Bioactive Constituents from the Traditional Kurdish plant Iris persica

In the first phytochemical investigation of non-volatile secondary metabolites from the Kurdish traditional plant Iris persica L, (-)-embinin was isolated from flowers and leaves, isovitexin from flowers, trans-resveratrol-3-O-β-D-glucopyranoside from rhizomes and tectorigenin from bulbs. The complete NMR spectra of embinin are reported for the first time. In an MTT assay, embinin showed an inhibition activity higher than the well-known antitumor drug cisplatin against five of the six tested human tumor cells. Moreover, embinin showed a significant DPPH radical scavenging activity (IC50 value of 112.16) comparable to the reference antioxidant ascorbic acid. The remarkable biological activities exhibited by the extracts of Iris persica and isolated compounds have validated the uses of I. persica in the traditional medicine of Kurdistan.

[1]  Guoyong Xie,et al.  Four new C-glycosylflavones from the leaves of Iris lactea Pall. var. chinensis (Fisch.) Koidz. , 2017 .

[2]  M. Maggiolini,et al.  Composition, Antifungal and Antiproliferative Activities of the Hydrodistilled Oils from Leaves and Flower Heads of Pterocephalus nestorianus Nábělek , 2017, Chemistry & biodiversity.

[3]  P. Proksch,et al.  New acetylated flavone C-glycosides from Iris lactea , 2017 .

[4]  G. Vidari,et al.  Phytochemistry and Ethnopharmacology of Some Medicinal Plants Used in the Kurdistan Region of Iraq , 2016, Natural product communications.

[5]  G. Vidari,et al.  New 3,4‐Secocycloartane and 3,4‐Secodammarane Triterpenes from the Ecuadorian Plant Coussarea macrophylla , 2015, Chemistry & biodiversity.

[6]  K. Skalicka‐Woźniak,et al.  Major secondary metabolites of Iris spp. , 2015, Phytochemistry Reviews.

[7]  Minjian Qin,et al.  C-glycosylflavones from the leaves of Iris tectorum Maxim. , 2012 .

[8]  D. Hu,et al.  Chemical Constituents of the Ethyl Acetate Extract of Belamcanda chinensis (L.) DC Roots and Their Antitumor Activities , 2012, Molecules.

[9]  C. Pan,et al.  Tectorigenin inhibits IFN-γ/LPS-induced inflammatory responses in murine macrophage RAW 264.7 cells , 2008, Archives of pharmacal research.

[10]  İ. Çalış,et al.  Phenolic Compounds from Scutellaria pontica , 2002 .

[11]  J. Mérillon,et al.  Trans-resveratrol-3-O-β-glucoside (piceid) in cell suspension cultures of vitis vinifera , 1996 .

[12]  J. Harborne,et al.  Methylated C-glycosylflavones as taxonomic markers in orchids of the subtribe Ornithocephalinae. , 1994, Phytochemistry.

[13]  N. Watanabe,et al.  A Simple Screening Method for Antioxidants and Isolation of Several Antioxidants Produced by Marine Bacteria from Fish and Shellfish , 1994 .

[14]  K. Shimada,et al.  Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion , 1992 .

[15]  T. Mosmann.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.

[16]  K. Yagishita,et al.  On the Structure of a New C-Glycosyl Flavone Embinin, Isolated from the Petals of Iris germanica Linnaeous , 1968 .

[17]  P. Kaššák.  Secondary metabolites of the choosen genus iris species , 2012 .

[18]  H. Kosaka,et al.  Antimutagenic activity of isoflavone from Pueraria lobata. , 2001, Journal of agricultural and food chemistry.

[19]  R. Hilsenbeck,et al.  C-glycosylflavones from Siphonoglossa sessilis , 1983 .