Hepatitis B vaccination in infants of mothers infected with human immunodeficiency virus

A study was conducted to investigate the immunogenicity of a recombinant DNA hepatitis B vaccine in neonates and children of HIV‐infected women. Immunization against hepatitis B consisted of three 10 μg doses of the vaccine administered on a 0‐, 1‐ and 6‐month schedule. The children were followed up for an average of 11 months. Of the 118 HIV‐positive neonates who participated in the study, 95 lost their HIV antibodies during the follow‐up period. Most (94.2%) of the latter who completed the study responded to the vaccine. Of the 23 who remained HIV‐positive, 17 completed the study and 7 produced hepatitis B antibodies. © 1995 Wiley‐Liss, inc.

[1]  J. Pinto-Martin,et al.  Responses to measles immunization in children infected with human immunodeficiency virus. , 1994, The Journal of pediatrics.

[2]  C. Schechter,et al.  IMMUNOGENICITY OF HEPATITIS B VACCINE IN HUMAN IMMUNODEFICIENCY VIRUS‐INFECTED CHILDREN , 1993, The Pediatric infectious disease journal.

[3]  I. Keet,et al.  Insufficient response to hepatitis B vaccination in HIV-positive homosexual men. , 1992, AIDS.

[4]  I. Keet,et al.  Orogenital sex and the transmission of HIV among homosexual men , 1992, AIDS.

[5]  M. Bruguera,et al.  Impaired Response to Recombinant Hepatitis B Vaccine in HIV‐Infected Persons , 1992, Journal of clinical gastroenterology.

[6]  N. Principi,et al.  Impaired response to hepatitis B vaccine in HIV infected children. , 1992, Vaccine.

[7]  N. Wade.  Immunologic considerations in pediatric HIV infection , 1991 .

[8]  S. Hadler,et al.  Outcome of hepatitis B virus infection in homosexual men and its relation to prior human immunodeficiency virus infection. , 1991, The Journal of infectious diseases.

[9]  B. Polk,et al.  Comparative immunogenicity of plasma and recombinant hepatitis B virus vaccines in homosexual men. , 1988, JAMA.

[10]  S. Hadler.  Hepatitis B prevention and human immunodeficiency virus (HIV) infection. , 1988, Annals of internal medicine.

[11]  H. Handsfield,et al.  Antibody to human immunodeficiency virus (HIV) and suboptimal response to hepatitis B vaccination. , 1988, Annals of internal medicine.

[12]  M. Hilleman.  Hepatitis B and AIDS and the promise for their control by vaccines. , 1988, Vaccine.

[13]  W. Szmuness,et al.  Hepatitis B vaccine in patients receiving hemodialysis. Immunogenicity and efficacy. , 1984, The New England journal of medicine.

[14]  A. Fauci,et al.  Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. , 1983, The New England journal of medicine.