The effects of acute physical activity on severity of seizures induced in rats by homocysteine thiolactone

OBJECTIVES: The aim of this study was to determine the effects of acute, single boost of physical activity on seizures induced by homocysteine thiolactone in rats, using treadmill for small experimental animals as a paradigm of physical activity. MATERIAL AND METHODS: After adaptation to the treadmill, Wistar albino rats were randomly divided into acute physical activity and sedentary group. Animals from the acute physical activity group ran at the speed of 25 m/min for 30 min, while the sedentary group spent the same time in the treadmill with the speed of 0 m/min. Immediately after completion of the training, all animals were administered with the D, L homocysteine thiolactone at a dose of 5.5 mmol/kg, i.p. Convulsive behavior (incidence, severity, seizure latency and number of seizure episodes per rat) was observed during the next 90 min. RESULTS: After acute administration of homocysteine, the latency to the first seizure in trained group wasn’t significantly shortened, nor the number of convulsive episodes per rat ,compared to the sedentary group of animals. Also, there was no statistically significant difference between groups in the incidence and intensity of convulsive episodes. CONCLUSION: Based on the results of this study we can conclude that acute boost of physical activity does not potentiates seizures induced by homocysteine thiolactone in rat, what is a favorable conclusion for patients with epilepsy.

[1]  J. Pimentel,et al.  Epilepsy and physical exercise , 2015, Seizure.

[2]  M. Čolović,et al.  Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress , 2013, International Journal of Sports Medicine.

[3]  J. Brugada,et al.  Response to Letters Regarding Article, “Cardiac Arrhythmogenic Remodeling in a Rat Model of Long-Term Intensive Exercise Training” , 2011 .

[4]  Erdal Agar,et al.  Short-duration swimming exercise decreases penicillin-induced epileptiform ECoG activity in rats. , 2010, Acta neurobiologiae experimentalis.

[5]  Sérgio Gomes da Silva,et al.  The potential role of physical exercise in the treatment of epilepsy , 2010, Epilepsy & Behavior.

[6]  Djuro Macut,et al.  Two Types of Seizures in Homocysteine Thiolactone-Treated Adult Rats, Behavioral and Electroencephalographic Study , 2009, Cellular and Molecular Neurobiology.

[7]  G. Puntel,et al.  Swimming training prevents pentylenetetrazol‐induced inhibition of Na+, K+‐ATPase activity, seizures, and oxidative stress , 2009, Epilepsia.

[8]  K. Jöckel,et al.  Running: the risk of coronary events : Prevalence and prognostic relevance of coronary atherosclerosis in marathon runners. , 2008, European heart journal.

[9]  M. Sperling,et al.  Self-perception of seizure precipitants and their relation to anxiety level, depression, and health locus of control in epilepsy , 2008, Seizure.

[10]  Sérgio Gomes da Silva,et al.  Effects of different types of physical exercise on the staining of parvalbumin-positive neurons in the hippocampal formation of rats with epilepsy , 2007, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[11]  C. Bouchard,et al.  Effect of regular exercise on homocysteine concentrations: the HERITAGE Family Study , 2006, European Journal of Applied Physiology.

[12]  E. Wirrell,et al.  Physical Activity in Children/Teens with Epilepsy Compared with That in Their Siblings without Epilepsy , 2006, Epilepsia.

[13]  P. Sachdev.  Homocysteine and brain atrophy , 2005, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[14]  Mei-Hua Huang,et al.  Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging. , 2005, The American journal of medicine.

[15]  L. Hoffer.  Homocysteine remethylation and trans-sulfuration. , 2004, Metabolism: clinical and experimental.

[16]  F. Scorza,et al.  Physical training reverts hippocampal electrophysiological changes in rats submitted to the pilocarpine model of epilepsy , 2004, Physiology & Behavior.

[17]  N. Fountain,et al.  Epilepsy and athletics. , 2003, Clinics in sports medicine.

[18]  K M Kessler,et al.  Primary prevention of coronary heart disease in women through diet and lifestyle. , 2000, The New England journal of medicine.

[19]  L. Goldstein,et al.  Seizure precipitants and perceived self-control of seizures in adults with poorly-controlled epilepsy , 2000, Epilepsy Research.

[20]  J. Spatt,et al.  Subjective perception of seizure precipitants: results of a questionnaire study , 1998, Seizure.

[21]  B. McEwen,et al.  Chronic stress alters synaptic terminal structure in hippocampus. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[22]  M. Trimble,et al.  Stress and epilepsy , 1997 .

[23]  B. Steinhoff,et al.  Leisure Time Activity and Physical Fitness in Patients with Epilepsy , 1996, Epilepsia.

[24]  Y. Løyning,et al.  Physical Exercise in Women with Intractable Epilepsy , 1994, Epilepsia.

[25]  E. LaPlante,et al.  Seized: Temporal Lobe Epilepsy as a Medical, Historical, and Artistic Phenomenon , 1993 .

[26]  S. Johannessen,et al.  Effect of Physical Training on Aerobic Capacity, Seizure Occurrence, and Serum Level of Antiepileptic Drugs in Adults with Epilepsy , 1990, Epilepsia.

[27]  O. Lushnikov,et al.  [Psychophysiology of sports addiction (exercises addiction)]. , 2011, Fiziologiia cheloveka.

[28]  F. Scorza,et al.  Physical Activity and Epilepsy , 2008, Sports medicine.

[29]  M. Brodie,et al.  Quality of life and psychosocial development in adolescents with epilepsy: a qualitative investigation using focus group methods , 2004, Seizure.

[30]  Anson,et al.  DIET , LIFESTYLE , AND THE RISK OF TYPE 2 DIABETES MELLITUS IN WOMEN , 2001 .

[31]  Shapiro Js,et al.  Primary prevention of coronary heart disease in women through diet and lifestyle. , 2000, The New England journal of medicine.

[32]  B. Libet.  "Subjective perception". , 1990, Science.

[33]  G. Copinschi,et al.  EFFECT OF MUSCULAR EXERCISE ON THE PLASMA LEVEL CORTISOL IN MAN. , 1965, Acta endocrinologica.