A prospective, phase II, single-centre, cross-sectional, randomised study investigating Dehydroepiandrosterone supplementation and its Profile in Trauma: ADaPT
暂无分享,去创建一个
J. Lord | K. Brock | C. Greig | F. Shaheen | M. Foster | C. Potter | W. Arlt | A. Taylor | K. Yakoub | K. McGee | J. Hazeldine | A. Desai | D. Barton | V. Homer | E. Toman | Conor Bentley | L. Gilligan | A. Athwal | R. Carrera | Katie Young | C. Ermogenous | Gurneet Sur | Victoria Homer
[1] J. Lord,et al. Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient , 2019, Burns & Trauma.
[2] Qi Wang,et al. A systematic review and meta-analysis of randomized placebo-controlled trials of DHEA supplementation of bone mineral density in healthy adults , 2019, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
[3] N. Crabtree,et al. Increased central adiposity and decreased subcutaneous adipose tissue 11β‐hydroxysteroid dehydrogenase type 1 are associated with deterioration in glucose tolerance—A longitudinal cohort study , 2019, Clinical Endocrinology.
[4] S. Wen,et al. Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate in Alzheimer's Disease: A Systematic Review and Meta-Analysis , 2019, Front. Aging Neurosci..
[5] J. Bion,et al. Mapping the Steroid Response to Major Trauma From Injury to Recovery: A Prospective Cohort Study , 2019, bioRxiv.
[6] J. Bion,et al. Mapping the Steroid Response to Major Trauma From Injury to Recovery: A Prospective Cohort Study , 2019, bioRxiv.
[7] J. Gibney,et al. A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics , 2019, JCI insight.
[8] Paul J. Harrison,et al. Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury : A prospective cohort , 2019 .
[9] T. van der Poll,et al. An Unbalanced Inflammatory Cytokine Response Is Not Associated With Mortality Following Sepsis: A Prospective Cohort Study , 2017, Critical care medicine.
[10] L. Moldawer,et al. Persistent Inflammation, Immunosuppression and Catabolism Syndrome. , 2017, Critical care clinics.
[11] M. Huang,et al. Regulation of drug-metabolizing enzymes by local and systemic liver injuries , 2016, Expert opinion on drug metabolism & toxicology.
[12] M. Blankenstein,et al. Comparison of 7 Published LC-MS/MS Methods for the Simultaneous Measurement of Testosterone, Androstenedione, and Dehydroepiandrosterone in Serum. , 2015, Clinical chemistry.
[13] P. Newsholme,et al. Novel dehydroepiandrosterone troche supplementation improves the serum androgen profile of women undergoing in vitro fertilization , 2015, Drug design, development and therapy.
[14] P. Foster,et al. The Regulation of Steroid Action by Sulfation and Desulfation , 2015, Endocrine reviews.
[15] T. Quasim,et al. The incidence of intensive care unit-acquired weakness syndromes: A systematic review , 2015, Journal of the Intensive Care Society.
[16] D. Heyland,et al. Gastric residual volume in critically ill patients: a dead marker or still alive? , 2015, Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.
[17] J. Lord,et al. Depressive symptoms post hip fracture in older adults are associated with phenotypic and functional alterations in T cells , 2014, Immunity & Ageing.
[18] J. Lord,et al. The systemic immune response to trauma: an overview of pathophysiology and treatment , 2014, The Lancet.
[19] J. Lord,et al. Depressive symptoms in hip fracture patients are associated with reduced monocyte superoxide production , 2014, Experimental Gerontology.
[20] J. Bion,et al. The endocrine response to severe trauma: the Steroids and Immunity from injury to Rehabilitation (SIR) study , 2014 .
[21] J. Lord,et al. The immune-endocrine mechanisms of trauma-induced sarcopenia , 2014 .
[22] N. Crabtree,et al. Hyperandrogenemia Predicts Metabolic Phenotype in Polycystic Ovary Syndrome: The Utility of Serum Androstenedione , 2014, The Journal of clinical endocrinology and metabolism.
[23] J. Lord,et al. Depressive symptoms are associated with reduced neutrophil function in hip fracture patients , 2013, Brain, Behavior, and Immunity.
[24] N. Samaras,et al. A review of age-related dehydroepiandrosterone decline and its association with well-known geriatric syndromes: is treatment beneficial? , 2013, Rejuvenation research.
[25] D. Carroll,et al. Depression following hip fracture is associated with increased physical frailty in older adults: the role of the cortisol: dehydroepiandrosterone sulphate ratio , 2013, BMC Geriatrics.
[26] B. Gupta,et al. A Comparative Study of CEE, Tibolone, and DHEA as Hormone Replacement Therapy for Surgical Menopause , 2013, The Journal of Obstetrics and Gynecology of India.
[27] J. Ivy,et al. Effect of acute DHEA administration on free testosterone in middle-aged and young men following high-intensity interval training , 2013, European Journal of Applied Physiology.
[28] D. Rennie,et al. SPIRIT 2013 statement: defining standard protocol items for clinical trials. , 2013, Annals of internal medicine.
[29] G. Homuth,et al. A SULT2A1 genetic variant identified by GWAS as associated with low serum DHEAS does not impact on the actual DHEA/DHEAS ratio , 2012, Journal of molecular endocrinology.
[30] S. Fujita,et al. Increased muscular dehydroepiandrosterone levels are associated with improved hyperglycemia in obese rats. , 2011, American journal of physiology. Endocrinology and metabolism.
[31] Ajit S Narang,et al. Role of tumor vascular architecture in drug delivery. , 2011, Advanced drug delivery reviews.
[32] K. Chapman,et al. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights , 2011, Molecular and Cellular Endocrinology.
[33] J. Lord,et al. Dehydroepiandrosterone as a regulator of immune cell function , 2010, The Journal of Steroid Biochemistry and Molecular Biology.
[34] J. Lord,et al. Dehydroepiandrosterone sulfate directly activates protein kinase C-beta to increase human neutrophil superoxide generation. , 2010, Molecular endocrinology.
[35] P. Kobbe,et al. Dehydroepiandrosterone (DHEA): a steroid with multiple effects. Is there any possible option in the treatment of critical illness? , 2010, Current medicinal chemistry.
[36] R. Korpela,et al. Even low-grade inflammation impacts on small intestinal function. , 2010, World journal of gastroenterology.
[37] V. Montori,et al. A systematic review and meta-analysis of randomized placebo-controlled trials of DHEA treatment effects on quality of life in women with adrenal insufficiency. , 2009, The Journal of clinical endocrinology and metabolism.
[38] P. Toft,et al. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine Pathophysiology of the Systemic Inflammatory Response after Major Accidental Trauma , 2009 .
[39] C. Ohlsson,et al. Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations. , 2009, The Journal of clinical endocrinology and metabolism.
[40] L. Rasmussen,et al. The early IL‐6 and IL‐10 response in trauma is correlated with injury severity and mortality , 2009, Acta anaesthesiologica Scandinavica.
[41] B. Casserly,et al. The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients. , 2008, Clinics in chest medicine.
[42] G. Franklin,et al. Systemic inflammation after trauma. , 2007, Injury.
[43] I. Chaudry,et al. Metabolic modulators following trauma sepsis: Sex hormones , 2007, Critical care medicine.
[44] I. Chaudry,et al. INFLUENCE OF SEX AND AGE ON MODS AND CYTOKINES AFTER MULTIPLE INJURIES , 2007, Shock.
[45] R. Bérubé,et al. Metabolism of DHEA in postmenopausal women following percutaneous administration , 2007, The Journal of Steroid Biochemistry and Molecular Biology.
[46] D. Annane,et al. Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock. , 2006, The Journal of clinical endocrinology and metabolism.
[47] E. K. Alpar,et al. Raised cortisol:DHEAS ratios in the elderly after injury: potential impact upon neutrophil function and immunity , 2005, Aging cell.
[48] B. Allolio,et al. Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging. , 2005, The Journal of clinical endocrinology and metabolism.
[49] B. Keevil,et al. Development of a method for the measurement of dehydroepiandrosterone sulphate by liquid chromatography-tandem mass spectrometry , 2005, Annals of clinical biochemistry.
[50] B. Allolio,et al. No evidence for hepatic conversion of dehydroepiandrosterone (DHEA) sulfate to DHEA: in vivo and in vitro studies. , 2005, The Journal of clinical endocrinology and metabolism.
[51] D. Rubinow,et al. Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression. , 2005, Archives of general psychiatry.
[52] A. Genazzani,et al. Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency , 2004, The aging male : the official journal of the International Society for the Study of the Aging Male.
[53] M. Shapiro,et al. Multiple organ failure in trauma patients. , 2003, The Journal of trauma.
[54] László Tóth,et al. The New Injury Severity Score Is a Better Predictor of Extended Hospitalization and Intensive Care Unit Admission Than the Injury Severity Score in Patients With Multiple Orthopaedic Injuries , 2003, Journal of orthopaedic trauma.
[55] R. Day,et al. Pharmacokinetics of estradiol, progesterone, testosterone and dehydroepiandrosterone after transbuccal administration to postmenopausal women , 2003, Climacteric : the journal of the International Menopause Society.
[56] J. Herbert,et al. Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone‐induced suppression , 2002, The European journal of neuroscience.
[57] M. Fassnacht,et al. Dehydroepiandrosterone supplementation in healthy men with an age-related decline of dehydroepiandrosterone secretion. , 2001, The Journal of clinical endocrinology and metabolism.
[58] J. Desborough. The stress response to trauma and surgery. , 2000, British journal of anaesthesia.
[59] B. Allolio,et al. Biotransformation of oral dehydroepiandrosterone in elderly men: significant increase in circulating estrogens. , 1999, The Journal of clinical endocrinology and metabolism.
[60] I. Chaudry,et al. Dehydroepiandrosterone restores immune function following trauma-haemorrhage by a direct effect on T lymphocytes. , 1999, Cytokine.
[61] I. Chaudry,et al. Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage. , 1998, Archives of surgery.
[62] P. Zabel,et al. Gender differences in human sepsis. , 1998, Archives of surgery.
[63] R. Haubrich,et al. The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age‐advanced men and women , 1998, Clinical endocrinology.
[64] P. Chanson,et al. Panhypopituitarism as a model to study the metabolism of dehydroepiandrosterone (DHEA) in humans. , 1997, The Journal of clinical endocrinology and metabolism.
[65] P. Hornsby. Biosynthesis of DHEAS by the Human Adrenal Cortex and Its Age‐Related Decline , 1995, Annals of the New York Academy of Sciences.
[66] S. Yen,et al. Replacement of DHEA in Aging Men and Women , 1995, Annals of the New York Academy of Sciences.
[67] V. Koivisto,et al. Physiological importance of dehydroepiandrosterone , 1994, The Lancet.
[68] N. Orentreich,et al. Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men. , 1992, The Journal of clinical endocrinology and metabolism.
[69] N. Orentreich,et al. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. , 1984, The Journal of clinical endocrinology and metabolism.
[70] D. Trunkey,et al. Analysis of 425 consecutive trauma fatalities: An autopsy study , 1974 .
[71] N. Narang,et al. SUBLINGUAL MUCOSA AS A ROUTE FOR SYSTEMIC DRUG DELIVERY , 2011 .
[72] M. Siemionow,et al. Dehydroepiandrosterone protects muscle flap microcirculatory hemodynamics from ischemia/reperfusion injury: an experimental in vivo study. , 1997, The Journal of trauma.