Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

[1]  D. Borchelt,et al.  Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function , 2012, Neurobiology of Aging.

[2]  N. Sharpless.  Hot topics in stem cells and self‐renewal: 2010 , 2010, Aging cell.

[3]  C. Tirolo,et al.  Glia as a turning point in the therapeutic strategy of Parkinson's disease. , 2010, CNS & neurological disorders drug targets.

[4]  W. Streit,et al.  Microglial Activation and Neuroinflammation in Alzheimer's Disease: A Critical Examination of Recent History , 2010, Front. Ag. Neurosci..

[5]  A. Granholm,et al.  A dual-hit animal model for age-related parkinsonism , 2010, Progress in Neurobiology.

[6]  E. Arenas,et al.  Emerging roles of Wnts in the adult nervous system , 2010, Nature Reviews Neuroscience.

[7]  M. Sofroniew,et al.  Astrocytes: biology and pathology , 2009, Acta Neuropathologica.

[8]  V. Russell,et al.  Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency. , 2009, Parkinsonism & related disorders.

[9]  M. Schachner,et al.  Cross‐Talk Between Stem Cells and the Dysfunctional Brain is Facilitated by Manipulating the Niche: Evidence from an Adhesion Molecule , 2009, Stem cells.

[10]  M. Chesselet,et al.  Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease. , 2009, Free radical biology & medicine.

[11]  B. Song,et al.  Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS , 2009, The Journal of Neuroscience.

[12]  P. Monk,et al.  Astrocyte function and role in motor neuron disease: A future therapeutic target? , 2009, Glia.

[13]  T. Duka,et al.  α‐Synuclein contributes to GSK‐3β‐catalyzed Tau phosphorylation in Parkinson's disease models , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[14]  Yong Shen,et al.  Interruption of β-Catenin Signaling Reduces Neurogenesis in Alzheimer's Disease , 2009, The Journal of Neuroscience.

[15]  J. Cazareth,et al.  Involvment of Cytosolic and Mitochondrial GSK-3β in Mitochondrial Dysfunction and Neuronal Cell Death of MPTP/MPP+-Treated Neurons , 2009, PloS one.

[16]  K. Fabel,et al.  Rostro‐Caudal Gradual Loss of Cellular Diversity Within the Periventricular Regions of the Ventricular System , 2009, Stem cells.

[17]  E. Hirsch,et al.  Neuroinflammation in Parkinson's disease: a target for neuroprotection? , 2009, The Lancet Neurology.

[18]  M. Sikorska,et al.  Astrocyte-secreted GDNF and glutathione antioxidant system protect neurons against 6OHDA cytotoxicity , 2009, Neurobiology of Disease.

[19]  P. Gasque,et al.  The Multiple Roles of the Innate Immune System in the Regulation of Apoptosis and Inflammation in the Brain , 2009, Journal of neuropathology and experimental neurology.

[20]  Y. Kan,et al.  Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte , 2009, Proceedings of the National Academy of Sciences.

[21]  O. Lindvall,et al.  Brain inflammation and adult neurogenesis: The dual role of microglia , 2009, Neuroscience.

[22]  A. London,et al.  Boosting T-cell immunity as a therapeutic approach for neurodegenerative conditions: The role of innate immunity , 2009, Neuroscience.

[23]  M. Taketo,et al.  Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis , 2009, Nature Neuroscience.

[24]  D. D. Di Monte,et al.  Macrophage Antigen Complex-1 Mediates Reactive Microgliosis and Progressive Dopaminergic Neurodegeneration in the MPTP Model of Parkinson’s Disease1 , 2008, The Journal of Immunology.

[25]  A. Storch,et al.  Endogenous Regeneration in Parkinson's Disease: Do We Need Orthotopic Dopaminergic Neurogenesis? , 2008, Stem cells.

[26]  Enrique M. Toledo,et al.  Wnt signaling in neuroprotection and stem cell differentiation , 2008, Progress in Neurobiology.

[27]  N. Inestrosa,et al.  Frizzled‐1 is involved in the neuroprotective effect of Wnt3a against Aβ oligomers , 2008, Journal of cellular physiology.

[28]  Jau-Shyong Hong,et al.  Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. , 2008, Trends in immunology.

[29]  D. Chen,et al.  Induction of Neurogenesis in Nonconventional Neurogenic Regions of the Adult Central Nervous System by Niche Astrocyte‐Produced Signals , 2008, Stem cells.

[30]  K. Maiese,et al.  The Wnt signaling pathway: aging gracefully as a protectionist? , 2008, Pharmacology & therapeutics.

[31]  P. Mcgeer,et al.  Glial reactions in Parkinson's disease , 2008, Movement disorders : official journal of the Movement Disorder Society.

[32]  Y. Xing,et al.  A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function , 2008, The Journal of Neuroscience.

[33]  H. Okano,et al.  β‐Catenin Signaling Promotes Proliferation of Progenitor Cells in the Adult Mouse Subventricular Zone , 2007, Stem cells.

[34]  W. Streit,et al.  The effects of aging, injury and disease on microglial function: a case for cellular senescence. , 2007, Neuron glia biology.

[35]  K. Maiese,et al.  Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways. , 2007, Cellular signalling.

[36]  Yizheng Wang,et al.  Inhibition of glycogen synthase kinase-3β protects dopaminergic neurons from MPTP toxicity , 2007, Neuropharmacology.

[37]  Fumitaka Osakada,et al.  Wnt Signaling Promotes Regeneration in the Retina of Adult Mammals , 2007, The Journal of Neuroscience.

[38]  R. Jope,et al.  Glycogen Synthase Kinase-3 (GSK3): Inflammation, Diseases, and Therapeutics , 2007, Neurochemical Research.

[39]  Huaxi Xu,et al.  Phosphorylation of tau antagonizes apoptosis by stabilizing β-catenin, a mechanism involved in Alzheimer's neurodegeneration , 2007, Proceedings of the National Academy of Sciences.

[40]  S. Przedborski,et al.  Protocol for the MPTP mouse model of Parkinson's disease , 2007, Nature Protocols.

[41]  Gerd Kempermann,et al.  Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus , 2006, Neurobiology of Aging.

[42]  W. Wurst,et al.  Genetic networks controlling the development of midbrain dopaminergic neurons , 2006, The Journal of physiology.

[43]  R. Nusse,et al.  Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors* , 2006, Journal of Biological Chemistry.

[44]  F. Gage,et al.  Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. , 2006, Stem cells and development.

[45]  H. Okano,et al.  Dynamic temporal and cell type-specific expression of Wnt signaling components in the developing midbrain. , 2006, Experimental cell research.

[46]  M. Gerlach,et al.  Multipotent Neural Stem Cells from the Adult Tegmentum with Dopaminergic Potential Develop Essential Properties of Functional Neurons , 2006, Stem cells.

[47]  J. H. Kim,et al.  Increase in Proliferation and Differentiation of Neural Progenitor Cells Isolated from Postnatal and Adult Mice Brain by Wnt-3a and Wnt-5a , 2006, Molecular and Cellular Biochemistry.

[48]  C. Tirolo,et al.  Estrogen, neuroinflammation and neuroprotection in Parkinson’s disease: Glia dictates resistance versus vulnerability to neurodegeneration , 2006, Neuroscience.

[49]  H. Paudel,et al.  Over‐expression of heme oxygenase‐1 promotes oxidative mitochondrial damage in rat astroglia , 2006, Journal of cellular physiology.

[50]  N. Wood,et al.  Expanding insights of mitochondrial dysfunction in Parkinson's disease , 2006, Nature Reviews Neuroscience.

[51]  G. Castelo-Branco,et al.  Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion , 2006, Molecular and Cellular Neuroscience.

[52]  B. Fisher,et al.  Behavioral motor recovery in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐lesioned squirrel monkey (Saimiri sciureus): Changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteins , 2006, Journal of neuroscience research.

[53]  Yaniv Ziv,et al.  Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells , 2006, Molecular and Cellular Neuroscience.

[54]  Maria Speranza Desole,et al.  Hormones Are Key Actors in Gene X Environment Interactions Programming the Vulnerability to Parkinson's Disease: Glia as a Common Final Pathway , 2005, Annals of the New York Academy of Sciences.

[55]  Fred H. Gage,et al.  Wnt signalling regulates adult hippocampal neurogenesis , 2005, Nature.

[56]  B. Marchetti,et al.  To be or not to be (inflamed)--is that the question in anti-inflammatory drug therapy of neurodegenerative disorders? , 2005, Trends in pharmacological sciences.

[57]  G. Comi,et al.  Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism , 2005, Nature.

[58]  R. Lovell-Badge,et al.  Open access, freely available online PLoS BIOLOGY Neuronal Migration and Ventral Subtype Identity in the Telencephalon Depend on SOX1 , 2022 .

[59]  P. Salinas,et al.  Signalling in neural development: WNTS in the vertebrate nervous system: from patterning to neuronal connectivity , 2005, Nature Reviews Neuroscience.

[60]  Pamela Maher,et al.  Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6‐methyl‐phenyl‐tetrahydropyridine toxicity , 2005, Journal of neurochemistry.

[61]  Pier Andrea Serra,et al.  Glucocorticoid receptor–nitric oxide crosstalk and vulnerability to experimental parkinsonism: pivotal role for glia–neuron interactions , 2005, Brain Research Reviews.

[62]  G. Castelo-Branco,et al.  GSK-3β inhibition/β-catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons , 2004, Journal of Cell Science.

[63]  M. Horne,et al.  Glial responses associated with dopaminergic striatal reinnervation following lesions of the rat substantia nigra , 2004, Brain Research.

[64]  C. Thiele,et al.  Glycogen synthase kinase 3β (GSK3β) mediates 6‐ hydroxydopamine‐induced neuronal death , 2004 .

[65]  H. Gendelman,et al.  Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[66]  M. Youdim,et al.  Prevention of MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) dopaminergic neurotoxicity in mice by chronic lithium: involvements of Bcl-2 and Bax , 2004, Neuropharmacology.

[67]  G. Petzinger,et al.  Tyrosine hydroxylase and dopamine transporter expression following 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced neurodegeneration of the mouse nigrostriatal pathway , 2004, Journal of neuroscience research.

[68]  C. Tirolo,et al.  Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1). , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[69]  Rossana Migheli,et al.  Glucocorticoid receptor deficiency increases vulnerability of the nigrostriatal dopaminergic system: critical role of glial nitric oxide , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[70]  P. Horner,et al.  New roles for astrocytes: The nightlife of an ‘astrocyte’. La vida loca! , 2003, Trends in Neurosciences.

[71]  M. Horne,et al.  Timecourse of striatal re‐innervation following lesions of dopaminergic SNpc neurons of the rat , 2003, The European journal of neuroscience.

[72]  Bin Liu,et al.  Critical role of microglial NADPH oxidase‐derived free radicals in the in vitro MPTP model of Parkinson's disease , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[73]  Angelo L. Vescovi,et al.  Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis , 2003, Nature.

[74]  N. Inestrosa,et al.  Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils , 2003, Molecular Psychiatry.

[75]  W. Streit.  Microglia as neuroprotective, immunocompetent cells of the CNS , 2002, Glia.

[76]  M. Horne,et al.  The Role of Interleukin-1, Interleukin-6, and Glia in Inducing Growth of Neuronal Terminal Arbors in Mice , 2002, The Journal of Neuroscience.

[77]  G. Monaco,et al.  The Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induces Apoptosis in Mouse Nigrostriatal Glia , 2002, The Journal of Biological Chemistry.

[78]  Fred H. Gage,et al.  Astroglia induce neurogenesis from adult neural stem cells , 2002, Nature.

[79]  Dong-Kug Choi,et al.  Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease , 2002, The Journal of Neuroscience.

[80]  M. Vila,et al.  The role of glial cells in Parkinson's disease , 2001, Current opinion in neurology.

[81]  George Paxinos,et al.  The Mouse Brain in Stereotaxic Coordinates , 2001 .

[82]  Wolfgang Wurst,et al.  Fate of Midbrain Dopaminergic Neurons Controlled by the Engrailed Genes , 2001, The Journal of Neuroscience.

[83]  Arturo Alvarez-Buylla,et al.  A unified hypothesis on the lineage of neural stem cells , 2001, Nature Reviews Neuroscience.

[84]  A. Beaudet,et al.  Basic fibroblast growth factor (bFGF) acts on both neurons and glia to mediate the neurotrophic effects of astrocytes on LHRH neurons in culture , 2000, Synapse.

[85]  A. Patapoutian,et al.  Roles of Wnt proteins in neural development and maintenance , 2000, Current Opinion in Neurobiology.

[86]  M. Horne,et al.  Axonal sprouting following lesions of the rat substantia nigra , 2000, Neuroscience.

[87]  K. McNaught,et al.  Altered Glial Function Causes Neuronal Death and Increases Neuronal Susceptibility to 1‐Methyl‐4‐Phenylpyridinium‐ and 6‐Hydroxydopamine‐Induced Toxicity in Astrocytic/Ventral Mesencephalic Co‐Cultures , 1999, Journal of neurochemistry.

[88]  E. Snyder,et al.  Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes , 1999, Nature Biotechnology.

[89]  A. Álvarez-Buylla,et al.  Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[90]  Geoffrey A. Donnan,et al.  Activated Macrophages and Microglia Induce Dopaminergic Sprouting in the Injured Striatum and Express Brain-Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor , 1999, The Journal of Neuroscience.

[91]  A. Ho,et al.  Induction of Interleukin-1 Associated with Compensatory Dopaminergic Sprouting in the Denervated Striatum of Young Mice: Model of Aging and Neurodegenerative Disease , 1998, The Journal of Neuroscience.

[92]  E. Bézard,et al.  Compensatory mechanisms in experimental and human Parkinsonism: towards a dynamic approach , 1998, Progress in Neurobiology.

[93]  Jörg Stappert,et al.  β‐catenin is a target for the ubiquitin–proteasome pathway , 1997 .

[94]  William Slikker,et al.  Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration , 1997, Brain Research.

[95]  G. Kreutzberg.  Microglia: a sensor for pathological events in the CNS , 1996, Trends in Neurosciences.

[96]  Y. Agid,et al.  Dopaminergic sprouting in the rat striatum after partial lesion of the substantia nigra , 1996, Brain Research.

[97]  R. Burke,et al.  Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. , 1995, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.

[98]  T. Takeshima,et al.  Mesencephalic type 1 astrocytes rescue dopaminergic neurons from death induced by serum deprivation , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[99]  J. Engele,et al.  The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia [published erratum appears in J Neurosci 1992 Mar;12(3):685] , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[100]  R. Burke,et al.  An assessment of the validity of densitometric measures of striatal tyrosine hydroxylase-positive fibers: relationship to apomorphine-induced rotations in 6-hydroxydopamine lesioned rats , 1990, Journal of Neuroscience Methods.

[101]  J. Langston,et al.  Aging and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of dopaminergic neurons in the substantia nigra , 1987, Brain Research.

[102]  M. Abercrombie.  Estimation of nuclear population from microtome sections , 1946, The Anatomical record.

[103]  P. Gasque,et al.  Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins. , 2007, International review of neurobiology.

[104]  R Kemler,et al.  beta-catenin is a target for the ubiquitin-proteasome pathway. , 1997, The EMBO journal.

[105]  O. Hornykiewicz,et al.  Parkinson's disease and the adaptive capacity of the nigrostriatal dopamine system: possible neurochemical mechanisms. , 1993, Advances in neurology.

[106]  J. Schwarts,et al.  Preparation and characterization of type 1 astrocytes cultured from adult rat cortex, cerebellum, and striatum , 1992, Glia.