Orodispersible films: Towards drug delivery in special populations.

Orodispersible films (ODF) hold promise as a novel delivery method, with the potential to deliver tailored therapies to different patient populations. This article reviews the current strides of ODF technology and some of its unmet quality and manufacturing aspects. A topic highlights opportunities and limitations of inkjet printed ODF as a population-specific drug delivery. Overall, this article aims to stimulate further research to fill the current knowledge gap between manufacturing and administration requirements of ODF targeting specific patient subpopulations such as geriatrics.

[1]  Maren Preis,et al.  Orally Disintegrating Films and Mini-Tablets—Innovative Dosage Forms of Choice for Pediatric Use , 2015, AAPS PharmSciTech.

[2]  Paul D. Schmitt,et al.  Finding the Needle in the Haystack: Characterization of Trace Crystallinity in a Commercial Formulation of Paclitaxel Protein-Bound Particles by Raman Spectroscopy Enabled by Second Harmonic Generation Microscopy. , 2015, Molecular pharmaceutics.

[3]  Niklas Sandler,et al.  Rapid interferometric imaging of printed drug laden multilayer structures , 2014, Scientific Reports.

[4]  Niklas Sandler,et al.  Improvement of dissolution rate of indomethacin by inkjet printing. , 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[5]  Niklas Sandler,et al.  A step toward development of printable dosage forms for poorly soluble drugs. , 2013, Journal of pharmaceutical sciences.

[6]  S. Murad,et al.  Crystallization of acetaminophen on chitosan films blended with different acids , 2015 .

[7]  Gintaras V. Reklaitis,et al.  Supervisory Control of a Drop on Demand Mini-manufacturing System for Pharmaceuticals , 2014 .

[8]  R. Bhupendra,et al.  A SHORT REVIEW ON "A NOVEL APPROACH IN ORAL FAST DISSOLVING DRUG DELIVERY SYSTEM" , 2012 .

[9]  Eloi Ramon,et al.  Up-scaling of the manufacturing of all-inkjet-printed organic thin-film transistors: Device performance and manufacturing yield of transistor arrays , 2016 .

[10]  N. Sandler,et al.  Quantification of caffeine and loperamide in printed formulations by infrared spectroscopy , 2016 .

[11]  Jonathan Stringer,et al.  Formation and stability of lines produced by inkjet printing. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[12]  G. Reklaitis,et al.  Modelling of Crystallization of Solid Oral Drug Forms in a Dropwise Additive Manufacturing System , 2015 .

[13]  E. Bendas,et al.  Pharmaceutical and Pharmacokinetic Evaluation of a Novel Fast Dissolving Film Formulation of Flupentixol Dihydrochloride , 2014, AAPS PharmSciTech.

[14]  S. Simões,et al.  Oral films: Current status and future perspectives II - Intellectual property, technologies and market needs. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[15]  Ellen Hilgert,et al.  DEVELOPMENT OF PHARMACEUTICAL INK FORMULATIONS WITH SILICA NANOPARTICLES FOR INKJET PRINTING , 2015 .

[16]  Paul D. Schmitt,et al.  Parts per Million Powder X-ray Diffraction. , 2015, Analytical chemistry.

[17]  I. Hutchings,et al.  How PEDOT:PSS solutions produce satellite-free inkjets , 2012 .

[18]  Yanlin Song,et al.  Controllable Printing Droplets for High‐Resolution Patterns , 2014, Advanced materials.

[19]  K. Izutsu,et al.  Differences in salivary flow rates in elderly subjects using xerostomatic medications. , 1991, Oral surgery, oral medicine, and oral pathology.

[20]  Sandeep Arora,et al.  Orally dissolving strips: A new approach to oral drug delivery system , 2013, International journal of pharmaceutical investigation.

[21]  J. Rantanen,et al.  The Future of Pharmaceutical Manufacturing Sciences , 2015, Journal of pharmaceutical sciences.

[22]  S. Prodduturi,et al.  Development of an antifungal denture adhesive film for oral candidiasis utilizing hot melt extrusion technology , 2015, Expert opinion on drug delivery.

[23]  I. Hutchings,et al.  Links between fluid rheology and drop-on-demand jetting and printability , 2008, NIP & Digital Fabrication Conference.

[24]  T. Dupont,et al.  Capillary flow as the cause of ring stains from dried liquid drops , 1997, Nature.

[25]  Eva Maria Hoffmann,et al.  Advances in orodispersible films for drug delivery , 2011, Expert opinion on drug delivery.

[26]  Graziano Onder,et al.  Defining Patient Centric Pharmaceutical Drug Product Design , 2016, The AAPS Journal.

[27]  A. Zuppa,et al.  Special population considerations and regulatory affairs for clinical research , 2015, Clinical research and regulatory affairs.

[28]  Leena Kumari Prasad,et al.  Electrostatic powder deposition to prepare films for drug delivery , 2015 .

[29]  Jörg Breitkreutz,et al.  Orodispersible drug formulations for children and elderly. , 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[30]  S. Prodduturi,et al.  Production and Characterization of Hot-Melt Extruded Films Containing Clotrimazole , 2003, Drug development and industrial pharmacy.

[31]  Hsin-Yun Hsu,et al.  Drop Printing of Pharmaceuticals: Effect of Molecular Weight on PEG Coated-Naproxen/PEG3350 Solid Dispersions. , 2015, AIChE journal. American Institute of Chemical Engineers.

[32]  J. Breitkreutz,et al.  Comparative investigations on different polymers for the preparation of fast‐dissolving oral films , 2010, The Journal of pharmacy and pharmacology.

[33]  Niklas Sandler,et al.  Behavior of printable formulations of loperamide and caffeine on different substrates--effect of print density in inkjet printing. , 2013, International journal of pharmaceutics.

[34]  M. Qadir,et al.  Orally disintegrating films: A modern expansion in drug delivery system , 2015, Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society.

[35]  J. Schierholz,et al.  Have inadequate delivery systems hampered the clinical success of inhaled disodium cromoglycate? Time for reconsideration , 2011, Expert opinion on drug delivery.

[36]  G. Garg,et al.  A Short Review on "A Novel Approach in Oral Fast Dissolving Drug Delivery System and Their Patents" , 2011 .

[37]  Maren Preis,et al.  Oromucosal film preparations: points to consider for patient centricity and manufacturing processes , 2016, Expert opinion on drug delivery.

[38]  Adnan Nasir,et al.  Polyglycolic acid microneedles modified with inkjet-deposited antifungal coatings. , 2015, Biointerphases.

[39]  Niklas Sandler,et al.  Hyperspectral imaging in quality control of inkjet printed personalised dosage forms. , 2015, International journal of pharmaceutics.

[40]  C. L. Ventola Medical Applications for 3D Printing: Current and Projected Uses. , 2014, P & T : a peer-reviewed journal for formulary management.

[41]  Shane Z. Sullivan,et al.  Kinetic Trapping of Metastable Amino Acid Polymorphs , 2014, Journal of the American Chemical Society.

[42]  Abdul W. Basit,et al.  Personalised dosing: Printing a dose of one's own medicine. , 2015, International journal of pharmaceutics.

[43]  S. Gaisford,et al.  Quantifying crystallisation rates of amorphous pharmaceuticals with dynamic mechanical analysis (DMA). , 2012, International journal of pharmaceutics.

[44]  Jukka Rantanen,et al.  Social aspects in additive manufacturing of pharmaceutical products , 2017, Expert opinion on drug delivery.

[45]  Kuang-Hwei Lee–Smeltzer,et al.  Finding the needle , 2000 .

[46]  Ronan Daly,et al.  Inkjet printing for pharmaceutics - A review of research and manufacturing. , 2015, International journal of pharmaceutics.

[47]  G. Jabbour,et al.  Inkjet Printing—Process and Its Applications , 2010, Advanced materials.

[48]  Ginny Allain,et al.  Personalized medicine. , 2012, MLO: medical laboratory observer.

[49]  Niklas Sandler,et al.  Inkjet printing of drug substances and use of porous substrates-towards individualized dosing. , 2011, Journal of pharmaceutical sciences.

[50]  N. Molina-Frechero,et al.  Differences in Salivary Flow Level, Xerostomia, and Flavor Alteration in Mexican HIV Patients Who Did or Did Not Receive Antiretroviral Therapy , 2013, AIDS research and treatment.

[51]  Gareth R Williams,et al.  Fast dissolving paracetamol/caffeine nanofibers prepared by electrospinning. , 2014, International journal of pharmaceutics.

[52]  R. Peck,et al.  The right dose for every patient: a key step for precision medicine , 2015, Nature Reviews Drug Discovery.

[53]  Brian Derby,et al.  Ink-jet delivery of particle suspensions by piezoelectric droplet ejectors , 2005 .

[54]  Hywel D Williams,et al.  Strategies to Address Low Drug Solubility in Discovery and Development , 2013, Pharmacological Reviews.

[55]  N. Genina Fabrication of printed drug-delivery systems , 2013 .

[56]  J. Epstein,et al.  Hyposalivation in elderly patients. , 2006, Journal.

[57]  J. C. Visser,et al.  Personalized Medicine in Pediatrics: The Clinical Potential of Orodispersible Films , 2016, AAPS PharmSciTech.

[58]  Laura Hirshfield,et al.  Dropwise additive manufacturing of pharmaceutical products for solvent-based dosage forms. , 2014, Journal of pharmaceutical sciences.

[59]  Niklas Sandler,et al.  Tailoring controlled-release oral dosage forms by combining inkjet and flexographic printing techniques. , 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[60]  V. Subramanian,et al.  Systematic design of jettable nanoparticle-based inkjet inks: rheology, acoustics, and jettability. , 2014, Langmuir : the ACS journal of surfaces and colloids.

[61]  Sandeep Karki,et al.  Thin films as an emerging platform for drug delivery , 2016 .

[62]  J. Rantanen,et al.  Visualization and Non-Destructive Quantification of Inkjet-Printed Pharmaceuticals on Different Substrates Using Raman Spectroscopy and Raman Chemical Imaging , 2017, Pharmaceutical Research.

[63]  B. Derby Inkjet Printing of Functional and Structural Materials: Fluid Property Requirements, Feature Stability, and Resolution , 2010 .

[64]  P. Lamy Geriatric drug therapy. , 1986, American family physician.

[65]  J. Khinast,et al.  Printing medicines as orodispersible dosage forms: Effect of substrate on the printed micro-structure. , 2016, International journal of pharmaceutics.

[66]  H. Patil,et al.  Development of a fast dissolving film of epinephrine hydrochloride as a potential anaphylactic treatment for pediatrics , 2017, Pharmaceutical development and technology.

[67]  M. Repka,et al.  Oral transmucosal delivery of domperidone from immediate release films produced via hot-melt extrusion technology , 2013, Pharmaceutical development and technology.

[68]  Shane J. Stafslien,et al.  Inkjet printing for pharmaceutical applications , 2014 .

[69]  Ning Yan,et al.  Piezoelectric Ink‐Jet Printing of Horseradish Peroxidase: Effect of Ink Viscosity Modifiers on Activity , 2007 .

[70]  G. Tucker,et al.  Current Challenges and Potential Opportunities for the Pharmaceutical Sciences to Make Global Impact: An FIP Perspective. , 2016, Journal of pharmaceutical sciences.

[71]  Kunn Hadinoto,et al.  Combining inkjet printing and amorphous nanonization to prepare personalized dosage forms of poorly-soluble drugs. , 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[72]  M. Repka,et al.  Development, optimization and in vivo characterization of domperidone-controlled release hot-melt-extruded films for buccal delivery , 2016, Drug development and industrial pharmacy.

[73]  J. Stokes,et al.  Oral processing, texture and mouthfeel: from rheology to tribology and beyond , 2013 .

[74]  Maren Preis,et al.  Perspective: Concepts of printing technologies for oral film formulations. , 2015, International journal of pharmaceutics.

[75]  Changqing Zhang,et al.  Three-dimensional printing of strontium-containing mesoporous bioactive glass scaffolds for bone regeneration. , 2014, Acta biomaterialia.

[76]  Ana Filipa Borges,et al.  Oral films: Current status and future perspectives: I - Galenical development and quality attributes. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[77]  Elçin Içten,et al.  Dropwise additive manufacturing of pharmaceutical products for melt-based dosage forms. , 2015, Journal of pharmaceutical sciences.

[78]  A. Zimmer,et al.  Geriatric drug therapy: Neglecting the inevitable majority , 2010, Ageing Research Reviews.