Quantitative analysis of carotid artery Doppler spectral waveforms: diagnostic value of parameters.

Continuous-wave ultrasonic Doppler recordings made at the carotid bifurcation have been processed by spectrum analysis and off-line microprocessor software. Data reduction algorithms were defined and tested prior to incorporation in an integrated, hard-wired device. Subsequent analysis of waveforms in real-time provided measures of peak and mode frequencies and degree of spectral broadening. Correlation of results with 123 angiographically visualized internal carotid arteries showed that peak and mode frequencies generally increased with degree of stenosis while the systolic window decreased. Ratios of peak and mode frequencies in the proximal to the distal internal carotid artery and the systolic window at the distal internal carotid artery were retrospectively found to have diagnostic value with a combination of these three parameters providing the best overall accuracy.

[1]  R. Gosling,et al.  Imaging the Carotid Bifurcation Using Continuous-Wave Doppler-Shift Ultrasound and Spectral Analysis , 1978, Stroke.

[2]  D. Giddens,et al.  Measurements of Disordered Flows Distal to Subtotal Vascular Stenoses in the Thoracic Aortas of Dogs , 1976, Circulation research.

[3]  D. Strandness,et al.  The effects of atherosclerosis on the transmission of ultrasound. , 1969, The Journal of surgical research.

[4]  R M Nerem,et al.  An in vivo study of aortic flow disturbances. , 1972, Cardiovascular research.

[5]  R. Reneman,et al.  Local Doppler audio spectra in normal and stenosed carotid arteries in man. , 1979, Ultrasound in medicine & biology.

[6]  Enzo O. Macagno,et al.  Computational and experimental study of a captive annular eddy , 1967, Journal of Fluid Mechanics.

[7]  D. Hokanson,et al.  Noninvasive ultrasonic carotid angiography: prospective validation by contrast arteriography. , 1976, Surgery.

[8]  J M Reid,et al.  Quantitation of Carotid Stenosis with Continuous‐Wave (C‐W) Doppler Ultrasound , 1979, Stroke.

[9]  G. R. Curry,et al.  A Comparison of 424 Carotid Bifurcations Examined by Angiography and the Doppler Echoflow , 1978 .

[10]  V. Newhouse,et al.  Vortex characterization and identification by ultrasound Doppler , 1981 .

[11]  S. E. Rittgers,et al.  Real-Time Spectrum Analysis and Display of Directional Doppler Ultrasound Blood Velocity Signals , 1980, IEEE Transactions on Biomedical Engineering.

[12]  D. Giddens,et al.  Steady flow in a model of the human carotid bifurcation. Part I--flow visualization. , 1982, Journal of biomechanics.

[13]  D J Phillips,et al.  Detection of carotid occlusive disease by ultrasonic imaging and pulsed Doppler spectrum analysis. , 1979, Surgery.

[14]  R. Ackerman.  A perspective on noninvasive diagnosis of carotid disease , 1979, Neurology.

[15]  D. Giddens,et al.  Characterization and evolution poststenotic flow disturbances. , 1981, Journal of biomechanics.

[16]  S. E. Cook,et al.  Real-time B-mode carotid imaging in diagnosis of cerebrovascular disease. , 1981, Surgery.

[17]  S. Rittgers,et al.  Real-time Doppler spectrum analysis: predictive value in defining operable carotid artery disease. , 1982, Archives of surgery.

[18]  Bernard Sigel,et al.  Pulsed doppler ultrasound detection of flow disturbances in arteriosclerosis , 1976, Journal of clinical ultrasound : JCU.

[19]  R. Hobson,et al.  Comparison of pulsed Doppler and real-time B-mode echo arteriography for noninvasive imaging of the extracranial carotid arteries. , 1980, Surgery.

[20]  R. Rutherford,et al.  The use of velocity wave form analysis in the diagnosis of carotid artery occlusive disease. , 1977, Surgery.

[21]  D J Phillips,et al.  Carotid Artery Velocity Patterns in Normal and Stenotic Vessels , 1980, Stroke.

[22]  C. Metz.  Basic principles of ROC analysis. , 1978, Seminars in nuclear medicine.

[23]  E De Nigris,et al.  [Ultrasonics in medicine]. , 1978, Minerva medica.

[24]  G. Leopold,et al.  Ultrasonic imaging of the carotid arterial system. , 1980, American journal of surgery.