Analog Electronic System for Simulating Biological Neurons

This paper deals with the implementation of an analog electronic system capable of emulating and/or characterizing the electrical activity of biological neurons. We detail the main characteristics and performances of the system, and point out its litheness as an experimentation tool: • high level of modeling accuracy, validated by simple and hybrid experiments. • analog modeling principle, and possibility to emulate, in real time a large range of neurons or neural networks, thanks to a set of programmable parameters, • model implementation simplicity, owing to a dedicated hardware and software interface.

[1]  Michael A. Arbib,et al.  The handbook of brain theory and neural networks , 1995, A Bradford book.

[2]  D. McCormick,et al.  Mechanisms of oscillatory activity in guinea‐pig nucleus reticularis thalami in vitro: a mammalian pacemaker. , 1993, The Journal of physiology.

[3]  Idan Segev,et al.  Methods in neuronal modeling: From synapses to networks , 1989 .

[4]  R. Douglas,et al.  A silicon neuron , 1991, Nature.

[5]  E. Marder,et al.  Activity-dependent regulation of conductances in model neurons. , 1993, Science.

[6]  Y. Deval,et al.  A BiCMOS implementation of the Hodgkin-Huxley formalism , 1996, Proceedings of Fifth International Conference on Microelectronics for Neural Networks.

[7]  D. McCormick,et al.  Cellular mechanisms of a synchronized oscillation in the thalamus. , 1993, Science.

[8]  William R. Softky,et al.  Single-cell models , 1998 .

[9]  G. Le Masson,et al.  From conductances to neural network properties: analysis of simple circuits using the hybrid network method. , 1995 .

[10]  Thierry Bal,et al.  Sensory gating mechanisms of the thalamus , 1994, Current Opinion in Neurobiology.

[11]  A. Hodgkin,et al.  A quantitative description of membrane current and its application to conduction and excitation in nerve , 1990 .

[12]  D. McCormick,et al.  Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro. , 1995, The Journal of physiology.

[13]  T J Sejnowski,et al.  Ionic mechanisms for intrinsic slow oscillations in thalamic relay neurons. , 1993, Biophysical journal.

[14]  S. Le Masson,et al.  Accurate analog VLSI model of calcium-dependent bursting neurons , 1997, Proceedings of International Conference on Neural Networks (ICNN'97).

[15]  S. Le Masson,et al.  Analog circuits for modeling biological neural networks: design and applications , 1999, IEEE Transactions on Biomedical Engineering.

[16]  R. Meech,et al.  Calcium-dependent potassium activation in nervous tissues. , 1978, Annual review of biophysics and bioengineering.