Exploring the Link between ACE Insertion/Deletion (I/D) Polymorphism and Uterine Leiomyomas

ACE ُذٌٌو ذو زعا یسبسرًَبو ِو ًبسذوػ رد لَلع بّ ی حؽزس یلٍزػ لبیلسٍذًا یه دَؽ ٍ نشغیع رد لزشٌو يیغًبسَیضًآ يیًر ُذٌٌو ىَخربؾف زعا . ىص يیا ذخاٍ هی لد ی فرَه ی نغ یخرد / یفذح ( I/D ) بث ِو زعا یشفبث ٍ یهزع حغع ؼیاشفا ACE ظجسزه یه ذؽبث . یعرزث ِؼلبغه يیا فذّ طبجسرا نغیفرَه یلد يیا مَیه ِث لاشثا ٍ یًص زعا . يسرزب شٍر : درَه ِؼلبغه هی رد یذّبؽ ، 55 ٍ یوحر یبهَیهَیل ِث لاشجه ربویث 78 رزث درَه نلبع نًبخ سا ظد .ذٌشفزگ رازل یع زیبضر تغو ، ًَِوً یبّ ىَخ غوخ رٍآ ی ٍ جازخشعا DNA ػٍر ظعَس Salting-out .زفزگ مبدًا خیسًَص يییؼس ث سا ُدبفشـعا ب ؼٌـواٍ PCR ذیدزگ مبدًا . رلاَقحه ذًبث ٍد ُذؽ زیثىس 190 ٍ 490 ُذٌّد ىبؾً تیسزس ِث ِو ار یسبث زفخ للآ D ٍ للآ I ذٌشغّ ار .ذًداد ىبؾً ٍُزگ ِغیبمه بّ سا ُدبفشعا بث یبو شیلبًآ غثزه زفزگ مبدًا . :جياتً ظًبوزف لآ ل D ربویث ٍُزگ رد 55 / 0 لزشٌو ٍُزگ رد ٍ 51 / 0 ظًبوزف يیٌچوّ .زعا ُدَث للآ I ِث ذّبؽ ٍ ربویث ٍُزگ رد تیسزس 45 / 0 ٍ 49 / 0 .ذًدَث داد ىبؾً حیبشً ِو يشفزگ زظً رد بث سًَص ی خ II غخزه خیسًَص ىاٌَػ ِث ، رَگیسَوّ دازفا DD ظًبؽ سا زغخ یزشؾیث ِث لاشثا یازث یوحر مَیه ذًرادرَخزث ظًبؽ زجغً( 37 / 1 ) رد يیا ؛ ِو زعا یلبح رَگیسٍزشّ دازفا زغخ ظًبؽ یا ِثبؾه غخزه خیسًَص بث II .ذًداد ىبؾً ثحب : ىَخربؾف لابث ِث رَع لثبل یْخَس بث یوحر یبّذیئٍزجیف رد طبجسرا زعا . ُذؽ ـخؾه ِو تیعآ هیسٍزلىعاٍزسآ قٍزػ یًَخ نحر ٍ زف آ ی بّذٌ ی یثبْشلا يىوه ىآ سا یؽبً زعا یوحر مَیه دبدیا رد یوْه ؼمً یسبث ِؼلبغه .ذٌو زضبح ِغثار ار یشجثه يیث لد ی فرَه ی نغ ACE (I/D) داد ىبؾً یوحر مَیه ِث لاشثا ٍ . يیا ِشفبی نْه ؼمً زث یذّبؽ نشغیع يیًر – ًآ یض شًصَسبد رد يیغًبسَ مَیه زعا . تاولك یديلك : ىص ACE1 ، ل ی هَ ی بهَ ، لد ی فرَه ی نغ يیًر نشغیع ،یفذح /یخرد يیغًبسَیشًآ

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