Focus Issue: Noncoding RNAs in cancer

Science Signaling features work that shows how noncoding RNAs—particularly miRNAs—regulate mechanisms driving tumor growth and progression. Through various means, noncoding RNAs regulate the expression of genes, many of which are associated with cellular homeostasis. Noncoding RNAs—especially microRNAs—are critical regulators of the mechanisms underlying numerous processes in cell biology, particularly those involved in the development and progression of cancer. This special issue of Science Signaling sheds light on the physiological and pathophysiological functions of this distinct class of molecules.

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[2]  S. Wiemann,et al.  EGF induces microRNAs that target suppressors of cell migration: miR-15b targets MTSS1 in breast cancer , 2015, Science Signaling.

[3]  D. Iliopoulos.  MicroRNA Circuits Regulate the Cancer-Inflammation Link , 2014, Science Signaling.

[4]  L. Poliseno.  Pseudogenes: Newly Discovered Players in Human Cancer , 2012, Science Signaling.

[5]  Bo W. Han,et al.  Potential Pathological and Functional Links Between Long Noncoding RNAs and Hematopoiesis , 2013, Science Signaling.

[6]  Focus Issue: Mechanisms of Gene Regulation , 2008, Science Signaling.

[7]  W. Wong.  Focus Issue: Signals for Gene Expression , 2010, Science Signaling.

[8]  N. Kosaka,et al.  Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells , 2014, Science Signaling.

[9]  Shuang Huang,et al.  Signaling by p38 MAPK Stimulates Nuclear Localization of the Microprocessor Component p68 for Processing of Selected Primary MicroRNAs , 2013, Science Signaling.

[10]  C. Croce,et al.  miR-29 Acts as a Decoy in Sarcomas to Protect the Tumor Suppressor A20 mRNA from Degradation by HuR , 2013, Science Signaling.

[11]  Konstantinos J. Mavrakis,et al.  Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia , 2014, Science Signaling.

[12]  C. Bloomfield,et al.  Intronic miR-3151 Within BAALC Drives Leukemogenesis by Deregulating the TP53 Pathway , 2014, Science Signaling.

[13]  A. Richardson,et al.  STAT3 Induction of miR-146b Forms a Feedback Loop to Inhibit the NF-κB to IL-6 Signaling Axis and STAT3-Driven Cancer Phenotypes , 2014, Science Signaling.