Intermittent Therapy with Terbinafine for Dermatophyte Toe‐Onychomycosis: A New Approach

Terbinafine, an orally active antifungal agent of the allylamine class, is effective in the treatment of dermatophyte onycomycosis. Its pharmacologic and pharmacokinetic properties give strong support to the possibility that intermittent treatment courses may be equally effective in onychomycosis in general.

[1]  L. Millérioux,et al.  Levels of terbinafine in plasma, stratum corneum, dermis-epidermis (without stratum corneum), sebum, hair and nails during and after 250 mg terbinafine orally once per day for four weeks. , 1993, Acta dermato-venereologica.

[2]  S. Shuster,et al.  Single dose treatment of fungal nail disease , 1992, The Lancet.

[3]  A. Finlay.  Pharmacokinetics of terbinafine in the nail. , 1992, The British journal of dermatology.

[4]  M. Goodfield.  Short‐duration therapy with terbinafine for dermatophyteonychomycosis: A multicentre trial , 1992, The British journal of dermatology.

[5]  M. Crijns,et al.  A randomized treatment duration‐finding study of terbinafine in onychomycosis , 1992, The British journal of dermatology.

[6]  L. Petersen,et al.  Management of radiation-induced plantar hyperkeratosis with DuoDERM hydrocolloid occlusion and shaving : a randomized controlled trial , 1992 .

[7]  N. Zaias.  Management of onychomycosis with oral terbinafine. , 1990, Journal of the American Academy of Dermatology.

[8]  A. Finlay,et al.  Nail matrix kinetics of systemic terbinafine in onychomycosis , 1990 .

[9]  A. Finlay,et al.  Nail matrix kinetics of oral terbinafine in onychomycosis and normal nails , 1990 .

[10]  E. Evans,et al.  Treatment of dermatophyte infection of the finger‐ and toe‐nails with terbinafine (SF 86‐327, Lamisil), an orally active fungicidal agent , 1989, The British journal of dermatology.

[11]  Y. Clayton.  In vitro activity of terbinafine , 1989, Clinical and experimental dermatology.

[12]  G. Petrányi,et al.  Antifungal activity of the allylamine derivative terbinafine in vitro , 1987, Antimicrobial Agents and Chemotherapy.

[13]  N. Ryder.  Specific inhibition of fungal sterol biosynthesis by SF 86-327, a new allylamine antimycotic agent , 1985, Antimicrobial Agents and Chemotherapy.

[14]  N S Ryder,et al.  Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. , 1984, Science.