Increased birthweight after prenatal dietary supplementation of rural African women.

Birthweight data from 197 rural Gambian women who received an energy-dense prenatal dietary supplement over a 4-y period (net intake = 430 kcal/d) was compared with data from 182 women from 4 baseline years. Preintervention birthweights averaged 2944 +/- 43 (SEM) g when women were in positive energy balance during the dry harvest season (pregnancy weight gain greater than 1200 g/mo). Birthweights decreased to 2808 +/- 41 g (p less than 0.01) in the wet season when food shortages and agricultural work caused negative energy balance (weight gain less than 500 g/mo). There were no detectable secular trends in the baseline data. Supplementation was ineffective during the dry season but highly effective during the wet season: +225 +/- 56 g, p less than 0.001 (unadjusted) or +200 +/- 53 g, p less than 0.001 (adjusted for sex, season, and parity) by between-child multiple regression analysis; +231 +/- 65 g, p less than 0.001 by within-mother analysis. The proportion of low-birthweight babies (less than 2501 g) decreased from 23.7-7.5%, p less than 0.002. The observed threshold effect emphasizes the importance of selective targeting of interventions to truly at-risk groups.

[1]  R. Sawers,et al.  Dietary supplementation in pregnancy. , 1986, British medical journal.

[2]  H. Bantje.  A multiple regression analysis of variables influencing birthweight. , 1986, Tropical and geographical medicine.

[3]  W. Crosby,et al.  Effect of food supplementation (WIC) during pregnancy on birth weight. , 1985, The American journal of clinical nutrition.

[4]  E. Pollitt,et al.  Outcome of maternal nutritional supplementation: a comprehensive review of the Bacon Chow study. , 1985, The American journal of clinical nutrition.

[5]  R. Pearse,et al.  Birthweight between 14 and 42 weeks' gestation. , 1985, Archives of disease in childhood.

[6]  P. Rosso.  A new chart to monitor weight gain during pregnancy. , 1985, The American journal of clinical nutrition.

[7]  A. Briend.  DO MATERNAL ENERGY RESERVES LIMIT FETAL GROWTH? , 1985, The Lancet.

[8]  R. Feachem,et al.  Interventions for the control of diarrhoeal diseases among young children: prevention of low birth weight. , 1985, Bulletin of the World Health Organization.

[9]  A. Prentice,et al.  Metabolic consequences of fasting during Ramadan in pregnant and lactating women. , 1983, Human nutrition. Clinical nutrition.

[10]  A. Prentice,et al.  Dietary supplementation of lactating Gambian women. I. Effect on breast-milk volume and quality. , 1983, Human nutrition. Clinical nutrition.

[11]  T. Cole,et al.  Dietary protein energy supplementation of pregnant Asian mothers at Sorrento, Birmingham. II: Selective during third trimester only. , 1982, British medical journal.

[12]  T. Cole,et al.  Dietary protein energy supplementation of pregnant Asian mothers at Sorrento, Birmingham. I: Unselective during second and third trimesters. , 1982, British medical journal.

[13]  L. Allen.  Provision of nutrient supplements to pregnant women , 1982 .

[14]  P. Jutsum,et al.  Anthropometric assessment of nutritional status in pregnant women: a reference table of weight-for-height by week of pregnancy. , 1982, The American journal of clinical nutrition.

[15]  M. B. Raghu,et al.  Estimation of gestational age in Zambian newborn infants. , 1981, Annals of tropical paediatrics.

[16]  A. Prentice,et al.  Long-term energy balance in child-bearing Gambian women. , 1981, The American journal of clinical nutrition.

[17]  D. Rush.  Nutritional services during pregnancy and birthweight: a retrospective matched pair analysis. , 1981, Canadian Medical Association journal.

[18]  M. Susser.  Prenatal nutrition, birthweight, and psychological development: an overview of experiments, quasi-experiments, and natural experiments in the past decade. , 1981, The American journal of clinical nutrition.

[19]  Z. Stein,et al.  A randomized controlled trial of prenatal nutritional supplementation in New York City. , 1980, Pediatrics.

[20]  A. Lechtig,et al.  Maternal food supplementation and infant health: results of a study in rural areas of Guatemala. , 1980 .

[21]  B. Switzer,et al.  Medical evaluation of the special supplemental food program for women, infants, and children. , 1979, The American journal of clinical nutrition.

[22]  A. Lechtig,et al.  Conclusions of the SAREC/WHO Workshop on Birth-Weight Distribution -- an indicator of social development. , 1978, Archivos latinoamericanos de nutricion.

[23]  Huenemann Rl,et al.  Effect of nutritional supplementation in pregnancy. I. Outcome of pregnancy. , 1978 .

[24]  R. Martorell,et al.  Effect of food supplementation during pregnancy on birthweight. , 1975, Pediatrics.

[25]  Simpson Jw,et al.  Responsibility of the obstetrician to the fetus. II. Influence of prepregnancy weight and pregnancy weight gain on birthweight. , 1975 .

[26]  S. Premakumari,et al.  Energy and protein requirements. , 1986, WHO chronicle.

[27]  M. Brueton,et al.  Gestational age assessment in Nigerian newborn infants. , 1973, Archives of disease in childhood.

[28]  Ademowore As,et al.  Relationships of maternal nutrition and weight gain to newborn birthweight. , 1972 .

[29]  L M Dubowitz,et al.  Clinical assessment of gestational age in the newborn infant. , 1970, The Journal of pediatrics.

[30]  Butler Nr,et al.  Section 2. The Perinatal Mortality Survey. , 1969 .