New directions in liposome gene delivery

The history of liposomes, progress in liposome gene delivery, and future directions are discussed. Specific characteristics of liposomes and DNA:liposome complexes have been identified that are essential for optimal delivery and gene expression. Of particular interest are the requirements for increased delivery and high levels of gene expression in vivo. At present, significant efforts are focused towards achieving specific delivery and gene expression in target organs and tissues.

[1]  D. Liggitt,et al.  In vivo gene delivery. Efficient transfection of T lymphocytes in adult mice. , 1993, The Journal of biological chemistry.

[2]  R. Podgornik,et al.  The Structure of DNA−Liposome Complexes , 1997 .

[3]  T. Ochiya,et al.  Gene transfer and expression in progeny after intravenous DNA injection into pregnant mice , 1995, Nature Genetics.

[4]  A. Thierry,et al.  Characterization of liposome-mediated gene delivery: expression, stability and pharmacokinetics of plasmid DNA , 1997, Gene Therapy.

[5]  Y. Tan,et al.  In vivo gene delivery to the liver using reconstituted chylomicron remnants as a novel nonviral vector. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[6]  B. Sternberg.  Morphology of Cationic Liposome/DNA Complexes in Relation to Their Chemical Composition , 1996 .

[7]  H. Strey,et al.  Improved DNA: liposome complexes for increased systemic delivery and gene expression , 1997, Nature Biotechnology.

[8]  D. Lasič.  LIPOSOMES in GENE DELIVERY , 1997 .

[9]  L. Mahan,et al.  Systemic gene therapy: biodistribution and long-term expression of a transgene in mice. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[10]  Leaf Huang,et al.  Time-dependent maturation of cationic liposome–DNA complex for serum resistance , 1998, Gene Therapy.

[11]  J. Marshall,et al.  A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[12]  K. Mislick,et al.  Evidence for the role of proteoglycans in cation-mediated gene transfer. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[13]  D. Papahadjopoulos,et al.  Stabilization of cationic liposome‐plasmid DNA complexes by polyamines and poly(ethylene glycol)‐phospholipid conjugates for efficient in vivo gene delivery , 1997, FEBS letters.

[14]  F. Szoka,et al.  Effects of complement depletion on the pharmacokinetics and gene delivery mediated by cationic lipid-DNA complexes. , 1998, Human gene therapy.

[15]  H. D. Liggitt,et al.  Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery , 1997, Nature Biotechnology.

[16]  P. Felgner.  Improvements in cationic liposomes for in vivo gene transfer. , 1996, Human gene therapy.

[17]  G. Karlsson,et al.  Complexes between cationic liposomes and DNA visualized by cryo-TEM. , 1995, Biochimica et biophysica acta.

[18]  R. Scheule,et al.  Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung. , 1996, Human gene therapy.

[19]  F. Liu,et al.  Factors controlling the efficiency of cationic lipid-mediated transfection in vivo via intravenous administration , 1997, Gene Therapy.

[20]  D. Liggitt,et al.  Cationic Liposome-mediated Intravenous Gene Delivery (*) , 1995, The Journal of Biological Chemistry.

[21]  C. Y. Chow,et al.  A novel series of amphiphilic imidazolinium compounds for in vitro and in vivo gene delivery. , 1995, Biochemistry.

[22]  I. Pastan,et al.  In vitro and in vivo liposome-mediated gene transfer leads to human MDR1 expression in mouse bone marrow progenitor cells. , 1996, Human gene therapy.

[23]  D. Liggitt,et al.  Systemic gene expression after intravenous DNA delivery into adult mice. , 1993, Science.