Development of Intra-Orbital Follicular Lymphoma and Intra-Oral MALT-Type Lymphoma in a Single Patient

An 81-year-old woman with intra-orbital follicular large-cell lymphoma and intra-oral low-grade B-cell lymphoma, compatible with MALT-type lymphoma, is reported. Several hematopathologic features indicated that the two morphologically different lymphomas were originated from a single clone of cells, but no definite evidence to confirm this possibility could be obtained. Result of chemotherapy indicated difference in sensi tivity of lymphoma cells of the two lesions to cytotoxic drugs.

[1]  B. Nathwani,et al.  Nodal benign and malignant monocytoid B cells with and without follicular lymphomas: a comparative study of follicular colonization, light chain restriction, bcl-2, and t(14;18) in 39 cases. , 1995, Human pathology.

[2]  N. Harris.  Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue and monocytoid B-cell lymphoma. Related entities that are distinct from other low-grade B-cell lymphomas. , 1993, Archives of pathology & laboratory medicine.

[3]  B. Nathwani,et al.  Monocytoid B-cell lymphomas: an assessment of diagnostic criteria and a perspective on histogenesis. , 1992, Human pathology.

[4]  J. Gribben,et al.  All advanced stage non-Hodgkin's lymphomas with a polymerase chain reaction amplifiable breakpoint of bcl-2 have residual cells containing the bcl-2 rearrangement at evaluation and after treatment. , 1991, Blood.

[5]  P. Isaacson,et al.  Follicular Colonization in B‐Cell Lymphoma of Mucosa‐Associated Lymphoid Tissue , 1991, The American journal of surgical pathology.

[6]  R. Warnke,et al.  Monocytoid B-cell lymphoma: a study of 36 cases. , 1991, Human pathology.

[7]  J. Radford,et al.  Monocytoid B cell lymphoma. , 1991, Journal of clinical pathology.

[8]  A. Morley,et al.  Monoclonality in B cell lymphoma detected in paraffin wax embedded sections using the polymerase chain reaction. , 1990, Journal of clinical pathology.

[9]  A. Morley,et al.  Development of a highly sensitive assay, based on the polymerase chain reaction, for rare B‐lymphocyte clones in a polyclonal population , 1990, British Journal of Haematology.

[10]  J. Chan,et al.  An unusual morphological variant of follicular lymphoma. Report of two cases , 1988, Histopathology.

[11]  J. Chan,et al.  Monocytoid B-cell lymphoma. , 1987, Human pathology.

[12]  H. Rappaport,et al.  Monocytoid B-cell lymphoma. A novel B-cell neoplasm. , 1986, The American journal of pathology.

[13]  P. Isaacson,et al.  Malignant lymphoma of mucosa‐associated lymphoid tissue. A distinctive type of B‐cell lymphoma , 1983, Cancer.

[14]  E. Vizcarra,et al.  [T-cell rich B-cell lymphoma]. , 1996, Medicina clinica.

[15]  H. Nakamine,et al.  Monocytoid B-Cell Lymphoma(MBCL). Report of 47 Japanese Patients and Review of the Literature with Regard to the Relation between MBCL and Low-Grade B-Cell Lymphoma Arising from the Mucosa-Associated Lymphoid Tissue(MALT Lymphoma). , 1993 .