Radiotracers for Imaging Electroporation a

Radiotracer imaging can be used to assess the extent of soft tissue damage in victims of electrical trauma; for over 20 years, this has been done.1–5 Radiotracer imaging can also be used with in vivo animal models to develop methods for the investigation of electrical injury and for the assessment of therapeutic agents for electrical injuries. We have applied radiotracer imaging techniques involving a high-resolution small-field-of-view gamma camera to the in vivo study of electrical injury. Specifically, we have used radiotracer imaging and an animal model of electroporation injury in skeletal muscle to examine the effects of novel therapies for the treatment of the electroporation component of electrical injury. Detailed here is our investigation of four radiotracers that might be used for assessment of such therapies.

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