Benign metastasizing leiomyoma of the lung: PET findings.

We report the case of pulmonary benign metastasizing leiomyoma in an asymptomatic 64-year-old woman who underwent hysterectomy for a uterine leiomyoma 26 years earlier. Routine chest radiograph revealed bilateral diffuse nodular opacities within the pulmonary lobes. Thoracic computed tomography (CT) scan showed peripheral lung nodules that do not display contrast enhancement. Positron emission tomography (PET)-CT with 18F-fluorodeoxyglucose (18F-FDG PET-CT) demonstrated no significant metabolic activity of the nodules. The lesions were diagnosed as benign metastasizing leiomyoma by histopathologic examination. To our best knowledge, this is the first case studied combining CT and FDG PET-CT technique.

[1]  J. Fletcher,et al.  Distinctive Cytogenetic Profile in Benign Metastasizing Leiomyoma: Pathogenetic Implications , 2007, The American journal of surgical pathology.

[2]  M. Shida,et al.  F-18 fluorodeoxyglucose uptake in leiomyomatous uterus , 2006, International Journal of Gynecologic Cancer.

[3]  Jin Mo Goo,et al.  False Positive and False Negative FDG-PET Scans in Various Thoracic Diseases , 2006, Korean journal of radiology.

[4]  A. Osadchy,et al.  Pulmonary benign metastasising leiomyomas presenting as fluid-containing masses on CT in a patient with two unrelated malignancies. , 2005, The British journal of radiology.

[5]  David A Mankoff,et al.  Evolving role of positron emission tomography in breast cancer imaging. , 2005, Seminars in nuclear medicine.

[6]  S. Özalp,et al.  Uptake of 2-[18F]fluoro-2-deoxy-D-glucose in uterine leiomyoma: imaging of four patients by coincidence positron emission tomography , 2004, Nuclear medicine communications.

[7]  D. Grisaru,et al.  Normal and abnormal 18F-FDG endometrial and ovarian uptake in pre- and postmenopausal patients: assessment by PET/CT. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[8]  N. Umesaki,et al.  Positron emission tomography with (18)F-fluorodeoxyglucose of uterine sarcoma: a comparison with magnetic resonance imaging and power Doppler imaging. , 2001, Gynecologic oncology.

[9]  J. Esteban,et al.  Benign metastasizing leiomyoma of the uterus: histologic and immunohistochemical characterization of primary and metastatic lesions. , 1999, Archives of pathology & laboratory medicine.

[10]  R L Wahl,et al.  Procedure guideline for tumor imaging using fluorine-18-FDG. Society of Nuclear Medicine. , 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[11]  V. Sforza,et al.  Pedunculated pulmonary leiomyoma with large cyst formation. , 1993, The Annals of thoracic surgery.

[12]  K. Burgess,et al.  Miliary pattern as presentation of leiomyomatosis of the lung. , 1987, Chest.

[13]  Fred G. Silva,et al.  Pulmonary metastases (with admixed epithelial elements) from smooth muscle neoplasms: Report of nine cases, including three males , 1979, The American journal of surgical pathology.

[14]  Linda Johnson,et al.  Positron emission tomography and leiomyomas: clinicopathologic analysis of 3 cases of PET scan-positive leiomyomas and literature review. , 2007, Gynecologic oncology.

[15]  E. Müller-Ruchholtz,et al.  Immunohistological detection of estrogen and progesterone receptors in multiple and well differentiated leiomyomatous lung tumors in women with uterine leiomyomas (so-called benign metastasizing leiomyomas). A report on 5 cases. , 1996, Pathology, research and practice.

[16]  P. Steiner Metastasizing fibroleiomyoma of the uterus: Report of a case and review of the literature. , 1939, The American journal of pathology.