Comparison of the Amplitude/Intensity Function of the Auditory Evoked N1m and N1 Components

This study compared the intensity dependence of the auditory evoked N1 and N1m components in 10 healthy subjects. The evoked responses were recorded simultaneously at 33 channels for the auditory evoked potentials (AEP) and with a 37-channel magnetometer for the auditory evoked fields (AEF). They were satisfactorily modeled by a tangential and a radial dipole per hemisphere for the N1 component and a tangential dipole in the left hemisphere for the N1m component. The tangential dipoles showed different dipole characteristics. The amplitude of the AEP rose significantly with increasing stimulus intensity whereas the amplitudes of the AEF tended to plateau between the highest intensities. The magnetic dipole shifted to the surface of the skull with higher stimulus intensity whereas the electric tangential dipole moved to the center of the skull. The latencies decreased with increasing stimulus intensity.

[1]  P. Teale,et al.  Auditory M100 component 1: relationship to Heschl's gyri. , 1994, Brain research. Cognitive brain research.

[2]  T. Picton,et al.  The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. , 1987, Psychophysiology.

[3]  Michael Scherg,et al.  Dipole sources potentials of the auditory cortex in normal subjects and in patients with temporal lobe lesions , 1990 .

[4]  S. Joutsiniemi Comparison between electric evoked potentials, source dipole components and magnetic evoked fields elicited by noise/square‐wave stimuli , 1988, Acta neurologica Scandinavica.

[5]  R Salmelin,et al.  Information processing in the human brain: magnetoencephalographic approach. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[6]  S. Baumann,et al.  Localization of auditory response sources using magnetoencephalography and magnetic resonance imaging. , 1990, Archives of neurology.

[7]  J. Mäkelä,et al.  Long-latency auditory evoked magnetic fields. , 1990, Advances in neurology.

[8]  J. Wolpaw Single unit activity vs. amplitude of the epidural evoked potential in primary auditory cortex of awake cats. , 1979, Electroencephalography and clinical neurophysiology.

[9]  John F. Brugge,et al.  PATTERNS OF ACTIVITY OF SINGLE NEURONS OF THE AUDITORY CORTEX IN MONKEY , 1973 .

[10]  R. Ilmoniemi,et al.  MEG VERSUS EEG LOCALIZATION TEST. REPLY , 1991 .

[11]  L. Kaufman,et al.  On the relation between somatic evoked potentials and fields. , 1981, The International journal of neuroscience.

[12]  K. Lehnertz,et al.  Neuromagnetic evidence of an amplitopic organization of the human auditory cortex. , 1989, Electroencephalography and clinical neurophysiology.

[13]  S. Williamson MEG versus EEG localization test , 1991, Annals of neurology.

[14]  M J Campbell,et al.  The monoaminergic innervation of primate neocortex. , 1986, Human neurobiology.

[15]  M Hoke,et al.  Causes of differences in the input-output characteristics of simultaneously recorded auditory evoked magnetic fields and potentials. , 1986, Audiology : official organ of the International Society of Audiology.

[16]  H Koch,et al.  A 37-channel DC SQUID magnetometer system. , 1991, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[17]  S. Foote,et al.  Intensity-amplitude relationships in monkey event-related potentials: parallels to human augmenting-reducing responses. , 1991, Electroencephalography and clinical neurophysiology.

[18]  D Mrowinski,et al.  Intensity dependence of auditory evoked dipole source activity. , 1994, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[19]  S. Foote,et al.  Distribution of choline acetyltransferase‐, serotonin‐, dopamine‐β‐hydroxylase‐, tyrosine hydroxylase‐immunoreactive fibers in monkey primary auditory cortex , 1987, The Journal of comparative neurology.

[20]  MEG, EEG and ECoG: discussion , 1994, Acta neurologica Scandinavica. Supplementum.

[21]  C. Elberling,et al.  Auditory magnetic fields from the human cortex. Influence of stimulus intensity. , 1981, Scandinavian Audiology.

[22]  T W Picton,et al.  Separation and identification of event-related potential components by brain electric source analysis. , 1991, Electroencephalography and clinical neurophysiology. Supplement.

[23]  D. P. Phillips,et al.  Neurons in the cat's primary auditory cortex distinguished by their responses to tones and wide-spectrum noise , 1985, Hearing Research.

[24]  Georg Juckel,et al.  Intensity dependence of auditory evoked potentials as an indicator of central serotonergic neurotransmission: A new hypothesis , 1993, Biological Psychiatry.

[25]  K Saermark,et al.  Dependence of the auditory evoked magnetic field (100 msec signal) of the human brain on the intensity of the stimulus. , 1985, Electroencephalography and clinical neurophysiology.

[26]  R. Ilmoniemi,et al.  MEG versus EEG localization test , 1991 .

[27]  M Reite,et al.  Auditory evoked magnetic fields: response amplitude vs. stimulus intensity. , 1982, Electroencephalography and clinical neurophysiology.