Extensive conservation of sex chromosome organization between cat and human revealed by parallel radiation hybrid mapping.

A radiation hybrid (RH)-derived physical map of 25 markers on the feline X chromosome (including 19 Type I coding loci and 6 Type II microsatellite markers) was compared to homologous marker order on the human and mouse X chromosome maps. Complete conservation of synteny and marker order was observed between feline and human X chromosomes, whereas the same markers identified a minimum of seven rearranged syntenic segments between mouse and cat/human X chromosome marker order. Within the blocks, the feline, human, and mouse marker order was strongly conserved. Similarly, Y chromosome locus order was remarkably conserved between cat and human Y chromosomes, with only one marker (SMCY) position rearranged between the species. Tight linkage and a conserved gene order for a segment encoding three genes, DFFRY-DBY-UTY in human, mouse, and cat Y chromosomes, coupled with demonstrated deletion effects of these genes on reproductive impairment in both human and mouse, implicates the region as critical for Y-mediated sperm production.

[1]  S. O’Brien,et al.  A human genome map of comparative anchor tagged sequences. , 1999, The Journal of heredity.

[2]  A A Schäffer,et al.  A genetic linkage map of microsatellites in the domestic cat (Felis catus). , 1999, Genomics.

[3]  S. O’Brien,et al.  Development of a feline whole genome radiation hybrid panel and comparative mapping of human chromosome 12 and 22 loci. , 1999, Genomics.

[4]  F. Galibert,et al.  A whole-genome radiation hybrid map of the dog genome. , 1998, Genomics.

[5]  C. Disteche,et al.  Mapping of the murine Tbl1 gene reveals a new rearrangement between mouse and human X Chromosomes , 1998, Mammalian Genome.

[6]  J. Graves,et al.  The origin and evolution of the pseudoautosomal regions of human sex chromosomes. , 1998, Human molecular genetics.

[7]  P. Lijnzaad,et al.  A physical map of 30,000 human genes. , 1998, Science.

[8]  M. Mitchell,et al.  Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. , 1998, Human molecular genetics.

[9]  M. Mitchell,et al.  The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region. , 1998, Human molecular genetics.

[10]  H. Hishigaki,et al.  Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes , 1998, Cytogenetic and Genome Research.

[11]  N. Archidiacono,et al.  Evolution of chromosome Y in primates , 1998, Chromosoma.

[12]  Daniel Vaiman,et al.  Comparative cytogenetic mapping reveals chromosome rearrangements between the X chromosomes of two closely related mammalian species (cattle and goats) , 1998, Cytogenetic and Genome Research.

[13]  T. Robinson,et al.  A molecular cytogenetic analysis of X chromosome repatterning in the Bovidae: transpositions, inversions, and phylogenetic inference , 1998, Cytogenetic and Genome Research.

[14]  J. Womack,et al.  Parallel radiation hybrid mapping: a powerful tool for high-resolution genomic comparison. , 1998, Genome research.

[15]  N. M. Brooke,et al.  A molecular timescale for vertebrate evolution , 1998, Nature.

[16]  S. O'Brien,et al.  Patterns of Y and X chromosome DNA sequence divergence during the Felidae radiation. , 1998, Genetics.

[17]  L. Stubbs,et al.  Zooming in on the human-mouse comparative map: genome conservation re-examined on a high-resolution scale. , 1997, Genome research.

[18]  Maria R. Davis,et al.  A first-generation whole genome-radiation hybrid map spanning the mouse genome. , 1997, Genome research.

[19]  S. O’Brien,et al.  Comparative genomics: lessons from cats. , 1997, Trends in genetics : TIG.

[20]  J. Spencer,et al.  Comparative gene mapping in the domestic cat (Felis catus). , 1997, The Journal of heredity.

[21]  D. Church,et al.  A radiation hybrid map of human chromosome 5 with integration of cytogenetic, genetic, and transcript maps. , 1997, Genome research.

[22]  E. Stewart,et al.  An STS-based radiation hybrid map of the human genome. , 1997, Genome research.

[23]  H. Satoh,et al.  A proposed nomenclature of the domestic cat karyotype. , 1997, Cytogenetics and cell genetics.

[24]  N. Archidiacono,et al.  Evolution of chromosome Y in primates. , 1997, European journal of histochemistry : EJH.

[25]  M A Ferguson-Smith,et al.  Conservation of human vs. feline genome organization revealed by reciprocal chromosome painting. , 1997, Cytogenetics and cell genetics.

[26]  T. F. Laughlin,et al.  Comparative anchor tagged sequences (CATS) for integrative mapping of mammalian genomes , 1997, Nature Genetics.

[27]  J. Spencer,et al.  Comparative mapping identifies the fusion point of an ancient mammalian X-autosomal rearrangement. , 1996, Genomics.

[28]  A. Edelmann,et al.  Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11. , 1996, Human molecular genetics.

[29]  J. W. Foster,et al.  Construction of a mouse whole-genome radiation hybrid panel and application to MMU11. , 1996, Genomics.

[30]  G. Gyapay,et al.  A radiation hybrid map of the human genome. , 1996, Human molecular genetics.

[31]  Yun-Fai Chris Lau,et al.  Report of the Second International Workshop on Y Chromosome Mapping 1995. , 1994 .

[32]  K Lange,et al.  Statistical methods for polyploid radiation hybrid mapping. , 1995, Genome research.

[33]  J. Graves The origin and function of the mammalian Y chromosome and Y‐borne genes – an evolving understanding , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

[34]  M. Boehnke Multipoint analysis for radiation hybrid mapping. , 1992, Annals of medicine.

[35]  M. Sutcliffe,et al.  Analysis of the testes of H-Y negative XOSxrb mice suggests that the spermatogenesis gene (Spy) acts during the differentiation of the A spermatogonia. , 1989, Development.

[36]  T. Nesterova,et al.  Subchromosomal localization and order of GLA, PGK1, HPRT, and G6PD loci on the X chromosome of the American mink (Mustela vison). , 1988, Cytogenetics and cell genetics.

[37]  S. O’Brien,et al.  Mammalian genome organization: an evolutionary view. , 1988, Annual review of genetics.

[38]  S. O’Brien,et al.  Conserved regions of homologous G-banded chromosomes between orders in mammalian evolution: carnivores and primates. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[39]  S. Ohno,et al.  Ancient Linkage Groups and Frozen Accidents , 1973, Nature.