neurological Sciences.

[154]  J. Lopez-Escamez,et al.  Impact of Treatment on Health-Related Quality of Life in Patients with Posterior Canal Benign Paroxysmal Positional Vertigo , 2003, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[155]  F. Cooksey,et al.  Rehabilitation in Vestibular Injuries , 1946, Proceedings of the Royal Society of London. Series B, Biological sciences.

[156]  P Rudge,et al.  Positional down beating nystagmus in 50 patients: cerebellar disorders and possible anterior semicircular canalithiasis , 2002, Journal of neurology, neurosurgery, and psychiatry.

[157]  Lindsey M Tilling,et al.  Falls as a complication of diabetes mellitus in older people. , 2006, Journal of diabetes and its complications.

[158]  G. Banfield,et al.  Does vestibular habituation still have a place in the treatment of benign paroxysmal positional vertigo? , 2000, The Journal of laryngology and otology.

[159]  M. Gufoni,et al.  [Repositioning maneuver in benign paroxysmal vertigo of horizontal semicircular canal]. , 1998, Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale.

[160]  A. Håkansson,et al.  Benign Paroxysmal Positional Vertigo among Elderly Patients in Primary Health Care , 2005, Gerontology.

[161]  C. S. Hallpike,et al.  The Pathology, Symptomatology and Diagnosis of Certain Common Disorders of the Vestibular System , 1952, Proceedings of the Royal Society of Medicine.

[162]  Richard A. Roberts,et al.  Treatment of benign paroxysmal positional vertigo: necessity of postmaneuver patient restrictions. , 2005, Journal of the American Academy of Audiology.

[163]  R. Haynes,et al.  Optimal search strategies for retrieving systematic reviews from Medline: analytical survey , 2004, BMJ : British Medical Journal.

[164]  E. Sargent,et al.  Success of posterior semicircular canal occlusion and application of the dizziness handicap inventory. , 2005, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[165]  S. Berrettini,et al.  The Treatment of Horizontal Canal Positional Vertigo: Our Experience in 66 Cases , 2002, The Laryngoscope.

[166]  T. O'dowd,et al.  A systematic review of vertigo in primary care. , 2001, The British journal of general practice : the journal of the Royal College of General Practitioners.

[167]  B. E. Maki,et al.  Measuring balance in the elderly: validation of an instrument. , 1992, Canadian journal of public health = Revue canadienne de sante publique.

[168]  Erna Kentala,et al.  A Practical Assessment Algorithm for Diagnosis of Dizziness , 2003, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[169]  U. Rosenhall,et al.  Prevalence of dizziness and vertigo in an urban elderly population. , 2004, Journal of Vestibular Research-Equilibrium & Orientation.

[170]  S. Imbaud Genieys [Vertigo, dizziness and falls in the elderly]. , 2007, Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris.

[171]  A. Duprat,et al.  A combined approach for the treatment of cervical vertigo. , 2000, Journal of manipulative and physiological therapeutics.

[172]  John M. Epley,et al.  The Canalith Repositioning Procedure: For Treatment of Benign Paroxysmal Positional Vertigo , 1992, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[173]  L. Hall,et al.  Magnetic resonance imaging of the brain and brain-stem in elderly patients with dizziness. , 1990, Age and ageing.

[174]  M. B. Gillespie In response to The canalith repositioning procedure for benign positional vertigo: A meta‐analysis , 2011, The Laryngoscope.

[175]  J. Touchon,et al.  Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study , 2006, BMJ : British Medical Journal.

[176]  M. Tinetti,et al.  Risk factors for falls among elderly persons living in the community. , 1988, The New England journal of medicine.

[177]  Y. Choung,et al.  ‘Bow and Lean Test’ to Determine the Affected Ear of Horizontal Canal Benign Paroxysmal Positional Vertigo , 2006, The Laryngoscope.

[178]  J. Phillips,et al.  The role of the vestibular assessment. , 2009, The Journal of laryngology and otology.

[179]  A. Clarke,et al.  Acute migrainous vertigo: clinical and oculographic findings. , 2004, Brain : a journal of neurology.

[180]  H. Cohen,et al.  Benign Paroxysmal Positional Vertigo and Comorbid Conditions , 2004, ORL.

[181]  D. Welling,et al.  Intracranial Tumors Mimicking Benign Paroxysmal Positional Vertigo , 1996, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[182]  L. J. Teixeira,et al.  Manobras para o tratamento da vertigem posicional paroxística benigna: revisão sistemática da literatura , 2006 .

[183]  R. Labadie,et al.  Treatment of Benign Positional Vertigo Using the Semont Maneuver: Efficacy in Patients Presenting Without Nystagmus , 2002, The Laryngoscope.

[184]  A. Detsky,et al.  Relationships between authors of clinical practice guidelines and the pharmaceutical industry. , 2002, JAMA.

[185]  L. Crevits,et al.  Benign paroxysmal positional vertigo of the horizontal canal. , 1996, Journal of neurology, neurosurgery, and psychiatry.

[186]  F. O. Black,et al.  Effects of Vestibular Rehabilitation on Dizziness and Imbalance , 1992, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[187]  Thomas Lempert,et al.  A Positional Maneuver for Treatment of Horizontal‐Canal Benign Positional Vertigo , 1996, The Laryngoscope.

[188]  K. Mizukoshi,et al.  Quantitative analysis of the visual vestibulo-ocular reflex using sinusoidal rotation in patients with peripheral vestibular disorders. , 1984, Acta oto-laryngologica. Supplementum.

[189]  B. Troost,et al.  Exercise therapy for positional vertigo , 1992, Neurology.

[190]  H. Neuhauser,et al.  The interrelations of migraine, vertigo, and migrainous vertigo , 2001, Neurology.

[191]  J. Byles,et al.  A Quality Use of Medicines program for general practitioners and older people: a cluster randomised controlled trial , 2007, The Medical journal of Australia.

[192]  Sumit K Agrawal,et al.  Diagnosis and management of benign paroxysmal positional vertigo (BPPV). , 2003, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[193]  David A. Froehling,et al.  Benign positional vertigo: incidence and prognosis in a population-based study in Olmsted County, Minnesota. , 1991, Mayo Clinic proceedings.

[194]  Sirpa Hartikainen,et al.  Medication as a risk factor for falls: critical systematic review. , 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

[195]  C. Newman,et al.  When paroxysmal positioning vertigo isn't benign. , 1995, Journal of the American Academy of Audiology.

[196]  J. Hornibrook Horizontal Canal Benign Positional Vertigo , 2004, The Annals of otology, rhinology, and laryngology.

[197]  Richard A. Roberts,et al.  Utility Measures of Health-Related Quality of Life in Patients Treated for Benign Paroxysmal Positional Vertigo , 2009, Ear and hearing.

[198]  T. Lempert,et al.  Benign Paroxysmal Positional Vertigo: Current Status of Medical Management , 2004, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[199]  B. Mokri,et al.  Meniere's disease: A 30‐Year epidemiologic and clinical study in rochester, mn, 1951‐1980. , 1984, The Laryngoscope.

[200]  Anders Engeland,et al.  Risk of road traffic accidents associated with the prescription of drugs: a registry-based cohort study. , 2007, Annals of epidemiology.

[201]  Michael C Schubert,et al.  Disorders of balance and vestibular function in US adults: data from the National Health and Nutrition Examination Survey, 2001-2004. , 2009, Archives of internal medicine.

[202]  M. Malkoff,et al.  Isolated vertigo as a manifestation of vertebrobasilar ischemia , 1996, Neurology.

[203]  E. Prokopakis,et al.  Benign Paroxysmal Positional Vertigo: 10‐Year Experience in Treating 592 Patients with Canalith Repositioning Procedure , 2005, The Laryngoscope.

[204]  M. Perracini,et al.  Circumstances and consequences of falls in elderly people with vestibular disorder , 2006, Brazilian journal of otorhinolaryngology.

[205]  V. Rupa Persistent vertigo following particle repositioning maneuvers: an analysis of causes. , 2004, Archives of otolaryngology--head & neck surgery.

[206]  P A Dekker-de Kiefte,et al.  Diagnosis and Treatment , 2020, Diabetes.

[207]  R B Daroff,et al.  Physical therapy for benign paroxysmal positional vertigo. , 1980, Archives of otolaryngology.

[208]  H. Neuhauser,et al.  A modified Epley’s procedure for self-treatment of benign paroxysmal positional vertigo , 1999, Neurology.

[209]  M. Arriaga,et al.  Benign Positional Vertigo: Prognostic Factors , 2004, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[210]  E. Kentala,et al.  Vertigo in Patients with Benign Paroxysmal Positional Vertigo , 2000, Acta oto-laryngologica. Supplementum.

[211]  D. Passali,et al.  The management of horizontal-canal paroxysmal positional vertigo. , 1998, Acta oto-laryngologica.

[212]  J. Mullol,et al.  H1 antihistamines: psychomotor performance and driving. , 2006, Journal of investigational allergology & clinical immunology.

[213]  Jose A. Lopez-Escamez,et al.  Health-Related Quality of Life in Patients over Sixty Years Old with Benign Paroxysmal Positional Vertigo , 2004, Gerontology.

[214]  T. Carlow Medical treatment of nystagmus and ocular motor disorders. , 1986, International ophthalmology clinics.

[215]  J. Wilson,et al.  Evaluation of investigations to diagnose the cause of dizziness in elderly people: a community based controlled study , 1996, BMJ.

[216]  Richard A. Roberts,et al.  Prevalence of vestibulopathy in benign paroxysmal positional vertigo patients with and without prior otologic history Prevalencia de vestibulopatía en pacientes con vértigo postural paroxístico benigno (BPPV), con y sin historia previa de patología otológica , 2005, International journal of audiology.

[217]  R. Baloh,et al.  Dizziness: neurological emergencies. , 1998, Neurologic clinics.

[218]  M. Redfern,et al.  Vestibulo-ocular function in anxiety disorders. , 2007, Journal of vestibular research : equilibrium & orientation.

[219]  L. Proctor,et al.  Benign Paroxysmal Positional Vertigo , 1997, The Laryngoscope.

[220]  J. Nedzelski,et al.  Diagnoses in a dizziness unit. , 1986, The Journal of otolaryngology.

[221]  Norré Me Reliability of examination data in the diagnosis of benign paroxysmal positional vertigo , 1995 .

[222]  Aniruddha M. Deshpande,et al.  Standardized Reporting of Clinical Practice Guidelines: A Proposal from the Conference on Guideline Standardization , 2003, Annals of Internal Medicine.

[223]  K. Tokumasu,et al.  Vestibular training for benign paroxysmal positional vertigo. Its efficacy in comparison with antivertigo drugs. , 1994, Archives of otolaryngology--head & neck surgery.

[224]  C. Powers,et al.  Quality Indicators for the Management and Prevention of Falls and Mobility Problems in Vulnerable Elders , 2001, Annals of Internal Medicine.

[225]  K. Snidvongs,et al.  Canalith Repositioning for Benign Paroxysmal Positional Vertigo: A Randomized, Controlled Trial , 2000, Ear, nose, & throat journal.

[226]  G. Magliulo,et al.  Physical treatment of horizontal canal benign positional vertigo , 2007, European Archives of Oto-Rhino-Laryngology.

[227]  J. Lopez-Escamez,et al.  [Diagnosis of common causes of vertigo using a structured clinical history]. , 2000, Acta otorrinolaringologica espanola.

[228]  K. Yimtae,et al.  A Randomized Trial of the Canalith Repositioning Procedure , 2003, The Laryngoscope.

[229]  K. Hanley,et al.  Symptoms of vertigo in general practice: a prospective study of diagnosis. , 2002, The British journal of general practice : the journal of the Royal College of General Practitioners.

[230]  M. Alessandrini,et al.  Long-Term Postural Abnormalities in Benign Paroxysmal Positional Vertigo , 2002, ORL.

[231]  L. Özlüoğlu,et al.  The canalith repositioning maneuver in patients with benign positional vertigo , 2000, European Archives of Oto-Rhino-Laryngology.

[232]  Terry D Fife Benign paroxysmal positional vertigo. , 2009, Seminars in neurology.

[233]  Martti Juhola,et al.  Discovering Diagnostic Rules from a Neurotologic Database with Genetic Algorithms , 1999, The Annals of otology, rhinology, and laryngology.

[234]  Vestibular falls. , 1993, Journal of vestibular research : equilibrium & orientation.

[235]  J. Masdeu,et al.  Vertigo and hearing loss. American College of Radiology. ACR Appropriateness Criteria. , 2000, Radiology.

[236]  Thomas Lempert,et al.  Vertigo: epidemiologic aspects. , 2009, Seminars in neurology.

[237]  S. Kim,et al.  The results of vestibular evoked myogenic potentials, with consideration of age-related changes, in vestibular neuritis, benign paroxysmal positional vertigo, and Meniere's disease. , 2008, Acta oto-laryngologica.

[238]  B. Blakley A Randomized, Controlled Assessment of the Canalith Repositioning Maneuver , 1994, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[239]  S. Whitney,et al.  Usefulness of the Dizziness Handicap Inventory in the Screening for Benign Paroxysmal Positional Vertigo , 2005, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.