Method using high performance liquid chromatography (HPLC) to measure Rivaroxaban intermediate content

The invention relates to a method using high performance liquid chromatography (HPLC) to measure the Rivaroxaban intermediate content. The method is used to control the quality of Rivaroxaban intermediate. In HPLC, a chromatography column (4.6*150 mm, 5[mu]m) is filled with octadecyl silane bonded silica gel, and an acidic water solution and an organic modifier are taken as the mobile phase. The provided method can effectively separate Rivaroxaban intermediate from other impurities, and has the advantages of high separation degree and sensitivity, good repeatability and durability, short analysis time, simple operation, and reliable and stable results.