Microfluidic organs-on-chips

[1]  D. Siegel,et al.  Patient-specific 3D microfluidic tissue model for multiple myeloma. , 2014, Tissue engineering. Part C, Methods.

[2]  George A. Truskey,et al.  Modeling the mitochondrial cardiomyopathy of Barth syndrome with iPSC and heart-on-chip technologies , 2014, Nature Medicine.

[3]  J. Collins,et al.  Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro , 2014, Nature Methods.

[4]  S. Bhatia,et al.  Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues. , 2014, Tissue engineering. Part A.

[5]  Wenxin Wang.  Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer , 2014 .

[6]  F. Bois,et al.  Evaluation of a liver microfluidic biochip to predict in vivo clearances of seven drugs in rats. , 2014, Journal of pharmaceutical sciences.

[7]  Hongli Lin,et al.  Induction of epithelial-to-mesenchymal transition in proximal tubular epithelial cells on microfluidic devices. , 2014, Biomaterials.

[8]  ZilberbergJenny,et al.  Patient-specific 3D microfluidic tissue model for multiple myeloma. , 2014 .

[9]  Timothy J. Mitchison,et al.  Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments , 2013, Proceedings of the National Academy of Sciences.

[10]  Hongbin Yu,et al.  Special Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac , 2013 .

[11]  Stephen B. McMahon,et al.  Probing Functional Properties of Nociceptive Axons Using a Microfluidic Culture System , 2013, PloS one.

[12]  Tien Anh Nguyen,et al.  Microfluidic chip with integrated electrical cell-impedance sensing for monitoring single cancer cell migration in three-dimensional matrixes. , 2013, Analytical chemistry.

[13]  J. Rocheleau,et al.  A microfluidic device designed to induce media flow throughout pancreatic islets while limiting shear-induced damage. , 2013, Lab on a chip.

[14]  Donald E Ingber,et al.  Mechanobiology and developmental control. , 2013, Annual review of cell and developmental biology.

[15]  Seung-Woo Cho,et al.  A microfluidic array for quantitative analysis of human neural stem cell self-renewal and differentiation in three-dimensional hypoxic microenvironment. , 2013, Biomaterials.

[16]  Eric Leclerc,et al.  Metabolic characterization of primary rat hepatocytes cultivated in parallel microfluidic biochips. , 2013, Journal of pharmaceutical sciences.

[17]  Daniel C Leslie,et al.  Clear castable polyurethane elastomer for fabrication of microfluidic devices. , 2013, Lab on a chip.

[18]  Madeline A. Lancaster,et al.  Cerebral organoids model human brain development and microcephaly , 2013, Nature.

[19]  K. Chien,et al.  A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells , 2013, Nature Cell Biology.

[20]  D. Ingber,et al.  Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. , 2013, Integrative biology : quantitative biosciences from nano to macro.

[21]  Donald E Ingber,et al.  Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation. , 2013, Integrative biology : quantitative biosciences from nano to macro.

[22]  Josue A. Goss,et al.  Microfluidic heart on a chip for higher throughput pharmacological studies. , 2013, Lab on a chip.

[23]  Uwe Marx,et al.  Integrating biological vasculature into a multi-organ-chip microsystem. , 2013, Lab on a chip.

[24]  A. van den Berg,et al.  Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device. , 2013, Lab on a chip.

[25]  Uwe Marx,et al.  Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion. , 2013, Lab on a chip.

[26]  Lucas H. Hofmeister,et al.  Scaling and systems biology for integrating multiple organs-on-a-chip. , 2013, Lab on a chip.

[27]  F. Sonntag,et al.  A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture. , 2013, Lab on a chip.

[28]  Lei Wang,et al.  Simultaneous generation of gradients with gradually changed slope in a microfluidic device for quantifying axon response. , 2013, Analytical chemistry.

[29]  Roger D Kamm,et al.  Mechanisms of tumor cell extravasation in an in vitro microvascular network platform. , 2013, Integrative biology : quantitative biosciences from nano to macro.

[30]  Anne E Carpenter,et al.  Identification of small molecules for human hepatocyte expansion and iPS differentiation , 2013, Nature chemical biology.

[31]  Brendon M. Baker,et al.  Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients. , 2013, Lab on a chip.

[32]  Chien-Chung Peng,et al.  A microfluidic cell culture array with various oxygen tensions. , 2013, Lab on a chip.

[33]  Nitish V. Thakor,et al.  Neuromuscular junction in a microfluidic device , 2013, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[34]  Yu-Hsiang Hsu,et al.  A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays. , 2013, Lab on a chip.

[35]  Bryson M. Brewer,et al.  Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts. , 2013, Lab on a chip.

[36]  Anne E Carpenter,et al.  A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax. , 2013, Cell host & microbe.

[37]  H. Vandenburgh,et al.  Skeletal muscle atrophy in bioengineered skeletal muscle: a new model system. , 2013, Tissue engineering. Part A.

[38]  Pierre J Magistretti,et al.  Astrocyte-neuron co-culture on microchips based on the model of SOD mutation to mimic ALS. , 2013, Integrative biology : quantitative biosciences from nano to macro.

[39]  H. Clevers,et al.  Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications , 2013, Science.

[40]  Kevin Kit Parker,et al.  Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip , 2013, Proceedings of the National Academy of Sciences.

[41]  Wenxin Wang,et al.  Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer. , 2013, Biomaterials.

[42]  David J Beebe,et al.  Hormonally responsive breast cancer cells in a microfluidic co-culture model as a sensor of microenvironmental activity. , 2013, Integrative biology : quantitative biosciences from nano to macro.

[43]  Duc-Huy T Nguyen,et al.  Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro , 2013, Proceedings of the National Academy of Sciences.

[44]  Yi-Chung Tung,et al.  Electrofluidic pressure sensor embedded microfluidic device: a study of endothelial cells under hydrostatic pressure and shear stress combinations. , 2013, Lab on a chip.

[45]  D. K. Wood,et al.  Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c3lc41300d Click here for additional data file. , 2013, Lab on a chip.

[46]  Yvonne Will,et al.  Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans. , 2013, Toxicological sciences : an official journal of the Society of Toxicology.

[47]  Cécile Legallais,et al.  Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and Its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips. , 2013, Toxicological sciences : an official journal of the Society of Toxicology.

[48]  Sara I. Montanez-Sauri,et al.  Enabling screening in 3D microenvironments: probing matrix and stromal effects on the morphology and proliferation of T47D breast carcinoma cells. , 2013, Integrative biology : quantitative biosciences from nano to macro.

[49]  Yu-Hsiang Hsu,et al.  In vitro perfused human capillary networks. , 2013, Tissue engineering. Part C, Methods.

[50]  R. Kamm,et al.  In Vitro Model of Tumor Cell Extravasation , 2013, PloS one.

[51]  Yan Wang,et al.  Study on Invadopodia Formation for Lung Carcinoma Invasion with a Microfluidic 3D Culture Device , 2013, PloS one.

[52]  Lauren L Bischel,et al.  Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels. , 2013, Biomaterials.

[53]  E. Leclerc,et al.  Investigation of ifosfamide nephrotoxicity induced in a liver–kidney co‐culture biochip , 2013, Biotechnology and bioengineering.

[54]  John P. Wikswo,et al.  Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems , 2013, IEEE Transactions on Biomedical Engineering.

[55]  A. Berg,et al.  BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function , 2013, Biomedical microdevices.

[56]  Albert Folch,et al.  A microfluidic microelectrode array for simultaneous electrophysiology, chemical stimulation, and imaging of brain slices. , 2013, Lab on a chip.

[57]  J. Cuevas,et al.  A modular approach to create a neurovascular unit-on-a-chip. , 2013, Lab on a chip.

[58]  R. Greek,et al.  Systematic Reviews of Animal Models: Methodology versus Epistemology , 2013, International journal of medical sciences.

[59]  Cécile Legallais,et al.  Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips , 2013, Xenobiotica; the fate of foreign compounds in biological systems.

[60]  Albert van den Berg,et al.  Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner , 2013, Proceedings of the National Academy of Sciences.

[61]  Elisa Cimetta,et al.  Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells. , 2013, Lab on a chip.

[62]  Daniel C Leslie,et al.  A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice , 2012, Science Translational Medicine.

[63]  H. Alsaid,et al.  An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure , 2012, Science Translational Medicine.

[64]  Ali Khademhosseini,et al.  Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation , 2012, PloS one.

[65]  Roger D Kamm,et al.  A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils. , 2012, Lab on a chip.

[66]  Ji-Yen Cheng,et al.  In vitro electrical-stimulated wound-healing chip for studying electric field-assisted wound-healing process. , 2012, Biomicrofluidics.

[67]  R. Kamm,et al.  Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function , 2012, Proceedings of the National Academy of Sciences.

[68]  Jennifer Yang,et al.  On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’ devices , 2012, Biomedical microdevices.

[69]  Roger D Kamm,et al.  Three-dimensional extracellular matrix-mediated neural stem cell differentiation in a microfluidic device. , 2012, Lab on a chip.

[70]  D. Ingber,et al.  Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. , 2012, Lab on a chip.

[71]  Josue A. Goss,et al.  Muscle on a chip: in vitro contractility assays for smooth and striated muscle. , 2012, Journal of pharmacological and toxicological methods.

[72]  Hanseup Kim,et al.  Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB). , 2012, Lab on a chip.

[73]  Cécile Legallais,et al.  Analysis of transcriptomic and proteomic profiles demonstrates improved Madin–Darby canine kidney cell function in a renal microfluidic biochip , 2012, Biotechnology progress.

[74]  Sangeeta N Bhatia,et al.  A Biophysical Indicator of Vaso-occlusive Risk in Sickle Cell Disease , 2022 .

[75]  Gordon B Mills,et al.  Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. , 2012, Cancer cell.

[76]  Cécile Legallais,et al.  Metabolomics-on-a-chip and predictive systems toxicology in microfluidic bioartificial organs. , 2012, Analytical chemistry.

[77]  F. Bois,et al.  Zonation related function and ubiquitination regulation in human hepatocellular carcinoma cells in dynamic vs. static culture conditions , 2012, BMC Genomics.

[78]  F. Atienzar,et al.  Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins , 2012, Cell Biology and Toxicology.

[79]  Thomas Boudou,et al.  A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues. , 2012, Tissue engineering. Part A.

[80]  Megan L. McCain,et al.  Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip. , 2011, Lab on a chip.

[81]  D. Pappas,et al.  Ischemia/reperfusion injury of primary porcine cardiomyocytes in a low-shear microfluidic culture and analysis device. , 2011, The Analyst.

[82]  Kelvin H. Lee,et al.  The effect of astrocytes on the induction of barrier properties in aortic endothelial cells , 2011, Biotechnology progress.

[83]  S. Ostrovidov,et al.  A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson's disease. , 2011, Biomicrofluidics.

[84]  Minseok Seo,et al.  High-throughput combinatorial cell co-culture using microfluidics. , 2011, Integrative biology : quantitative biosciences from nano to macro.

[85]  Nitish V. Thakor,et al.  Efficient Generation of Schwann Cells from Human Embryonic Stem Cell-Derived Neurospheres , 2011, Stem Cell Reviews and Reports.

[86]  Cécile Legallais,et al.  A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening. , 2011, International journal of pharmaceutics.

[87]  Shuichi Takayama,et al.  Epithelium damage and protection during reopening of occluded airways in a physiologic microfluidic pulmonary airway model , 2011, Biomedical microdevices.

[88]  Kevin W Eliceiri,et al.  Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects. , 2011, Integrative biology : quantitative biosciences from nano to macro.

[89]  R. Kamm,et al.  Differentiation of Embryonic Stem Cells into Cardiomyocytes in a Compliant Microfluidic System , 2011, Annals of Biomedical Engineering.

[90]  Michael L Shuler,et al.  Murine in vitro model of the blood-brain barrier for evaluating drug transport. , 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[91]  Gordana Vunjak-Novakovic,et al.  Patterning osteogenesis by inducible gene expression in microfluidic culture systems. , 2011, Integrative biology : quantitative biosciences from nano to macro.

[92]  C. Cannizzaro,et al.  Microfluidic device generating stable concentration gradients for long term cell culture: application to Wnt3a regulation of β-catenin signaling. , 2010, Lab on a chip.

[93]  James J Hickman,et al.  Tissue engineering the mechanosensory circuit of the stretch reflex arc: sensory neuron innervation of intrafusal muscle fibers. , 2010, Biomaterials.

[94]  Sangeeta N Bhatia,et al.  Multiplexed, high-throughput analysis of 3D microtissue suspensions. , 2010, Integrative biology : quantitative biosciences from nano to macro.

[95]  Palaniappan Sethu,et al.  Microfluidic cardiac cell culture model (μCCCM). , 2010, Analytical chemistry.

[96]  S. Bolz,et al.  A microfluidic platform for probing small artery structure and function. , 2010, Lab on a chip.

[97]  Jong Hwan Sung,et al.  Integration of in silico and in vitro platforms for pharmacokinetic–pharmacodynamic modeling , 2010, Expert opinion on drug metabolism & toxicology.

[98]  L. V. Van Laake,et al.  Reporter-Based Isolation of Induced Pluripotent Stem Cell– and Embryonic Stem Cell–Derived Cardiac Progenitors Reveals Limited Gene Expression Variance , 2010, Circulation research.

[99]  Uwe Marx,et al.  Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure. , 2010, Journal of biotechnology.

[100]  D. Ingber,et al.  Reconstituting Organ-Level Lung Functions on a Chip , 2010, Science.

[101]  M. Yarmush,et al.  A microfluidic hepatic coculture platform for cell-based drug metabolism studies. , 2010, Biochemical pharmacology.

[102]  Shuichi Takayama,et al.  Fabrication of two-layered channel system with embedded electrodes to measure resistance across epithelial and endothelial barriers. , 2010, Analytical chemistry.

[103]  Luke P. Lee,et al.  Non-invasive microfluidic gap junction assay. , 2010, Integrative biology : quantitative biosciences from nano to macro.

[104]  Gordana Vunjak-Novakovic,et al.  Micropatterned three‐dimensional hydrogel system to study human endothelial–mesenchymal stem cell interactions , 2010, Journal of tissue engineering and regenerative medicine.

[105]  Jong Hwan Sung,et al.  A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip. , 2010, Lab on a chip.

[106]  Sangeeta N. Bhatia,et al.  Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures , 2010, Proceedings of the National Academy of Sciences.

[107]  Matthew H. M. Lim,et al.  Perfused multiwell plate for 3D liver tissue engineering. , 2010, Lab on a chip.

[108]  Tza-Huei Wang,et al.  Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture. , 2009, Lab on a chip.

[109]  Hanry Yu,et al.  Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments. , 2009, Lab on a chip.

[110]  R. Hetzer,et al.  Pulmonary Tissue Engineering using Dual-Compartment Polymer Scaffolds with Integrated Vascular Tree , 2009, The International journal of artificial organs.

[111]  Donald Wlodkowic,et al.  Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells. , 2009, Lab on a chip.

[112]  M. Yarmush,et al.  Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance , 2009, Proceedings of the National Academy of Sciences.

[113]  M. Yarmush,et al.  Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human. , 2009, Biochemical pharmacology.

[114]  Mandy B. Esch,et al.  Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity , 2009, Biotechnology and bioengineering.

[115]  Teck Chuan Lim,et al.  A microfluidic 3D hepatocyte chip for drug toxicity testing. , 2009, Lab on a chip.

[116]  Shuichi Takayama,et al.  Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells , 2009, PloS one.

[117]  Jong Hwan Sung,et al.  A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs. , 2009, Lab on a chip.

[118]  D. Ingber,et al.  TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling , 2009, Circulation research.

[119]  Michael L Shuler,et al.  A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers , 2009, Biotechnology and bioengineering.

[120]  S. E. Eklund,et al.  Metabolic Discrimination of Select List Agents by Monitoring Cellular Responses in a Multianalyte Microphysiometer , 2009, Sensors.

[121]  Michael L Shuler,et al.  Incorporation of 3T3‐L1 Cells To Mimic Bioaccumulation in a Microscale Cell Culture Analog Device for Toxicity Studies , 2008, Biotechnology progress.

[122]  Yordan Kostov,et al.  The Design and Fabrication of Three‐Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors , 2008, Biotechnology progress.

[123]  Eli J. Weinberg,et al.  In vitro analysis of a hepatic device with intrinsic microvascular-based channels , 2008, Biomedical microdevices.

[124]  Nancy A. Monteiro-Riviere,et al.  Characterization of microfluidic human epidermal keratinocyte culture , 2008, Cytotechnology.

[125]  E. Kroon,et al.  Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo , 2008, Nature Biotechnology.

[126]  Shuichi Takayama,et al.  Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems , 2007, Proceedings of the National Academy of Sciences.

[127]  G. Whitesides,et al.  Muscular Thin Films for Building Actuators and Powering Devices , 2007, Science.

[128]  Luke P. Lee,et al.  An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture. , 2007, Biotechnology and bioengineering.

[129]  Godfrey L. Smith,et al.  Metabolic monitoring of the electrically stimulated single heart cell within a microfluidic platform. , 2006, Lab on a chip.

[130]  B. J. Kane,et al.  Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes. , 2006, Analytical chemistry.

[131]  L. Samson,et al.  A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction. , 2005, Current drug metabolism.

[132]  Neil Kaplowitz,et al.  Idiosyncratic drug hepatotoxicity , 2005, Nature Reviews Drug Discovery.

[133]  B. Chung,et al.  Human neural stem cell growth and differentiation in a gradient-generating microfluidic device. , 2005, Lab on a chip.

[134]  Milica Radisic,et al.  Mathematical model of oxygen distribution in engineered cardiac tissue with parallel channel array perfused with culture medium containing oxygen carriers. , 2005, American journal of physiology. Heart and circulatory physiology.

[135]  S. Bhatia,et al.  In vitro zonation and toxicity in a hepatocyte bioreactor. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[136]  J. Vacanti,et al.  Endothelialized Networks with a Vascular Geometry in Microfabricated Poly(dimethyl siloxane) , 2004 .

[137]  Frank Stahl,et al.  Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties. , 2003, Drug metabolism and disposition: the biological fate of chemicals.

[138]  S. Bhatia,et al.  Formation of steady-state oxygen gradients in vitro: application to liver zonation. , 2003, Biotechnology and bioengineering.

[139]  Masahiko Hoshijima,et al.  Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. , 2003, Biotechnology and bioengineering.

[140]  Donald E Ingber,et al.  Mechanobiology and diseases of mechanotransduction , 2003, Annals of medicine.

[141]  G. Whitesides,et al.  Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device , 2002, Nature Biotechnology.

[142]  G. Whitesides,et al.  Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[143]  G. Whitesides,et al.  Patterning proteins and cells using soft lithography. , 1999, Biomaterials.

[144]  M L Yarmush,et al.  Effect of cell–cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[145]  M. Schmidt,et al.  Molding of deep polydimethylsiloxane microstructures for microfluidics and biological applications. , 1999, Journal of biomechanical engineering.

[146]  G. Whitesides,et al.  Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane). , 1998, Analytical chemistry.

[147]  C. S. Chen,et al.  Geometric control of cell life and death. , 1997, Science.

[148]  Daniel I. C. Wang,et al.  Engineering cell shape and function. , 1994, Science.

[149]  R. L. Ehrmann,et al.  The growth of cells on a transparent gel of reconstituted rat-tail collagen. , 1956, Journal of the National Cancer Institute.

[150]  R. G. Harrison.  The outgrowth of the nerve fiber as a mode of protoplasmic movement. , 1910, The Journal of experimental zoology.

[151]  Sara I. Montanez-Sauri,et al.  Enabling screening in 3 D microenvironments : probing matrix and stromal effects on the morphology and proliferation of T 47 D breast carcinoma cells † , 2013 .

[152]  M. Bissell,et al.  Three-dimensional cultures of mouse mammary epithelial cells. , 2013, Methods in molecular biology.

[153]  E. Verpoorte,et al.  An alternative approach based on microfluidics to study drug metabolism and toxicity using liver and intestinal tissue , 2010 .

[154]  S. Bhatia,et al.  Microscale culture of human liver cells for drug development , 2008, Nature Biotechnology.

[155]  Laurent Griscom,et al.  Development of a Renal Microchip for In Vitro Distal Tubule Models , 2007, Biotechnology progress.

[156]  M. Toner,et al.  Cellular Micropatterns on Biocompatible Materials , 1998, Biotechnology progress.