Current Strategies and Future Directions to Optimize ACL Reconstruction in Adolescent Patients

The incidence of anterior cruciate ligament (ACL) injuries in the pediatric population has risen in recent years. These injuries have historically presented a management dilemma in skeletally immature patients with open physes and significant growth remaining at time of injury. While those nearing skeletal maturity may be treated with traditional, transphyseal adult techniques, these same procedures risk iatrogenic damage to the growth plates and resultant growth disturbances in younger patients with open physes. Moreover, conservative management is non-optimal as significant instabilities of the knee remain. Despite the development of physeal-sparing reconstructive techniques for younger patients, there remains debate over which procedure may be most suitable on a patient to patient basis. Meanwhile, the drivers behind clinical and functional outcomes following ACL reconstruction remain poorly understood. Therefore, current strategies are not yet capable of optimizing surgical ACL reconstruction on an individualized basis with absolute confidence. Instead, aims to improve surgical treatment of ACL tears in skeletally immature patients will rely on additional approaches in the near future. Namely, finite element models have emerged as a tool to model complex knee joint biomechanics. The inclusion of several individualized variables such as bone age, three dimensional geometries around the knee joint, tunnel positioning, and graft tension collectively present a possible means of better understanding and even predicting how to enhance surgical decision-making. Such a tool would serve surgeons in optimizing ACL reconstruction in the skeletally immature individuals, in order to improve clinical outcomes as well as reduce the rate of post-operative complications.

[1]  Grana Wa,et al.  Anterior cruciate ligament reconstruction in the immature athlete: long-term results of intra-articular reconstruction. , 2001 .

[2]  T. Ganley,et al.  All-epiphyseal Anterior Cruciate Ligament Reconstruction in Skeletally Immature Patients , 2010, Clinical orthopaedics and related research.

[3]  M. Kocher,et al.  Transphyseal anterior cruciate ligament reconstruction in skeletally immature pubescent adolescents. , 2007, The Journal of bone and joint surgery. American volume.

[4]  N. Iwasaki,et al.  Effects of initial graft tension on clinical outcome after anatomic double-bundle anterior cruciate ligament reconstruction: comparison of two graft tension protocols , 2016, BMC Musculoskeletal Disorders.

[5]  Peter D. Fabricant,et al.  Anterior Cruciate Ligament Injuries in Children and Adolescents. , 2016, The Orthopedic clinics of North America.

[6]  C. Nissen,et al.  Anterior Cruciate Ligament Reconstruction in Skeletally Immature Patients: Early Results Using a Hybrid Physeal-Sparing Technique , 2018, Orthopaedic journal of sports medicine.

[7]  Freddie H. Fu,et al.  In situ forces in the anterior cruciate ligament and its bundles in response to anterior tibial loads , 1997, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[8]  Brian R Wolf,et al.  Optimizing Graft Placement in Anterior Cruciate Ligament Reconstruction: A Finite Element Analysis , 2016, The Journal of Knee Surgery.

[9]  L. Micheli,et al.  Prevention, treatment, and rehabilitation of anterior cruciate ligament injuries in children , 2017, Open access journal of sports medicine.

[10]  D. Hunt,et al.  Transphyseal anterior cruciate ligament reconstruction in the skeletally immature: follow-up to a minimum of sixteen years of age. , 2013, The Journal of bone and joint surgery. American volume.

[11]  Michael J. Collins,et al.  Growth Abnormalities Following Anterior Cruciate Ligament Reconstruction in the Skeletally Immature Patient: A Systematic Review. , 2016, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[12]  S. Gabriel,et al.  Systematic Review of the Literature , 2021, Adherence to Antiretroviral Therapy among Perinatal Women in Guyana.

[13]  E. Mohammadi,et al.  Barriers and facilitators related to the implementation of a physiological track and trigger system: A systematic review of the qualitative evidence , 2017, International journal for quality in health care : journal of the International Society for Quality in Health Care.

[14]  George Pickering,et al.  What is Basic Science? , 1961, Nature.

[15]  M. Kocher,et al.  Physeal sparing reconstruction of the anterior cruciate ligament in skeletally immature prepubescent children and adolescents. , 2006, The Journal of bone and joint surgery. American volume.

[16]  A. Diméglio,et al.  Lower-limb growth: how predictable are predictions? , 2008, Journal of children's orthopaedics.

[17]  Freddie H Fu,et al.  The lateral intercondylar ridge--a key to anatomic anterior cruciate ligament reconstruction. , 2007, The Journal of bone and joint surgery. American volume.

[18]  A. Anderson,et al.  Tears of the anterior cruciate ligament in adolescents. , 1986, The Journal of bone and joint surgery. American volume.

[19]  R. Seil,et al.  Growth disturbances without growth arrest after ACL reconstruction in children , 2010, Knee Surgery, Sports Traumatology, Arthroscopy.

[20]  M. Tompkins,et al.  ACL Tears in School-Aged Children and Adolescents Over 20 Years , 2017, Pediatrics.

[21]  W. Grana,et al.  Anterior cruciate ligament reconstruction in the immature athlete: long-term results of intra-articular reconstruction. , 2001, The American journal of knee surgery.

[22]  Pierluigi Cuomo,et al.  Double-bundle "anatomic" anterior cruciate ligament reconstruction: a cadaveric study of tunnel positioning with a transtibial technique. , 2007, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[23]  J. Gagné Literature Review , 2018, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[24]  Yong-Beom Park,et al.  Anatomic placement of the femoral tunnel by a modified transtibial technique using a large-offset femoral tunnel guide: A cadaveric study. , 2016, The Knee.

[25]  Clare K Fitzpatrick,et al.  Developing simulations to reproduce in vivo fluoroscopy kinematics in total knee replacement patients. , 2014, Journal of biomechanics.

[26]  C. Kaeding,et al.  ACL Graft and Contralateral ACL Tear Risk within Ten Years Following Reconstruction: A Systematic Review , 2015, JBJS reviews.

[27]  R. Marx,et al.  Growth Arrest Following ACL Reconstruction With Hamstring Autograft in Skeletally Immature Patients: A Review of 4 Cases , 2016, Journal of pediatric orthopedics.

[28]  C. Kaeding,et al.  Surgical techniques and outcomes after anterior cruciate ligament reconstruction in preadolescent patients. , 2010, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[29]  C. Spritzer,et al.  Femoral Tunnel Placement During Anterior Cruciate Ligament Reconstruction , 2009, The American journal of sports medicine.

[30]  Thomas Tampere,et al.  Peak stresses shift from femoral tunnel aperture to tibial tunnel aperture in lateral tibial tunnel ACL reconstructions: a 3D graft-bending angle measurement and finite-element analysis , 2017, Knee Surgery, Sports Traumatology, Arthroscopy.

[31]  Derik L Davis,et al.  A Study of Epiphyses in the Young Prepubescent Knee Using Magnetic Resonance Imaging , 2014, Orthopaedic journal of sports medicine.

[32]  N. Mohtadi,et al.  Managing Anterior Cruciate Ligament Deficiency in the Skeletally Immature Individual: A Systematic Review of the Literature , 2006, Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine.

[33]  F. Catani,et al.  Load sharing and ligament strains in balanced, overstuffed and understuffed UKA. A validated finite element analysis. , 2014, The Journal of arthroplasty.

[34]  T. Cheng,et al.  Overview of Injuries in the Young Athlete , 2003, Sports medicine.

[35]  Lutz Dürselen,et al.  Material Models and Properties in the Finite Element Analysis of Knee Ligaments: A Literature Review , 2014, Front. Bioeng. Biotechnol..

[36]  J. Gregg,et al.  Anterior cruciate ligament injuries in skeletally immature patients. , 2002, Orthopedics.

[37]  Shu-guang Gao,et al.  Outcomes of anterior cruciate ligament reconstruction using single-bundle versus double-bundle technique: meta-analysis of 19 randomized controlled trials. , 2013, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[38]  Scott Tashman,et al.  The location of femoral and tibial tunnels in anatomic double-bundle anterior cruciate ligament reconstruction analyzed by three-dimensional computed tomography models. , 2010, The Journal of bone and joint surgery. American volume.

[39]  Scott Tashman,et al.  A computerized analysis of femoral condyle radii in ACL intact and contralateral ACL reconstructed knees using 3D CT , 2010, Knee Surgery, Sports Traumatology, Arthroscopy.

[40]  T. Matsushita,et al.  Three-Dimensional Analysis of Bone Tunnel Changes After Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction Using Multidetector-Row Computed Tomography , 2014, The American journal of sports medicine.

[41]  M. Doblaré,et al.  A finite element simulation of the effect of graft stiffness and graft tensioning in ACL reconstruction. , 2005, Clinical biomechanics.

[42]  P. Greis,et al.  A survey of the tension applied to a doubled hamstring tendon graft for reconstruction of the anterior cruciate ligament. , 2002, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[43]  R. Radić,et al.  Analysis of biomechanical properties of patellar ligament graft and quadruple hamstring tendon graft. , 2015, Injury.

[44]  Ming Zhang,et al.  Effect of tibial drill-guide angle on the mechanical environment at bone tunnel aperture after anatomic single-bundle anterior cruciate ligament reconstruction , 2014, International Orthopaedics.

[45]  Scott Tashman,et al.  Anatomic Single- and Double-Bundle Anterior Cruciate Ligament Reconstruction, Part 1 , 2011, The American journal of sports medicine.

[46]  F. Girgis,et al.  The cruciate ligaments of the knee joint. Anatomical, functional and experimental analysis. , 1975, Clinical orthopaedics and related research.

[47]  B Calvo,et al.  Influence of the tunnel angle in ACL reconstructions on the biomechanics of the knee joint. , 2006, Clinical biomechanics.

[48]  Yoon-Hyuk Kim,et al.  Biomechanical evaluation of double bundle augmentation of posterior cruciate ligament using finite element analysis. , 2010, Clinical biomechanics.

[49]  S. Fucentese,et al.  Complications after epiphyseal reconstruction of the anterior cruciate ligament in prepubescent children , 2016, Knee Surgery, Sports Traumatology, Arthroscopy.

[50]  B. Wolf,et al.  Infection following Anterior Cruciate Ligament Reconstruction: An Analysis of 6,389 Cases , 2016, The Journal of Knee Surgery.

[51]  M. Kocher,et al.  Physeal sparing reconstruction of the anterior cruciate ligament in skeletally immature prepubescent children and adolescents. Surgical technique. , 2006, The Journal of bone and joint surgery. American volume.

[52]  C. Gupte,et al.  Current concepts of the management of anterior cruciate ligament injuries in children. , 2013, The bone & joint journal.

[53]  Freddie H Fu,et al.  Anatomic single- and double-bundle anterior cruciate ligament reconstruction flowchart. , 2010, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[54]  D. Griffin,et al.  Finite-Element Analysis , 1975 .