RET/PTC and PAX8/PPARγ chromosomal rearrangements in post‐Chernobyl thyroid cancer and their association with iodine‐131 radiation dose and other characteristics

Childhood exposure to iodine‐131 from the 1986 nuclear accident in Chernobyl, Ukraine, led to a sharp increase in papillary thyroid carcinoma (PTC) incidence in regions surrounding the reactor. Data concerning the association between genetic mutations in PTCs and individual radiation doses are limited.

[1]  Keiko Takahashi,et al.  Rearranged anaplastic lymphoma kinase (ALK) gene in adult-onset papillary thyroid cancer amongst atomic bomb survivors. , 2012, Thyroid : official journal of the American Thyroid Association.

[2]  Marina N. Nikiforova,et al.  Molecular genetics and diagnosis of thyroid cancer , 2011, Nature Reviews Endocrinology.

[3]  J. Rosai,et al.  The Chernobyl thyroid cancer experience: pathology. , 2011, Clinical oncology (Royal College of Radiologists (Great Britain)).

[4]  Jay H. Lubin,et al.  I-131 Dose Response for Incident Thyroid Cancers in Ukraine Related to the Chornobyl Accident , 2011, Environmental health perspectives.

[5]  K. Arihiro,et al.  RET/PTC rearrangements preferentially occurred in papillary thyroid cancer among atomic bomb survivors exposed to high radiation dose. , 2008, Cancer research.

[6]  K. Kopecky,et al.  ret/PTC activation is not associated with individual radiation dose estimates in a pilot study of neoplastic thyroid nodules arising in Russian children and adults exposed to Chernobyl fallout. , 2008, Thyroid : official journal of the American Thyroid Association.

[7]  D. Henson,et al.  Changing Patterns in the Incidence and Survival of Thyroid Cancer with Follicular Phenotype—Papillary, Follicular, and Anaplastic: A Morphological and Epidemiological Study , 2007, Endocrine pathology.

[8]  K. Arihiro,et al.  The presence of BRAF point mutation in adult papillary thyroid carcinomas from atomic bomb survivors correlates with radiation dose , 2007, Molecular carcinogenesis.

[9]  M. Tronko,et al.  A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident , 2006, Cancer.

[10]  M. Nikiforova,et al.  Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity. , 2006, The Journal of clinical endocrinology and metabolism.

[11]  V. V. Markov,et al.  A cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident: thyroid cancer in Ukraine detected during first screening. , 2006, Journal of the National Cancer Institute.

[12]  A. Bouville,et al.  Questionnaire- and Measurement-Based Individual Thyroid Doses in Ukraine Resulting from the Chornobyl Nuclear Reactor Accident , 2006, Radiation research.

[13]  Peter Jacob,et al.  Cancer consequences of the Chernobyl accident: 20 years on , 2006, Journal of radiological protection : official journal of the Society for Radiological Protection.

[14]  D. Fink,et al.  Iodine excretion in regions of Ukraine affected by the Chornobyl Accident: experience of the Ukrainian-American cohort study of thyroid cancer and other thyroid diseases. , 2005, Thyroid : official journal of the American Thyroid Association.

[15]  Elisabeth Cardis,et al.  Risk of thyroid cancer after exposure to 131I in childhood. , 2005, Journal of the National Cancer Institute.

[16]  Y. Nikiforov,et al.  Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: a model of carcinogenic chromosomal rearrangement induced by ionizing radiation. , 2005, The Journal of clinical endocrinology and metabolism.

[17]  M. Pierotti,et al.  Proximity of TPR and NTRK1 rearranging loci in human thyrocytes. , 2005, Cancer research.

[18]  K. Kopecky,et al.  Risk of Thyroid Cancer in the Bryansk Oblast of the Russian Federation after the Chernobyl Power Station Accident , 2004, Radiation research.

[19]  Daniel J Fink,et al.  A Cohort Study of Thyroid Cancer and Other Thyroid Diseases after the Chornobyl Accident: Objectives, Design and Methods , 2004, Radiation research.

[20]  A. Bouville,et al.  Uncertainties in thyroid dose reconstruction after Chernobyl. , 2003, Radiation protection dosimetry.

[21]  Yuri E Nikiforov,et al.  High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. , 2003, Cancer research.

[22]  M. Nikiforova,et al.  PAX8-PPAR&ggr; Rearrangement in Thyroid Tumors: RT-PCR and Immunohistochemical Analyses , 2002, The American journal of surgical pathology.

[23]  M. Nikiforova,et al.  Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells. , 2000, Science.

[24]  H. Rabes,et al.  Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[25]  T. Seyama,et al.  Preferential induction of RET/PTC1 rearrangement by X-ray irradiation , 2000, Oncogene.

[26]  A. Pinchera,et al.  Post-Chernobyl thyroid carcinoma in Belarus children and adolescents: comparison with naturally occurring thyroid carcinoma in Italy and France. , 1997, The Journal of clinical endocrinology and metabolism.

[27]  A. Bounacer,et al.  High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation , 1997, Oncogene.

[28]  Y. Nikiforov,et al.  Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children. , 1997, Cancer research.

[29]  A. Karaoglou,et al.  Childhood thyroid cancer since accident at Chernobyl , 1995, BMJ.

[30]  D. Pierce,et al.  Joint analysis of site-specific cancer risks for the atomic bomb survivors. , 1993, Radiation research.

[31]  Anne Lohrli.  Chapman and Hall , 1985 .

[32]  B. Modan,et al.  Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies. 1995. , 2012, Radiation research.

[33]  M. Schott.  Molecular Testing for Mutations in Improving the Fine-Needle Aspiration Diagnosis of Thyroid Nodules , 2010 .

[34]  Matthew J Hayat,et al.  Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) Program. , 2007, The oncologist.

[35]  Y. Nikiforov.  Radiation-induced thyroid cancer: What we have learned from Chernobyl , 2006, Endocrine pathology.

[36]  Eric R. Ziegel,et al.  Generalized Linear Models:Generalized Linear Models , 2002 .

[37]  M. Kendall.  Theoretical Statistics , 1956, Nature.