Intelligent Recognition of Lung Nodule Combining Rule-based and C-SVM Classifiers

Abstract Computer-aided detection(CAD) system for lung nodules plays the important role in the diagnosis of lung cancer. In this paper, an improved intelligent recognition method of lung nodule in HRCT combing rule-based and cost-sensitive support vector machine(C-SVM) classifiers is proposed for detecting both solid nodules and ground-glass opacity(GGO) nodules(part solid and nonsolid). This method consists of several steps. Firstly, segmentation of regions of interest(ROIs), including pulmonary parenchyma and lung nodule candidates, is a difficult task. On one side, the presence of noise lowers the visibility of low-contrast objects. On the other side, different types of nodules, including small nodules, nodules connecting to vasculature or other structures, part-solid or nonsolid nodules, are complex, noisy, weak edge or difficult to define the boundary. In order to overcome the difficulties of obvious boundary-leak and slow evolvement speed problem in segmentatioin of weak edge, an overall segmentatio...

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