Analgesic, anti-inflammatory and antipyretic activities of ethanol extract of Annona senegalensis leaves in experimental animal models

Background: This study was carried out to establish the analgesic, anti-inflammatory and antipyretic effects of the ethanol extract of Anonna senegalensis leaves in experimental animals. Methods: The analgesic activity was measured using the abdominal constriction and tail flick tests. The antiinflammatory activity was performed using xylene and egg-albumen paw induced tests, while the antipyretic activity was measured using brewer’s yeast and 2, 4 dinitrophenol induced pyrexia tests, respectively. Results: The leaf extract at all doses used exhibited significant (p<0.05) analgesic, anti-inflammatory and antipyretic activities. Conclusions: Results show that ethanol leaf extract of Anonna senegalensis possess therapeutic potential against pains and feverish conditions, supporting the claims of its this plant as remedy for similar ailments.

[1]  J. Nečas,et al.  Carrageenan: a review. , 2018 .

[2]  S. Essien,et al.  Anti-Inflammatory, Antipyretic and Anti-Nociceptive Activities of the Ethanol Stem Bark Extract of Salacia lehmbachii , 2017 .

[3]  G. Akuodor,et al.  Pharmacological evaluation of the aqueous stem bark extract of Bombax buonopozense in the relief of pain and fever , 2016 .

[4]  R. Nair,et al.  Medicinal value of Bael, Aegle marmelos , 2016 .

[5]  G. Akuodor,et al.  Antinociceptive, anti-inflammatory and antipyretic effects of ethanolic root bark extract of Icacina senegalensis in rodents - , 2016 .

[6]  F. Hock.  Drug Discovery and Evaluation: Pharmacological Assays , 2016, Springer International Publishing.

[7]  Lloyd H. Michael,et al.  The Guide for the Care and Use of Laboratory Animals. , 2016, ILAR journal.

[8]  A. Guantai,et al.  Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants , 2015, BMC Complementary and Alternative Medicine.

[9]  E. O. Irokanulo,et al.  Effect of Aqueous Leaf Extract of Annona senegalensis on Selected Testicular Function Indices of Wistar Rats , 2015 .

[10]  S. Tandon,et al.  Pharmacological and phytochemical evaluation of Ocimum sanctum root extracts for its antiinflammatory, analgesic and antipyretic activities , 2015, Pharmacognosy magazine.

[11]  Md. Abdullah Aziz.  Qualitative phytochemical screening and evaluation of anti-inflammatory, analgesic and antipyretic activities of Microcos paniculata barks and fruits. , 2015, Journal of integrative medicine.

[12]  T. S. S. Targino,et al.  Evaluation of the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice. , 2015, Acta cirurgica brasileira.

[13]  G. Akuodor,et al.  Analgesic, Anti-Inflammatory and Antipyretic Potential of the Stem Bark Extract of Stachytarpheta indica , 2015 .

[14]  R. Panneerselvam,et al.  Screening of antioxidant potential of the medicinal plant Bacopa monnieri (L.) Pennell , 2013 .

[15]  G. Akuodor,et al.  Evaluation of antipyretic potential of Pseudocedrela kotschyi Schweint. Harms (Meliaceae). , 2013 .

[16]  S. Gawade.  Acetic acid induced painful endogenous infliction in writhing test on mice , 2012, Journal of pharmacology & pharmacotherapeutics.

[17]  R. Sarin,et al.  Antimicrobial efficacy of Murraya koenigii (Linn.) Spreng. root extracts , 2011 .

[18]  Guan-Jhong Huang,et al.  Analgesic Effects and the Mechanisms of Anti-Inflammation of Hispolon in Mice , 2010, Evidence-based complementary and alternative medicine : eCAM.

[19]  P. Nwafor,et al.  Antiinflammatory, analgesic and antipyretic activities of ethanolic root extract of Croton zambesicus. , 2010, Pakistan journal of pharmaceutical sciences.

[20]  P. Akah,et al.  Neuropharmacological evaluation of Annona senegalensis leaves , 2010 .

[21]  N. Lall,et al.  Antimicrobial activity of medicinal plants against oral microorganisms. , 2008, Journal of ethnopharmacology.

[22]  A. Kar,et al.  Annona squamosa seed extract in the regulation of hyperthyroidism and lipid-peroxidation in mice: possible involvement of quercetin. , 2007, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[23]  A. Sowemimo,et al.  Toxicity and mutagenic activity of some selected Nigerian plants. , 2007, Journal of ethnopharmacology.

[24]  J. Okogun,et al.  In vivo trypanocidal activity of Annona senegalensis Pers. leaf extract against Trypanosoma brucei brucei. , 2007, Journal of ethnopharmacology.

[25]  O. Adeyemi,et al.  Analgesic, Antipyretic and Anti-Inflammatory Properties of Mezoneuron Benthamianum Baill (Caesalpiniaceae) , 2006 .

[26]  A. Akindele,et al.  Analgesic activity of the aqueous leaf extract of Byrsocarpus coccineus , 2006 .

[27]  D. N. Muanza,et al.  Antibacterial and Antifungal Activities of Nine Medicinal Plants from Zaire , 1994 .