Assessment of Vitamin D Levels in Relation to Statin Therapy in Elderly Hypertensive Patients with Comorbidities

Abstract Background: Statin therapy is commonly used on the long term in hypertensive patients with dyslipidemia and can interfere with vitamin D metabolism. Overweight/obesity and type 2 diabetes mellitus (DM) are frequently associated with hypertension. The aim of the study was the assessment of vitamin D status in elderly hypertensive patients with metabolic comorbidities with/without statin therapy, in relation to body mass index (BMI) and lipid profile parameters. Material and methods: The study group included 89 hypertensive patients (61 statin-treated) admitted to the Cardiovascular Rehabilitation Clinical Hospital in Târgu Mureș between 2019 and 2021. Vitamin D levels were measured by ELISA method, lipid profile parameters by photometric procedures. Calculated values were LDL-cholesterol and BMI. Results: Obesity and DM were present in association with hypertension in 51% of the subjects. A total of 89% of the enrolled hypertensive patients had hypovitaminosis D. Average serum vitamin D of the studied subjects was 14.27 ± 11.96 ng/mL. No significant difference was obtained in vitamin D levels depending on gender, the presence/absence of statin therapy, and DM as a comorbidity. A negative correlation was seen between serum HDL-cholesterol and triglyceride concentrations (r = –0.3988, p = 0.0008) and between HDL levels and BMI (r = –0.3114, p = 0.0475). Conclusions: Suboptimal vitamin D levels were present in the majority of the studied hypertensive patients regardless of the statin therapy, which reveals the importance of concomitant assessment of vitamin D levels, especially in elderly subjects presenting chronic metabolic comorbidities.

[1]  M. Croitoru,et al.  Oxidative stress and metabolic parameters in hypertensive patients with/without diabetes mellitus in cardiovascular risk evaluation , 2022, Revista Romana de Medicina de Laborator.

[2]  G. Sangiorgi,et al.  Current Options and Future Perspectives in the Treatment of Dyslipidemia , 2022, Journal of clinical medicine.

[3]  Amy E. Morgan,et al.  The Interdependency and Co-Regulation of the Vitamin D and Cholesterol Metabolism , 2021, Cells.

[4]  Martha Montalván,et al.  The Effect of Statins on Serum Vitamin D Concentrations Among Older Adults , 2020, Cureus.

[5]  Yumei Zhang,et al.  The Effect of Vitamin D Supplementation on Glycemic Control in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis , 2018, Nutrients.

[6]  M. Mazidi,et al.  Effect of statins on serum vitamin D concentrations: a systematic review and meta‐analysis , 2017, European journal of clinical investigation.

[7]  K. Bairy,et al.  Statin use and risk of diabetes mellitus. , 2015, World journal of diabetes.

[8]  G. Lip,et al.  Analysis of vitamin D levels in patients with and without statin-associated myalgia - a systematic review and meta-analysis of 7 studies with 2420 patients. , 2015, International journal of cardiology.

[9]  P. Thompson,et al.  The relationship of vitamin D deficiency to statin myopathy. , 2011, Atherosclerosis.

[10]  Samuel Szomstein,et al.  Association of Body Mass Index and Lipid Profiles: Evaluation of a Broad Spectrum of Body Mass Index Patients Including the Morbidly Obese , 2011, Obesity surgery.

[11]  J. Genest,et al.  Effect of Obesity on High‐density Lipoprotein Metabolism , 2007, Obesity.