Cancer and circulatory disease risks for a human mission to Mars: Private mission considerations

Abstract In addition to traditional interest by various governments in space exploration, there is growing interest in private missions to Mars and other deep space destinations within the next decade. Private missions could consider persons not restricted by radiation limits; however there remains an interest in the level of risk to be encountered. The major risk for space travel is cancer from galactic cosmic rays (GCR), while circulatory diseases in suggested in some but not all epidemiology studies at modest doses (

[1]  J. Little,et al.  Induction of sister chromatid exchanges by extremely low doses of alpha-particles. , 1992, Cancer research.

[2]  Jack Valentin,et al.  Relative biological effectiveness (RBE), quality factor (Q), and radiation weighting factor (wR) , 2003 .

[3]  E. Wright,et al.  Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation , 2003, Oncogene.

[4]  Francis A. Cucinotta,et al.  Space Radiation Cancer Risk Projections and Uncertainties - 2010 , 2011 .

[5]  Olivier Laurent,et al.  Systematic Review and Meta-analysis of Circulatory Disease from Exposure to Low-Level Ionizing Radiation and Estimates of Potential Population Mortality Risks , 2012, Environmental health perspectives.

[6]  Non-Targeted Effects Models Predict Significantly Higher Mars Mission Cancer Risk than Targeted Effects Models , 2017, Scientific Reports.

[7]  Javier Gómez-Elvira,et al.  Comparison of Martian surface ionizing radiation measurements from MSL‐RAD with Badhwar‐O'Neill 2011/HZETRN model calculations , 2014 .

[8]  J. Baulch,et al.  What happens to your brain on the way to Mars , 2015, Science Advances.

[9]  Premkumar B. Saganti,et al.  NON-TARGETED EFFECTS LEAD TO A PARIDIGM SHIFT IN RISK ASSESSMENT FOR A MISSION TO THE EARTH'S MOON OR MARTIAN MOON PHOBOS. , 2018, Radiation protection dosimetry.

[10]  F. Cucinotta.  A New Approach to Reduce Uncertainties in Space Radiation Cancer Risk Predictions , 2015, PloS one.

[11]  S. C. Sharma,et al.  Inactivation of cells by heavy ion bombardment. , 1971, Radiation research.

[12]  G. Reitz,et al.  An Adaptive Response to Uncertainty Generates Positive and Negative Contrast Effects , 2014 .

[13]  M. Hada,et al.  Induction of Chromosomal Aberrations at Fluences of Less Than One HZE Particle per Cell Nucleus , 2014, Radiation research.

[14]  F A Cucinotta,et al.  Space Radiation and Cataracts in Astronauts , 2001, Radiation research.

[15]  A. Vasavada,et al.  Mars’ Surface Radiation Environment Measured with the Mars Science Laboratory’s Curiosity Rover , 2014, Science.

[16]  D. Fairchild,et al.  Harderian Gland Tumorigenesis: Low-Dose and LET Response , 2016, Radiation Research.

[17]  E. J. Ainsworth,et al.  High-LET radiation carcinogenesis. , 1985 .

[18]  Bahram Parvin,et al.  Targeted and nontargeted effects of ionizing radiation that impact genomic instability. , 2008, Cancer research.

[19]  M. Barcellos-Hoff,et al.  HZE Radiation Non-Targeted Effects on the Microenvironment That Mediate Mammary Carcinogenesis , 2016, Front. Oncol..

[20]  nasa,et al.  Technical Evaluation of the NASA Model for Cancer Risk to Astronauts Due to Space Radiation , 2019 .

[21]  Paul L. Hink,et al.  ELEMENTAL COMPOSITION AND ENERGY SPECTRA OF GALACTIC COSMIC RAYS DURING SOLAR CYCLE 23 , 2009 .

[22]  岩崎 民子.  SOURCES AND EFFECTS OF IONIZING RADIATION : United Nations Scientific Committee on the Effects of Atomic Radiation UNSCEAR 2000 Report to the General Assembly, with Scientific Annexes , 2002 .

[23]  L T Chylack,et al.  Radiation Cataractogenesis: Epidemiology and Biology , 2010, Radiation research.

[24]  G. Reitz,et al.  ICRP Publication 123: Assessment of Radiation Exposure of Astronauts in Space , 2013 .

[25]  Francis A. Cucinotta,et al.  Space Radiation Risks for Astronauts on Multiple International Space Station Missions , 2014, PloS one.

[26]  Leif E. Peterson,et al.  NASA Study of Cataract in Astronauts (NASCA). Report 1: Cross-Sectional Study of the Relationship of Exposure to Space Radiation and Risk of Lens Opacity , 2009, Radiation research.

[27]  P. Powers-Risius,et al.  The relative biological effect of high-Z, high-LET charged particles for spermatogonial killing. , 1981, Radiation research.

[28]  A. Takamori,et al.  Mortality Analysis of the Life Span Study (LSS) Cohort Taking into Account Multiple Causes of Death Indicated in Death Certificates , 2016, Radiation Research.

[29]  W. Morgan.  Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: I. Radiation-Induced Genomic Instability and Bystander Effects In Vitro , 2003, Radiation research.

[30]  F. Cucinotta,et al.  Predictions of space radiation fatality risk for exploration missions. , 2017, Life sciences in space research.

[31]  Francis A. Cucinotta,et al.  Space radiation risks to the central nervous system , 2014 .

[32]  M. Little,et al.  Non-targeted effects of ionising radiation--implications for low dose risk. , 2013, Mutation research.

[33]  F. Cucinotta,et al.  Safe days in space with acceptable uncertainty from space radiation exposure. , 2015, Life sciences in space research.

[34]  Lisa C. Simonsen,et al.  Radiation climate map for analyzing risks to astronauts on the mars surface from galactic cosmic rays , 2004 .

[35]  Premkumar B. Saganti,et al.  Relative Biological Effectiveness of HZE Particles for Chromosomal Exchanges and Other Surrogate Cancer Risk Endpoints , 2016, PloS one.

[36]  David J Brenner,et al.  Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away. , 2005, Proceedings of the National Academy of Sciences of the United States of America.