Nitrous oxide in labour predicted newborn screening total homocysteine and is a potential risk factor for infant vitamin B12 deficiency

Risk factors for vitamin B12 deficiency in infants are not fully understood. The aim of the study was to assess predictors of total homocysteine and methylmalonic acid analysed in newborn screening dried blood spots.

[1]  Henriette Paulsen,et al.  Lower iron stores were associated with suboptimal gross motor scores in infants at 3–7 months , 2022, Acta paediatrica.

[2]  E. Eklund,et al.  Breastfed Infants With Spells, Tremor, or Irritability: Rule Out Vitamin B12 Deficiency. , 2022, Pediatric neurology.

[3]  P. Held,et al.  Screening for Methylmalonic and Propionic Acidemia: Clinical Outcomes and Follow-Up Recommendations , 2022, International journal of neonatal screening.

[4]  Henriette Paulsen,et al.  Reference material for Hammersmith Infant Neurological Examination scores based on healthy, term infants aged 3 to 7 months. , 2022, The Journal of pediatrics.

[5]  E. Eklund,et al.  The prevalence and clinical relevance of hyperhomocysteinemia suggesting vitamin B12 deficiency in presumed healthy infants. , 2021, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.

[6]  J. A. Arranz,et al.  Implementation of second-tier tests in newborn screening for the detection of vitamin B12 related acquired and genetic disorders: results on 258,637 newborns , 2021, Orphanet Journal of Rare Diseases.

[7]  S. Grünert,et al.  Health Outcomes of Infants With Vitamin B12 Deficiency Identified by Newborn Screening and Early Treated. , 2021, The Journal of pediatrics.

[8]  S. Wortmann,et al.  Elevated Homocysteine after Elevated Propionylcarnitine or Low Methionine in Newborn Screening Is Highly Predictive for Low Vitamin B12 and Holo-Transcobalamin Levels in Newborns , 2020, Diagnostics.

[9]  S. Ferdinandusse,et al.  Performance of Expanded Newborn Screening in Norway Supported by Post-Analytical Bioinformatics Tools and Rapid Second-Tier DNA Analyses , 2020, International journal of neonatal screening.

[10]  Roanna S George,et al.  Use of Dried Blood Spot Specimens to Monitor Patients with Inherited Metabolic Disorders , 2020, International journal of neonatal screening.

[11]  K. Weiss,et al.  Newborn Screening for Vitamin B12 Deficiency in Germany-Strategies, Results, and Public Health Implications. , 2019, The Journal of pediatrics.

[12]  M. Vallejo,et al.  Pro-Con Debate: Nitrous Oxide for Labor Analgesia , 2019, BioMed research international.

[13]  K. Õunap,et al.  High incidence of low vitamin B12 levels in Estonian newborns , 2018, Molecular genetics and metabolism reports.

[14]  Rashonda M Lewis,et al.  Nitrous Oxide for the Management of Labor Pain: A Systematic Review , 2012, Anesthesia and analgesia.

[15]  P. Pattengale,et al.  Simple, Fast, and Simultaneous Detection of Plasma Total Homocysteine, Methylmalonic Acid, Methionine, and 2-Methylcitric Acid Using Liquid Chromatography and Mass Spectrometry (LC/MS/MS). , 2013, JIMD reports.

[16]  A. El-Sohemy,et al.  Effect of Nitrous Oxide Exposure during Surgery on the Homocysteine Concentrations of Children , 2012, Anesthesiology.

[17]  J. Christodoulou,et al.  Homocysteine measurement in dried blood spot for neonatal detection of homocystinurias. , 2011, JIMD reports.

[18]  P. Rinaldo,et al.  Determination of total homocysteine, methylmalonic acid, and 2-methylcitric acid in dried blood spots by tandem mass spectrometry. , 2010, Clinical chemistry.

[19]  M. Maze,et al.  Biologic Effects of Nitrous Oxide: A Mechanistic and Toxicologic Review , 2008, Anesthesiology.

[20]  S. McCann,et al.  Measurement of total homocysteine in plasma and blood spots using liquid chromatography-tandem mass spectrometry: comparison with the plasma Abbott IMx method , 2003, Annals of clinical biochemistry.

[21]  J. Pacala Vitamin B12 deficiency. , 1993, The Journal of family practice.

[22]  A. Charlett,et al.  Influence of vitamin B12 status on the inactivation of methionine synthase by nitrous oxide. , 1992, British journal of anaesthesia.

[23]  B. Hultberg,et al.  Homocysteine export from erythrocytes and its implication for plasma sampling. , 1992, Clinical chemistry.

[24]  R. Matthews,et al.  Cobalamin‐dependent methionine synthase , 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[25]  J. Nunn Clinical aspects of the interaction between nitrous oxide and vitamin B12. , 1987, British journal of anaesthesia.

[26]  I. Chanarin Cobalamins and nitrous oxide: a review. , 1980, Journal of clinical pathology.

[27]  G. Marx,et al.  Placental Transmission of Nitrous Oxide , 1970, Anesthesiology.

[28]  S. J. Baker,et al.  Vitamin-B12 Deficiency in Pregnancy and the Puerperium , 1962, British medical journal.

[29]  N. Doblhamer Vitamin B12. , 1950, Wiener medizinische Wochenschrift.