Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis

[1]  S. Cregan,et al.  Inhibition of Metabotropic Glutamate Receptor Signaling by the Huntingtin-binding Protein Optineurin* , 2005, Journal of Biological Chemistry.

[2]  S. Ferguson,et al.  Phosphorylation-independent Regulation of Metabotropic Glutamate Receptor 1 Signaling Requires G Protein-coupled Receptor Kinase 2 Binding to the Second Intracellular Loop* , 2005, Journal of Biological Chemistry.

[3]  P. H. Anborgh,et al.  Ral and Phospholipase D2-Dependent Pathway for Constitutive Metabotropic Glutamate Receptor Endocytosis , 2004, The Journal of Neuroscience.

[4]  Y. Smith,et al.  Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the monkey subthalamic nucleus , 2004, The Journal of comparative neurology.

[5]  S. Mundell,et al.  Desensitization and internalization of metabotropic glutamate receptor 1a following activation of heterologous Gq/11-coupled receptors. , 2004, Biochemistry.

[6]  S. Mundell,et al.  Agonist‐independent internalization of metabotropic glutamate receptor 1a is arrestin‐ and clathrin‐dependent and is suppressed by receptor inverse agonists , 2004, Journal of neurochemistry.

[7]  P. H. Anborgh,et al.  G Protein-coupled Receptor Kinase 2 Regulator of G Protein Signaling Homology Domain Binds to Both Metabotropic Glutamate Receptor 1a and Gαq to Attenuate Signaling* , 2004, Journal of Biological Chemistry.

[8]  J. Russell,et al.  Protection against glucose‐induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3 , 2004, Journal of neurochemistry.

[9]  Y. Smith,et al.  Distribution of mGluR1α and mGluR5 immunolabeling in primate prefrontal cortex , 2003 .

[10]  C. Carman,et al.  Differential interaction of GRK2 with members of the Gαqfamily , 2003 .

[11]  J. Geurts,et al.  Altered expression patterns of group I and II metabotropic glutamate receptors in multiple sclerosis. , 2003, Brain : a journal of neurology.

[12]  Erich E Wanker,et al.  The hunt for huntingtin function: interaction partners tell many different stories. , 2003, Trends in biochemical sciences.

[13]  R. Lefkowitz,et al.  Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ , 2003, Science.

[14]  P. Conn,et al.  G protein-coupled receptor kinases regulate metabotropic glutamate receptor 5 function and expression , 2003, Neuropharmacology.

[15]  J. Olivo-Marin,et al.  The Metabotropic Glutamate Receptor mGluR5 Is Endocytosed by a Clathrin-independent Pathway* , 2003, The Journal of Biological Chemistry.

[16]  A. Porcellini,et al.  Role of G Protein-coupled Receptor Kinase 4 and β-Arrestin 1 in Agonist-stimulated Metabotropic Glutamate Receptor 1 Internalization and Activation of Mitogen-activated Protein Kinases* , 2003, The Journal of Biological Chemistry.

[17]  S. Ferguson,et al.  Protein Kinase C Isoform-specific Differences in the Spatial-Temporal Regulation and Decoding of Metabotropic Glutamate Receptor1a-stimulated Second Messenger Responses* , 2003, The Journal of Biological Chemistry.

[18]  P. Calabresi,et al.  Corticostriatal LTP requires combined mGluR1 and mGluR5 activation , 2003, Neuropharmacology.

[19]  S. Mundell,et al.  Agonist‐induced internalization of metabotropic glutamate receptor 1A: structural determinants for protein kinase C‐ and G protein‐coupled receptor kinase‐mediated internalization , 2003, Journal of neurochemistry.

[20]  S. Ferguson,et al.  Mechanisms of metabotropic glutamate receptor desensitization: role in the patterning of effector enzyme activation , 2002, Neurochemistry International.

[21]  P. H. Anborgh,et al.  β-Arrestins regulate a Ral-GDS–Ral effector pathway that mediates cytoskeletal reorganization , 2002, Nature Cell Biology.

[22]  P. H. Anborgh,et al.  Phosphorylation-independent Regulation of Metabotropic Glutamate Receptor Signaling by G Protein-coupled Receptor Kinase 2* , 2002, The Journal of Biological Chemistry.

[23]  P. Conn,et al.  Distinct physiological roles of the Gq‐coupled metabotropic glutamate receptors co‐expressed in the same neuronal populations , 2002, Journal of cellular physiology.

[24]  R. Ritch,et al.  Adult-Onset Primary Open-Angle Glaucoma Caused by Mutations in Optineurin , 2002, Science.

[25]  P. H. Anborgh,et al.  Agonist-stimulated and tonic internalization of metabotropic glutamate receptor 1a in human embryonic kidney 293 cells: agonist-stimulated endocytosis is beta-arrestin1 isoform-specific. , 2001, Molecular pharmacology.

[26]  R A Challiss,et al.  Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors. , 2001, The Biochemical journal.

[27]  G. Bhave,et al.  Metabotropic glutamate receptors on peripheral sensory neuron terminals as targets for the development of novel analgesics , 2001, Molecular Psychiatry.

[28]  D. Kelvin,et al.  Spatial-Temporal Patterning of Metabotropic Glutamate Receptor-mediated Inositol 1,4,5-Triphosphate, Calcium, and Protein Kinase C Oscillations , 2001, The Journal of Biological Chemistry.

[29]  S. Carlton,et al.  Metabotropic glutamate 1α receptors on peripheral primary afferent fibers: their role in nociception , 2001, Brain Research.

[30]  F. Nicoletti,et al.  Metabotropic Glutamate Receptor Subtypes as Targets for Neuroprotective Drugs , 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[31]  F. Conquet,et al.  Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice , 2001, Nature Neuroscience.

[32]  S. Mundell,et al.  Agonist‐induced internalization of the metabotropic glutamate receptor 1a is arrestin‐ and dynamin‐dependent , 2001, Journal of neurochemistry.

[33]  J. Lipski,et al.  Differential expression of Group I metabotropic glutamate receptors in motoneurons at low and high risk for degeneration in ALS , 2001, Neuroreport.

[34]  P. Calabresi,et al.  Selective involvement of mGlu1 receptors in corticostriatal LTD , 2001, Neuropharmacology.

[35]  P. Calabresi,et al.  Selective Blockade of Type-1 Metabotropic Glutamate Receptors Induces Neuroprotection by Enhancing Gabaergic Transmission , 2001, Molecular and Cellular Neuroscience.

[36]  R. Anwyl,et al.  NMDA receptor‐ and metabotropic glutamate receptor‐dependent synaptic plasticity induced by high frequency stimulation in the rat dentate gyrus in vitro , 2001, The Journal of physiology.

[37]  J. Sweatt,et al.  Leitmotifs in the biochemistry of LTP induction: amplification, integration and coordination , 2001, Journal of neurochemistry.

[38]  R. Gereau,et al.  Peripheral group I metabotropic glutamate receptors modulate nociception in mice , 2001, Nature Neuroscience.

[39]  S. Ferguson,et al.  Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. , 2001, Pharmacological reviews.

[40]  Colin Blakemore,et al.  PLC-β1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex , 2001, Nature Neuroscience.

[41]  Wei-Yang Lu,et al.  Activation of Synaptic NMDA Receptors Induces Membrane Insertion of New AMPA Receptors and LTP in Cultured Hippocampal Neurons , 2001, Neuron.

[42]  G. Gerber,et al.  Dual modulation of excitatory synaptic transmission by agonists at group I metabotropic glutamate receptors in the rat spinal dorsal horn , 2000, Brain Research.

[43]  S. Nakanishi,et al.  G Protein-coupled Receptor Kinase-mediated Desensitization of Metabotropic Glutamate Receptor 1A Protects against Cell Death* , 2000, The Journal of Biological Chemistry.

[44]  F. Nicoletti,et al.  The G‐protein‐coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1 , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[45]  Yuchun Gu,et al.  Expression of Functional Metabotropic Glutamate Receptors in Primary Cultured Rat Osteoblasts , 2000, The Journal of Biological Chemistry.

[46]  Y. Smith,et al.  Activation of Metabotropic Glutamate Receptor 5 Has Direct Excitatory Effects and Potentiates NMDA Receptor Currents in Neurons of the Subthalamic Nucleus , 2000, The Journal of Neuroscience.

[47]  B. Meldrum,et al.  Anticonvulsant activity of two metabotropic glutamate Group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893) , 2000, Neuropharmacology.

[48]  F. D. da Silva,et al.  Upregulation of metabotropic glutamate receptor subtype mGluR3 and mGluR5 in reactive astrocytes in a rat model of mesial temporal lobe epilepsy , 2000, The European journal of neuroscience.

[49]  F. Nicoletti,et al.  Expression of functional mGlu5 metabotropic glutamate receptors in human melanocytes , 2000, Journal of cellular physiology.

[50]  R. Duvoisin,et al.  Opposing effects of protein kinase C and protein kinase A on metabotropic glutamate receptor signaling: selective desensitization of the inositol trisphosphate/Ca2+ pathway by phosphorylation of the receptor-G protein-coupling domain. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[51]  T. Knöpfel,et al.  Selective blockade of mGlu5 metabotropic glutamate receptors protects rat hepatocytes against hypoxic damage , 2000, Hepatology.

[52]  B. Gähwiler,et al.  G-protein-independent signaling mediated by metabotropic glutamate receptors , 1999, Nature Neuroscience.

[53]  J. Harris,et al.  Neuroprotective Actions of Novel and Potent Ligands of Group I and Group II Metabotropic Glutamate Receptors , 1999, Annals of the New York Academy of Sciences.

[54]  C. Carman,et al.  Selective Regulation of Gαq/11 by an RGS Domain in the G Protein-coupled Receptor Kinase, GRK2* , 1999, The Journal of Biological Chemistry.

[55]  A. Kriegstein,et al.  Endogenous activation of metabotropic glutamate receptors in neocortical development causes neuronal calcium oscillations. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[56]  F. Bordi,et al.  Group I metabotropic glutamate receptors: implications for brain diseases , 1999, Progress in Neurobiology.

[57]  P. Calabresi,et al.  Metabotropic Glutamate Receptors and Cell-Type-Specific Vulnerability in the Striatum: Implication for Ischemia and Huntington's Disease , 1999, Experimental Neurology.

[58]  M. Lohse,et al.  Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[59]  S. Ikeda,et al.  Expression of RGS2 Alters the Coupling of Metabotropic Glutamate Receptor 1a to M-Type K+ and N-Type Ca2+ Channels , 1999, Neuron.

[60]  O. Pulido,et al.  Immunochemical localization of the metabotropic glutamate receptors in the rat heart , 1999, Brain Research Bulletin.

[61]  F. Ciruela,et al.  Interactions of the C Terminus of Metabotropic Glutamate Receptor Type 1␣ with Rat Brain Proteins: Evidence for a Direct Interaction with Tubulin , 2022 .

[62]  M. von Zastrow,et al.  Regulated Endocytosis of G-protein-coupled Receptors by a Biochemically and Functionally Distinct Subpopulation of Clathrin-coated Pits* , 1998, The Journal of Biological Chemistry.

[63]  D. Plenz,et al.  Regulation of the Nigrostriatal Pathway by Metabotropic Glutamate Receptors during Development , 1998, The Journal of Neuroscience.

[64]  Jian Kang,et al.  Interaction of an Adenovirus E3 14.7-Kilodalton Protein with a Novel Tumor Necrosis Factor Alpha-Inducible Cellular Protein Containing Leucine Zipper Domains , 1998, Molecular and Cellular Biology.

[65]  N. Hirokawa,et al.  Visualization of the Dynamics of Synaptic Vesicle and Plasma Membrane Proteins in Living Axons , 1998, The Journal of cell biology.

[66]  P. Conn,et al.  RGS4 Inhibits Signaling by Group I Metabotropic Glutamate Receptors , 1998, The Journal of Neuroscience.

[67]  F. Ciruela,et al.  Differential internalisation of mGluR1 splice variants in response to agonist and phorbol esters in permanently transfected BHK cells , 1997, FEBS letters.

[68]  Ayae Kinoshita,et al.  Differential Presynaptic Localization of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus , 1997, The Journal of Neuroscience.

[69]  R. Stoffel,et al.  Phosphorylation and Desensitization of Human Endothelin A and B Receptors , 1997, The Journal of Biological Chemistry.

[70]  J. Roder,et al.  Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP , 1997, The Journal of Neuroscience.

[71]  P. Calabresi,et al.  Enhancement of NMDA responses by group I metabotropic glutamate receptor activation in striatal neurones , 1997, British journal of pharmacology.

[72]  J. Thorner,et al.  RGS Proteins and Signaling by Heterotrimeric G Proteins* , 1997, The Journal of Biological Chemistry.

[73]  T. Valiante,et al.  Metabotropic glutamate receptors coupled to IP3 production mediate inhibition of IAHP in rat dentate granule neurons. , 1996, Journal of neurophysiology.

[74]  Shigetada Nakanishi,et al.  Control of calcium oscillations by phosphorylation of metabotropic glutamate receptors , 1996, Nature.

[75]  D. Schoepp,et al.  Pharmacological characterization of desensitization in a human mGlulα‐expressing non‐neuronal cell line co‐transfected with a glutamate transporter , 1996, British journal of pharmacology.

[76]  R. Lefkowitz,et al.  Phosphorylation of the Type 1A Angiotensin II Receptor by G Protein-coupled Receptor Kinases and Protein Kinase C* , 1996, The Journal of Biological Chemistry.

[77]  P. Calabresi,et al.  The corticostriatal projection: from synaptic plasticity to dysfunctions of the basal ganglia , 1996, Trends in Neurosciences.

[78]  J. Bockaert,et al.  Get receptive to metabotropic glutamate receptors , 1995, Current Opinion in Neurobiology.

[79]  E. Mulvihill,et al.  Agonist mediated phosphorylation of metabotropic glutamate receptor 1 alpha by protein kinase C in permanently transfected BHK cells. , 1995, Biochemical Society Transactions.

[80]  R. Duvoisin,et al.  The metabotropic glutamate receptors: Structure and functions , 1995, Neuropharmacology.

[81]  G. Collingridge,et al.  Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1 , 1994, Nature.

[82]  Shigetada Nakanishi,et al.  Metabotropic glutamate receptors: Synaptic transmission, modulation, and plasticity , 1994, Neuron.

[83]  S. Tonegawa,et al.  Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice , 1994, Cell.

[84]  H. Sugiyama,et al.  Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5. , 1994, Biochemical and biophysical research communications.

[85]  M. Miras-Portugal,et al.  Rapid Desensitization of the Metabotropic Glutamate Receptor that Facilitates Glutamate Release in Rat Cerebrocortical Nerve Terminals , 1994, The European journal of neuroscience.

[86]  Shigetada Nakanishi,et al.  Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain , 1993, Neuroscience Letters.

[87]  P. Somogyi,et al.  The metabotropic glutamate receptor (mGluRlα) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction , 1993, Neuron.

[88]  L. Lebioda,et al.  Identification of the N-terminal region in rhodopsin kinase involved in its interaction with rhodopsin. , 1993, The Journal of biological chemistry.

[89]  S. Nakanishi,et al.  Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. , 1992, The Journal of biological chemistry.

[90]  S. Nakanishi,et al.  Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluRl, in transfected CHO cells , 1992, Neuron.

[91]  E. Aronica,et al.  Desensitization of Metabotropic Glutamate Receptors in Neuronal Cultures , 1991, Journal of neurochemistry.

[92]  D. Schoepp,et al.  Selective inhibition of excitatory amino acid-stimulated phosphoinositide hydrolysis in the rat hippocampus by activation of protein kinase C. , 1988, Biochemical pharmacology.

[93]  K. Kugiyama,et al.  Role of Protein Kinase C , 2005 .

[94]  S. Ferguson,et al.  Characterization of GRK2 RH domain-dependent regulation of GPCR coupling to heterotrimeric G proteins. , 2004, Methods in enzymology.

[95]  C. Carman,et al.  Differential interaction of GRK2 with members of the G alpha q family. , 2003, Biochemistry.

[96]  Takaaki AbeS,et al.  Molecular Characterization of a Novel Metabotropic Glutamate Receptor mGluR 5 Coupled to Inositol Phosphate / Ca 2 + Signal Transduction , 2001 .

[97]  B. Strockbine,et al.  Whither goest the RGS proteins? , 1999, Critical reviews in biochemistry and molecular biology.

[98]  S. Heinemann,et al.  Role of Protein Kinase C Phosphorylation in Rapid Desensitization of Metabotropic Glutamate Receptor 5 , 1998, Neuron.

[99]  J. Benovic,et al.  The role of receptor kinases and arrestins in G protein-coupled receptor regulation. , 1998, Annual review of pharmacology and toxicology.

[100]  J. Pin,et al.  Pharmacology and functions of metabotropic glutamate receptors. , 1997, Annual review of pharmacology and toxicology.

[101]  J. Shine,et al.  Protein-coupled Receptors , 1996 .