Long non-coding RNAs: a new frontier in the study of human diseases.

[1]  Kotb Abdelmohsen,et al.  Posttranscriptional gene regulation by long noncoding RNA. , 2013, Journal of molecular biology.

[2]  R. Micura,et al.  Long non-coding RNAs as targets for cytosine methylation , 2013, RNA biology.

[3]  Weining Yang,et al.  Versican 3′‐untranslated region (3′‐UTR) functions as a ceRNA in inducing the development of hepatocellular carcinoma by regulating miRNA activity , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[4]  Eda Yildirim,et al.  Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice , 2013, Cell.

[5]  Howard Y. Chang,et al.  Detection of Long Non-Coding RNA in Archival Tissue: Correlation with Polycomb Protein Expression in Primary and Metastatic Breast Carcinoma , 2012, PloS one.

[6]  R. Spizzo,et al.  Long non-coding RNAs and cancer: a new frontier of translational research? , 2012, Oncogene.

[7]  David G. Knowles,et al.  The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression , 2012, Genome research.

[8]  Kotb Abdelmohsen,et al.  LincRNA-p21 suppresses target mRNA translation. , 2012, Molecular cell.

[9]  Subbaya Subramanian,et al.  Competing endogenous RNA database , 2012, Bioinformation.

[10]  P. Schirmacher,et al.  Loss of the abundant nuclear non-coding RNA MALAT1 is compatible with life and development , 2012, RNA biology.

[11]  Chaolin Zhang,et al.  The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult. , 2012, Cell reports.

[12]  Sven Diederichs,et al.  The hallmarks of cancer , 2012, RNA biology.

[13]  Ahmad M. Khalil,et al.  Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs , 2012, Nucleic acids research.

[14]  J. Bähler,et al.  Exploring long non-coding RNAs through sequencing. , 2012, Seminars in cell & developmental biology.

[15]  V. Abraira,et al.  Mutation of Rubie, a Novel Long Non-Coding RNA Located Upstream of Bmp4, Causes Vestibular Malformation in Mice , 2012, PloS one.

[16]  S. Koschmieder,et al.  The Long Noncoding MALAT-1 RNA Indicates a Poor Prognosis in Non-small Cell Lung Cancer and Induces Migration and Tumor Growth , 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[17]  S. Oesterreich,et al.  Epigenetics in breast cancer: what's new? , 2011, Breast Cancer Research.

[18]  S. Miyano,et al.  Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. , 2011, Cancer research.

[19]  D. Cacchiarelli,et al.  A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA , 2011, Cell.

[20]  A. Chinnaiyan,et al.  The emergence of lncRNAs in cancer biology. , 2011, Cancer discovery.

[21]  N. Zaffaroni,et al.  Characterization of novel antisense HIF-1α transcripts in human cancers , 2011, Cell cycle.

[22]  P. Pandolfi,et al.  A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language? , 2011, Cell.

[23]  John T. Wei,et al.  Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression , 2011, Nature Biotechnology.

[24]  Howard Y. Chang,et al.  Long noncoding RNAs and human disease. , 2011, Trends in cell biology.

[25]  J. Mattick,et al.  SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer. , 2011, RNA.

[26]  Shiping Liu,et al.  The sequence, structure and evolutionary features of HOTAIR in mammals , 2011, BMC Evolutionary Biology.

[27]  Carolyn J. Brown,et al.  The functional role of long non-coding RNA in human carcinomas , 2011, Molecular Cancer.

[28]  Zhenhua Li,et al.  ncRAN, a newly identified long noncoding RNA, enhances human bladder tumor growth, invasion, and survival. , 2011, Urology.

[29]  J. Rinn,et al.  Large non-coding RNAs: missing links in cancer? , 2010, Human molecular genetics.

[30]  J. Lieberman,et al.  Desperately seeking microRNA targets , 2010, Nature Structural &Molecular Biology.

[31]  B. Blencowe,et al.  The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. , 2010, Molecular cell.

[32]  Howard Y. Chang,et al.  Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes , 2010, Science.

[33]  J. Rinn,et al.  A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response , 2010, Cell.

[34]  P. Pandolfi,et al.  A coding-independent function of gene and pseudogene mRNAs regulates tumour biology , 2010, Nature.

[35]  S. Raguz,et al.  Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. , 2010, Molecular cell.

[36]  A. Gabory,et al.  The H19 locus: Role of an imprinted non‐coding RNA in growth and development , 2010, BioEssays : news and reviews in molecular, cellular and developmental biology.

[37]  W. Engel,et al.  Increased BACE1 mRNA and noncoding BACE1-antisense transcript in sporadic inclusion-body myositis muscle fibers—Possibly caused by endoplasmic reticulum stress , 2010, Neuroscience Letters.

[38]  Jiayi Wang,et al.  CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer , 2010, Nucleic acids research.

[39]  Howard Y. Chang,et al.  Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis , 2010, Nature.

[40]  Yunli Zhou,et al.  Maternally expressed gene 3 (MEG3) noncoding ribonucleic acid: isoform structure, expression, and functions. , 2010, Endocrinology.

[41]  Jiajia Wang,et al.  Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion. , 2010, Acta biochimica et biophysica Sinica.

[42]  A. Gabrielsen,et al.  Relationship between CAD Risk Genotype in the Chromosome 9p21 Locus and Gene Expression. Identification of Eight New ANRIL Splice Variants , 2009, PloS one.

[43]  T. Hughes,et al.  Establishing legitimacy and function in the new transcriptome. , 2009, Briefings in functional genomics & proteomics.

[44]  J. Disterhoft,et al.  Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry. , 2009, Nature neuroscience.

[45]  S. French,et al.  The regulation of non-coding RNA expression in the liver of mice fed DDC. , 2009, Experimental and molecular pathology.

[46]  W. Hahn,et al.  An RNA dependent RNA polymerase formed by hTERT and the RNase MRP RNA , 2009, Nature.

[47]  C. Kanduri,et al.  Epigenetics of imprinted long non-coding RNAs , 2009, Epigenetics.

[48]  D. Spector,et al.  Long noncoding RNAs: functional surprises from the RNA world. , 2009, Genes & development.

[49]  Ricky W. Johnstone,et al.  Epigenetics in cancer: Targeting chromatin modifications , 2009, Molecular Cancer Therapeutics.

[50]  Ru Huang,et al.  The function of non-coding RNAs in genomic imprinting , 2009, Development.

[51]  Abraham Hochberg,et al.  Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis , 2009, European journal of gastroenterology & hepatology.

[52]  L. Murphy,et al.  Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides , 2009, Nucleic acids research.

[53]  Hervé Seitz,et al.  Redefining MicroRNA Targets , 2009, Current Biology.

[54]  M. Ohira,et al.  High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25.1, is associated with poor prognosis in neuroblastoma. , 2009, International journal of oncology.

[55]  J. Mattick,et al.  Long non-coding RNAs: insights into functions , 2009, Nature Reviews Genetics.

[56]  C. Ponting,et al.  Evolution and Functions of Long Noncoding RNAs , 2009, Cell.

[57]  W. Reik,et al.  The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing , 2009, Development.

[58]  Lan Jin,et al.  Biological basis for restriction of microRNA targets to the 3' untranslated region in mammalian mRNAs. , 2009, Nature structural & molecular biology.

[59]  D. Bartel.  MicroRNAs: Target Recognition and Regulatory Functions , 2009, Cell.

[60]  M. Mourtada-Maarabouni,et al.  GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer , 2009, Oncogene.

[61]  Jeannie T. Lee,et al.  Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome , 2008, Science.

[62]  G. Critchley,et al.  Novel noncoding antisense RNA transcribed from human anti-NOS2A locus is differentially regulated during neuronal differentiation of embryonic stem cells. , 2008, RNA.

[63]  T. Morgan,et al.  Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase , 2008, Nature Medicine.

[64]  Jeannie T. Lee,et al.  Intersection of the RNA Interference and X-Inactivation Pathways , 2008, Science.

[65]  Naoki Takahashi,et al.  The GAS5 (growth arrest-specific transcript 5) gene fuses to BCL6 as a result of t(1;3)(q25;q27) in a patient with B-cell lymphoma. , 2008, Cancer genetics and cytogenetics.

[66]  C. Wahlestedt,et al.  A Novel RNA Transcript with Antiapoptotic Function Is Silenced in Fragile X Syndrome , 2008, PloS one.

[67]  A. Feinberg,et al.  Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA , 2008, Nature.

[68]  Howard Y. Chang,et al.  Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs , 2007, Cell.

[69]  P. Stadler,et al.  RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription , 2007, Science.

[70]  A. Feinberg.  Phenotypic plasticity and the epigenetics of human disease , 2007, Nature.

[71]  I. Bièche,et al.  Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. , 2007, Cancer research.

[72]  M. Karin,et al.  A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas , 2007, Oncogene.

[73]  Ana Serra Barros,et al.  Repression of the human dihydrofolate reductase gene by a non-coding interfering transcript , 2007, Nature.

[74]  S. McWeeney,et al.  An Antisense Transcript Induced by Wnt/β-Catenin Signaling Decreases E2F4* , 2007, Journal of Biological Chemistry.

[75]  Meng Li,et al.  Rapid Identification of UCA1 as a Very Sensitive and Specific Unique Marker for Human Bladder Carcinoma , 2006, Clinical Cancer Research.

[76]  T. Ebner,et al.  Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8 , 2006, Nature Genetics.

[77]  Brian S. Clark,et al.  The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator. , 2006, Genes & development.

[78]  Shridar Ganesan,et al.  X chromosomal abnormalities in basal-like human breast cancer. , 2006, Cancer cell.

[79]  A. Pastore,et al.  Fragile X Mental Retardation Protein (FMRP) Binds Specifically to the Brain Cytoplasmic RNAs BC1/BC200 via a Novel RNA-binding Motif* , 2005, Journal of Biological Chemistry.

[80]  A. Iacoangeli,et al.  BC200 RNA in invasive and preinvasive breast cancer. , 2004, Carcinogenesis.

[81]  F. van Coppenolle,et al.  Hormonal regulation of H19 gene expression in prostate epithelial cells. , 2004, The Journal of endocrinology.

[82]  P H Watson,et al.  The steroid receptor RNA activator is the first functional RNA encoding a protein , 2004, FEBS letters.

[83]  J. Mattick.  RNA regulation: a new genetics? , 2004, Nature Reviews Genetics.

[84]  Wei Zhang,et al.  Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients , 2004, Oncogene.

[85]  O. Ogawa,et al.  XISTunmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer , 2004, The Lancet.

[86]  D. Danila,et al.  A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells. , 2003, The Journal of clinical endocrinology and metabolism.

[87]  F. Penault-Llorca,et al.  aHIF but not HIF-1α transcript is a poor prognostic marker in human breast cancer , 2003, Breast Cancer Research.

[88]  Michael Thomas,et al.  MALAT-1, a novel noncoding RNA, and thymosin β4 predict metastasis and survival in early-stage non-small cell lung cancer , 2003, Oncogene.

[89]  C. Deng,et al.  BRCA1 Supports XIST RNA Concentration on the Inactive X Chromosome , 2002, Cell.

[90]  C. Vaché,et al.  Natural antisense transcripts of hypoxia-inducible factor 1alpha are detected in different normal and tumour human tissues. , 2002, Gene.

[91]  J. Squire,et al.  Identification of a novel gene NCRMS on chromosome 12q21 with differential expression between Rhabdomyosarcoma subtypes , 2002, Oncogene.

[92]  D. Barlow,et al.  Quantitative genetics: Turning up the heat on QTL mapping , 2002, Nature Reviews Genetics.

[93]  M. Augustus,et al.  PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[94]  S. Wakana,et al.  Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q , 2000, Genes to cells : devoted to molecular & cellular mechanisms.

[95]  Helmut Dotzlaw,et al.  Expression of the steroid receptor RNA activator in human breast tumors. , 1999, Cancer research.

[96]  J. Steitz,et al.  Classification of gas5 as a Multi-Small-Nucleolar-RNA (snoRNA) Host Gene and a Member of the 5′-Terminal Oligopyrimidine Gene Family Reveals Common Features of snoRNA Host Genes , 1998, Molecular and Cellular Biology.

[97]  J. Brosius,et al.  Expression of neural BC200 RNA in human tumours , 1997, The Journal of pathology.

[98]  S. Fukuhara,et al.  Significance of rearrangement of the BCL6 gene in B-cell lymphoid neoplasms. , 1997, Leukemia & lymphoma.

[99]  Katsuki Ito,et al.  Loss of H19 imprinting in esophageal cancer. , 1996, Cancer research.

[100]  O. Mäkitie,et al.  Cartilage-hair hypoplasia — clinical manifestations in 108 Finnish patients , 1993, European Journal of Pediatrics.

[101]  Carolyn J. Brown,et al.  A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome , 1991, Nature.

[102]  E. Dees,et al.  The product of the H19 gene may function as an RNA , 1990, Molecular and cellular biology.

[103]  Ming Liu,et al.  Long intergenic noncoding RNA HOTAIR is overexpressed and regulates PTEN methylation in laryngeal squamous cell carcinoma. , 2013, The American journal of pathology.

[104]  Howard Y. Chang,et al.  Long intergenic noncoding RNAs: new links in cancer progression. , 2011, Cancer research.

[105]  C. Glass,et al.  The long arm of long noncoding RNAs: roles as sensors regulating gene transcriptional programs. , 2011, Cold Spring Harbor perspectives in biology.

[106]  David Malkin,et al.  Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma. , 2010, Cancer research.

[107]  K. Zatloukal,et al.  Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. , 2007, Gastroenterology.

[108]  K. Sugimura,et al.  A novel steroid receptor co-activator protein (SRAP) as an alternative form of steroid receptor RNA-activator gene: expression in prostate cancer cells and enhancement of androgen receptor activity. , 2003, The Biochemical journal.