Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases

In the mammalian central nervous system, receptors for excitatory amino acid neurotransmitters such as the alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid (AMPA)-kainate receptor mediate a large fraction of excitatory transmission. Currents induced by activation of the AMPA-kainate receptor were potentiated by agents that specifically stimulate adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase A (PKA) activity or were supported by intracellular application of the catalytic subunit of PKA by itself or in combination with cAMP. Furthermore, depression of these currents by a competitive inhibitor of PKA indicates that AMPA-kainate receptors are regulated by endogenous PKA. Endogenous protein phosphatases also regulate these receptors because an inhibitor of cellular phosphates enhanced kainate currents. Modulation of PKA and phosphatases may regulate the function of these receptors and thus contribute to synaptic plasticity in hippocampal neurons.

[1]  P. Greengard,et al.  Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons , 1991, Science.

[2]  S. Heinemann,et al.  Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA , 1991, Nature.

[3]  Robert C. Malenka,et al.  Postsynaptic factors control the duration of synaptic enhancement in area CA1 of the hippocampus , 1991, Neuron.

[4]  J. Henley,et al.  The non-NMDA receptors: types, protein structure and molecular biology. , 1990, Trends in pharmacological sciences.

[5]  L. Huang,et al.  Modulation of glycine receptor chloride channels by cAMP-dependent protein kinase in spinal trigeminal neurons , 1990, Nature.

[6]  R. Axel,et al.  A family of glutamate receptor genes: Evidence for the formation of heteromultimeric receptors with distinct channel properties , 1990, Neuron.

[7]  B. Sakmann,et al.  Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. , 1990, Science.

[8]  B. Sakmann,et al.  A family of AMPA-selective glutamate receptors. , 1990, Science.

[9]  S. Ozawa,et al.  Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones. , 1990, The Journal of physiology.

[10]  P. Cohen,et al.  Okadaic acid: a new probe for the study of cellular regulation. , 1990, Trends in biochemical sciences.

[11]  J. Watkins,et al.  Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. , 1990, Trends in pharmacological sciences.

[12]  R. Tsien,et al.  Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP. , 1989, Science.

[13]  L. Trussell,et al.  Glutamate receptor desensitization and its role in synaptic transmission , 1989, Neuron.

[14]  I. Módy,et al.  Regulation of N‐methyl‐D‐aspartate receptors revealed by intracellular dialysis of murine neurones in culture. , 1989, The Journal of physiology.

[15]  M. Dichter,et al.  Quisqualate activates a rapidly inactivating high conductance ionic channel in hippocampal neurons. , 1989, Science.

[16]  B. Yusta,et al.  Comparison of the Effects of Forskolin and Dibutyryl Cyclic AMP in Neuroblastoma Cells: Evidence that Some of the Actions of Dibutyryl Cyclic AMP Are Mediated by Butyrate , 1988, Journal of neurochemistry.

[17]  R. Nicoll,et al.  A persistent postsynaptic modification mediates long-term potentiation in the hippocampus , 1988, Neuron.

[18]  R. Horn,et al.  Muscarinic activation of ionic currents measured by a new whole-cell recording method , 1988, The Journal of general physiology.

[19]  M. W. Brown,et al.  CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rat hippocampal slices , 1988, Neuroscience Letters.

[20]  John E. Dowling,et al.  Dopamine enhances excitatory amino acid-gated conductances in cultured retinal horizontal cells , 1987, Nature.

[21]  O. Krishtal,et al.  Excitatory amino acid receptors in hippocampal neurons: Kainate fails to desensitize them , 1986, Neuroscience Letters.

[22]  P. Forscher,et al.  Modulation of calcium channels by norepinephrine in internally dialyzed avian sensory neurons , 1985, The Journal of general physiology.

[23]  A. Ishida,et al.  Quisqualate and L-glutamate inhibit retinal horizontal-cell responses to kainate. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[24]  B. Jastorff,et al.  Physico-chemical characterization of cyclic nucleotides by reversed-phase high-performance liquid chromatography: II. Quantitative determination of hydrophobicity , 1985 .