Leveraging Large-scale Behavioral Profiling in Zebrafish to Explore Neuroactive Polypharmacology.
暂无分享,去创建一个
Michael J. Keiser | Michael J Keiser | Leo Gendelev | Matthew N. McCarroll | D. Kokel | David Kokel | Matthew N McCarroll | Leo Gendelev
[1] R. Iyengar,et al. Systems pharmacology: network analysis to identify multiscale mechanisms of drug action. , 2012, Annual review of pharmacology and toxicology.
[2] Urban Liebel,et al. Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology. , 2012, Trends in biotechnology.
[3] R. Gerlai,et al. MK-801 increases locomotor activity in a context-dependent manner in zebrafish , 2016, Behavioural Brain Research.
[4] M. Markowicz,et al. Adaptation of High-Throughput Screening in Drug Discovery—Toxicological Screening Tests , 2011, International journal of molecular sciences.
[5] Evan J. Kyzar,et al. Zebrafish models to study drug abuse-related phenotypes , 2011, Reviews in the neurosciences.
[6] G. Griebel,et al. 50 years of hurdles and hope in anxiolytic drug discovery , 2013, Nature Reviews Drug Discovery.
[7] Diogo R. Lara,et al. Effects of anxiolytics in zebrafish: Similarities and differences between benzodiazepines, buspirone and ethanol , 2011, Pharmacology Biochemistry and Behavior.
[8] M. Sundvik,et al. The comparative neuroanatomy and neurochemistry of zebrafish CNS systems of relevance to human neuropsychiatric diseases , 2010, Neurobiology of Disease.
[9] Ethan K. Scott,et al. Optogenetic dissection of a behavioral module in the vertebrate spinal cord , 2009, Nature.
[10] Masahiko Sugimoto,et al. A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development , 2010, BMC Developmental Biology.
[11] A. Pradhan,et al. Zebrafish sexual behavior: role of sex steroid hormones and prostaglandins , 2015, Behavioral and Brain Functions.
[12] Michael R Hamblin,et al. Photochemical activation of TRPA1 channels in neurons and animals , 2013, Nature chemical biology.
[13] Siddharth Gaikwad,et al. Unique and potent effects of acute ibogaine on zebrafish: The developing utility of novel aquatic models for hallucinogenic drug research , 2013, Behavioural Brain Research.
[14] J. Bajorath,et al. Polypharmacology: challenges and opportunities in drug discovery. , 2014, Journal of medicinal chemistry.
[15] L. Wodicka,et al. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology , 2014, Nature chemical biology.
[16] Ralf Mikut,et al. Identification of Nonvisual Photomotor Response Cells in the Vertebrate Hindbrain , 2013, The Journal of Neuroscience.
[17] Bryan L. Roth,et al. Chemical Informatics and Target Identification in a Zebrafish Phenotypic Screen , 2011, Nature chemical biology.
[18] D. Prober,et al. Melatonin Is Required for the Circadian Regulation of Sleep , 2015, Neuron.
[19] Michael J. Keiser,et al. Large Scale Prediction and Testing of Drug Activity on Side-Effect Targets , 2012, Nature.
[20] R. Gerlai,et al. Serotonin antagonists induce anxiolytic and anxiogenic-like behavior in zebrafish in a receptor-subtype dependent manner , 2014, Pharmacology Biochemistry and Behavior.
[21] Su Guo,et al. Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes , 2010, Neurobiology of Disease.
[22] D. Balciunas,et al. Extreme Thermal Noxious Stimuli Induce Pain Responses in Zebrafish Larvae , 2014, Journal of cellular physiology.
[23] J. Hogenesch,et al. A Genome-wide Screen Id entifies PAPP-AA-Mediated IGFR Signaling as a Novel Regulator of Habituation Learning , 2013 .
[24] Evan J. Kyzar,et al. Three-Dimensional Neurophenotyping of Adult Zebrafish Behavior , 2011, PloS one.
[25] Stephan C F Neuhauss,et al. Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond. , 2013, Zebrafish.
[26] Ethan K. Scott,et al. Filtering of Visual Information in the Tectum by an Identified Neural Circuit , 2010, Science.
[27] Emmanuel Mignot,et al. Genomic and functional conservation of sedative-hypnotic targets in the zebrafish , 2007, Pharmacogenetics and genomics.
[28] Michael Granato,et al. Sensorimotor Gating in Larval Zebrafish , 2007, The Journal of Neuroscience.
[29] Randall T Peterson,et al. 15 years of zebrafish chemical screening. , 2015, Current opinion in chemical biology.
[30] Siddharth Gaikwad,et al. Characterization of behavioral and endocrine effects of LSD on zebrafish , 2010, Behavioural Brain Research.
[31] Maria F. Sassano,et al. In Silico Molecular Comparisons of C. elegans and Mammalian Pharmacology Identify Distinct Targets That Regulate Feeding , 2013, PLoS biology.
[32] D. Prober,et al. Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish , 2015, eLife.
[33] Evan J. Kyzar,et al. Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology , 2012, Progress in Neuro-Psychopharmacology and Biological Psychiatry.
[34] Michael J. Keiser,et al. Relating protein pharmacology by ligand chemistry , 2007, Nature Biotechnology.
[35] S. Ryu,et al. The behavior of larval zebrafish reveals stressor-mediated anorexia during early vertebrate development , 2014, Front. Behav. Neurosci..
[36] B. Roth,et al. Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia , 2004, Nature Reviews Drug Discovery.
[37] S. Higashijima,et al. The habenula is crucial for experience-dependent modification of fear responses in zebrafish , 2010, Nature Neuroscience.
[38] A. Stewart,et al. Perspectives on zebrafish models of hallucinogenic drugs and related psychotropic compounds. , 2013, ACS chemical neuroscience.
[39] Michael J. Keiser,et al. Predicting new molecular targets for known drugs , 2009, Nature.
[40] N. Craddock,et al. Genetics of bipolar disorder , 1999, Journal of medical genetics.
[41] Silvio Morato,et al. Scototaxis as anxiety-like behavior in fish , 2010, Nature Protocols.
[42] Randall T Peterson,et al. Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish. , 2008, Briefings in functional genomics & proteomics.
[43] Kyu-Won Kim,et al. Functional and developmental analysis of the blood–brain barrier in zebrafish , 2008, Brain Research Bulletin.
[44] J. Dowling,et al. Small molecule developmental screens reveal the logic and timing of vertebrate development. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[45] S. Haggarty,et al. Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation , 2010, Science.
[46] Lani F. Wu,et al. Molecular Systems Biology 6; Article number 369; doi:10.1038/msb.2010.22 Citation: Molecular Systems Biology 6:369 , 2022 .
[47] Evan J. Kyzar,et al. Behavioral effects of bidirectional modulators of brain monoamines reserpine and d-amphetamine in zebrafish , 2013, Brain Research.
[48] Antonio Carrieri,et al. Recent trends and future prospects in computational GPCR drug discovery: from virtual screening to polypharmacology. , 2013, Current topics in medicinal chemistry.
[49] Maria F. Sassano,et al. Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides. , 2015, Chemistry & biology.
[50] Michael C Neale,et al. Evidence for multiple genetic factors underlying DSM-IV criteria for major depression. , 2013, JAMA psychiatry.
[51] Christian Laggner,et al. Rapid behavior—based identification of neuroactive small molecules in the zebrafish , 2009, Nature chemical biology.
[52] C. Spencer,et al. Biological Insights From 108 Schizophrenia-Associated Genetic Loci , 2014, Nature.
[53] Florian Engert,et al. A Convergent and Essential Interneuron Pathway for Mauthner-Cell-Mediated Escapes , 2015, Current Biology.
[54] B. Roth,et al. The Multiplicity of Serotonin Receptors: Uselessly Diverse Molecules or an Embarrassment of Riches? , 2000 .
[55] B. Eliceiri,et al. Zebrafish model of the blood-brain barrier: morphological and permeability studies. , 2011, Methods in molecular biology.
[56] Alexander F Schier,et al. Behavioral screening for neuroactive drugs in zebrafish , 2012, Developmental neurobiology.
[57] A. Giordano,et al. The zebrafish as a model for nociception studies , 2013, Journal of cellular physiology.
[58] Steven G Potkin,et al. Atypical antipsychotic drug actions: unitary or multiple mechanisms for ‘atypicality’? , 2003, Clinical Neuroscience Research.
[59] Differential effects of acute administration of SCH-23390, a D1 receptor antagonist, and of ethanol on swimming activity, anxiety-related responses, and neurochemistry of zebrafish , 2015, Psychopharmacology.
[60] Scott C. Baraban,et al. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet Syndrome treatment , 2013, Nature Communications.
[61] Maria F. Sassano,et al. Automated design of ligands to polypharmacological profiles , 2012, Nature.
[62] John P. Overington,et al. Probing the links between in vitro potency, ADMET and physicochemical parameters , 2011, Nature Reviews Drug Discovery.
[63] Monica Gomes Lima,et al. Fingerprinting of Psychoactive Drugs in Zebrafish Anxiety-Like Behaviors , 2014, PloS one.
[64] H. Burgess,et al. The Dorsal Raphe Modulates Sensory Responsiveness during Arousal in Zebrafish , 2012, The Journal of Neuroscience.
[65] G. Peng,et al. Effects of lorazepam and WAY-200070 in larval zebrafish light/dark choice test , 2015, Neuropharmacology.
[66] J. L. Snekser,et al. Fin-mutant female zebrafish (Danio rerio) exhibit differences in association preferences for male fin length , 2009, Behavioural Processes.
[67] Randall T Peterson,et al. Using the zebrafish photomotor response for psychotropic drug screening. , 2011, Methods in cell biology.
[68] H. Wolburg,et al. Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion , 2010, Proceedings of the National Academy of Sciences.
[69] Florian Engert,et al. A high-throughput assay for quantifying appetite and digestive dynamics. , 2015, American journal of physiology. Regulatory, integrative and comparative physiology.
[70] D. Raible,et al. Modeling Nociception in Zebrafish: A Way Forward for Unbiased Analgesic Discovery , 2015, PloS one.
[71] Xiuyun Liu,et al. Influences of acute ethanol exposure on locomotor activities of zebrafish larvae under different illumination. , 2015, Alcohol.
[72] Drew N. Robson,et al. Brain-wide neuronal dynamics during motor adaptation in zebrafish , 2012, Nature.