Genetic epidemiology of hip and knee osteoarthritis

[1]  K. Nakashima,et al.  [The Rotterdam study]. , 2011, Nihon rinsho. Japanese journal of clinical medicine.

[2]  D. Shi,et al.  Genetic polymorphism of PITX1 in susceptibility to knee osteoarthritis in a Chinese Han population: a case–control study , 2011, Rheumatology International.

[3]  Banu Bayram,et al.  DD genotype of ace gene I/D polymorphism is associated in a turkish study population with osteoarthritis , 2011, Molecular Biology Reports.

[4]  Bjarni V. Halldórsson,et al.  Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22 , 2010, Annals of the rheumatic diseases.

[5]  D. Shi,et al.  Association of the leptin gene with knee osteoarthritis susceptibility in a Han Chinese population: a case–control study , 2010, Journal of Human Genetics.

[6]  Toshihiro Tanaka,et al.  Prediction model for knee osteoarthritis based on genetic and clinical information , 2010, Arthritis Research & Therapy.

[7]  A. Hofman,et al.  The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance , 2010, Annals of the rheumatic diseases.

[8]  C. Cooper,et al.  Involvement of different risk factors in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes. , 2010, Arthritis and rheumatism.

[9]  J. Katz,et al.  Getting to the heart of the matter: osteoarthritis takes its place as part of the metabolic syndrome , 2010, Current opinion in rheumatology.

[10]  J. Houwing-Duistermaat,et al.  Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility , 2010, Annals of the rheumatic diseases.

[11]  T. Spector,et al.  Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. , 2010, Arthritis and rheumatism.

[12]  Jason H. Moore,et al.  Missing heritability and strategies for finding the underlying causes of complex disease , 2010, Nature Reviews Genetics.

[13]  E. Ramón-Gallegos,et al.  A COL2A1 gene polymorphism is related with advanced stages of osteoarthritis of the knee in Mexican Mestizo population , 2010, Rheumatology International.

[14]  A. Hofman,et al.  Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index , 2010, Annals of the rheumatic diseases.

[15]  A. Dopazo,et al.  Large-scale gene expression in bone marrow mesenchymal stem cells: a putative role for COL10A1 in osteoarthritis , 2010, Annals of the rheumatic diseases.

[16]  R. Altman,et al.  Report of the American College of Rheumatology Pain Management Task Force , 2010, Arthritis care & research.

[17]  T. Spector,et al.  A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis. , 2010, Osteoarthritis and cartilage.

[18]  M. King,et al.  Genetic Heterogeneity in Human Disease , 2010, Cell.

[19]  H. Brenner,et al.  The (−765 G→C) promoter variant of the COX-2/PTGS2 gene is associated with a lower risk for end-stage hip and knee osteoarthritis , 2010, Annals of the rheumatic diseases.

[20]  C. Hengstenberg,et al.  Genetics in neuroendocrine immunology: implications for rheumatoid arthritis and osteoarthritis , 2010, Annals of the New York Academy of Sciences.

[21]  Yusuke Nakamura,et al.  New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study , 2010, PloS one.

[22]  Minna Männikkö,et al.  Pain perception is altered by a nucleotide polymorphism in SCN9A , 2010, Proceedings of the National Academy of Sciences.

[23]  Yusuke Nakamura,et al.  Identification of sequence polymorphisms in CALM2 and analysis of association with hip osteoarthritis in a Japanese population , 2010, Journal of Bone and Mineral Metabolism.

[24]  J. Magaña,et al.  Association of the calcitonin gene (CA) polymorphism with osteoarthritis of the knee in a Mexican mestizo population. , 2010, The Knee.

[25]  M. Lavigne,et al.  Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression , 2010, Arthritis research & therapy.

[26]  Bjarni V. Halldórsson,et al.  A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. , 2010, Arthritis and rheumatism.

[27]  P. Woratanarat,et al.  Association of estrogen receptor-alpha single-nucleotide polymorphism (codon 594 G-->A) and Thai patients affected by knee osteoarthritis. , 2009, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.

[28]  S. Abramson,et al.  Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations , 2010 .

[29]  I. Kerna,et al.  Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort. , 2009, Osteoarthritis and cartilage.

[30]  M. Paulsson,et al.  The knee osteoarthritis susceptibility locus DVWA on chromosome 3p24.3 is the 5' part of the split COL6A4 gene. , 2009, Matrix biology : journal of the International Society for Matrix Biology.

[31]  A. Hofman,et al.  Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women. , 2009, Arthritis and rheumatism.

[32]  L. Southam,et al.  Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism. , 2009, Arthritis and rheumatism.

[33]  Bjarni V. Halldórsson,et al.  Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. , 2009, Arthritis and rheumatism.

[34]  S. Abramson,et al.  Developments in the scientific understanding of osteoarthritis , 2009, Arthritis research & therapy.

[35]  D. Shi,et al.  Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations. , 2009, Human molecular genetics.

[36]  Eran Halperin,et al.  SNP imputation in association studies , 2009, Nature Biotechnology.

[37]  Felix Eckstein,et al.  Radiologic markers of osteoarthritis progression , 2009, Current opinion in rheumatology.

[38]  T. Spector,et al.  Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes. , 2009, Osteoarthritis and cartilage.

[39]  J. Gómez-Reino,et al.  Role of European mitochondrial DNA haplogroups in the prevalence of hip osteoarthritis in Galicia, Northern Spain , 2009, Annals of the rheumatic diseases.

[40]  J. DiStefano,et al.  TSH-based protocol, tablet instability, and absorption effects on L-T4 bioequivalence. , 2009, Thyroid : official journal of the American Thyroid Association.

[41]  R. Elston,et al.  Finding genes underlying human disease , 2009, Clinical genetics.

[42]  A. Hofman,et al.  A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain. , 2009, Arthritis and rheumatism.

[43]  M. Erdal,et al.  Association of (−1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms) , 2009, Rheumatology International.

[44]  Andrew D. Johnson,et al.  Bmc Medical Genetics an Open Access Database of Genome-wide Association Results , 2009 .

[45]  D. Shi,et al.  Genetic polymorphisms of interleukin-1β (−511C/T) and interleukin-1 receptor antagonist (86-bpVNTR) in susceptibility to knee osteoarthritis in a Chinese Han population , 2009, Rheumatology International.

[46]  T. Spector,et al.  Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations , 2008, Annals of the rheumatic diseases.

[47]  A. Hofman,et al.  Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study , 2008, Annals of the rheumatic diseases.

[48]  K. Malizos,et al.  Association of KLOTHO gene polymorphisms with knee osteoarthritis in Greek population , 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[49]  D. Shi,et al.  Lack of association between the CALM1 core promoter polymorphism (-16C/T) and susceptibility to knee osteoarthritis in a Chinese Han population , 2008, BMC Medical Genetics.

[50]  R. Moskowitz,et al.  Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians. , 2008, Osteoarthritis and cartilage.

[51]  A. Hofman,et al.  Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts. , 2008, Osteoarthritis and cartilage.

[52]  R. Eastell,et al.  Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty. , 2008, Arthritis and rheumatism.

[53]  J. Ioannidis.  Calibration of credibility of agnostic genome‐wide associations , 2008, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[54]  M. Erdal,et al.  Tumour necrosis factor alpha -308G/A gene polymorphism: lack of association with knee osteoarthritis in a Turkish population. , 2008, Clinical and experimental rheumatology.

[55]  Yusuke Nakamura,et al.  Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis , 2008, Nature Genetics.

[56]  J. Arenas,et al.  Mitochondrial DNA haplogroups: role in the prevalence and severity of knee osteoarthritis. , 2008, Arthritis and rheumatism.

[57]  D. Shi,et al.  Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections , 2008, Annals of the rheumatic diseases.

[58]  H. Rangel-Villalobos,et al.  Increase levels of apo-A1 and apo B are associated in knee osteoarthritis: lack of association with VEGF-460 T/C and +405 C/G polymorphisms , 2008, Rheumatology International.

[59]  Cornelia M van Duijn,et al.  Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. , 2008, Human molecular genetics.

[60]  Yusuke Nakamura,et al.  A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese. , 2008, Human molecular genetics.

[61]  K. Malizos,et al.  Association of the CALM1 core promoter polymorphism with knee osteoarthritis in patients of Greek origin. , 2008, Genetic testing.

[62]  A. Hofman,et al.  Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. , 2008, American journal of human genetics.

[63]  W. Park,et al.  Aspartic acid repeat polymorphism of the asporin gene with susceptibility to osteoarthritis of the knee in a Korean population. , 2008, The Knee.

[64]  D. Shi,et al.  A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility. , 2008, Human molecular genetics.

[65]  D. Shi,et al.  Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis , 2008, Arthritis research & therapy.

[66]  R. Lories.  Joint homeostasis, restoration, and remodeling in osteoarthritis. , 2008, Best practice & research. Clinical rheumatology.

[67]  M. Haider,et al.  Prevalence of angiotensin-converting enzyme gene insertion-deletion polymorphism in patients with primary knee osteoarthritis. , 2008, Clinical and experimental rheumatology.

[68]  N. Hamajima,et al.  Interleukin-1β gene polymorphism associated with radiographic signs of osteoarthritis of the knee , 2008, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[69]  John Loughlin,et al.  Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis. , 2008, Arthritis and rheumatism.

[70]  S. Gabriel,et al.  Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. , 2008, Arthritis and rheumatism.

[71]  D. Shi,et al.  Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility , 2008, Journal of Human Genetics.

[72]  K. Muir,et al.  Attempt to replicate published genetic associations in a large, well-defined osteoarthritis case-control population (the GOAL study). , 2007, Osteoarthritis and cartilage.

[73]  M. Karsdal,et al.  Calcitonin Affects Both Bone and Cartilage , 2007 .

[74]  J. Martel-Pelletier,et al.  New Emerging Role of Pitx1 Transcription Factor in Osteoarthritis Pathogenesis , 2007, Clinical orthopaedics and related research.

[75]  T. Spector,et al.  The additive effect of individual genes in predicting risk of knee osteoarthritis , 2007, Annals of the rheumatic diseases.

[76]  M. Nevitt,et al.  Estrogen receptor alpha genotype is associated with a reduced prevalence of radiographic hip osteoarthritis in elderly Caucasian women. , 2007, Osteoarthritis and cartilage.

[77]  Naoyuki Kamatani,et al.  Meta-analysis of association between the ASPN D-repeat and osteoarthritis. , 2007, Human molecular genetics.

[78]  J. Sinsheimer,et al.  Genetic influences in the aetiology of anteromedial osteoarthritis of the knee. , 2007, The Journal of bone and joint surgery. British volume.

[79]  D. Shi,et al.  Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese Population , 2007, Journal of Human Genetics.

[80]  M. Erdal,et al.  Lack of association polymorphisms of the IL1RN, IL1A, and IL1B genes with knee osteoarthritis in Turkish patients. , 2007, Clinical and investigative medicine. Medecine clinique et experimentale.

[81]  Yusuke Nakamura,et al.  A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis , 2007, Nature Genetics.

[82]  T. Spector,et al.  Genetic influence on the progression of radiographic knee osteoarthritis: a longitudinal twin study. , 2007, Osteoarthritis and cartilage.

[83]  F. Blanco,et al.  Cell death and apoptosis in osteoarthritic cartilage. , 2007, Current drug targets.

[84]  Yong Wang,et al.  Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese , 2006, Journal of Human Genetics.

[85]  M. Nevitt,et al.  Frizzled-related protein variants are risk factors for hip osteoarthritis. , 2006, Arthritis and rheumatism.

[86]  J. Katz,et al.  Total joint replacement in osteoarthritis. , 2006, Best practice & research. Clinical rheumatology.

[87]  T. Spector,et al.  Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. , 2006, Arthritis and rheumatism.

[88]  R. Elston,et al.  Hip joint replacement surgery for idiopathic osteoarthritis aggregates in families , 2006, Arthritis research & therapy.

[89]  E. Regan,et al.  Extracellular superoxide dismutase and oxidant damage in osteoarthritis. , 2005, Arthritis and rheumatism.

[90]  E. Schwarz,et al.  Smad3‐Deficient Chondrocytes Have Enhanced BMP Signaling and Accelerated Differentiation , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[91]  G. Zhai,et al.  The genetic contribution to longitudinal changes in knee structure and muscle strength: a sibpair study. , 2005, Arthritis and rheumatism.

[92]  J. Kirwan,et al.  Haplotypes of the low-density lipoprotein receptor-related protein 5 (LRP5) gene: are they a risk factor in osteoarthritis? , 2005, Osteoarthritis and cartilage.

[93]  Kozo Nakamura,et al.  A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese. , 2005, Human molecular genetics.

[94]  A. Fourie,et al.  ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro , 2005, Nature.

[95]  P. Dieppe,et al.  Pathogenesis and management of pain in osteoarthritis , 2005, The Lancet.

[96]  Yusuke Nakamura,et al.  An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis , 2005, Nature Genetics.

[97]  K. Muir,et al.  Genetic risk of knee osteoarthritis: a sibling study , 2004, Annals of the rheumatic diseases.

[98]  Hun-Kuk Park,et al.  Estrogen receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population , 2004, Arthritis research & therapy.

[99]  Toshihiro Tanaka.  The International HapMap Project , 2003, Nature.

[100]  M. Tortorella,et al.  The usual suspects: verdict not guilty? , 2003, Arthritis and rheumatism.

[101]  H. Snieder,et al.  Genetic contribution to cartilage volume in women: a classical twin study. , 2003, Rheumatology.

[102]  S. Yim,et al.  Angiotensin converting enzyme gene polymorphism in Korean patients with primary knee osteoarthritis , 2003, Experimental & Molecular Medicine.

[103]  C. Platsoucas,et al.  Role of T cells in the pathogenesis of osteoarthritis. , 2002, Arthritis and rheumatism.

[104]  C. Deng,et al.  TGF-β/Smad3 Signals Repress Chondrocyte Hypertrophic Differentiation and Are Required for Maintaining Articular Cartilage , 2001, The Journal of cell biology.

[105]  M. Doherty,et al.  Assessment of a genetic contribution to osteoarthritis of the hip: sibling study , 2000, BMJ : British Medical Journal.

[106]  C. Hartmann,et al.  Dual roles of Wnt signaling during chondrogenesis in the chicken limb. , 2000, Development.

[107]  F. Luyten,et al.  Mechanisms of GDF-5 action during skeletal development. , 1999, Development.

[108]  J S Sinsheimer,et al.  Genetic influences in end-stage osteoarthritis. Sibling risks of hip and knee replacement for idiopathic osteoarthritis. , 1997, The Journal of bone and joint surgery. British volume.

[109]  Janet S. Sinsheimer,et al.  GENETIC INFLUENCES IN END-STAGE OSTEOARTHRITIS: SIBLING RISKS OF HIP AND KNEE REPLACEMENT FOR IDIOPATHIC OSTEOARTHRITIS , 1997 .

[110]  J TRUETA,et al.  Osteoarthritis of the hip: a study of the nature and evolution of the disease. , 1953, The Journal of bone and joint surgery. British volume.

[111]  Li-li Feng.  Wnt/ beta -Catenin Signaling in the Pathogenesis of Osteoarthritis , 2011 .

[112]  A. Nelson.  Different risk factors are involved in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes , 2010 .

[113]  T. Spector,et al.  The contribution of genes to osteoarthritis. , 2009, The Medical clinics of North America.

[114]  Atlanta,et al.  Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. , 2008, Arthritis and rheumatism.

[115]  M. Karsdal,et al.  Calcitonin affects both bone and cartilage: a dual action treatment for osteoarthritis? , 2007, Annals of the New York Academy of Sciences.

[116]  T. Spector,et al.  Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. , 2007, Arthritis and rheumatism.

[117]  Y. Lee,et al.  Osteoarthritis susceptibility loci defined by genome scan meta-analysis , 2006, Rheumatology International.

[118]  W. B. van den Berg.  Lessons from animal models of osteoarthritis. , 2001, Current opinion in rheumatology.