Noninvasive estimation of pressure difference of left and right ventricle based on young — Laplace model

The paper proposes a mathematical model about the relationship between the curvature radius changes of interventricular septal configuration and the pressure difference of left and right ventricular based on Young-Laplace model. The method of noninvasive detection of pressure difference of left and right ventricular is discussed. In this paper a ventricular model which can simulate the deformation of interventricular septal configuration in differential pressure is designed and produced. After scanning the ventricular model by CT, the boundary of the ventricular model is extracted and the curvature radius of the boundary is calculated. Software ANSYS is used to simulate the curvature of the ventricular septum model and verify the experiment. Then a relationship between the deformation of ventricular septum and the pressure difference of ventricle was established by the Hooke's law combined with the modified Young-Laplace model. After the verification, the modified Young-Laplace model can be applied to estimate pressure difference in ventricle. This paper contributes the development of noninvasive medical diagnosis of abnormal ventricular pressure.