The differential effects of haloperidol and methamphetamine on time estimation in the rat

Forty rats were trained to make a left lever response if a signal (white noise) was 2.5s and to make a right lever response if the signal was 6.3s. When seven intermediate signal durations, to which responses were not reinforced, were randomly interspersed the probability of a right-lever (‘long’) response increased as a function of signal duration. Methamphetamine shifted this psychometric function leftward and decreased its slope: haloperidol also decreased the slope but shifted the function rightward. A combination of haloperidol and methamphetamine led to a function similar to the saline control function. The leftward shift probably reflects an increase in the speed of an internal clock, and the rightward shift probably reflects a decrease in its speed. Since methamphetamine releases several catecholamines, including dopamine, and haloperidol blocks dopamine receptors, it is plausible that the horizontal location of the psychometric function (the speed of the clock) is related to the effective level of dopamine.

[1]  E. Segal.  Effects of dl-amphetamine under concurrent VI DRL reinforcement. , 1962, Journal of the experimental analysis of behavior.

[2]  T. Robbins,et al.  Amphetamine-induced disruption of temporal discrimination by response disinhibition. , 1973, Nature: New biology.

[3]  L. Gollub,et al.  A detailed analysis of the effects of d-amphetamine on behavior under fixed-interval schedules. , 1974, Journal of the experimental analysis of behavior.

[4]  R. Church,et al.  Bisection of temporal intervals. , 1977, Journal of experimental psychology. Animal behavior processes.

[5]  R. Ridley,et al.  An analysis of visual object reversal learning in the marmoset after amphetamine and haloperidol , 1981, Pharmacology Biochemistry and Behavior.

[6]  S. Roberts,et al.  Isolation of an internal clock. , 1981, Journal of experimental psychology. Animal behavior processes.

[7]  R. Church,et al.  Methamphetamine and time estimation. , 1981, Journal of experimental psychology. Animal behavior processes.

[8]  P. Cook,et al.  Dopaminergic mediation of the interoceptive cue produced by d-amphetamine in rats , 1975, Psychopharmacologia.

[9]  R. Wise,et al.  Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats , 1976, Psychopharmacology.

[10]  M. Key,et al.  Differential effects of chlordiazepoxide and d-amphetamine on responding maintained by a DRL schedule of reinforcement , 2004, Psychopharmacologia.