High-speed integrated particle sorters based on dielectrophoresis

In this paper dielectrophoretic particle sorters are experimentally analysed. The sorters have novel electrode configurations, optimised for high-speed sorting. Increased performance has been achieved by applying plane electrodes instead of line electrodes to increase the dielectrophoretic force. The performance has been further increased by applying a larger number of outlets, to decrease the required particle displacement. Measurements were performed for four different electrode configurations. The best structures achieve more than three times the performance of the classical line electrodes.

[1]  G. Fuhr,et al.  Paired microelectrode system: dielectrophoretic particle sorting and force calibration , 1999 .

[2]  Mehmet Toner,et al.  A microfabrication-based dynamic array cytometer. , 2002, Analytical chemistry.

[3]  Thomas B. Jones,et al.  Electromechanics of Particles , 1995 .

[4]  H Morgan,et al.  The dielectrophoretic levitation and separation of latex beads in microchips , 2001, Electrophoresis.

[5]  H Morgan,et al.  Separation of submicron bioparticles by dielectrophoresis. , 1999, Biophysical journal.

[6]  H. Morgan,et al.  Microdevices for dielectrophoretic flow - through cell separation , 2003, IEEE Engineering in Medicine and Biology Magazine.

[7]  S G Shirley,et al.  Dielectrophoretic sorting of particles and cells in a microsystem. , 1998, Analytical chemistry.

[8]  Masao Washizu,et al.  Molecular dielectrophoresis of bio-polymers , 1992, Conference Record of the 1992 IEEE Industry Applications Society Annual Meeting.

[9]  M. Stelzle,et al.  Dielectrophoretic Separation and Accumulation of (Bio)Particles in Micro-Fabricated Continuous Flow Systems , 2001 .

[10]  R. Bashir,et al.  Dielectrophoretic separation and manipulation of live and heat-treated cells of Listeria on microfabricated devices with interdigitated electrodes , 2002 .

[11]  J. H. Nieuwenhuis,et al.  Improved dielectrophoretic particle actuators for microfluidics , 2003, Proceedings of IEEE Sensors 2003 (IEEE Cat. No.03CH37498).

[12]  S. Gawad,et al.  Leukocytes Discrimination by Impedance Spectroscopy Flow Cytometry , 2002 .