The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

[1]  K. Wüthrich,et al.  Conformation of [Cd7]-metallothionein-2 from rat liver in aqueous solution determined by nuclear magnetic resonance spectroscopy. , 1991, Journal of molecular biology.

[2]  D. Kirschner,et al.  Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. , 1990, Science.

[3]  M. Hasegawa,et al.  The presence of a novel protein in calf serum that recognizes beta amyloid in the formalin-fixed section. , 1990, The American journal of pathology.

[4]  T. Tuñón,et al.  Neuronal alterations in patients with dementia: a Golgi study on biopsy samples , 1990, Neuroscience Letters.

[5]  M. Hasegawa,et al.  Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease , 1990, Neuron.

[6]  A. Delacourte.  General and dramatic glial reaction in Alzheimer brains , 1990, Neurology.

[7]  Y. Saito,et al.  The neurite-initiating effect of a tripeptide aldehyde protease inhibitor on PC12h cells. , 1989, Journal of biochemistry.

[8]  K. Kosik,et al.  Microtubular reorganization and dendritic growth response in alzheimer's disease , 1989, Annals of neurology.

[9]  W. Griffin,et al.  Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[10]  A. Matus,et al.  The adult rat olfactory system expresses microtubule-associated proteins found in the developing brain , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[11]  L. Butcher,et al.  Developing cholinergic basal forebrain neurons are sensitive to thyroid hormone , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[12]  W. Tourtellotte,et al.  Changes in brain gene expression shared by scrapie and Alzheimer disease. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[13]  L. Butcher,et al.  Neurotrophic agents may exacerbate the pathologic cascade of Alzheimer's disease , 1989, Neurobiology of Aging.

[14]  Y. Ihara.  What mediates between β-amyloid and paired helical filaments? , 1989, Neurobiology of Aging.

[15]  David M. A. Mann,et al.  Cerebral amyloidosis, ageing and Alzheimer's disease; A contribution from studies on Down's syndrome , 1989, Neurobiology of Aging.

[16]  L. Villa-komaroff,et al.  Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. , 1989, Science.

[17]  Y. Ihara,et al.  [A semiquantitative study on Alzheimer neurofibrillary tangles demonstrated immunohistochemically with anti-tau antibodies, in the brains of non-demented and demented old people]. , 1989, No to shinkei = Brain and nerve.

[18]  C. Cotman,et al.  Amyloid beta protein enhances the survival of hippocampal neurons in vitro. , 1989, Science.

[19]  Y. Uchida,et al.  Neurotrophic action of Alzheimer's disease brain extract is due to the loss of inhibitory factors for survival and neurite formation of cerebral cortical neurons , 1989, Brain Research.

[20]  A. Schäffer,et al.  Biochemistry of metallothionein. , 1988, Biochemistry.

[21]  R. Martins,et al.  A4 amyloid protein deposition and the diagnosis of Alzheimer's disease , 1988, Neurology.

[22]  L. Wolfson,et al.  Clinico‐pathologic studies in dementia , 1988, Neurology.

[23]  Y. Ihara,et al.  The car☐yl third of tau is tightly bound to paired helical filaments , 1988, Neuron.

[24]  Y. Ihara.  Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease , 1988, Brain Research.

[25]  A. Matus,et al.  PC12 cells express juvenile microtubule-associated proteins during nerve growth factor-induced neurite outgrowth , 1988, The Journal of cell biology.

[26]  D. Neary,et al.  THE PROGRESSION OF THE PATHOLOGICAL CHANGES OF ALZHEIMER'S DISEASE IN FRONTAL AND TEMPORAL NEOCORTEX EXAMINED BOTH AT BIOPSY AND AT AUTOPSY , 1988, Neuropathology and applied neurobiology.

[27]  J. Walker,et al.  Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[28]  D. Selkoe,et al.  Immunochemical identification of the serine protease inhibitor α 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease , 1988, Cell.

[29]  Y. Ihara,et al.  Alzheimer's disease brain extract stimulates the survival of cerebral cortical neurons from neonatal rats. , 1988, Biochemical and biophysical research communications.

[30]  S. Shiojiri,et al.  Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity , 1988, Nature.

[31]  C. Dinarello,et al.  Biology of interleukin 1 , 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[32]  H. Braak,et al.  Neuropil Threads Occur in Dendrites of Tangle—Bearing Nerve Cells , 1988, Neuropathology and applied neurobiology.

[33]  K. Kosik,et al.  Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease , 1987, Annals of neurology.

[34]  T. Kitamura,et al.  GFA-protein gene expression on the astroglia in cow and rat brains , 1987, Brain Research.

[35]  S. Prusiner,et al.  Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids. , 1987, Laboratory investigation; a journal of technical methods and pathology.

[36]  W. Frey,et al.  Ganglioside monoclonal antibody (A2B5) labels Alzheimer's neurofibrillary tangles , 1987, Neurology.

[37]  R. Terry,et al.  An immunohistochemical quantification of fibrous astrocytes in the aging human cerebral cortex , 1987, Neurobiology of Aging.

[38]  C. Holden.  NIMH review of fraud charge moves slowly. , 1986, Science.

[39]  T. Arendt,et al.  Dendritic changes in the basal nucleus of meynert and in the diagonal band nucleus in Alzheimer's disease—A quantitative Golgi investigation , 1986, Neuroscience.

[40]  A. Delacourte,et al.  Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments , 1986, Journal of the Neurological Sciences.

[41]  S. Mirra,et al.  Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau) , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[42]  D. Selkoe,et al.  Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[43]  H. Wiśniewski,et al.  Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. , 1986, The Journal of biological chemistry.

[44]  H. Braak,et al.  Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques , 1986, Neuroscience Letters.

[45]  Y. Ihara,et al.  One of the antigenic determinants of paired helical filaments is related to tau protein. , 1986, Journal of biochemistry.

[46]  B. Wang,et al.  Crystal structure of Cd,Zn metallothionein. , 1985, Science.

[47]  G K Wilcock,et al.  Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[48]  A. Hirano,et al.  Nucleus raphe dorsalis in Alzheimer's disease: Neurofibrillary tangles and loss of large neurons , 1985, Annals of neurology.

[49]  M. Karin.  Metallothioneins: Proteins in search of function , 1985, Cell.

[50]  A. Goldberg,et al.  The distribution and binding of zinc in the hippocampus , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[51]  S. Yen,et al.  Neurofibrillary tangles in senile dementia of the Alzheimer type share an antigenic determinant with intermediate filaments of the vimentin class. , 1983, The American journal of pathology.

[52]  D. Selkoe,et al.  Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins , 1983, Nature.

[53]  J. Ulrich,et al.  Neuritic plaques in senile dementia of Alzheimer type: a Golgi analysis in the hippocampal region , 1983, Brain Research.

[54]  M. Roth,et al.  Cortical neuronal counts in normal elderly controls and demented patients , 1983, Neurobiology of Aging.

[55]  P. C. Huang,et al.  Immunochemical detection of metallothionein in specific epithelial cells of rat organs. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[56]  J. Coyle,et al.  Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. , 1982, Science.

[57]  W. Bondareff,et al.  Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia , 1982, Neurology.

[58]  S H Appel,et al.  A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease , 1981, Annals of neurology.

[59]  J. Garvey,et al.  Detection of circulating metallothionein in rats injected with zinc or cadmium. , 1981, Science.

[60]  R. DeTeresa,et al.  Some morphometric aspects of the brain in senile dementia of the alzheimer type , 1981, Annals of neurology.

[61]  G. Blessed,et al.  Cell loss in the locus coeruleus in senile dementia of Alzheimer type , 1981, Journal of the Neurological Sciences.

[62]  R. Terry,et al.  Fibrous Astrocytes in Senile Dementia of the Alzheimer Type , 1981, Journal of neuropathology and experimental neurology.

[63]  M. Paula-Barbosa,et al.  Dendritic degeneration and regrowth in the cerebral cortex of patients with Alzheimer's disease , 1980, Journal of the Neurological Sciences.

[64]  M. Rapport,et al.  Glial fibrillary acidic protein and Alzheimer‐type senile dementia , 1980, Neurology.

[65]  Arnold B. Scheibel,et al.  Dendritic sprouting in Alzheimer's presenile dementia , 1978, Experimental Neurology.

[66]  Y. Ihara,et al.  β-Amyloid Plaques and Dementia: An Immunohistochemical Study , 1990 .

[67]  J. Brion,et al.  Senile Dementia of the Alzheimer Type: Morphological and Immunocytochemical Studies , 1985 .

[68]  Yasuo Ihara,et al.  Immunocytochemical study on senile plaques in Alzheimer's disease. II. Abnormal dendrites in senile plaques as revealed by antimicrotubule-associated proteins (MAPs) immunostaining. , 1983 .

[69]  G. Markelonis,et al.  Chicken serum transferrin duplicates the myotrophic effects of sciatin on cultured muscle cells , 1982, Journal of neuroscience research.

[70]  M. Cherian,et al.  Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of rat liver and kidney. , 1982, Toxicology.

[71]  D. Higgins,et al.  See Blockindiscussions, Blockinstats, Blockinand Blockinauthor Blockinprofiles Blockinfor Blockinthis Blockinpublication Clustal: Blockina Blockinpackage Blockinfor Blockinperforming Multiple Blockinsequence Blockinalignment Blockinon Blockina Minicomputer Article Blockin Blockinin Blockin , 2022 .