Fiber optic biosensor for monitoring protein binding kinetics

The proposed optical fiber biosensor is used to study the qualitative and quantitative aspects of biomolecular recognition in real time. This approach is able to apply for measuring the association and dissociation rate constants of the reaction between biomolecules.

[1]  B. Bluestein,et al.  Fiber optic evanescent wave immunosensors for medical diagnostics. , 1990, Trends in biotechnology.

[2]  Detecting E.coli-O157 with fiber optic biosensor , 2003, CLEO/Pacific Rim 2003. The 5th Pacific Rim Conference on Lasers and Electro-Optics (IEEE Cat. No.03TH8671).

[3]  C. Visser,et al.  C-reactive protein as a cardiovascular risk factor: more than an epiphenomenon? , 1999, Circulation.

[4]  R. Karlsson,et al.  Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system. , 1991, Journal of immunological methods.

[5]  W. Koenig,et al.  High-sensitivity C-reactive protein and cardiovascular risk in patients with coronary heart disease , 2002, Current opinion in cardiology.

[6]  C. Visser,et al.  CRP, a major culprit in complement-mediated tissue damage in acute myocardial infarction? , 2001, International immunopharmacology.

[7]  Judith Rishpon,et al.  An amperometric biosensor for real-time analysis of molecular recognition , 1998 .

[8]  M. Shields A hypothesis resolving the apparently disparate activities of native and altered forms of human C-reactive protein , 1993, Immunologic research.

[9]  P. Ridker,et al.  Novel clinical markers of vascular wall inflammation. , 2001, Circulation research.

[10]  H. Gewurz,et al.  Antigenic, electrophoretic and binding alterations of human C-reactive protein modified selectively in the absence of calcium. , 1983, Molecular immunology.

[11]  R. Ross The pathogenesis of atherosclerosis: a perspective for the 1990s , 1993, Nature.

[12]  G. Taubes Does Inflammation Cut to the Heart of the Matter? , 2002, Science.

[13]  C. Maule,et al.  Detection and quantification of biomolecular interactions with optical biosensors , 1995 .

[14]  Y H Chang,et al.  Detection of protein A produced by Staphylococcus aureus with a fiber-optic-based biosensor. , 1996, Bioscience, biotechnology, and biochemistry.