Evaluation of Multiple Voxel-Based Morphometry Approaches and Applications in the Analysis of White Matter Changes in Temporal Lobe Epilepsy

The purpose of this study was to compare multiple voxel-based morphometry (VBM) approaches and analyze the whole-brain white matter (WM) changes in the unilateral temporal lobe epilepsy (TLE) patients relative to controls. In our study, the performance of the VBM approaches, including standard VBM, optimized VBM and VBM-DARTEL, was evaluated via a simulation, and then these VBM approaches were applied to the real data obtained from the TLE patients and controls. The results from simulation show that VBM-DARTEL performs the best among these VBM approaches. For the real data, WM reductions were found in the ipsilateral temporal lobe, the contralateral frontal and occipital lobes, the bilateral parietal lobes, cingulated gyrus, parahippocampal gyrus and brainstem of the left-TLE patients by VBM-DARTEL, which is consistent with previous studies. Our study demonstrated that DARTEL was the most robust and reliable approach for VBM analysis.

[1]  Karl J. Friston,et al.  Unified segmentation , 2005, NeuroImage.

[2]  John Ashburner,et al.  A fast diffeomorphic image registration algorithm , 2007, NeuroImage.

[3]  D. Louis Collins,et al.  Whole-brain voxel-based statistical analysis of gray matter and white matter in temporal lobe epilepsy , 2004, NeuroImage.

[4]  U. C. Wieshmann,et al.  Comparison of standard and optimized voxel-based morphometry for analysis of brain changes associated with temporal lobe epilepsy , 2004, NeuroImage.

[5]  Marie Chupin,et al.  Can voxel based morphometry, manual segmentation and automated segmentation equally detect hippocampal volume differences in acute depression? , 2009, NeuroImage.

[6]  Martha Elizabeth Shenton,et al.  Voxel-Based Morphometric Analysis of Gray Matter in First Episode Schizophrenia , 2002, NeuroImage.

[7]  M. J. Brodie,et al.  Seizure frequency and lateralization affect progression of atrophy in temporal lobe epilepsy , 2010 .

[8]  Neil Roberts,et al.  Voxel-Based Morphometric Comparison of Hippocampal and Extrahippocampal Abnormalities in Patients with Left and Right Hippocampal Atrophy , 2002, NeuroImage.

[9]  Michael A Yassa,et al.  A quantitative evaluation of cross-participant registration techniques for MRI studies of the medial temporal lobe , 2009, NeuroImage.

[10]  J. Baron,et al.  In Vivo Mapping of Gray Matter Loss with Voxel-Based Morphometry in Mild Alzheimer's Disease , 2001, NeuroImage.

[11]  Christos Davatzikos,et al.  Simulation of tissue atrophy using a topology preserving transformation model , 2006, IEEE Transactions on Medical Imaging.

[12]  Karl J. Friston,et al.  Voxel-Based Morphometry—The Methods , 2000, NeuroImage.

[13]  Karl J. Friston,et al.  A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains , 2001, NeuroImage.