Association of estrogen receptor β (ESR2) gene polymorphism with blood pressure

AbstractWe investigated the association between a dinucleotide (cytosine-adenine; CA) repeat polymorphism located in the flanking region of the human estrogen receptor β (ESR2) gene and systemic blood pressure in 187 healthy postmenopausal Japanese women. The genotype was classified as “A” through “O” according to the number of these repeats from 18 to 32. When we separated the subjects into two groups — bearing at least one “I” allele (26 CA repeats) and those who did not — we found that the former subjects had significantly higher systolic blood pressure than the latter (mean ± SD, 146.0 ± 25.0 vs 136.6 ± 23.4; P = 0.032). These data suggest that genetic variation at the ESR2 locus may be associated with some determinants of blood pressure, and that there is a possible involvement of this polymorphism in causing hypertension in Japanese women.

[1]  R. White,et al.  Estrogen relaxes coronary arteries by opening BKCa channels through a cGMP-dependent mechanism. , 1995, Circulation research.

[2]  P. Chambon,et al.  Nuclear receptors enhance our understanding of transcription regulation. , 1988, Trends in genetics : TIG.

[3]  N. Golden,et al.  in Women with , 1992 .

[4]  S. Lehrer,et al.  Estrogen receptor variant and hypertension in women. , 1993, Hypertension.

[5]  Hajime Orimo,et al.  Isolation and radiation hybrid mapping of dinucleotide repeat polymorphism at the human estrogen receptor β locus , 1998, Journal of Human Genetics.

[6]  J. J. Smith,et al.  Estrogen inhibits the response-to-injury in a mouse carotid artery model. , 1995, The Journal of clinical investigation.

[7]  J. Gustafsson,et al.  Generation and reproductive phenotypes of mice lacking estrogen receptor b (gene targetingyestrogen actionyovaryyfolliculogenesisyfertility) , 1998 .

[8]  M. Emi,et al.  Isolation and radiation hybrid mapping of dinucleotide repeat polymorphism at the human matrix Gla protein (MGP) locus , 1998, Journal of Human Genetics.

[9]  J. Gustafsson,et al.  Cloning of a novel receptor expressed in rat prostate and ovary. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[10]  K. Umesono,et al.  The nuclear receptor superfamily: The second decade , 1995, Cell.

[11]  S. Cummings,et al.  Hormone therapy to prevent disease and prolong life in postmenopausal women , 1992, Annals of internal medicine.

[12]  Y. Ouchi,et al.  Association of estrogen receptor beta gene polymorphism with bone mineral density. , 2000, Biochemical and biophysical research communications.

[13]  S. Kudoh,et al.  Association of diffuse panbronchiolitis with microsatellite polymorphism of the human interleukin 8 (IL-8) gene , 1999, Journal of Human Genetics.

[14]  R. Evans,et al.  The steroid and thyroid hormone receptor superfamily. , 1988, Science.

[15]  The effect of postmenopausal estrogen therapy on bone density in elderly women. , 1993 .

[16]  R. Karas,et al.  Estrogen and the blood vessel wall , 1994, Current opinion in cardiology.

[17]  Y. Ouchi,et al.  Estrogen inhibits cuff-induced intimal thickening of rat femoral artery: effects on migration and proliferation of vascular smooth muscle cells. , 1997, Atherosclerosis.

[18]  J. Gustafsson,et al.  Increased expression of estrogen receptor-beta mRNA in male blood vessels after vascular injury. , 1998, Circulation research.

[19]  Y. Ouchi,et al.  The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and in vitro. , 1998, Biochemical and biophysical research communications.

[20]  M. Emi,et al.  Association of radial bone mineral density with CA repeat polymorphism at the interleukin 6 locus in postmenoposal Japanese women , 1999, Journal of Human Genetics.

[21]  J. Gustafsson,et al.  Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[22]  V. Dzau,et al.  Genomics and hypertension: concepts, potentials, and opportunities. , 1999, Hypertension.

[23]  K. Korach,et al.  Estrogen receptor null mice: what have we learned and where will they lead us? , 1999, Endocrine reviews.

[24]  R. Karas,et al.  The protective effects of estrogen on the cardiovascular system. , 2002, The New England journal of medicine.

[25]  A. Nègre-Salvayre,et al.  Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[26]  M. Emi,et al.  Five familial hypercholesterolemic kindreds in Japan with novel mutations of the LDL receptor gene , 1998, Journal of Human Genetics.

[27]  R. Karas,et al.  Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice , 1997, Nature Medicine.