Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

[1]  T. Hansen,et al.  Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3) , 1996, Nature.

[2]  O. Pedersen,et al.  A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies. , 1996, The Journal of clinical investigation.

[3]  C. Kahn,et al.  Molecular scanning of the insulin receptor substrate.1 (IRS-1) gene in Japanese patients with NIDDM: identification of five novel polymorphisms , 1996 .

[4]  B. Lamothe,et al.  Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. , 1996, The EMBO journal.

[5]  L. Tartaglia,et al.  Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor , 1996, Science.

[6]  L. Tartaglia,et al.  Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice , 1996, Cell.

[7]  浦 幸子.  Molecular scanning of the IRS-1 gene in Japanese patients with non-insulin-dependent diabetes mellitus : identification of five novel polymorphisms in IRS-1 gene , 1996 .

[8]  Mark D. Johnson,et al.  Early neonatal death in mice homozygous for a null allele of the insulin receptor gene , 1996, Nature Genetics.

[9]  M. Stoffel,et al.  Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1) , 1996, Nature.

[10]  C. Kahn,et al.  4PS/Insulin Receptor Substrate (IRS)-2 Is the Alternative Substrate of the Insulin Receptor in IRS-1-deficient Mice (*) , 1995, The Journal of Biological Chemistry.

[11]  William Arbuthnot Sir Lane,et al.  Role of IRS-2 in insulin and cytokine signalling , 1995, Nature.

[12]  T. Hansen,et al.  Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1 , 1995, The Lancet.

[13]  F. Giorgino,et al.  Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. , 1995, The Journal of clinical investigation.

[14]  C. Kahn,et al.  Insulin action and the insulin signaling network. , 1995, Endocrine reviews.

[15]  J. Beckmann,et al.  A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q , 1995, Nature Genetics.

[16]  M. Maffei,et al.  Positional cloning of the mouse obese gene and its human homologue , 1995, Nature.

[17]  M. Maffei,et al.  Positional cloning of the mouse obese gene and its human homologue , 1994, Nature.

[18]  C. Kahn,et al.  Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene , 1994, Nature.

[19]  T. Yagi,et al.  Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 , 1994, Nature.

[20]  M. Laakso,et al.  Insulin receptor substrate-1 variants in non-insulin-dependent diabetes. , 1994, The Journal of clinical investigation.

[21]  C. R. Kahn,et al.  Insulin Action, Diabetogenes, and the Cause of Type II Diabetes , 1994, Diabetes.

[22]  J. Blenis,et al.  Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation , 1994, Molecular and cellular biology.

[23]  J. Olefsky,et al.  Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[24]  S. Bonner-Weir.  Regulation of pancreatic beta-cell mass in vivo. , 1994, Recent progress in hormone research.

[25]  E. Ravussin,et al.  Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. , 1993, The New England journal of medicine.

[26]  M. White,et al.  Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1 , 1993, Molecular and cellular biology.

[27]  M. Derouet,et al.  Insulin resistance in the GK rat: decreased receptor number but normal kinase activity in liver. , 1993, The American journal of physiology.

[28]  J. Pessin,et al.  Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling. , 1993, The Journal of biological chemistry.

[29]  T. Hansen,et al.  Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus , 1993, The Lancet.

[30]  C. Kahn,et al.  Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats. , 1993, The Journal of clinical investigation.

[31]  A. Cherniack,et al.  Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes. , 1993, Science.

[32]  A. Ullrich,et al.  The SH2/SH3 domain‐containing protein GRB2 interacts with tyrosine‐phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. , 1993, The EMBO journal.

[33]  S. Bonner-Weir,et al.  Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice. , 1993, The Journal of clinical investigation.

[34]  Simeon I. Taylor,et al.  Homozygous deletion of the human insulin receptor gene results in leprechaunism , 1993, Nature Genetics.

[35]  I. Godsland,et al.  Role of glucose and insulin resistance in development of type 2 diabetes mellitus , 1992, The Lancet.

[36]  Simeon I. Taylor,et al.  Lilly Lecture: Molecular Mechanisms of Insulin Resistance: Lessons From Patients With Mutations in the Insulin-Receptor Gene , 1992, Diabetes.

[37]  M J Saad,et al.  Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. , 1992, The Journal of clinical investigation.

[38]  R. N. Bergman,et al.  Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study , 1992, The Lancet.

[39]  B. Margolis,et al.  Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation. , 1992, The EMBO journal.

[40]  D. Pipeleers.  Heterogeneity in Pancreatic β-cell Population , 1992, Diabetes.

[41]  J. Beckmann,et al.  Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus , 1992, Nature.

[42]  J. Parsons,et al.  Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion. , 1992, Endocrinology.

[43]  J. Beckmann,et al.  Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus , 1992, Nature.

[44]  C. Kahn,et al.  Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein , 1991, Nature.

[45]  M. Igarashi,et al.  [Syndromes of insulin resistance]. , 1991, Nihon rinsho. Japanese journal of clinical medicine.

[46]  S. Rich.  Mapping Genes in Diabetes: Genetic Epidemiological Perspective , 1990, Diabetes.

[47]  J. Leahy,et al.  Compensatory Growth of Pancreatic β-Cells in Adult Rats After Short-Term Glucose Infusion , 1989, Diabetes.

[48]  W. Pories,et al.  Insulin-Receptor Kinase Activity of Adipose Tissue From Morbidly Obese Humans With and Without NIDDM , 1987, Diabetes.

[49]  G. Dohm,et al.  Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes. , 1987, The Journal of clinical investigation.

[50]  S. Gammeltoft,et al.  The insulin receptor kinase. , 1985, Biochimie.

[51]  J. A. Scarlett,et al.  Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus. , 1982, The American journal of physiology.

[52]  J. A. Scarlett,et al.  Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus. , 1981, The Journal of clinical investigation.

[53]  J. Olefsky,et al.  Insulin Binding, Internalization, and Insulin Receptor Regulation in Fibroblasts from Type II, Non-insulin-dependent Diabetic Subjects , 1981, Diabetes.

[54]  C. Kahn,et al.  Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting. , 1976, The Journal of clinical investigation.

[55]  J Roth,et al.  Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance. , 1973, The Journal of biological chemistry.

[56]  E. Joslin,et al.  Joslin's Diabetes Mellitus , 1971 .