The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells.

[1]  Ophir D Klein,et al.  Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. , 2013, Cell reports.

[2]  A. Llombart‐Bosch,et al.  Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. , 2012, Human pathology.

[3]  Martin Dugas,et al.  Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia , 2012, Nature Medicine.

[4]  Wenjun Guo,et al.  Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State , 2012, Cell.

[5]  David A. Orlando,et al.  Enhancer decommissioning by LSD1 during embryonic stem cell differentiation , 2012, Nature.

[6]  Peter Dirks,et al.  Cancer stem cells: an evolving concept , 2012, Nature Reviews Cancer.

[7]  D. Ward,et al.  Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties. , 2011, Cancer research.

[8]  A. Rocha,et al.  Distinct stem cells contribute to mammary gland development and maintenance , 2011, Nature.

[9]  V. Dixit,et al.  USP1 Deubiquitinates ID Proteins to Preserve a Mesenchymal Stem Cell Program in Osteosarcoma , 2011, Cell.

[10]  S. Gygi,et al.  A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development. , 2011, Molecular cell.

[11]  J. C. Belmonte,et al.  LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells , 2011, Nature Cell Biology.

[12]  B. Ponder,et al.  Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers , 2011, International journal of cancer.

[13]  P. Nuciforo,et al.  An Atlas of Altered Expression of Deubiquitinating Enzymes in Human Cancer , 2011, PloS one.

[14]  O. Dovey,et al.  Lysine-Specific Demethylase 1 Regulates the Embryonic Transcriptome and CoREST Stability , 2010, Molecular and Cellular Biology.

[15]  B. Zhou,et al.  The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine‐specific demethylase 1 , 2010, The EMBO journal.

[16]  R. Schüle,et al.  Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. , 2010, Carcinogenesis.

[17]  E. Kremmer,et al.  H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1. , 2010, Human pathology.

[18]  P. Hinds,et al.  Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis. , 2010, Cancer cell.

[19]  S. Baylin,et al.  Novel Oligoamine Analogues Inhibit Lysine-Specific Demethylase 1 and Induce Reexpression of Epigenetically Silenced Genes , 2009, Clinical Cancer Research.

[20]  Ryan D. Morin,et al.  Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution , 2009, Nature.

[21]  S. Gygi,et al.  Defining the Human Deubiquitinating Enzyme Interaction Landscape , 2009, Cell.

[22]  Keith D Wilkinson,et al.  Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. , 2009, Annual review of biochemistry.

[23]  Suimin Qiu,et al.  Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. , 2009, Cancer cell.

[24]  Taiping Chen,et al.  LSD1 demethylates histone and non-histone proteins , 2009, Epigenetics.

[25]  R. Versteeg,et al.  Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. , 2009, Cancer research.

[26]  Leonardo Morsut,et al.  FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination , 2009, Cell.

[27]  B. Zhou,et al.  Small C-terminal Domain Phosphatase Enhances Snail Activity through Dephosphorylation* , 2009, Journal of Biological Chemistry.

[28]  Yang Shi,et al.  Histone lysine demethylases: emerging roles in development, physiology and disease , 2007, Nature Reviews Genetics.

[29]  S. Elledge,et al.  The ubiquitin-specific protease USP28 is required for MYC stability , 2007, Nature Cell Biology.

[30]  C. Kuperwasser,et al.  Human breast cancer stem cell markers CD44 and CD24: enriching for cells with functional properties in mice or in man? , 2007, Breast Cancer Research.

[31]  Zhiyuan Hu,et al.  Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors , 2007, Genome Biology.

[32]  S. Baylin,et al.  Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes , 2007, Proceedings of the National Academy of Sciences.

[33]  Gratien G. Prefontaine,et al.  Opposing LSD1 complexes function in developmental gene activation and repression programmes , 2007, Nature.

[34]  Yi Zhang,et al.  Regulation of histone methylation by demethylimination and demethylation , 2007, Nature Reviews Molecular Cell Biology.

[35]  T. Mak,et al.  A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response , 2006, Cell.

[36]  Haiyan I. Li,et al.  Purification and unique properties of mammary epithelial stem cells , 2006, Nature.

[37]  François Vaillant,et al.  Generation of a functional mammary gland from a single stem cell , 2006, Nature.

[38]  F. Lan,et al.  Regulation of LSD1 histone demethylase activity by its associated factors. , 2005, Molecular cell.

[39]  Antoine H. F. M. Peters,et al.  LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription , 2005, Nature.

[40]  Yang Shi,et al.  Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1 , 2004, Cell.

[41]  Timothy Cardozo,et al.  The SCF ubiquitin ligase: insights into a molecular machine , 2004, Nature Reviews Molecular Cell Biology.

[42]  Bob Y. Liu,et al.  The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[43]  A. Rao.  Faculty Opinions recommendation of Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. , 2003 .

[44]  René Bernards,et al.  Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB , 2003, Nature.

[45]  G. Dontu,et al.  In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. , 2003, Genes & development.

[46]  E. Li,et al.  The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation , 2009, Nature Genetics.