论文信息 - Next-generation protein drugs - 字舞流文

Next-generation protein drugs

Ankyrin repeats generate high-affinity protein binders with biophysical properties that may favor therapeutic applications.

I. Tomlinson | Ian M Tomlinson

[1] J. Scott,et al. Searching for peptide ligands with an epitope library. , 1990, Science.

[2] S. Smerdon,et al. The ankyrin repeat: a diversity of interactions on a common structural framework. , 1999, Trends in biochemical sciences.

[3] A. Plückthun,et al. High-affinity binders selected from designed ankyrin repeat protein libraries , 2004, Nature Biotechnology.

[4] Janice M. Reichert,et al. Monoclonal antibodies in the clinic , 2001, Nature Biotechnology.

[5] A. Steinkasserer,et al. Transferrin Trojan Horses as a Rational Approach for the Biological Delivery of Therapeutic Peptide Domains* , 1999, The Journal of Biological Chemistry.

[6] W. Dower,et al. An in vitro polysome display system for identifying ligands from very large peptide libraries. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[7] L. James,et al. Crystal structure of HEL4, a soluble, refoldable human V(H) single domain with a germ-line scaffold. , 2004, Journal of molecular biology.