High prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic Hispanics

In this study, we estimated the prevalence of Helicobacter pylori infection and histologic gastritis in 58 asymptomatic Hispanic adult volunteers (mean age, 41 years; 59% male) by endoscopic biopsy of the upper gastrointestinal tract. Forty-six subjects (79%) were found to harbor H. pylori in gastric biopsies, and all had histologic gastritis. Four other subjects were found to have gastritis in the absence of H. pylori. Similar prevalences of H. pylori and gastritis were noted in all age groups and also in American-born and immigrant Hispanics. Biopsy data and serologic studies of H. pylori antibodies correlated well. We conclude that H. pylori infection is an almost universal finding in the gastric mucosa of asymptomatic adult Hispanics, regardless of age. The clinical significance of these findings is unknown, but we speculate that H. pylori and its associated gastritis could have a role in the high incidence of gastric carcinoma in Hispanic populations.

[1]  C. Pope,et al.  Histological consequences of gastroesophageal reflux in man. , 1970, Gastroenterology.

[2]  J. Barthel,et al.  Gastritis and Campylobacter pylori in healthy, asymptomatic volunteers. , 1988, Archives of internal medicine.

[3]  D. Morgan,et al.  Nitrofurans in the treatment of gastritis associated with Campylobacter pylori. The Gastrointestinal Physiology Working Group of Cayetano Heredia and The Johns Hopkins Universities. , 1988, Gastroenterology.

[4]  C. Dooley,et al.  The clinical significance of Campylobacter pylori. , 1988, Annals of internal medicine.

[5]  B. Marshall,et al.  PROSPECTIVE DOUBLE-BLIND TRIAL OF DUODENAL ULCER RELAPSE AFTER ERADICATION OF CAMPYLOBACTER PYLORI , 1988, The Lancet.

[6]  D. Graham,et al.  Effect of age on the frequency of active Campylobacter pylori infection diagnosed by the [13C]urea breath test in normal subjects and patients with peptic ulcer disease. , 1988, The Journal of infectious diseases.

[7]  M. Blaser,et al.  Seroprevalence of Helicobacter pylori infections in Thailand. , 1990, The Journal of infectious diseases.

[8]  D. Graham,et al.  Campylobacter pyloridis gastritis: the past, the present, and speculations about the future. , 1987, The American journal of gastroenterology.

[9]  R. Feldman.  Campylobacter pylori in gastritis and peptic ulcer disease , 1990 .

[10]  P. Correa,et al.  Gastric cancer in Colombia. III. Natural history of precursor lesions. , 1976, Journal of the National Cancer Institute.

[11]  M. Collins,et al.  Transfer of Campylobacter pylori and Campylobacter mustelae to Helicobacter gen. nov. as Helicobacter pylori comb. nov. and Helicobacter mustelae comb. nov., Respectively , 1989 .

[12]  M. Siurala.  Gastritis, its fate and sequelae. , 1981, Annals of clinical research.

[13]  M. Blaser,et al.  Campylobacter pylori antibodies in humans. , 1988, Annals of internal medicine.

[14]  H. Zanen,et al.  Campylobacter pyloridis-associated chronic active antral gastritis. A prospective study of its prevalence and the effects of antibacterial and antiulcer treatment. , 1988, Gastroenterology.

[15]  M. Blaser.  Helicobacter pylori and the pathogenesis of gastroduodenal inflammation. , 1990, The Journal of infectious diseases.

[16]  F. Mégraud,et al.  Seroepidemiology of Campylobacter pylori infection in various populations , 1989, Journal of clinical microbiology.

[17]  D. Graham,et al.  N-acetylneuraminyllactose-binding fibrillar hemagglutinin of Campylobacter pylori: a putative colonization factor antigen , 1988, Infection and immunity.

[18]  M. Blaser,et al.  Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. , 1989, The New England journal of medicine.

[19]  J. Morris,et al.  Seroprevalence of Helicobacter pylori in Seventh-Day Adventists and other groups in Maryland. Lack of association with diet. , 1990, Archives of internal medicine.

[20]  B. Marshall,et al.  Pyloric Campylobacter infection and gastroduodenal disease , 1985, The Medical journal of Australia.

[21]  C. O'Morain,et al.  CAMPYLOBACTER PYLORI AND RECURRENCE OF DUODENAL ULCERS— A 12-MONTH FOLLOW-UP STUDY , 1987, The Lancet.