Articular Cartilage Tissue Engineering

Articular cartilage repair remains a challenge to surgeons and basic scientists. The field of tissue engineering allows the simultaneous use of material scaffolds, cells and signalling molecules to attempt to modulate the regenerative tissue. This review summarises the research that has been undertaken to date using this approach, with a particular emphasis on those techniques that have been introduced into clinical practice, via in vitro and preclinical studies.

[1]  W. Kulyk,et al.  Promotion of embryonic chick limb cartilage differentiation by transforming growth factor-beta. , 1989, Developmental Biology.

[2]  Kyriacos A Athanasiou,et al.  P188 reduces cell death and IGF-I reduces GAG release following single-impact loading of articular cartilage. , 2008, Journal of biomechanical engineering.

[3]  Li-Yu Sung,et al.  Combination of baculovirus-expressed BMP-2 and rotating-shaft bioreactor culture synergistically enhances cartilage formation , 2008, Gene Therapy.

[4]  F. N. Ghadially,et al.  Long-term results of deep defects in articular cartilage , 1977, Virchows Archiv B Cell Pathology.

[5]  P. Roughley,et al.  Cartilage proteoglycans: Structure and potential functions , 1994, Microscopy research and technique.

[6]  J. Malejczyk,et al.  Natural cell-mediated cytotoxic activity against isolated chondrocytes in the mouse. , 1985, Clinical and experimental immunology.

[7]  T D Brown,et al.  A dynamic finite element analysis of impulsive loading of the extension-splinted rabbit knee. , 1990, Journal of biomechanical engineering.

[8]  J. Buckwalter,et al.  Biomechanical modeling of repair articular cartilage: Effects of passive motion on osteochondral defects in monkey knee joints , 1998 .

[9]  W. Freed,et al.  BG01V: a variant human embryonic stem cell line which exhibits rapid growth after passaging and reliable dopaminergic differentiation. , 2004, Restorative neurology and neuroscience.

[10]  Danièle Noël,et al.  Cartilage engineering: a crucial combination of cells, biomaterials and biofactors. , 2009, Trends in biotechnology.

[11]  M. Akens,et al.  Changes in subchondral bone in cartilage resurfacing--an experimental study in sheep using different types of osteochondral grafts. , 2003, Osteoarthritis and cartilage.

[12]  M. Takigawa,et al.  CCN family 2/connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes. , 2008, Osteoarthritis and cartilage.

[13]  J. Mollenhauer.  Perspectives on articular cartilage biology and osteoarthritis. , 2008, Injury.

[14]  I. Sekiya,et al.  Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma , 2005, Cell and Tissue Research.

[15]  D Heinegård,et al.  Structure and biology of cartilage and bone matrix noncollagenous macromolecules , 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[16]  Miya Ishihara,et al.  Bioengineered chondrocyte sheets may be potentially useful for the treatment of partial thickness defects of articular cartilage. , 2006, Biochemical and biophysical research communications.

[17]  A. Lynn,et al.  Repair of defects in articular joints. Prospects for material-based solutions in tissue engineering. , 2004, The Journal of bone and joint surgery. British volume.

[18]  C. Jorgensen,et al.  Tissue engineering through autologous mesenchymal stem cells. , 2004, Current opinion in biotechnology.

[19]  V. Goldberg,et al.  Hyaluronic acid‐based polymers as cell carriers for tissue‐engineered repair of bone and cartilage , 1999, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[20]  D. Goldenberg,et al.  The association of amyloid deposits and osteoarthritis. , 1982, Arthritis and rheumatism.

[21]  Lars Engebretsen,et al.  A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years. , 2007, The Journal of bone and joint surgery. American volume.

[22]  C B Sledge,et al.  Matrix collagen type and pore size influence behaviour of seeded canine chondrocytes. , 1997, Biomaterials.

[23]  Robert Langer,et al.  Biodegradable Polymer Scaffolds for Tissue Engineering , 1994, Bio/Technology.

[24]  Farshid Guilak,et al.  Functional properties of cell-seeded three-dimensionally woven poly(epsilon-caprolactone) scaffolds for cartilage tissue engineering. , 2010, Tissue engineering. Part A.

[25]  J. Delee,et al.  Incidence of Injury in Texas Girls' High School Basketball , 1996, The American journal of sports medicine.

[26]  H J Mankin,et al.  Articular cartilage repair and transplantation. , 1998, Arthritis and rheumatism.

[27]  C. M. Agrawal,et al.  Effects of Aging And Dietary Restriction On The Structural Integrity of Rat Articular Cartilage , 2004, Annals of Biomedical Engineering.

[28]  Post-Fracture, Late Debridement Resection Arthroplasty of the Ankle , 1985, Foot & ankle.

[29]  R. Cancedda,et al.  Production of angiogenesis inhibitors and stimulators is modulated by cultured growth plate chondrocytes during in vitro differentiation: dependence on extracellular matrix assembly. , 1995, European journal of cell biology.

[30]  J. Itskovitz‐Eldor,et al.  Human Feeder Layers for Human Embryonic Stem Cells1 , 2003, Biology of reproduction.

[31]  K E Healy,et al.  The role of vitronectin in the attachment and spatial distribution of bone-derived cells on materials with patterned surface chemistry. , 1997, Journal of biomedical materials research.

[32]  R. Haut,et al.  An investigation of biphasic failure criteria for impact-induced fissuring of articular cartilage. , 1998, Journal of biomechanical engineering.

[33]  R. F. Ker.  The design of soft collagenous load-bearing tissues. , 1999, The Journal of experimental biology.

[34]  E B Hunziker,et al.  Ultrastructure of adult human articular cartilage matrix after cryotechnical processing , 1997, Microscopy research and technique.

[35]  Mario Jolicoeur,et al.  Chondrocyte Aggregation in Suspension Culture Is GFOGER-GPP- and β1 Integrin-dependent* , 2008, Journal of Biological Chemistry.

[36]  G. Verbruggen,et al.  Culture of chondrocytes in alginate surrounded by fibrin gel: characteristics of the cells over a period of eight weeks , 2001, Annals of the rheumatic diseases.

[37]  Xin Zhang,et al.  The synergistic effects of microfracture, perforated decalcified cortical bone matrix and adenovirus-bone morphogenetic protein-4 in cartilage defect repair. , 2008, Biomaterials.

[38]  J. Fisher,et al.  Development and characterization of an acellular porcine medial meniscus for use in tissue engineering. , 2008, Tissue engineering. Part A.

[39]  R. E. Outerbridge.  THE ETIOLOGY OF CHONDROMALACIA PATELLAE , 1961 .

[40]  C. A. Poole.  Review. Articular cartilage chondrons: form, function and failure , 1997 .

[41]  W M Lai,et al.  An analysis of the unconfined compression of articular cartilage. , 1984, Journal of biomechanical engineering.

[42]  Hai Yao,et al.  Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study , 2010, The Lancet.

[43]  R. Lorentzon,et al.  Superior results with continuous passive motion compared to active motion after periosteal transplantation A retrospective study of human patella cartilage defect treatment , 1999, Knee Surgery, Sports Traumatology, Arthroscopy.

[44]  T. Kawamoto,et al.  Enhancement of Cell Adhesion and Spreading by a Cartilage-specific Noncollagenous Protein, Cartilage Matrix Protein (CMP/Matrilin-1), via Integrin α1β1 * , 1999, The Journal of Biological Chemistry.

[45]  J. Veerkamp,et al.  Development of tailor-made collagen-glycosaminoglycan matrices: EDC/NHS crosslinking, and ultrastructural aspects. , 2000, Biomaterials.

[46]  J. Verhaar,et al.  Specific enzymatic treatment of bovine and human articular cartilage: implications for integrative cartilage repair. , 2002, Arthritis and rheumatism.

[47]  S. Ishii,et al.  Débridement arthroplasty for primary osteoarthritis of the elbow. , 2004, The Journal of bone and joint surgery. American volume.

[48]  A. Maroudas,et al.  The correlation of fixed negative charge with glycosaminoglycan content of human articular cartilage. , 1969, Biochimica et biophysica acta.

[49]  G. Martin,et al.  Cross-linking of collagen and elastin. Properties of lysyl oxidase. , 1970, Biochemistry.

[50]  S. Madihally,et al.  Porous chitosan scaffolds for tissue engineering. , 1999, Biomaterials.

[51]  G. Vunjak‐Novakovic,et al.  Culture of organized cell communities. , 1998, Advanced drug delivery reviews.

[52]  A. Mikos,et al.  Marrow stromal osteoblast function on a poly(propylene fumarate)/beta-tricalcium phosphate biodegradable orthopaedic composite. , 2000, Biomaterials.

[53]  Riley J. Williams,et al.  Articular cartilage repair using a resorbable matrix scaffold. , 2008, Instructional course lectures.

[54]  R. Siebold,et al.  Combination of microfracture and periostal-flap for the treatment of focal full thickness articular cartilage lesions of the shoulder: a prospective study , 2003, Knee Surgery, Sports Traumatology, Arthroscopy.

[55]  O. Ringdén,et al.  HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. , 2003, Experimental hematology.

[56]  J. Elisseeff,et al.  Experimental model for cartilage tissue engineering to regenerate the zonal organization of articular cartilage. , 2003, Osteoarthritis and cartilage.

[57]  W. Lu,et al.  Mesenchymal Stem Cell-Based Repair of Articular Cartilage with Polyglycolic Acid-Hydroxyapatite Biphasic Scaffold , 2008, The International journal of artificial organs.

[58]  R. Lemperg,et al.  Histological, autoradiographic and microchemical studies of spontaneously healing osteochondral articular defects in adult rabbits , 2005, Calcified Tissue Research.

[59]  F. M. Schultz,et al.  Dynamic pressure transmission through agarose gels. , 2000, Tissue engineering.

[60]  F. Luyten,et al.  Characterized Chondrocyte Implantation Results in Better Structural Repair When Treating Symptomatic Cartilage Defects of the Knee in a Randomized Controlled Trial versus Microfracture , 2008, The American journal of sports medicine.

[61]  S. Kleis,et al.  The fluid dynamic and shear environment in the NASA/JSC rotating-wall perfused-vessel bioreactor. , 2000, Biotechnology and bioengineering.

[62]  W. B. van den Berg,et al.  Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation. , 1998, Osteoarthritis and cartilage.

[63]  G. Karsenty,et al.  PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways. , 2006, Developmental biology.

[64]  William J. O'Connor,et al.  The use of growth factors in cartilage repair. , 2000, The Orthopedic clinics of North America.

[65]  C. Legay,et al.  Influence of matricial molecules on growth and differentiation of entrapped chondrocytes. , 1993, Experimental cell research.

[66]  G. Vunjak‐Novakovic,et al.  Engineering complex tissues. , 2006, Tissue engineering.

[67]  C. White,et al.  Regulation of cartilage oligomeric matrix protein synthesis in human synovial cells and articular chondrocytes. , 1998, Arthritis and rheumatism.

[68]  S. Giannini,et al.  Autologous chondrocyte implantation in the knee joint: open compared with arthroscopic technique. Comparison at a minimum follow-up of five years. , 2008, The Journal of bone and joint surgery. American volume.

[69]  Chun-Chieh Huang,et al.  Mesenchymal Stem Cells in the Wharton's Jelly of the Human Umbilical Cord , 2004, Stem cells.

[70]  S. Moskalewski,et al.  Immune response by host after allogeneic chondrocyte transplant to the cartilage , 2002, Microscopy research and technique.

[71]  Rocky S Tuan,et al.  Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells. , 2008, Arthritis and rheumatism.

[72]  Fulin Chen,et al.  Autologous injectable tissue-engineered cartilage by using platelet-rich plasma: experimental study in a rabbit model. , 2007, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[73]  Vilmos Vécsei,et al.  Chondrogenesis of aged human articular cartilage in a scaffold-free bioreactor. , 2003, Tissue engineering.

[74]  R. Appleyard,et al.  Biomechanical, histological and immunohistological studies of patellar cartilage in an ovine model of osteoarthritis induced by lateral meniscectomy. , 1999, Osteoarthritis and cartilage.

[75]  J. Jansen,et al.  Effect of dual growth factor delivery on chondrogenic differentiation of rabbit marrow mesenchymal stem cells encapsulated in injectable hydrogel composites. , 2009, Journal of biomedical materials research. Part A.

[76]  M. Ueda,et al.  Cartilage formation by cultured chondrocytes in a new scaffold made of poly(L-lactide-ϵ-caprolactone) sponge , 2000 .

[77]  Yu-Ting Tsai,et al.  Process development of an acellular dermal matrix (ADM) for biomedical applications. , 2004, Biomaterials.

[78]  G. G. Niederauer,et al.  Porous, resorbable, fiber-reinforced scaffolds tailored for articular cartilage repair. , 2001, Tissue engineering.

[79]  G. Jay,et al.  Characterization of a bovine synovial fluid lubricating factor. I. Chemical, surface activity and lubricating properties. , 1992, Connective tissue research.

[80]  H. Lill,et al.  Autologous osteochondral mosaicplasty for treatment of a posttraumatic defect of the lateral tibial plateau: a case report with two-year follow-up. , 2005, Journal of orthopaedic trauma.

[81]  J. Mort,et al.  Modulation of the catabolic effects of interleukin‐1β on human articular chondrocytes by transforming growth factor‐β , 1996 .

[82]  S. Bruder,et al.  Growth kinetics, self‐renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation , 1997, Journal of cellular biochemistry.

[83]  S E Carver,et al.  Semi-continuous perfusion system for delivering intermittent physiological pressure to regenerating cartilage. , 1999, Tissue engineering.

[84]  P. Moghe.  Soft-Tissue Analogue Design and Tissue Engineering of Liver , 1996 .

[85]  E. Roark,et al.  Transforming growth factor‐β and bone morphogenetic protein‐2 act by distinct mechanisms to promote chick limb cartilage differentiation in vitro , 1994 .

[86]  J A Skinner,et al.  A prospective, randomised study comparing two techniques of autologous chondrocyte implantation for osteochondral defects in the knee: Periosteum covered versus type I/III collagen covered. , 2006, The Knee.

[87]  S. Yamanaka,et al.  Recent Stem Cell Advances: Induced Pluripotent Stem Cells for Disease Modeling and Stem Cell–Based Regeneration , 2010, Circulation.

[88]  R Langer,et al.  Dynamic Cell Seeding of Polymer Scaffolds for Cartilage Tissue Engineering , 1998, Biotechnology progress.

[89]  J. Glowacki,et al.  Low Oxygen Tension Enhances Chondroinduction by Demineralized Bone Matrix in Human Dermal Fibroblasts in vitro , 2005, Cells Tissues Organs.

[90]  Young Ha Kim,et al.  The effects of dynamic and three-dimensional environments on chondrogenic differentiation of bone marrow stromal cells , 2009, Biomedical materials.

[91]  G. Vunjak‐Novakovic,et al.  Composition of cell‐polymer cartilage implants , 1994, Biotechnology and bioengineering.

[92]  C. V. van Donkelaar,et al.  Development and validation of a novel bioreactor system for load‐ and perfusion‐controlled tissue engineering of chondrocyte‐constructs , 2008, Biotechnology and bioengineering.

[93]  R. Baron,et al.  Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation , 2005 .

[94]  M. Spector,et al.  Histologic analysis of tissue after failed cartilage repair procedures. , 1999, Clinical orthopaedics and related research.

[95]  W. Tsai,et al.  Modulation of Gene Expression of Rabbit Chondrocytes by Dynamic Compression in Polyurethane Scaffolds with Collagen Gel Encapsulation , 2009, Journal of biomaterials applications.

[96]  W. Horton,et al.  Transforming growth factor‐beta and fibroblast growth factor act synergistically to inhibit collagen II synthesis through a mechanism involving regulatory DNA sequences , 1989, Journal of cellular physiology.

[97]  M E Levenston,et al.  A versatile shear and compression apparatus for mechanical stimulation of tissue culture explants. , 2000, Journal of biomechanics.

[98]  Jennifer L West,et al.  Cell adhesion peptides alter smooth muscle cell adhesion, proliferation, migration, and matrix protein synthesis on modified surfaces and in polymer scaffolds. , 2002, Journal of biomedical materials research.

[99]  C. Brighton,et al.  The effect of oxygen tension on proteoglycan synthesis and aggregation in mammalian growth plate chondrocytes , 1991, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[100]  V. Mow,et al.  Biphasic creep and stress relaxation of articular cartilage in compression? Theory and experiments. , 1980, Journal of biomechanical engineering.

[101]  Miya Ishihara,et al.  The properties of bioengineered chondrocyte sheets for cartilage regeneration , 2009, BMC biotechnology.

[102]  Gwo‐Jaw Wang,et al.  Enhancement of chondrogenesis of human adipose derived stem cells in a hyaluronan-enriched microenvironment. , 2010, Biomaterials.

[103]  S. Trippel.  Growth factor actions on articular cartilage. , 1995, The Journal of rheumatology. Supplement.

[104]  C. Armstrong,et al.  Thickness and distribution of human femoral head articular cartilage. Changes with age. , 1977, Annals of the rheumatic diseases.

[105]  N. Südkamp,et al.  Is microfracture of chondral defects in the knee associated with different results in patients aged 40 years or younger? , 2006, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[106]  N. Sharkey,et al.  The fate of articular cartilage after transplantation of fresh and cryopreserved tissue-antigen-matched and mismatched osteochondral allografts in dogs. , 1989, The Journal of bone and joint surgery. American volume.

[107]  A I Caplan,et al.  In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. , 1998, Experimental cell research.

[108]  Kyriacos A. Athanasiou,et al.  Temporal Effects of Impact on Articular Cartilage Cell Death, Gene Expression, Matrix Biochemistry, and Biomechanics , 2008, Annals of Biomedical Engineering.

[109]  S. Dekel,et al.  Joint changes after overuse and peak overloading of rabbit knees in vivo. , 1978, Acta orthopaedica Scandinavica.

[110]  J. Ralphs,et al.  Organisation of the chondrocyte cytoskeleton and its response to changing mechanical conditions in organ culture , 1999, Journal of anatomy.

[111]  C. A. Poole,et al.  Chondrons in cartilage: Ultrastructural analysis of the pericellular microenvironment in adult human articular cartilages , 1987, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[112]  H. Weinans,et al.  Improved cartilage integration and interfacial strength after enzymatic treatment in a cartilage transplantation model , 2004, Arthritis research & therapy.

[113]  A. Mikos,et al.  Synthesis of poly(ethylene glycol)-tethered poly(propylene fumarate) and its modification with GRGD peptide , 2000 .

[114]  R. Jakob,et al.  Repair of superficial osteochondral defects with an autologous scaffold-free cartilage construct in a caprine model: implantation method and short-term results. , 2006, Osteoarthritis and cartilage.

[115]  J. Clark,et al.  The organisation of collagen fibrils in the superficial zones of articular cartilage. , 1990, Journal of anatomy.

[116]  R. Ferber,et al.  Gait mechanics after ACL reconstruction: implications for the early onset of knee osteoarthritis , 2008, British Journal of Sports Medicine.

[117]  W Herzog,et al.  Modeling axi-symmetrical joint contact with biphasic cartilage layers--an asymptotic solution. , 1996, Journal of biomechanics.

[118]  Thomas Häupl,et al.  Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction. , 2002, Arthritis and rheumatism.

[119]  D. Schurman,et al.  Effects of shear stress on nitric oxide and matrix protein gene expression in human osteoarthritic chondrocytes in vitro , 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[120]  J. Dekker,et al.  Structural joint changes, malalignment, and laxity in osteoarthritis of the knee , 2005, Scandinavian journal of rheumatology.

[121]  Ashutosh Chilkoti,et al.  A thermally responsive biopolymer for intra-articular drug delivery. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[122]  T. Trzaska,et al.  Articular cartilage defects: study of 25,124 knee arthroscopies. , 2007, The Knee.

[123]  H J Mankin,et al.  Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. , 1998, Instructional course lectures.

[124]  Barbara Lom,et al.  A versatile technique for patterning biomolecules onto glass coverslips , 1993, Journal of Neuroscience Methods.

[125]  Michael S Sacks,et al.  Effects of decellularization on the mechanical and structural properties of the porcine aortic valve leaflet. , 2008, Biomaterials.

[126]  Mandi J. Lopez,et al.  Comparison of chondrogenic potential in equine mesenchymal stromal cells derived from adipose tissue and bone marrow. , 2008, Veterinary surgery : VS.

[127]  G. Vunjak‐Novakovic,et al.  Gene transfer of a human insulin-like growth factor I cDNA enhances tissue engineering of cartilage. , 2002, Human gene therapy.

[128]  T. Iwatsubo,et al.  Theoretical investigation of an artificial joint with micro-pocket-covered component and biphasic cartilage on the opposite articulating surface. , 2003, Journal of biomechanical engineering.

[129]  V. Mow,et al.  Biphasic indentation of articular cartilage--I. Theoretical analysis. , 1987, Journal of biomechanics.

[130]  Depalma Af,et al.  Process of repair of articular cartilage demonstrated by histology and autoradiography with tritiated thymidine. , 1966 .

[131]  E. Thonar,et al.  Culture of chondrocytes in alginate gel: Variations in conditions of Gelation influence the structure of the alginate gel, and the arrangement and morphology of proliferating chondrocytes , 1998, In Vitro Cellular & Developmental Biology - Animal.

[132]  K. Brandt,et al.  Osteoarthritic changes in canine articular cartilage, subchondral bone, and synovium fifty-four months after transection of the anterior cruciate ligament. , 2010, Arthritis and rheumatism.

[133]  T. Churchill,et al.  Comparison of aortic valve allograft decellularization techniques in the rat. , 2006, Journal of biomedical materials research. Part A.

[134]  M. Sporn,et al.  Transforming growth factor-beta: biological function and chemical structure. , 1986, Science.

[135]  W M Lai,et al.  Biphasic indentation of articular cartilage--II. A numerical algorithm and an experimental study. , 1989, Journal of biomechanics.

[136]  J. Dodds,et al.  The split-line pattern of the distal femur: A consideration in the orientation of autologous cartilage grafts. , 2002, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[137]  R. Jaenisch,et al.  In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state , 2007, Nature.

[138]  A. Hinek,et al.  Cartilage macromolecules and the calcification of cartilage matrix , 1989, The Anatomical record.

[139]  S. Oh,et al.  Repair of osteochondral defects with a construct of mesenchymal stem cells and a polydioxanone/poly(vinyl alcohol) scaffold , 2008, Biotechnology and applied biochemistry.

[140]  R. G. Johnson,et al.  The early response of articular cartilage to ACL transection in a canine model. , 1990, Experimental pathology.

[141]  M. Miranda,et al.  Anteromedial tibial tubercle transfer without bone graft , 1990, The American journal of sports medicine.

[142]  M. Brittberg,et al.  Autologous chondrocyte transplantation. , 1999, Clinical orthopaedics and related research.

[143]  D. Rosen,et al.  Transforming growth factor‐beta modulates the expression of osteoblast and chondroblast phenotypes in vitro , 1988, Journal of cellular physiology.

[144]  Chad A. Cowan,et al.  Marked differences in differentiation propensity among human embryonic stem cell lines , 2008, Nature Biotechnology.

[145]  K. Athanasiou,et al.  Rapid phenotypic changes in passaged articular chondrocyte subpopulations , 2005, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[146]  Peter Müller,et al.  Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture , 1977, Nature.

[147]  E. Hunziker,et al.  Structural Barrier Principle for Growth Factor-Based Articular Cartilage Repair , 2001, Clinical orthopaedics and related research.

[148]  J. Mansour,et al.  Repair of large full-thickness articular cartilage defects with allograft articular chondrocytes embedded in a collagen gel. , 1998, Tissue engineering.

[149]  M. Nimni.  Polypeptide growth factors: targeted delivery systems. , 1997, Biomaterials.

[150]  J. Borrelli,et al.  Acute effects of cartilage impact. , 2004, Clinical orthopaedics and related research.

[151]  G. Dowd,et al.  Update on paediatric ACL injuries. , 2006, The Knee.

[152]  A. Lahm,et al.  Arthroskopische Technik der matrixassoziierten autologen Knorpelzelltransplantation am Kniegelenk , 2008, Operative Orthopädie und Traumatologie.

[153]  R. Jackson,et al.  Arthroscopic debridment is of value in selected patients , 1997 .

[154]  S. Elder,et al.  Potential use of chitosan as a cell scaffold material for cartilage tissue engineering. , 2002, Tissue engineering.

[155]  Arden,et al.  EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT) , 2003, Annals of the rheumatic diseases.

[156]  C. Kaps,et al.  Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results , 2009, Arthritis research & therapy.

[157]  G. Mandel,et al.  Monosodium urate monohydrate, the gout culprit. , 1976, Journal of the American Chemical Society.

[158]  K A Athanasiou,et al.  The effects of intra-articular methylprednisolone and exercise on the mechanical properties of articular cartilage in the horse. , 1998, Osteoarthritis and cartilage.

[159]  Antonios G Mikos,et al.  Effect of poly(ethylene glycol) molecular weight on tensile and swelling properties of oligo(poly(ethylene glycol) fumarate) hydrogels for cartilage tissue engineering. , 2002, Journal of biomedical materials research.

[160]  S. Gabriel,et al.  Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. , 2008, Arthritis and rheumatism.

[161]  Maurilio Marcacci,et al.  Patellofemoral Full-Thickness Chondral Defects Treated with Hyalograft-C , 2006, The American journal of sports medicine.

[162]  Farshid Guilak,et al.  Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide. , 2006, Biomaterials.

[163]  Thomas P Andriacchi,et al.  Rotational Changes at the Knee after ACL Injury Cause Cartilage Thinning , 2006, Clinical orthopaedics and related research.

[164]  D. Heymann,et al.  Recent advances in TGF-β effects on chondrocyte metabolism , 2002 .

[165]  M. Spector,et al.  Healing of canine articular cartilage defects treated with microfracture, a type‐II collagen matrix, or cultured autologous chondrocytes , 2000, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[166]  Morimichi Mizuno,et al.  Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells in pellet cultural system. , 2004, Experimental hematology.

[167]  A. Lichtenberg,et al.  Tissue engineering of heart valves: biomechanical and morphological properties of decellularized heart valves. , 2007, The Journal of heart valve disease.

[168]  L. Gibson,et al.  The effect of pore size on cell adhesion in collagen-GAG scaffolds. , 2005, Biomaterials.

[169]  A. Friedenstein.  Osteogenetic activity of transplanted transitional epithelium. , 1961, Acta anatomica.

[170]  David A Lee,et al.  Dynamic compressive strain influences chondrogenic gene expression in human mesenchymal stem cells. , 2006, Biorheology.

[171]  Pierre Weiss,et al.  Cartilage tissue engineering: towards a biomaterial-assisted mesenchymal stem cell therapy. , 2009, Current stem cell research & therapy.

[172]  Paolo Giannoni,et al.  Tissue engineering and cell therapy of cartilage and bone. , 2003, Matrix biology : journal of the International Society for Matrix Biology.

[173]  R Langer,et al.  Development of biomechanical properties and morphogenesis of in vitro tissue engineered cartilage. , 1995, Journal of biomedical materials research.

[174]  D. Felson,et al.  Structural factors associated with malalignment in knee osteoarthritis: the Boston osteoarthritis knee study. , 2005, Journal of Rheumatology.

[175]  J. Zwerina,et al.  The lonely death: Chondrocyte apoptosis in TNF-induced arthritis , 2007, Autoimmunity.

[176]  B. A. Byers,et al.  The beneficial effect of delayed compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3. , 2007, Osteoarthritis and cartilage.

[177]  R. Tuan,et al.  Developmental regulation of creatine kinase activity in cells of the epiphyseal growth cartilage , 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[178]  D. Lloyd,et al.  Tibio-femoral cartilage defects 3-5 years following arthroscopic partial medial meniscectomy. , 2008, Osteoarthritis and cartilage.

[179]  R. Cancedda,et al.  Comparative Evaluation of Autologous Chondrocyte Implantation and Mosaicplasty: A Multicentered Randomized Clinical Trial , 2005, Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine.

[180]  C. Helmick,et al.  Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. , 1998, Arthritis and rheumatism.

[181]  J. Thomson,et al.  Embryonic stem cell lines derived from human blastocysts. , 1998, Science.

[182]  E. Thonar,et al.  Cartilage growth and remodeling: modulation of balance between proteoglycan and collagen network in vitro with beta-aminopropionitrile. , 2008, Osteoarthritis and cartilage.

[183]  S. Kim,et al.  Injectable cartilage: using alginate and human chondrocytes. , 2009, Archives of facial plastic surgery.

[184]  H. Kleinman,et al.  Role of collagenous matrices in the adhesion and growth of cells , 1981, The Journal of cell biology.

[185]  F. Mallein-Gerin,et al.  Functions of Transforming Growth Factor-β Family Type I Receptors and Smad Proteins in the Hypertrophic Maturation and Osteoblastic Differentiation of Chondrocytes* , 2002, The Journal of Biological Chemistry.

[186]  M. Iwamoto,et al.  Fibroblast growth factor is an inhibitor of chondrocyte terminal differentiation. , 1990, The Journal of biological chemistry.

[187]  Edward C. Jones,et al.  The microfracture technique for the treatment of articular cartilage lesions in the knee. A prospective cohort study. , 2005, The Journal of bone and joint surgery. American volume.

[188]  S. O’Driscoll.  Current Concepts Review - The Healing and Regeneration of Articular Cartilage* , 1998 .

[189]  Jerry C. Hu,et al.  Low-density cultures of bovine chondrocytes: effects of scaffold material and culture system. , 2005, Biomaterials.

[190]  A. Caplan,et al.  Osteochondrogenic potential of marrow mesenchymal progenitor cells exposed to TGF‐β1 or PDGF‐BB as assayed in vivo and in vitro , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[191]  J. Kramer,et al.  In vitro differentiation of mouse ES cells: bone and cartilage. , 2003, Methods in enzymology.

[192]  R Langer,et al.  A biodegradable composite scaffold for cell transplantation , 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[193]  Christoph Gaissmaier,et al.  Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads. , 2004, Osteoarthritis and cartilage.

[194]  M. Zlatkin,et al.  Occupational and post-traumatic arthritis. , 1988, Radiologic clinics of North America.

[195]  J. Buckwalter,et al.  Interspecies comparisons of in situ intrinsic mechanical properties of distal femoral cartilage , 1991, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[196]  Gordana Vunjak-Novakovic,et al.  Tissue Engineering of Cartilage , 1999 .

[197]  G. Jay,et al.  Frictional properties of Hartley guinea pig knees with and without proteolytic disruption of the articular surfaces. , 2007, Osteoarthritis and cartilage.

[198]  D. D’Lima,et al.  Human chondrocyte apoptosis in response to mechanical injury. , 2001, Osteoarthritis and cartilage.

[199]  G. Lust,et al.  Characterization of cartilage metabolic response to static and dynamic stress using a mechanical explant test system. , 1997, Journal of biomechanics.

[200]  Jason A. Burdick,et al.  Sequential crosslinking to control cellular spreading in 3-dimensional hydrogels , 2009 .

[201]  M. Iwamoto,et al.  Fibroblast growth factor stimulates colony formation of differentiated chondrocytes in soft agar , 1987, Journal of cellular physiology.

[202]  Ashutosh Chilkoti,et al.  Characterization of a genetically engineered elastin-like polypeptide for cartilaginous tissue repair. , 2002, Biomacromolecules.

[203]  V C Mow,et al.  Variations in the intrinsic mechanical properties of human articular cartilage with age, degeneration, and water content. , 1982, The Journal of bone and joint surgery. American volume.

[204]  A. Reddi,et al.  Effects of TGF-β1 on alternative splicing of Superficial Zone Protein in articular cartilage cultures. , 2011, Osteoarthritis and cartilage.

[205]  P. A. Lucas,et al.  Stem cells isolated from adult rat muscle differentiate across all three dermal lineages , 2006, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[206]  A. Gross,et al.  Immunogenicity of allograft articular cartilage. , 1974, The Journal of bone and joint surgery. American volume.

[207]  R. Langer,et al.  Engineering substrate topography at the micro- and nanoscale to control cell function. , 2009, Angewandte Chemie.

[208]  C. M. Agrawal,et al.  Fabrication and Characterization of PLA-PGA Orthopedic Implants. , 1995, Tissue engineering.

[209]  H. Trivedi.  Immunobiology of rejection and adaptation. , 2007, Transplantation proceedings.

[210]  M. Perricaudet,et al.  Short‐Term BMP‐2 Expression Is Sufficient for In Vivo Osteochondral Differentiation of Mesenchymal Stem Cells , 2004, Stem cells.

[211]  J. Mason,et al.  Cartilage tissue engineering: current limitations and solutions. , 1999, Clinical orthopaedics and related research.

[212]  E. Thonar,et al.  Adult human chondrocytes cultured in alginate form a matrix similar to native human articular cartilage. , 1996, The American journal of physiology.

[213]  Kyriacos A Athanasiou,et al.  Effects of temporal hydrostatic pressure on tissue-engineered bovine articular cartilage constructs. , 2009, Tissue engineering. Part A.

[214]  E. Hunziker,et al.  Repair of Partial-Thickness Defects in Articular Cartilage: Cell Recruitment from the Synovial Membrane* , 1996, The Journal of bone and joint surgery. American volume.

[215]  C. Perka,et al.  The use of fibrin beads for tissue engineering and subsequential transplantation. , 2001, Tissue engineering.

[216]  J C Middleton,et al.  Synthetic biodegradable polymers as orthopedic devices. , 2000, Biomaterials.

[217]  M T Raimondi,et al.  A new bioreactor for the controlled application of complex mechanical stimuli for cartilage tissue engineering , 2008, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[218]  Donggang Yao,et al.  Chondrogenic derivatives of embryonic stem cells seeded into 3D polycaprolactone scaffolds generated cartilage tissue in vivo. , 2008 .

[219]  E Ruoslahti,et al.  RGD and other recognition sequences for integrins. , 1996, Annual review of cell and developmental biology.

[220]  C. Ingersoll,et al.  Arthrogenic muscle response of the quadriceps and hamstrings with chronic ankle instability. , 2007, Journal of athletic training.

[221]  A Ratcliffe,et al.  Mechanical and biochemical changes in the superficial zone of articular cartilage in canine experimental osteoarthritis , 1994, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[222]  C. Ohlsson,et al.  Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. , 1994, The New England journal of medicine.

[223]  Albert C. Chen,et al.  Depth‐dependent confined compression modulus of full‐thickness bovine articular cartilage , 1997, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[224]  R. Tuan,et al.  Mesenchymal stem cells in arthritic diseases , 2008, Arthritis research & therapy.

[225]  Brian J Cole,et al.  Overview of Existing Cartilage Repair Technology , 2008, Sports medicine and arthroscopy review.

[226]  S. Shalaby,et al.  The growth of chondrocytes into a fibronectin-coated biodegradable scaffold. , 2001, Journal of biomedical materials research.

[227]  G Meachim,et al.  Surface ultrastructure of mature adult human articular cartilage. , 1969, The Journal of bone and joint surgery. British volume.

[228]  M. Glimcher,et al.  Biochemical studies on repair cartilage resurfacing experimental defects in the rabbit knee. , 1980, The Journal of bone and joint surgery. American volume.

[229]  P. Aspenberg,et al.  CDMP‐2 induces bone or tendon‐like tissue depending on mechanical stimulation , 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[230]  D. Thompson,et al.  Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis. , 2005, Osteoarthritis and cartilage.

[231]  A. Kusakabe.  Subchondral cancellous bone in osteoarthrosis and rheumatoid arthritis of the femoral head , 1977, Archiv für orthopädische und Unfall-Chirurgie, mit besonderer Berücksichtigung der Frakturenlehre und der orthopädisch-chirurgischen Technik.

[232]  T. Kubo,et al.  Induction of chondrogenic phenotype in synovium-derived progenitor cells by intermittent hydrostatic pressure. , 2008, Osteoarthritis and cartilage.

[233]  H. Mankin,et al.  The turnover of adult rabbit articular cartilage. , 1969, The Journal of bone and joint surgery. American volume.

[234]  P. Greis,et al.  The Use of a Single Osteochondral Autograft Plug in the Treatment of a Large Osteochondral Lesion in the Femoral Condyle , 2006, The American journal of sports medicine.

[235]  D Amiel,et al.  The use of polylactic acid matrix and periosteal grafts for the reconstruction of rabbit knee articular defects. , 1991, Journal of biomedical materials research.

[236]  R. Haut,et al.  Mechanical responses of the rabbit patello-femoral joint to blunt impact. , 1995, Journal of biomechanical engineering.

[237]  K. Anseth,et al.  Crosslinked polyanhydrides for use in orthopedic applications: degradation behavior and mechanics. , 1999, Journal of biomedical materials research.

[238]  A. Nixon,et al.  Local and remote matrix responses to chondrocyte-laden collagen scaffold implantation in extensive articular cartilage defects. , 1995, Osteoarthritis and cartilage.

[239]  Mark A. Randolph,et al.  Tissue Engineered Neocartilage Using Plasma Derived Polymer Substrates and Chondrocytes , 1998, Plastic and reconstructive surgery.

[240]  A. Reddi,et al.  Increased accumulation of superficial zone protein (SZP) in articular cartilage in response to bone morphogenetic protein‐7 and growth factors , 2007, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[241]  R. Wait,et al.  Basic FGF mediates an immediate response of articular cartilage to mechanical injury , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[242]  H. E. Christensen,et al.  Local amyloid formation in the hip joint capsule in osteoarthritis. , 1973, Acta orthopaedica Scandinavica.

[243]  S. Bent,et al.  Chondrocytic differentiation of mesenchymal stem cells sequentially exposed to transforming growth factor‐β1 in monolayer and insulin‐like growth factor‐I in a three‐dimensional matrix , 2001, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[244]  P. Strzelczyk,et al.  Carbon fiber scaffolds in the surgical treatment of cartilage lesions. , 1999, Annals of transplantation.

[245]  R. Terkeltaub,et al.  Factor XIIIA mobilizes transglutaminase 2 to induce chondrocyte hypertrophic differentiation , 2008 .

[246]  J. Kelsey,et al.  Epidemiology of musculoskeletal impairments and associated disability. , 1984, American journal of public health.

[247]  Seonghun Park,et al.  Microscale frictional response of bovine articular cartilage from atomic force microscopy. , 2004, Journal of biomechanics.

[248]  Gwo‐Jaw Wang,et al.  Parathyroid hormone 1-34 inhibits terminal differentiation of human articular chondrocytes and osteoarthritis progression in rats. , 2009, Arthritis and rheumatism.

[249]  H. Nejadnik,et al.  Autologous Bone Marrow–Derived Mesenchymal Stem Cells Versus Autologous Chondrocyte Implantation , 2010, The American journal of sports medicine.

[250]  C B Sledge,et al.  Chondrocyte-seeded collagen matrices implanted in a chondral defect in a canine model. , 1998, Biomaterials.

[251]  W. B. van den Berg,et al.  Crosslinked type II collagen matrices: preparation, characterization, and potential for cartilage engineering. , 2002, Biomaterials.

[252]  A. Reddi,et al.  Induction of chondrogenesis and superficial zone protein accumulation in synovial side population cells by BMP‐7 and TGF‐β1 , 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[253]  D. Zukor,et al.  Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13. , 2002, Arthritis & Rheumatism.

[254]  V Vécsei,et al.  Dedifferentiation-associated changes in morphology and gene expression in primary human articular chondrocytes in cell culture. , 2002, Osteoarthritis and cartilage.

[255]  Jerry C. Hu,et al.  Mechanical characterization of differentiated human embryonic stem cells. , 2009, Journal of biomechanical engineering.

[256]  L. Bonassar,et al.  Comparison of Chondrogensis in Static and Perfused Bioreactor Culture , 2000, Biotechnology progress.

[257]  Kyriacos A. Athanasiou,et al.  Synergistic and Additive Effects of Hydrostatic Pressure and Growth Factors on Tissue Formation , 2008, PloS one.

[258]  G. Lust,et al.  Insulin-like growth factor-I enhances cell-based repair of articular cartilage. , 2002, The Journal of bone and joint surgery. British volume.

[259]  J. Bonaventure,et al.  Reexpression of cartilage-specific genes by dedifferentiated human articular chondrocytes cultured in alginate beads. , 1994, Experimental cell research.

[260]  R. Stewart,et al.  Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells , 2007, Science.

[261]  L. Pottenger,et al.  Effects of basic fibroblast growth factor, transforming growth factor‐β1, insulin‐like growth factor‐1, and insulin on human osteoarthritic articular cartilage explants , 1995, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[262]  L. New,et al.  Tgf-Beta promotes the growth of bovine chondrocytes in monolayer culture and the formation of cartilage tissue on three-dimensional scaffolds. , 1995, Tissue engineering.

[263]  K. Shakesheff,et al.  Creating biomimetic micro-environments with synthetic polymer-peptide hybrid molecules. , 1998, Journal of biomaterials science. Polymer edition.

[264]  C. M. Agrawal,et al.  New technique to extend the useful life of a biodegradable cartilage implant. , 1998, Tissue engineering.

[265]  S J Bryant,et al.  The effects of scaffold thickness on tissue engineered cartilage in photocrosslinked poly(ethylene oxide) hydrogels. , 2001, Biomaterials.

[266]  J. Khillan,et al.  Limb bud progenitor cells induce differentiation of pluripotent embryonic stem cells into chondrogenic lineage. , 2003, Differentiation; research in biological diversity.

[267]  M. Mörgelin,et al.  Age-related changes in the composition, the molecular stoichiometry and the stability of proteoglycan aggregates extracted from human articular cartilage. , 2003, The Biochemical journal.

[268]  C. L. Murphy,et al.  Effect of oxygen tension and alginate encapsulation on restoration of the differentiated phenotype of passaged chondrocytes. , 2001, Tissue engineering.

[269]  S. Jimenez,et al.  Effects of calcium deficiency on chondrocyte hypertrophy and type X collagen expression in chick embryonic sternum , 1993, Developmental dynamics : an official publication of the American Association of Anatomists.

[270]  V. Mow,et al.  Incompressibility of the solid matrix of articular cartilage under high hydrostatic pressures. , 1998, Journal of biomechanics.

[271]  C. Deng,et al.  TGF-β/Smad3 Signals Repress Chondrocyte Hypertrophic Differentiation and Are Required for Maintaining Articular Cartilage , 2001, The Journal of cell biology.

[272]  A. Grodzinsky,et al.  Mechanical regulation of cartilage biosynthetic behavior: physical stimuli. , 1994, Archives of biochemistry and biophysics.

[273]  J. Vacanti,et al.  Synthetic Polymers Seeded with Chondrocytes Provide a Template for New Cartilage Formation , 1991, Plastic and reconstructive surgery.

[274]  P. McFetridge,et al.  A mechanical evaluation of three decellularization methods in the design of a xenogeneic scaffold for tissue engineering the temporomandibular joint disc. , 2008, Acta biomaterialia.

[275]  Luo Zj,et al.  Light and low-frequency pulsatile hydrostatic pressure enhances extracellular matrix formation by bone marrow mesenchymal cells: an in-vitro study with special reference to cartilage repair. , 2007 .

[276]  R. Eavey,et al.  Tissue engineered cartilage: utilization of autologous serum and serum-free media for chondrocyte culture. , 2007, International journal of pediatric otorhinolaryngology.

[277]  F. Guilak,et al.  2010 Nicolas Andry Award: Multipotent Adult Stem Cells from Adipose Tissue for Musculoskeletal Tissue Engineering , 2010, Clinical orthopaedics and related research.

[278]  Differential behavior of auricular and articular chondrocytes in hyaluronic acid hydrogels. , 2008 .

[279]  Moonsoo Jin,et al.  Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds. , 2004, Journal of biomechanics.

[280]  S. Kawai,et al.  Chondrogenic differentiation of murine embryonic stem cells: Effects of culture conditions and dexamethasone , 2004, Journal of cellular biochemistry.

[281]  M. Sakuda,et al.  Stimulation of cartilage‐matrix proteoglycan synthesis by morphologically transformed chondrocytes grown in the presence of fibroblast growth factor and transforming growth factor‐beta , 1989, Journal of cellular physiology.

[282]  M. Englund,et al.  High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury. , 2004, Arthritis and rheumatism.

[283]  J. Vacanti,et al.  De Novo Cartilage Generation Using Calcium Alginate‐Chondrocyte Constructs , 1996, Plastic and reconstructive surgery.

[284]  V C Mow,et al.  Effects of proteoglycan extraction on the tensile behavior of articular cartilage , 1990, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[285]  C. B. Machado,et al.  The effect of a chitosan–gelatin matrix and dexamethasone on the behavior of rabbit mesenchymal stem cells , 2006, Biomedical materials.

[286]  Rik Huiskes,et al.  Causes of mechanically induced collagen damage in articular cartilage , 2006, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[287]  Kyriacos A Athanasiou,et al.  Effects of doxycycline on articular cartilage GAG release and mechanical properties following impact , 2008, Biotechnology and bioengineering.

[288]  Y. Zheng,et al.  Intravascular Ultrasound (IVUS): A Potential Arthroscopic Tool for Quantitative Assessment of Articular Cartilage , 2009, The open biomedical engineering journal.

[289]  Kyriacos A Athanasiou,et al.  Fibrochondrogenesis in Two Embryonic Stem Cell Lines: Effects of Differentiation Timelines , 2008, Stem cells.

[290]  Hiromichi Fujie,et al.  Cartilage repair using an in vitro generated scaffold-free tissue-engineered construct derived from porcine synovial mesenchymal stem cells. , 2007, Biomaterials.

[291]  Y. Tabata,et al.  Regeneration of Defects in Articular Cartilage in Rat Knee Joints by CCN2 (Connective Tissue Growth Factor) , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[292]  J. Vacanti,et al.  Cartilage Engineering from Ovine Umbilical Cord Blood Mesenchymal Progenitor Cells , 2005, Stem cells.

[293]  M. Krampera,et al.  Human bone marrow and adipose tissue mesenchymal stem cells: a user's guide. , 2010, Stem cells and development.

[294]  Stephen F Badylak,et al.  Decellularization of tissues and organs. , 2006, Biomaterials.

[295]  M. Shive,et al.  Biodegradation and biocompatibility of PLA and PLGA microspheres , 1997 .

[296]  G. Whitesides,et al.  Self-assembled organic monolayers: model systems for studying adsorption of proteins at surfaces , 1991, Science.

[297]  Udo Schumacher,et al.  Redifferentiation of chondrocytes and cartilage formation under intermittent hydrostatic pressure , 2006, Biotechnology Letters.

[298]  N. Halperin,et al.  Resurfacing of Goat Articular Cartilage by Chondrocytes Derived From Bone Marrow , 1996, Clinical orthopaedics and related research.

[299]  M. Raimondi,et al.  Engineered cartilage constructs subject to very low regimens of interstitial perfusion. , 2008, Biorheology.

[300]  Anders Lindahl,et al.  Indentation Stiffness of Repair Tissue after Autologous Chondrocyte Transplantation , 2005, Clinical orthopaedics and related research.

[301]  D R Carter,et al.  Effects of shear stress on articular chondrocyte metabolism. , 2000, Biorheology.

[302]  J S Jurvelin,et al.  Biphasic poroviscoelastic simulation of the unconfined compression of articular cartilage: I--Simultaneous prediction of reaction force and lateral displacement. , 2001, Journal of biomechanical engineering.

[303]  A. Mikos,et al.  Effects of biodegradable polymer particles on rat marrow-derived stromal osteoblasts in vitro. , 1998, Biomaterials.

[304]  N. Socci,et al.  Derivation of Multipotent Mesenchymal Precursors from Human Embryonic Stem Cells , 2005, PLoS medicine.

[305]  P. Robbins,et al.  Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy , 2005, Gene Therapy.

[306]  C. Sledge,et al.  Histological Evaluation of the Course of Healing of Canine Articular Cartilage Defects Treated with Cultured Autologous Chondrocytes , 1998 .

[307]  H. Watanabe,et al.  Roles of aggrecan, a large chondroitin sulfate proteoglycan, in cartilage structure and function. , 1998, Journal of biochemistry.

[308]  A. Ratcliffe,et al.  Two subpopulations of differentiated chondrocytes identified with a monoclonal antibody to keratan sulfate , 1985, The Journal of cell biology.

[309]  Eda T Bloom,et al.  Autologous cultured chondrocytes: adverse events reported to the United States Food and Drug Administration. , 2006, The Journal of bone and joint surgery. American volume.

[310]  D. R. Carter,et al.  In vitro stimulation of articular chondrocyte mRNA and extracellular matrix synthesis by hydrostatic pressure , 1996, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[311]  Zhen Li,et al.  Chondrogenesis of human bone marrow mesenchymal stem cells in fibrin-polyurethane composites is modulated by frequency and amplitude of dynamic compression and shear stress. , 2010, Tissue engineering. Part A.

[312]  S. Nehrer,et al.  Three-year clinical outcome after chondrocyte transplantation using a hyaluronan matrix for cartilage repair. , 2006, European journal of radiology.

[313]  M. Steinwachs.  New technique for cell-seeded collagen-matrix-supported autologous chondrocyte transplantation. , 2009, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[314]  M. Griffith,et al.  Fibrin glues in combination with mesenchymal stem cells to develop a tissue-engineered cartilage substitute. , 2011, Tissue engineering. Part A.

[315]  Hitoshi Hirata,et al.  Enhanced repair of large osteochondral defects using a combination of artificial cartilage and basic fibroblast growth factor. , 2005, Biomaterials.

[316]  A. Mikos,et al.  In vitro degradation of thin poly(DL-lactic-co-glycolic acid) films. , 1999, Journal of biomedical materials research.

[317]  W. Richter,et al.  Human articular chondrocytes secrete parathyroid hormone-related protein and inhibit hypertrophy of mesenchymal stem cells in coculture during chondrogenesis. , 2010, Arthritis and rheumatism.

[318]  Kris Dierickx,et al.  A critical assessment of the directive on tissue engineering of the European union. , 2007, Tissue engineering.

[319]  K. Abendroth,et al.  Osteoarthritis and bone: osteologic types of osteoarthritis of the hip , 1989, Skeletal radiology.

[320]  R. Loeser,et al.  Expression of beta 1 integrins by cultured articular chondrocytes and in osteoarthritic cartilage. , 1995, Experimental cell research.

[321]  G. Balian,et al.  Marrow stromal cells embedded in alginate for repair of osteochondral defects. , 2000, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[322]  E. Olson,et al.  Regulation of paraxis expression and somite formation by ectoderm- and neural tube-derived signals. , 1997, Developmental biology.

[323]  V. Mow,et al.  The ultrastructure and biomechanical significance of the tidemark of articular cartilage. , 1975, Clinical orthopaedics and related research.

[324]  R Langer,et al.  Design of nasoseptal cartilage replacements synthesized from biodegradable polymers and chondrocytes. , 1994, Biomaterials.

[325]  D. W. Jackson,et al.  Symptomatic articular cartilage degeneration: the impact in the new millennium. , 2001, Clinical orthopaedics and related research.

[326]  Zhongmin Jin,et al.  Biotribology of articular cartilage--a review of the recent advances. , 2008, Medical engineering & physics.

[327]  Jerry C. Hu,et al.  A self-assembling process in articular cartilage tissue engineering. , 2006, Tissue engineering.

[328]  C. Bassett,et al.  Histological observations on experimentally induced degeneration of articular cartilage. , 1970, The Journal of bone and joint surgery. American volume.

[329]  Kyriacos A. Athanasiou,et al.  Biodegradable Implants for the Treatment of Osteochondral Defects in a Goat Model , 1997 .

[330]  A. Mikos,et al.  Controlled release of transforming growth factor β1 from biodegradable polymer microparticles , 2000 .

[331]  Thomas Aigner,et al.  Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells. , 2003, Arthritis and rheumatism.

[332]  N. Stergiou,et al.  Three-Dimensional Tibiofemoral Kinematics of the Anterior Cruciate Ligament-Deficient and Reconstructed Knee during Walking * , 2003, The American journal of sports medicine.

[333]  A. Kane,et al.  BMP4 promotes chondrocyte proliferation and hypertrophy in the endochondral cranial base. , 2003, The International journal of developmental biology.

[334]  D. Dowson,et al.  Micro-elastohydrodynamic lubrication of synovial joints. , 1986, Engineering in medicine.

[335]  Kyriacos A Athanasiou,et al.  Chondroitinase ABC treatment results in greater tensile properties of self-assembled tissue-engineered articular cartilage. , 2009, Tissue engineering. Part A.

[336]  A I Caplan,et al.  A chemically defined medium supports in vitro proliferation and maintains the osteochondral potential of rat marrow-derived mesenchymal stem cells. , 1995, Experimental cell research.

[337]  M. Wimmer,et al.  Chondrocyte gene expression under applied surface motion. , 2006, Biorheology.

[338]  Zhen Li,et al.  Mechanical load modulates chondrogenesis of human mesenchymal stem cells through the TGF-β pathway , 2009, Journal of cellular and molecular medicine.

[339]  P. Torzilli,et al.  Effect of impact load on articular cartilage: cell metabolism and viability, and matrix water content. , 1999, Journal of biomechanical engineering.

[340]  Stephanie J Bryant,et al.  In situ forming degradable networks and their application in tissue engineering and drug delivery. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[341]  Ladina Ettinger,et al.  Enhanced matrix synthesis in de novo, scaffold free cartilage‐like tissue subjected to compression and shear , 2006, Biotechnology and bioengineering.

[342]  V. Juras,et al.  Kinematic biomechanical assessment of human articular cartilage transplants in the knee using 3-T MRI: an in vivo reproducibility study , 2009, European Radiology.

[343]  D. Studer,et al.  Collagen fibrillogenesis by chondrocytes in alginate. , 2002, Tissue engineering.

[344]  Yilin Cao,et al.  [Influence of transforming growth factor-beta1 inducing time on chondrogenesis of bone marrow stromal cells (BMSCs): in vitro experiment with porcine BMSCs]. , 2007, Zhonghua yi xue za zhi.

[345]  B. Pietra.  Transplantation immunology 2003: simplified approach. , 2003, Pediatric clinics of North America.

[346]  Jerry C. Hu,et al.  Matrix Development in Self-Assembly of Articular Cartilage , 2008, PloS one.

[347]  Koichi Masuda,et al.  A novel two‐step method for the formation of tissue‐engineered cartilage by mature bovine chondrocytes: The alginate‐recovered‐chondrocyte (ARC) method , 2003, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[348]  R. Sah,et al.  Treatment of cartilage with β‐aminopropionitrile accelerates subsequent collagen maturation and modulates integrative repair , 2005, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[349]  D L Bader,et al.  The influence of mechanical loading on isolated chondrocytes seeded in agarose constructs. , 2000, Biorheology.

[350]  Stuart A. Newman,et al.  Role of transforming growth factor-β in chondrogenic pattern formation in the embryonic limb: Stimulation of mesenchymal condensation and fibronectin gene expression by exogenenous TGF-β and evidence for endogenous TGF-β-like activity , 1991 .

[351]  Li Ren,et al.  Genipin-cross-linked collagen/chitosan biomimetic scaffolds for articular cartilage tissue engineering applications. , 2010, Journal of biomedical materials research. Part A.

[352]  P. Sharpe,et al.  Interactions between Bmp‐4 and Msx‐1 act to restrict gene expression to odontogenic mesenchyme , 1998, Developmental dynamics : an official publication of the American Association of Anatomists.

[353]  K. Kuettner,et al.  Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism. , 1999, Biochemical and biophysical research communications.

[354]  M. Sittinger,et al.  Humoral immune response against minor collagens type IX and XI in patients with cartilage graft resorption after reconstructive surgery. , 1994, Annals of the rheumatic diseases.

[355]  C. Heath,et al.  Influence of intermittent pressure, fluid flow, and mixing on the regenerative properties of articular chondrocytes. , 1999, Biotechnology and bioengineering.

[356]  G. Boering,et al.  Resorbable poly(L-lactide) plates and screws for the fixation of zygomatic fractures. , 1987, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[357]  A. Grodzinsky,et al.  Mechanical and physicochemical determinants of the chondrocyte biosynthetic response , 1988, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[358]  Christina Eckhardt,et al.  Vascular Endothelial Growth Factor Gene‐Activated Matrix (VEGF165‐GAM) Enhances Osteogenesis and Angiogenesis in Large Segmental Bone Defects , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[359]  R. Salter,et al.  Biological resurfacing of full-thickness defects in patellar articular cartilage of the rabbit. Investigation of autogenous periosteal grafts subjected to continuous passive motion. , 1992, The Journal of bone and joint surgery. British volume.

[360]  B. J. Brewer,et al.  In vitro synthesis of tissue-specific type II collagen by healing cartilage. I. Short-term repair of cartilage by mature rabbits. , 1980, Arthritis and rheumatism.

[361]  P. Gratzer,et al.  Effectiveness of three extraction techniques in the development of a decellularized bone-anterior cruciate ligament-bone graft. , 2005, Biomaterials.

[362]  K A Athanasiou,et al.  Biomechanical Topography of Human Articular Cartilage in the First Metatarsophalangeal Joint , 1998, Clinical orthopaedics and related research.

[363]  S. Yasothornsrikul,et al.  Potential of an injectable chitosan/starch/beta-glycerol phosphate hydrogel for sustaining normal chondrocyte function. , 2010, International journal of pharmaceutics.

[364]  D. Newham,et al.  Arthrogenic quadriceps inhibition and rehabilitation of patients with extensive traumatic knee injuries. , 1994, Clinical science.

[365]  Moira A. Taylor,et al.  Effects of dietary intervention and quadriceps strengthening exercises on pain and function in overweight people with knee pain: randomised controlled trial , 2009, BMJ : British Medical Journal.

[366]  T. Glant,et al.  Cartilage proteoglycan-induced arthritis in BALB/c mice. Antibodies that recognize human and mouse cartilage proteoglycan and can cause depletion of cartilage proteoglycan with little or no synovitis. , 1990, Arthritis and rheumatism.

[367]  Hai-bin Wang,et al.  The support of matrix accumulation and the promotion of sheep articular cartilage defects repair in vivo by chitosan hydrogels. , 2010, Osteoarthritis and cartilage.

[368]  G. Vunjak‐Novakovic,et al.  Cultivation of cell–polymer tissue constructs in simulated microgravity , 1995, Biotechnology and bioengineering.

[369]  C. Kwoh,et al.  Effect of growth factors on the proliferation of fibroblasts from the medial collateral and anterior cruciate ligaments , 1995, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[370]  H Weinans,et al.  Contribution of collagen network features to functional properties of engineered cartilage. , 2008, Osteoarthritis and cartilage.

[371]  J A Skinner,et al.  Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised study. , 2005, The Journal of bone and joint surgery. British volume.

[372]  Robert L Sah,et al.  Perfusion increases cell content and matrix synthesis in chondrocyte three-dimensional cultures. , 2002, Tissue engineering.

[373]  P Connolly,et al.  Micropatterned substratum adhesiveness: a model for morphogenetic cues controlling cell behavior. , 1992, Experimental cell research.

[374]  D. Hale.  Basic transplantation immunology. , 2006, The Surgical clinics of North America.

[375]  M J Glimcher,et al.  Cell origin and differentiation in the repair of full-thickness defects of articular cartilage. , 1993, The Journal of bone and joint surgery. American volume.

[376]  R. Zhao,et al.  Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. , 2008, Cell Stem Cell.

[377]  G. Bentley,et al.  Phenotypic modulation in sub-populations of human articular chondrocytes in vitro. , 1990, Journal of cell science.

[378]  Youngju Kim,et al.  PTHrP promotes chondrogenesis and suppresses hypertrophy from both bone marrow-derived and adipose tissue-derived MSCs. , 2008, Biochemical and biophysical research communications.

[379]  P. D. Kraan,et al.  TGF-β and osteoarthritis , 2007 .

[380]  Heungsoo Shin,et al.  Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering. , 2007, Advanced drug delivery reviews.

[381]  M. Provencher,et al.  Minced Articular Cartilage—Basic Science, Surgical Technique, and Clinical Application , 2008, Sports medicine and arthroscopy review.

[382]  E Jones,et al.  Growing bone and cartilage. The role of mesenchymal stem cells. , 2006, The Journal of bone and joint surgery. British volume.

[383]  H. Auchincloss.  Xenogeneic transplantation. A review. , 1988, Transplantation.

[384]  G. Finkenzeller,et al.  Differential effects of BMP‐2 and TGF‐β1 on chondrogenic differentiation of adipose derived stem cells , 2007, Cell proliferation.

[385]  B. Obradovic,et al.  Integration of engineered cartilage , 2001, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[386]  W. B. van den Berg,et al.  Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint. , 1994, Laboratory investigation; a journal of technical methods and pathology.

[387]  J. Utikal,et al.  Induced Pluripotent Stem Cells Generated Without Viral Integration , 2008, Science.

[388]  Antonios G Mikos,et al.  Advances in drug delivery for articular cartilage. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[389]  P. Verschure,et al.  Responsiveness of articular cartilage from normal and inflamed mouse knee joints to various growth factors. , 1994, Annals of the rheumatic diseases.

[390]  W M Lai,et al.  Effects of nonlinear strain-dependent permeability and rate of compression on the stress behavior of articular cartilage. , 1981, Journal of biomechanical engineering.

[391]  L G Griffith,et al.  Effect of pore size and void fraction on cellular adhesion, proliferation, and matrix deposition. , 2001, Tissue engineering.

[392]  Sara Mantero,et al.  Clinical transplantation of a tissue-engineered airway , 2008, The Lancet.

[393]  A. Grodzinsky,et al.  Biosynthetic response of cartilage explants to dynamic compression , 1989, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[394]  Gerard A Ateshian,et al.  Modeling of neutral solute transport in a dynamically loaded porous permeable gel: implications for articular cartilage biosynthesis and tissue engineering. , 2003, Journal of biomechanical engineering.

[395]  J. Buckwalter,et al.  Age‐related decline in chondrocyte response to insulin‐like growth factor‐I: The role of growth factor binding proteins , 1997, Journal of Orthopaedic Research.

[396]  R. Johnson,et al.  Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning. , 1998, Developmental biology.

[397]  C. Toma,et al.  Repair of articular cartilage defects treated by microfracture and a three-dimensional collagen matrix. , 2005, Biomaterials.

[398]  W M O'Fallon,et al.  Direct medical costs unique to people with arthritis. , 1997, The Journal of rheumatology.

[399]  Yaou Zhang,et al.  β1-Integrin–collagen interaction reduces chondrocyte apoptosis , 1999 .

[400]  B. Prahl-Andersen,et al.  The growth of cartilage cells in vitro and the effect of intermittent compressive force. A histological evaluation. , 1987, Connective tissue research.

[401]  D L Bader,et al.  Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose , 1997, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[402]  R. Nishimura,et al.  A Newly Developed Immunoisolated Bioartificial Pancreas with Cell Sheet Engineering , 2008, Cell transplantation.

[403]  Dietmar W. Hutmacher,et al.  Coating of biomaterial scaffolds with the collagen-mimetic peptide GFOGER for bone defect repair. , 2010, Biomaterials.

[404]  Albert C. Chen,et al.  Integrative repair of articular cartilage in vitro: Adhesive strength of the interface region , 1995, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[405]  B. Obradovic,et al.  Evaluation of alginate hydrogels under in vivo–like bioreactor conditions for cartilage tissue engineering , 2010, Journal of materials science. Materials in medicine.

[406]  D. Bae,et al.  Cartilage healing after microfracture in osteoarthritic knees. , 2006, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[407]  Q Q Wu,et al.  Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: ion-channel dependent transduction of matrix deformation signals. , 2000, Experimental cell research.

[408]  N. Ghanem,et al.  Importance of Sports in Cartilage Regeneration after Autologous Chondrocyte Implantation , 2007, The American journal of sports medicine.

[409]  Kam W Leong,et al.  Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage. , 2007, Experimental cell research.

[410]  K. Shea,et al.  Anterior Cruciate Ligament Injury in Paediatric and Adolescent Patients , 2003, Sports medicine.

[411]  K. Ono,et al.  Primary culture of chondrocytes embedded in collagen gels. , 1982, Experimental cell biology.

[412]  G. Sukhikh,et al.  Human induced pluripotent stem cells derived from fetal neural stem cells successfully undergo directed differentiation into cartilage. , 2011, Stem cells and development.

[413]  W W Minuth,et al.  Engineering of cartilage tissue using bioresorbable polymer carriers in perfusion culture. , 1994, Biomaterials.

[414]  E B Hunziker,et al.  Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. , 2002, Osteoarthritis and cartilage.

[415]  Edward C. Jones,et al.  Chondral resurfacing of articular cartilage defects in the knee with the microfracture technique. Surgical technique. , 2006, The Journal of bone and joint surgery. American volume.

[416]  K. Brandt,et al.  Effects of static and cyclic compressive loading on articular cartilage plugs in vitro. , 1984, Arthritis and rheumatism.

[417]  H. Cheung,et al.  In vitro collagen biosynthesis in healing and normal rabbit articular cartilage. , 1978, The Journal of bone and joint surgery. American volume.

[418]  A. Mikos,et al.  Crosslinking characteristics of an injectable poly(propylene fumarate)/β‐tricalcium phosphate paste and mechanical properties of the crosslinked composite for use as a biodegradable bone cement , 1999 .

[419]  A. Ratcliffe,et al.  Human articular chondrocyte adhesion and proliferation on synthetic biodegradable polymer films. , 1999, Biomaterials.

[420]  D. Amiel,et al.  Integrative cartilage repair: Inhibition by β‐aminopropionitrile , 1999 .

[421]  A. Hoffmann,et al.  BMP signaling pathways in cartilage and bone formation. , 2001, Critical reviews in eukaryotic gene expression.

[422]  F. Barry,et al.  Mesenchymal stem cells: clinical applications and biological characterization. , 2004, The international journal of biochemistry & cell biology.

[423]  Walker Wr,et al.  An Investigation of the Therapeutic Value of the 'Copper Bracelet'-Dermal Assimilation of Copper in Arthritic/Rheumatoid Conditions , 1976 .

[424]  Haris S. Vasiliadis,et al.  Autologous Chondrocyte Implantation , 2010, The American journal of sports medicine.

[425]  S. Downes,et al.  The role of protein adsorption on chondrocyte adhesion to a heterocyclic methacrylate polymer system. , 2002, Biomaterials.

[426]  T Ochi,et al.  Repair of rabbit articular surfaces with allograft chondrocytes embedded in collagen gel. , 1989, The Journal of bone and joint surgery. British volume.

[427]  K J Gooch,et al.  IGF-I and mechanical environment interact to modulate engineered cartilage development. , 2001, Biochemical and biophysical research communications.

[428]  H. Inoue,et al.  Differential and synergistic actions of somatomedin-like growth factors, fibroblast growth factor and epidermal growth factor in rabbit costal chondrocytes. , 2005, European journal of biochemistry.

[429]  A. McMahon,et al.  Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. , 1998, Genes & development.

[430]  A J Nixon,et al.  Coordinate upregulation of cartilage matrix synthesis in fibrin cultures supplemented with exogenous insulin‐like growth factor‐I , 1999, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[431]  V C Mow,et al.  Viscoelastic shear properties of articular cartilage and the effects of glycosidase treatments , 1993, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[432]  Dale J. Federico,et al.  Results of Isolated Patellar Debridement for Patellofemoral Pain in Patients with Normal Patellar Alignment , 1997, The American journal of sports medicine.

[433]  A. Maroudas,et al.  Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition. , 1977, Annals of the rheumatic diseases.

[434]  N Mitchell,et al.  Healing of articular cartilage in intra-articular fractures in rabbits. , 1980, The Journal of bone and joint surgery. American volume.

[435]  J. Steadman,et al.  Microfracture: surgical technique and rehabilitation to treat chondral defects. , 2001, Clinical orthopaedics and related research.

[436]  R. Salter,et al.  The potential for regeneration of articular cartilage in defects created by chondral shaving and subchondral abrasion. An experimental investigation in rabbits. , 1991, The Journal of bone and joint surgery. American volume.

[437]  L. Bonassar,et al.  Review of injectable cartilage engineering using fibrin gel in mice and swine models. , 2006, Tissue engineering.

[438]  J M Mansour,et al.  The permeability of articular cartilage under compressive strain and at high pressures. , 1976, The Journal of bone and joint surgery. American volume.

[439]  Ivan Martin,et al.  Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering , 2010, Proceedings of the National Academy of Sciences.

[440]  S. Curtiss,et al.  Microfracture and bone morphogenetic protein 7 (BMP-7) synergistically stimulate articular cartilage repair. , 2006, Osteoarthritis and cartilage.

[441]  I. Palacios,et al.  Correlation between arthroscopic and histopathological grading systems of articular cartilage lesions in knee osteoarthritis. , 2009, Osteoarthritis and cartilage.

[442]  C. M. Agrawal,et al.  Applications of biodegradable lactides and glycolides in podiatry. , 1995, Clinics in podiatric medicine and surgery.

[443]  H. Thermann,et al.  Results of Microfracture in the Treatment of Articular Cartilage Defects of the Talus , 2005, Foot & ankle international.

[444]  Lorenzo Moroni,et al.  Chitosan/poly(epsilon-caprolactone) blend scaffolds for cartilage repair. , 2011, Biomaterials.

[445]  S. Woo,et al.  Large deformation nonhomogeneous and directional properties of articular cartilage in uniaxial tension. , 1979, Journal of biomechanics.

[446]  Nathan D. Gallant,et al.  Micropatterned surfaces to engineer focal adhesions for analysis of cell adhesion strengthening , 2002 .

[447]  M. Holmes,et al.  An analysis of the squeeze-film lubrication mechanism for articular cartilage. , 1992, Journal of biomechanics.

[448]  K. Grimmer,et al.  Recreational and sporting injury to the adolescent knee and ankle: Prevalence and causes. , 2000, The Australian journal of physiotherapy.

[449]  Magnus Lundberg,et al.  Treatment of osteochondral defects with autologous bone marrow in a hyaluronan-based delivery vehicle. , 2002, Tissue engineering.

[450]  Burton B. Yang,et al.  The roles of matrix molecules in mediating chondrocyte aggregation, attachment, and spreading , 2000, Journal of cellular biochemistry.

[451]  W C Hayes,et al.  Viscoelastic properties of human articular cartilage. , 1971, Journal of applied physiology.

[452]  C. Tabin,et al.  Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut. , 1995, Development.

[453]  J. Hui,et al.  A comparison between the chondrogenic potential of human bone marrow stem cells (BMSCs) and adipose-derived stem cells (ADSCs) taken from the same donors. , 2007, Tissue engineering.

[454]  M. Steinwachs,et al.  Aktuelle Behandlung des Knorpelschadens im Patellofemoralgelenk , 2008, Der Orthopäde.

[455]  H. Fujioka,et al.  Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells. , 2007, Osteoarthritis and cartilage.

[456]  X. Bi,et al.  A novel method for determination of collagen orientation in cartilage by Fourier transform infrared imaging spectroscopy (FT-IRIS). , 2005, Osteoarthritis and cartilage.

[457]  E. Hunziker,et al.  Removal of proteoglycans from the surface of defects in articular cartilage transiently enhances coverage by repair cells , 1998 .

[458]  L. Liotta,et al.  Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma. , 1982, Biochemistry.

[459]  J. Hubbell,et al.  Surface characteristics and biocompatibility of lactide-based poly(ethylene glycol) scaffolds for tissue engineering. , 1998, Journal of biomaterials science. Polymer edition.

[460]  R. Derynck,et al.  Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo , 1994, The Journal of cell biology.

[461]  G. Nuki,et al.  Experimentally-induced osteoarthritis in the dog. , 1973, Annals of the rheumatic diseases.

[462]  C. M. Agrawal,et al.  Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers. , 1996, Biomaterials.

[463]  J. E. Jeffrey,et al.  Matrix damage and chondrocyte viability following a single impact load on articular cartilage. , 1995, Archives of biochemistry and biophysics.

[464]  Alexander Augst,et al.  Effects of chondrogenic and osteogenic regulatory factors on composite constructs grown using human mesenchymal stem cells, silk scaffolds and bioreactors , 2008, Journal of The Royal Society Interface.

[465]  F. Luyten,et al.  Multipotent mesenchymal stem cells from adult human synovial membrane. , 2001, Arthritis and rheumatism.

[466]  C. Muehleman,et al.  Association between crystals and cartilage degeneration in the ankle. , 2008, The Journal of rheumatology.

[467]  P. Torzilli,et al.  Influence of stress rate on water loss, matrix deformation and chondrocyte viability in impacted articular cartilage. , 2005, Journal of biomechanics.

[468]  Robert Langer,et al.  Controlled‐release of IGF‐I and TGF‐β1 in a photopolymerizing hydrogel for cartilage tissue engineering , 2001, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[469]  J. Dines,et al.  Emerging Technologies and Fourth Generation Issues in Cartilage Repair , 2008, Sports medicine and arthroscopy review.

[470]  T. Guggi,et al.  Marrow stimulation techniques. , 2008, Injury.

[471]  N. Virani,et al.  The treatment of deep shoulder infection and glenohumeral instability with debridement, reverse shoulder arthroplasty and postoperative antibiotics. , 2008, The Journal of bone and joint surgery. British volume.

[472]  C F Dewey,et al.  Apparatus for subjecting living cells to fluid shear stress. , 1982, The Review of scientific instruments.

[473]  Masanori Kikuchi,et al.  Repair of large osteochondral defects in rabbits using porous hydroxyapatite/collagen (HAp/Col) and fibroblast growth factor‐2 (FGF‐2) , 2010, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[474]  M T Raimondi,et al.  Chondrocyte Response to High Regimens of Cyclic Hydrostatic Pressure in 3-Dimensional Engineered Constructs , 2008, The International journal of artificial organs.

[475]  F. Guilak,et al.  From articular fracture to posttraumatic arthritis: a black box that needs to be opened. , 2006, Journal of orthopaedic trauma.

[476]  S. Moskalewski,et al.  Transplants of Rat Chondrocytes Evoke Strong Humoral Response against Chondrocyte-Associated Antigen in Rabbits , 2003, Cell transplantation.

[477]  K. Guan,et al.  Differentiation plasticity of chondrocytes derived from mouse embryonic stem cells , 2002, Journal of Cell Science.

[478]  E. Koyama,et al.  Development of Articular Cartilage: What Do We Know About it and How May It Occur? , 2000, Connective tissue research.

[479]  Joseph M. Mansour,et al.  Mesenchymal Cell-Based Repair of Large Full Thickness Defects of Articular Cartilage , 1994 .

[480]  G. Vunjak‐Novakovic,et al.  Stem cell-based tissue engineering with silk biomaterials. , 2006, Biomaterials.

[481]  G. Ayala,et al.  Porcine cartilage transplants in the cynomolgus monkey. III. Transplantation of alpha-galactosidase-treated porcine cartilage. , 1998, Transplantation.

[482]  Y. R. Sheu,et al.  Hydrostatic pressure increases apoptosis in cartilage-constructs produced from human osteoarthritic chondrocytes. , 2006, Frontiers in bioscience : a journal and virtual library.

[483]  R Langer,et al.  Joint resurfacing using allograft chondrocytes and synthetic biodegradable polymer scaffolds. , 1994, Journal of biomedical materials research.

[484]  J. Suh,et al.  Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review. , 2000, Biomaterials.

[485]  V C Mow,et al.  The biphasic poroviscoelastic behavior of articular cartilage: role of the surface zone in governing the compressive behavior. , 1993, Journal of biomechanics.

[486]  Ivan Martin,et al.  Age related changes in human articular chondrocyte yield, proliferation and post-expansion chondrogenic capacity. , 2004, Osteoarthritis and cartilage.

[487]  Sang Young Lee,et al.  Thermosensitive chitosan-Pluronic hydrogel as an injectable cell delivery carrier for cartilage regeneration. , 2009, Acta biomaterialia.

[488]  V. Mow,et al.  Biomechanics of articular cartilage and determination of material properties. , 2008, Medicine and science in sports and exercise.

[489]  P. Guerne,et al.  Growth factor responsiveness of human articular chondrocytes: Distinct profiles in primary chondrocytes, subcultured chondrocytes, and fibroblasts , 1994, Journal of cellular physiology.

[490]  J. Verhaar,et al.  Tissue-engineered cartilage using serially passaged articular chondrocytes. Chondrocytes in alginate, combined in vivo with a synthetic (E210) or biologic biodegradable carrier (DBM). , 2000, Biomaterials.

[491]  J M Anderson,et al.  In vitro cytotoxicity and in vivo biocompatibility of poly(propylene fumarate-co-ethylene glycol) hydrogels. , 1999, Journal of biomedical materials research.

[492]  F. Watt,et al.  Subpopulations of chondrocytes from different zones of pig articular cartilage. Isolation, growth and proteoglycan synthesis in culture. , 1990, Journal of cell science.

[493]  A. Yanke,et al.  Outcomes of Autologous Chondrocyte Implantation in a Diverse Patient Population , 2009, The American journal of sports medicine.

[494]  I. Sekiya,et al.  BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells. , 2001, Biochemical and biophysical research communications.

[495]  M. Sandrin,et al.  Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopes. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[496]  G. Ateshian,et al.  Analysis of radial variations in material properties and matrix composition of chondrocyte-seeded agarose hydrogel constructs. , 2009, Osteoarthritis and cartilage.

[497]  K. Plath,et al.  Generation of human induced pluripotent stem cells from dermal fibroblasts , 2008, Proceedings of the National Academy of Sciences.

[498]  C. Armstrong,et al.  In vitro measurement of articular cartilage deformations in the intact human hip joint under load. , 1979, The Journal of bone and joint surgery. American volume.

[499]  L. L. Johnson.  Arthroscopic abrasion arthroplasty historical and pathologic perspective: present status. , 1986, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[500]  R. Sanderson,et al.  Syndecan, a developmentally regulated cell surface proteoglycan that binds extracellular matrix and growth factors. , 1990, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[501]  M. Endres,et al.  Formation of cartilage repair tissue in articular cartilage defects pretreated with microfracture and covered with cell‐free polymer‐based implants , 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[502]  L. Hangody,et al.  Autologous Osteochondral Mosaicplasty for the Treatment of Full-Thickness Defects of Weight-Bearing Joints: Ten Years of Experimental and Clinical Experience , 2003, The Journal of bone and joint surgery. American volume.

[503]  B. Mandelbaum,et al.  Articular Cartilage Repair in Soccer Players with Autologous Chondrocyte Transplantation , 2005, The American journal of sports medicine.

[504]  C Perka,et al.  Joint cartilage repair with transplantation of embryonic chondrocytes embedded in collagen-fibrin matrices. , 2000, Clinical and experimental rheumatology.

[505]  E. Roos,et al.  Knee osteoarthritis after meniscectomy: prevalence of radiographic changes after twenty-one years, compared with matched controls. , 1998, Arthritis and rheumatism.

[506]  R Langer,et al.  Effects of mixing intensity on tissue-engineered cartilage. , 2001, Biotechnology and bioengineering.

[507]  D. Docheva,et al.  Membrane-based cultures generate scaffold-free neocartilage in vitro: influence of growth factors. , 2010, Tissue engineering. Part A.

[508]  R Langer,et al.  Chondrogenesis in a cell-polymer-bioreactor system. , 1998, Experimental cell research.

[509]  M. Hincke,et al.  Strategies for articular cartilage lesion repair and functional restoration. , 2010, Tissue engineering. Part B, Reviews.

[510]  T. Schubert,et al.  Matrixassoziierte autogene Chondrozytentransplantation (MACT) , 2008, Operative Orthopädie und Traumatologie.

[511]  G. Beaupré,et al.  Hydrostatic Pressure Enhances Chondrogenic Differentiation of Human Bone Marrow Stromal Cells in Osteochondrogenic Medium , 2008, Annals of Biomedical Engineering.

[512]  D. Burt,et al.  Molecular cloning and expression of bone morphogenetic protein-7 in the chick epiphyseal growth plate. , 1994, Journal of molecular endocrinology.

[513]  B. Johnstone,et al.  Autologous mesenchymal progenitor cells in articular cartilage repair. , 1999, Clinical orthopaedics and related research.

[514]  A. Grodzinsky,et al.  Biosynthetic response of passaged chondrocytes in a type II collagen scaffold to mechanical compression. , 2003, Journal of biomedical materials research. Part A.

[515]  I. Thesleff,et al.  Syndecan from embryonic tooth mesenchyme binds tenascin. , 1989, The Journal of biological chemistry.

[516]  A J Verbout,et al.  Reliability, reproducibility and variability of the traditional Histologic/Histochemical Grading System vs the new OARSI Osteoarthritis Cartilage Histopathology Assessment System. , 2007, Osteoarthritis and cartilage.

[517]  D. Dunkler,et al.  Biomechanical properties of decellularized porcine pulmonary valve conduits. , 2007, Artificial organs.

[518]  A. Mikos,et al.  Review: tissue engineering for regeneration of articular cartilage. , 2000, Biomaterials.

[519]  J. Platt,et al.  Cardiac xenografts between primate species provide evidence for the importance of the alpha-galactosyl determinant in hyperacute rejection. , 1995, Journal of immunology.

[520]  F Eckstein,et al.  Knee cartilage of spinal cord-injured patients displays progressive thinning in the absence of normal joint loading and movement. , 2002, Arthritis and rheumatism.

[521]  F Leonard,et al.  Biodegradable poly(lactic acid) polymers. , 1971, Journal of biomedical materials research.

[522]  P. Butler,et al.  Injectable Cartilage Using Polyethylene Oxide Polymer Substrates , 1996, Plastic and reconstructive surgery.

[523]  U. Windberger,et al.  Marrow stimulation and chondrocyte transplantation using a collagen matrix for cartilage repair. , 2005, Osteoarthritis and cartilage.

[524]  G. Sharma,et al.  Synergistic effect of chondroitin sulfate and cyclic pressure on biochemical and morphological properties of chondrocytes from articular cartilage. , 2008, Osteoarthritis and cartilage.

[525]  A. Mikos,et al.  Preparation and characterization of poly(propylene fumarate-co-ethylene glycol) hydrogels. , 1998, Journal of biomaterials science. Polymer edition.

[526]  R. Haut,et al.  Rate of blunt impact loading affects changes in retropatellar cartilage and underlying bone in the rabbit patella. , 2002, Journal of biomechanics.

[527]  Robert M Nerem,et al.  Mechanical compression alters gene expression and extracellular matrix synthesis by chondrocytes cultured in collagen I gels. , 2002, Biomaterials.

[528]  Michael D West,et al.  Human embryonic stem cells derived without feeder cells , 2005, The Lancet.

[529]  S. Ichinose,et al.  Synovial Stem Cells Are Regionally Specified According to Local Microenvironments After Implantation for Cartilage Regeneration , 2007, Stem cells.

[530]  M. Kwan,et al.  Cartilage production by rabbit articular chondrocytes on polyglycolic acid scaffolds in a closed bioreactor system , 1995, Biotechnology and bioengineering.

[531]  A I Caplan,et al.  Hyaluronic acid bonded to cell-culture surfaces stimulates chondrogenesis in stage 24 limb mesenchyme cell cultures. , 1986, Developmental biology.

[532]  Vikas Prabhakar,et al.  Decellularized Native and Engineered Arterial Scaffolds for Transplantation , 2003, Cell transplantation.

[533]  Konrad Malinowski,et al.  Treatment of full thickness chondral lesions of the knee with microfracture in a group of athletes , 2005, Knee Surgery, Sports Traumatology, Arthroscopy.

[534]  E. Thonar,et al.  Chondrocyte extracellular matrix synthesis and turnover are influenced by static compression in a new alginate disk culture system. , 2000, Archives of biochemistry and biophysics.

[535]  A. Bjelle,et al.  Proteoglycan structure of bovine articular cartilage. Variation with age and in osteoarthrosis. , 1979, Scandinavian journal of rheumatology.

[536]  P Tugwell,et al.  OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence. , 2007, Osteoarthritis and cartilage.

[537]  A. Nixon,et al.  Enhanced repair of extensive articular defects by insulin‐like growth factor‐I‐laden fibrin composites , 1999, Journal of Orthopaedic Research.

[538]  G. Vunjak‐Novakovic,et al.  Cultivation of cell‐polymer cartilage implants in bioreactors , 1993, Journal of cellular biochemistry.

[539]  P. Cuevas,et al.  Basic fibroblast growth factor (FGF) promotes cartilage repair in vivo. , 1988, Biochemical and biophysical research communications.

[540]  M. Pitman,et al.  Chondrocyte transplantation using a collagen bilayer matrix for cartilage repair. , 1997, The Journal of bone and joint surgery. British volume.

[541]  A. Bronckers,et al.  OP‐1 (BMP‐7) Affects mRNA Expression of Type I, II, X Collagen, and Matrix Gla Protein in Ossifying Long Bones In Vitro , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[542]  Jose C. Merchuk,et al.  Why use air-lift bioreactors? , 1990 .

[543]  J. Baron,et al.  Regulation of growth plate chondrogenesis by bone morphogenetic protein-2. , 2001, Endocrinology.

[544]  G. Jay,et al.  Lubricating ability of aspirated synovial fluid from emergency department patients with knee joint synovitis. , 2004, The Journal of rheumatology.

[545]  Gordana Vunjak-Novakovic,et al.  Bioreactors mediate the effectiveness of tissue engineering scaffolds , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[546]  H. Hämmerle,et al.  The Effects of Collagen Fragments on the Extracellular Matrix Metabolism of Bovine and Human Chondrocytes , 2001, Connective tissue research.

[547]  Freddie H Fu,et al.  Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells. , 2006, Arthritis and rheumatism.

[548]  E. Thonar,et al.  Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate beads. , 1994, Journal of cell science.

[549]  J. Veldhuijzen,et al.  Cartilage response to mechanical force in high-density chondrocyte cultures. , 1985, Arthritis and rheumatism.

[550]  J. Jansen,et al.  Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair. , 2007, Osteoarthritis and cartilage.

[551]  W. B. van den Berg,et al.  Interaction of chondrocytes, extracellular matrix and growth factors: relevance for articular cartilage tissue engineering. , 2002, Osteoarthritis and cartilage.

[552]  T. Andriacchi,et al.  Interactions between kinematics and loading during walking for the normal and ACL deficient knee. , 2005, Journal of biomechanics.

[553]  W. Landis,et al.  Post‐translational control of collagen fibrillogenesis in mineralizing cultures of chick osteoblasts , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[554]  K. Miyazono,et al.  Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells , 1993, The Journal of cell biology.

[555]  L. Bolano,et al.  The immunology of bone and cartilage transplantation. , 1991, Orthopedics.

[556]  J. Urban,et al.  The effects of hydrostatic pressure on matrix synthesis in articular cartilage , 1991, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[557]  W. Akeson,et al.  Integrative articular cartilage repair: dependence on developmental stage and collagen metabolism. , 2002, Osteoarthritis and cartilage.

[558]  R. Loeser.  Growth factor regulation of chondrocyte integrins: Differential effects of insulin-like growth factor 1 and transforming growth factor β on α1β1 integrin expression and chondrocyte adhesion to type VI collagen , 1997 .

[559]  H. Helminen,et al.  Transcriptional activation in chondrocytes submitted to hydrostatic pressure. , 2000, Biorheology.

[560]  Lori A. Setton,et al.  Photocrosslinkable Hyaluronan as a Scaffold for Articular Cartilage Repair , 2004, Annals of Biomedical Engineering.

[561]  L. Csönge,et al.  Osteochondral resurfacing of the knee joint with allograft , 1998, International Orthopaedics.

[562]  Zhi Ding,et al.  Porous chitosan-gelatin scaffold containing plasmid DNA encoding transforming growth factor-beta1 for chondrocytes proliferation. , 2006, Biomaterials.

[563]  Kyriacos A Athanasiou,et al.  Effects of multiple chondroitinase ABC applications on tissue engineered articular cartilage , 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[564]  S E Carver,et al.  Increasing extracellular matrix production in regenerating cartilage with intermittent physiological pressure. , 1999, Biotechnology and bioengineering.

[565]  E. Kastenbauer,et al.  Resorbable polyesters in cartilage engineering: affinity and biocompatibility of polymer fiber structures to chondrocytes. , 1996, Journal of biomedical materials research.

[566]  Mohamed Mahfouz,et al.  Knee mechanics: a review of past and present techniques to determine in vivo loads. , 2005, Journal of biomechanics.

[567]  W M Lai,et al.  Fluid transport and mechanical properties of articular cartilage: a review. , 1984, Journal of biomechanics.

[568]  Kaleb Michaud,et al.  Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases , 2009, Arthritis research & therapy.

[569]  R Cancedda,et al.  In vitro morphogenesis of chick embryo hypertrophic cartilage , 1987, The Journal of cell biology.

[570]  Xu Cao,et al.  BMP signaling and HOX transcription factors in limb development. , 2003, Frontiers in bioscience : a journal and virtual library.

[571]  D Dowson,et al.  "Boosted lubrication" in synovial joints by fluid entrapment and enrichment. , 1968, Annals of the rheumatic diseases.

[572]  E. Brunette,et al.  Expansion of human embryonic stem cells in defined serum-free medium devoid of animal-derived products. , 2005, Biotechnology and bioengineering.

[573]  A. Grodzinsky,et al.  Combined effects of dynamic tissue shear deformation and insulin-like growth factor I on chondrocyte biosynthesis in cartilage explants. , 2003, Archives of biochemistry and biophysics.

[574]  B. P. Smith,et al.  Cartilage injuries: a review of 31,516 knee arthroscopies. , 1997, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[575]  Farshid Guilak,et al.  A biomimetic three-dimensional woven composite scaffold for functional tissue engineering of cartilage. , 2007, Nature materials.

[576]  M J Yaszemski,et al.  Ectopic bone formation by marrow stromal osteoblast transplantation using poly(DL-lactic-co-glycolic acid) foams implanted into the rat mesentery. , 1997, Journal of biomedical materials research.

[577]  Boon Chin Heng,et al.  Directing Stem Cell Differentiation into the Chondrogenic Lineage In Vitro , 2004, Stem cells.

[578]  G. Meachim.  Effect of age on the thickness of adult articular cartilage at he shoulder joint. , 1971, Annals of the rheumatic diseases.

[579]  L. Bonassar,et al.  The effect of dynamic compression on the response of articular cartilage to insulin‐like growth factor‐I , 2001, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[580]  A. Mikos,et al.  Synthetic biodegradable polymers for orthopaedic applications. , 1999, Clinical orthopaedics and related research.

[581]  Farshid Guilak,et al.  Composite scaffolds for cartilage tissue engineering. , 2008, Biorheology.

[582]  R M Rose,et al.  The response of joints to impact loading. II. In vivo behavior of subchondral bone. , 1972, Journal of biomechanics.

[583]  K. Anseth,et al.  Tissue engineering of cartilage. , 2003, Clinics in plastic surgery.

[584]  K. Athanasiou,et al.  Biomechanical topography of human ankle cartilage , 1995, Annals of Biomedical Engineering.

[585]  H. Ohgushi,et al.  Forced expression of Sox2 or Nanog in human bone marrow derived mesenchymal stem cells maintains their expansion and differentiation capabilities. , 2008, Experimental cell research.

[586]  M. Yaremchuk,et al.  Injectable tissue-engineered cartilage using a fibrin glue polymer. , 1999, Plastic and reconstructive surgery.

[587]  Maurilio Marcacci,et al.  Articular Cartilage Engineering with Hyalograft® C: 3-Year Clinical Results , 2005, Clinical orthopaedics and related research.

[588]  U. Galili.  Interaction of the natural anti-Gal antibody with alpha-galactosyl epitopes: a major obstacle for xenotransplantation in humans. , 1993, Immunology today.

[589]  T. Klein,et al.  Inhibition of integrative cartilage repair by proteoglycan 4 in synovial fluid. , 2005, Arthritis and rheumatism.

[590]  A. Bankhurst,et al.  The coexistence of gout and rheumatoid arthritis: case reports and a review of the literature. , 1980, The Journal of rheumatology.

[591]  F. Guilak,et al.  Chondrogenic differentiation of adipose-derived adult stem cells by a porous scaffold derived from native articular cartilage extracellular matrix. , 2009, Tissue engineering. Part A.

[592]  F. J. Dzida,et al.  Comparative study of the intrinsic mechanical properties of the human acetabular and femoral head cartilage , 1991, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[593]  V. Goldberg,et al.  Response of articular chondrocytes to pituitary fibroblst growth factor (FGF) , 1982, Journal of cellular physiology.

[594]  K. Gelse,et al.  Ex vivo gene therapy approaches to cartilage repair. , 2006, Advanced drug delivery reviews.

[595]  B. Cole,et al.  Prospective Evaluation of Prolonged Fresh Osteochondral Allograft Transplantation of the Femoral Condyle , 2006, The American journal of sports medicine.

[596]  K. Frosch,et al.  Influence of Platelet-Rich Plasma on Chondrogenic Differentiation and Proliferation of Chondrocytes and Mesenchymal Stem Cells , 2008, Cells Tissues Organs.

[597]  E. Ruoslahti,et al.  Peptides in cell adhesion: powerful tools for the study of integrin-ligand interactions. , 1996, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[598]  M. Urist.  Bone: Formation by Autoinduction , 1965, Science.

[599]  F. Guilak,et al.  Zonal variations in the three-dimensional morphology of the chondron measured in situ using confocal microscopy. , 2006, Osteoarthritis and cartilage.

[600]  Techung Lee,et al.  Phenotypic changes of adult porcine mesenchymal stem cells induced by prolonged passaging in culture , 2005, Journal of cellular physiology.

[601]  Steven B Cohen,et al.  Transforming growth factor-beta in calcium alginate beads for the treatment of articular cartilage defects in the rabbit. , 2002, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[602]  S. Bryant,et al.  Hydrogel properties influence ECM production by chondrocytes photoencapsulated in poly(ethylene glycol) hydrogels. , 2002, Journal of biomedical materials research.

[603]  A. Broadus,et al.  Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone-related protein in mice. , 2008, Arthritis and rheumatism.

[604]  S. Yamanaka,et al.  [Induction of pluripotent stem cells from mouse fibroblast cultures]. , 2006, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

[605]  L. White,et al.  MR imaging of cartilage repair procedures , 2003, Skeletal Radiology.

[606]  M. Schünke,et al.  [Redifferentiation of dedifferentiated joint cartilage cells in alginate culture. Effect of intermittent hydrostatic pressure and low oxygen partial pressure]. , 2000, Der Orthopade.

[607]  C. Tabin,et al.  Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth. , 1997, Development.

[608]  J. Platt,et al.  Transplantation of discordant xenografts: a review of progress. , 1990, Immunology today.

[609]  Jan Kramera,et al.  PII: S0925-4773(99)00339-1 , 2022 .

[610]  C. Archer,et al.  The reactions of articular cartilage to experimental wounding: role of apoptosis. , 2000, Arthritis and rheumatism.

[611]  A. Grodzinsky,et al.  Chondrocytes in agarose culture synthesize a mechanically functional extracellular matrix , 1992, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[612]  Anderson,et al.  Host response to tissue engineered devices. , 1998, Advanced drug delivery reviews.

[613]  Tomoo Ishii,et al.  Rotating three‐dimensional dynamic culture of adult human bone marrow‐derived cells for tissue engineering of hyaline cartilage , 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[614]  A F Mak,et al.  The apparent viscoelastic behavior of articular cartilage--the contributions from the intrinsic matrix viscoelasticity and interstitial fluid flows. , 1986, Journal of biomechanical engineering.

[615]  U. Galili,et al.  Porcine and bovine cartilage transplants in cynomolgus monkey: II. Changes in anti-Gal response during chronic rejection. , 1997, Transplantation.

[616]  Chad A. Cowan,et al.  A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. , 2010, The Journal of clinical investigation.

[617]  K. Minakuchi,et al.  Chondrocyte migration to fibronectin, type I collagen, and type II collagen. , 1997, Cell structure and function.

[618]  Y Hirasawa,et al.  Hydrostatic pressure induces expression of interleukin 6 and tumour necrosis factor α mRNAs in a chondrocyte-like cell line , 1998, Annals of the rheumatic diseases.

[619]  K. Athanasiou,et al.  Extracellular matrix cell adhesion peptides: functional applications in orthopedic materials. , 2000, Tissue engineering.

[620]  J. Connelly,et al.  Dynamic Compression Regulates the Expression and Synthesis of Chondrocyte‐Specific Matrix Molecules in Bone Marrow Stromal Cells , 2007, Stem cells.

[621]  K. Grimmer,et al.  Epidemiology of knee injuries among adolescents: a systematic review , 2007, British Journal of Sports Medicine.

[622]  R. Tuan,et al.  NuSerum, a synthetic serum replacement, supports chondrogenesis of embryonic chick limb bud mesenchymal cells in micromass culture , 1993, In Vitro Cellular & Developmental Biology - Animal.

[623]  E B Hunziker,et al.  Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable? , 1999, Osteoarthritis and cartilage.

[624]  N. Sgaglione,et al.  Cartilage Repair: Synthetics and Scaffolds: Basic Science, Surgical Techniques, and Clinical Outcomes , 2008, Sports medicine and arthroscopy review.

[625]  E. Thonar,et al.  Characterization of crosslinked collagens synthesized by mature articular chondrocytes cultured in alginate beads: comparison of two distinct matrix compartments. , 1996, Experimental cell research.

[626]  J. West,et al.  Cell migration through defined, synthetic extracellular matrix analogues , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[627]  G. Im,et al.  Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrow-derived cells? , 2005, Osteoarthritis and cartilage.

[628]  R Langer,et al.  Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers. , 1993, Journal of biomedical materials research.

[629]  C. Yeow,et al.  Cartilage repair using hyaluronan hydrogel-encapsulated human embryonic stem cell-derived chondrogenic cells. , 2010, Biomaterials.

[630]  U. Galili,et al.  Porcine and bovine cartilage transplants in cynomolgus monkey: I. A model for chronic xenograft rejection. , 1997, Transplantation.

[631]  T. B. Kirk,et al.  Study of the collagen structure in the superficial zone and physiological state of articular cartilage using a 3D confocal imaging technique , 2008, Journal of orthopaedic surgery and research.

[632]  B. Obradovic,et al.  Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue‐engineered cartilage , 1999, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[633]  R. Kandel,et al.  Characterization of proteoglycan accumulation during formation of cartilagenous tissue in vitro. , 1995, Osteoarthritis and cartilage.

[634]  D. Zukor,et al.  Fresh osteochondral allografts for post-traumatic defects in the knee. A survivorship analysis. , 1992, The Journal of bone and joint surgery. British volume.

[635]  J J Parkkinen,et al.  Altered Golgi apparatus in hydrostatically loaded articular cartilage chondrocytes. , 1993, Annals of the rheumatic diseases.

[636]  J. Puzas,et al.  Differential regulation of type‐II and type‐X collagen synthesis by parathyroid hormone‐related protein in chick growth‐plate chondrocytes , 1997, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[637]  B. Kulseng,et al.  Transplantation of alginate microcapsules: generation of antibodies against alginates and encapsulated porcine islet-like cell clusters. , 1999, Transplantation.

[638]  A. Braccini,et al.  Dynamic compression of cartilage constructs engineered from expanded human articular chondrocytes. , 2003, Biochemical and biophysical research communications.

[639]  M. Longaker,et al.  Mitogenic and chondrogenic effects of fibroblast growth factor-2 in adipose-derived mesenchymal cells. , 2006, Biochemical and biophysical research communications.

[640]  G. Ateshian,et al.  Scaffold degradation elevates the collagen content and dynamic compressive modulus in engineered articular cartilage. , 2009, Osteoarthritis and cartilage.

[641]  V C Mow,et al.  The intrinsic tensile behavior of the matrix of bovine articular cartilage and its variation with age. , 1980, The Journal of bone and joint surgery. American volume.

[642]  J. Mao.  Stem‐cell‐driven regeneration of synovial joints , 2005, Biology of the cell.

[643]  J. Buckwalter,et al.  Restoration of Injured or Degenerated Articular Cartilage , 1994, The Journal of the American Academy of Orthopaedic Surgeons.

[644]  Ann L. Johnson,et al.  Chitosan scaffolds: interconnective pore size and cartilage engineering. , 2006, Acta biomaterialia.

[645]  John Rollo,et al.  Biomaterials and scaffold design: key to tissue‐engineering cartilage , 2007, Biotechnology and applied biochemistry.

[646]  Stefano Zaffagnini,et al.  Arthroscopic Autologous Osteochondral Grafting for Cartilage Defects of the Knee , 2007, The American journal of sports medicine.

[647]  J. Elisseeff,et al.  In vitro prefabrication of human cartilage shapes using fibrin glue and human chondrocytes. , 1998, Annals of Plastic Surgery.

[648]  P. Robbins,et al.  Gene therapy for arthritis , 1998, Gene Therapy.

[649]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[650]  K J Gooch,et al.  Bone morphogenetic proteins-2, -12, and -13 modulate in vitro development of engineered cartilage. , 2002, Tissue engineering.

[651]  J. Burdick,et al.  The influence of degradation characteristics of hyaluronic acid hydrogels on in vitro neocartilage formation by mesenchymal stem cells. , 2009, Biomaterials.

[652]  Michel Vert,et al.  Processing of polycaprolactone and polycaprolactone-based copolymers into 3D scaffolds, and their cellular responses. , 2009, Tissue engineering. Part A.

[653]  E B Hunziker,et al.  Quantitative structural organization of normal adult human articular cartilage. , 2002, Osteoarthritis and cartilage.

[654]  R. Langer,et al.  Osteocompatibility of Photopolymerizable Anhydride Networks , 1998 .

[655]  Farshid Guilak,et al.  Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. , 2004, Biomaterials.

[656]  S. Roberts,et al.  Immunohistochemical study of collagen types I and II and procollagen IIA in human cartilage repair tissue following autologous chondrocyte implantation , 2009, The Knee.

[657]  A. U. Daniels,et al.  Mechanical properties of biodegradable polymers and composites proposed for internal fixation of bone. , 1990, Journal of applied biomaterials : an official journal of the Society for Biomaterials.

[658]  A. Mikos,et al.  Development of Poly(Propylene Fumarate-co-Ethylene Glycol) as an Injectable Carrier for Endothelial Cells , 1999, Cell transplantation.

[659]  D. Cooper,et al.  Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in humans. , 1992, Transplantation proceedings.

[660]  C. Ohlsson,et al.  Cellular aspects on treatment of cartilage injuries. , 1993, Agents and actions. Supplements.

[661]  A. Mikos,et al.  In vivo degradation of a poly(propylene fumarate)/beta-tricalcium phosphate injectable composite scaffold. , 1998, Journal of biomedical materials research.

[662]  J. West,et al.  Modification of surfaces with cell adhesion peptides alters extracellular matrix deposition. , 1999, Biomaterials.

[663]  T. Aigner,et al.  Transplantation of allograft chondrocytes embedded in agarose gel into cartilage defects of rabbits. , 1998, Osteoarthritis and cartilage.

[664]  D. Wolf,et al.  Reduced shear stress: A major component in the ability of mammalian tissues to form three‐dimensional assemblies in simulated microgravity , 1993, Journal of cellular biochemistry.

[665]  K. Hruska,et al.  In Vitro Generation of Scaffold Independent Neocartilage , 2001, Clinical orthopaedics and related research.

[666]  Y. Tabata,et al.  The regenerative effects of platelet-rich plasma on meniscal cells in vitro and its in vivo application with biodegradable gelatin hydrogel. , 2007, Tissue engineering.

[667]  E. Bueno,et al.  Wavy-walled bioreactor supports increased cell proliferation and matrix deposition in engineered cartilage constructs. , 2005, Tissue engineering.

[668]  J Grifka,et al.  Long-term effects of chondrospheres on cartilage lesions in an autologous chondrocyte implantation model as investigated in the SCID mouse model. , 2009, International journal of molecular medicine.

[669]  J. Elisseeff,et al.  Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks. , 2000, Journal of biomedical materials research.

[670]  Jennifer L. West,et al.  Tethered-TGF-β increases extracellular matrix production of vascular smooth muscle cells , 2001 .

[671]  M. Saito,et al.  Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. , 2002, Osteoarthritis and cartilage.

[672]  Bert R. Mandelbaum,et al.  Clinical Efficacy of the Microfracture Technique for Articular Cartilage Repair in the Knee , 2009, The American journal of sports medicine.

[673]  Smadar Cohen,et al.  The effect of immobilized RGD peptide in macroporous alginate scaffolds on TGFbeta1-induced chondrogenesis of human mesenchymal stem cells. , 2010, Biomaterials.

[674]  Y. Sun,et al.  The regenerative effect of platelet-rich plasma on healing in large osteochondral defects , 2010, International Orthopaedics.

[675]  M. Truppe,et al.  Collagen Expression in Tissue Engineered Cartilage of Aged Human Articular Chondrocytes in a Rotating Bioreactor , 2003, The International journal of artificial organs.

[676]  J. Farr.  Autologous Chondrocyte Implantation Improves Patellofemoral Cartilage Treatment Outcomes , 2007, Clinical orthopaedics and related research.

[677]  R. Cancedda,et al.  N-CAM and N-cadherin expression during in vitro chondrogenesis. , 1994, Experimental cell research.

[678]  S. Waldman,et al.  The effect of continuous culture on the growth and structure of tissue‐engineered cartilage , 2009, Biotechnology progress.

[679]  A. Vloon,et al.  Platelet-rich plasma: quantification of growth factor levels and the effect on growth and differentiation of rat bone marrow cells. , 2006, Tissue engineering.

[680]  Felix Eckstein,et al.  Relationship of meniscal damage, meniscal extrusion, malalignment, and joint laxity to subsequent cartilage loss in osteoarthritic knees. , 2008, Arthritis and rheumatism.

[681]  M. Elves.  Humoral immune response to allografts of bone. , 1974, International archives of allergy and applied immunology.

[682]  E. Menzel,et al.  Hyaluronidase and its substrate hyaluronan: biochemistry, biological activities and therapeutic uses. , 1998, Cancer letters.

[683]  G. Bentley,et al.  Effect of age on thickness of adult patellar articular cartilage. , 1977, Annals of the rheumatic diseases.

[684]  C. McDevitt,et al.  Stimulation of matrix formation in rabbit chondrocyte cultures by ascorbate. 1. Effect of ascorbate analogs and β‐aminopropionitrile , 1988, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[685]  S. Kelley,et al.  Role of pericellular matrix in development of a mechanically functional neocartilage. , 2003, Biotechnology and bioengineering.

[686]  D. Eyre,et al.  Collagen cross-linking in human bone and articular cartilage. Age-related changes in the content of mature hydroxypyridinium residues. , 1988, The Biochemical journal.

[687]  J L West,et al.  Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering. , 2001, Biomaterials.

[688]  R. Wilkins,et al.  The cellular physiology of articular cartilage , 1996, Experimental physiology.

[689]  A. Vaahtokari,et al.  Associations between transforming growth factor beta 1 RNA expression and epithelial-mesenchymal interactions during tooth morphogenesis. , 1991, Development.

[690]  Koji Mori,et al.  Ultrasound has the potential to detect degeneration of articular cartilage clinically, even if the information is obtained from an indirect measurement of intrinsic physical characteristics , 2009, Arthritis research & therapy.

[691]  S. Nishimura,et al.  Development of mature cartilage constructs using novel three-dimensional porous scaffolds for enhanced repair of osteochondral defects. , 2008, Journal of biomedical materials research. Part A.

[692]  M Hlavácek,et al.  The role of synovial fluid filtration by cartilage in lubrication of synovial joints--II. Squeeze-film lubrication: homogeneous filtration. , 1993, Journal of biomechanics.

[693]  M. Tammi,et al.  Expression of reduced amounts of structurally altered aggrecan in articular cartilage chondrocytes exposed to high hydrostatic pressure. , 1994, The Biochemical journal.

[694]  G. Bentley,et al.  A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee. , 2003, The Journal of bone and joint surgery. British volume.

[695]  L. Bonassar,et al.  Cell-based bonding of articular cartilage: An extended study. , 2003, Journal of biomedical materials research. Part A.

[696]  Hajime Ohgushi,et al.  Repair of articular cartilage defects in the patello‐femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees , 2007, Journal of tissue engineering and regenerative medicine.

[697]  D Amiel,et al.  Articular cartilage repair using allogeneic perichondrocyte-seeded biodegradable porous polylactic acid (PLA): a tissue-engineering study. , 1995, Journal of biomedical materials research.

[698]  A. Caplan.  Adult mesenchymal stem cells for tissue engineering versus regenerative medicine , 2007, Journal of cellular physiology.

[699]  F. Livesey,et al.  Regulation of tissue-engineered products in the European Union: where are we heading? , 2006, Regenerative medicine.

[700]  H. Pondenis,et al.  Effect of fibroblast growth factor-2 on equine mesenchymal stem cell monolayer expansion and chondrogenesis. , 2007, American journal of veterinary research.

[701]  R. Cancedda,et al.  Replicative aging and gene expression in long-term cultures of human bone marrow stromal cells. , 2002, Tissue engineering.

[702]  W McIntosh,et al.  Transdermal photopolymerization for minimally invasive implantation. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[703]  Milan Mrksich,et al.  Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates , 1999, In Vitro Cellular & Developmental Biology - Animal.

[704]  J. Mason,et al.  Stem Cells as Platforms for Delivery of Genes to Enhance Cartilage Repair , 2003, The Journal of bone and joint surgery. American volume.

[705]  W. Richter,et al.  Impact of growth factors and PTHrP on early and late chondrogenic differentiation of human mesenchymal stem cells , 2010, Journal of cellular physiology.

[706]  Zhibing Zhang,et al.  Gene expression profiles of dynamically compressed single chondrocytes and chondrons. , 2009, Biochemical and biophysical research communications.

[707]  Yu-Chen Hu,et al.  Baculovirus-mediated growth factor expression in dedifferentiated chondrocytes accelerates redifferentiation: effects of combinational transduction. , 2009, Tissue engineering. Part A.

[708]  M. Marcacci,et al.  Use of autologous grafts for reconstruction of osteochondral defects of the knee. , 1999, Orthopedics.

[709]  Gordana Vunjak-Novakovic,et al.  Engineering of Functional Cartilage Tissue Using Stem Cells from Synovial Lining: A Preliminary Study , 2008, Clinical orthopaedics and related research.

[710]  C. McDevitt,et al.  Meniscal transplantation using fresh and cryopreserved allografts , 1992, The American journal of sports medicine.

[711]  T. Aigner,et al.  Type X collagen expression in osteoarthritic and rheumatoid articular cartilage , 1993, Virchows Archiv. B, Cell pathology including molecular pathology.

[712]  L. Zon,et al.  BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway. , 2008, Cell stem cell.

[713]  T. Ichisaka,et al.  Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors , 2007, Cell.

[714]  M. Shive,et al.  Chitosan-glycerol phosphate/blood implants improve hyaline cartilage repair in ovine microfracture defects. , 2005, The Journal of bone and joint surgery. American volume.

[715]  Wei Wang,et al.  In vivo restoration of full-thickness cartilage defects by poly(lactide-co-glycolide) sponges filled with fibrin gel, bone marrow mesenchymal stem cells and DNA complexes. , 2010, Biomaterials.

[716]  Michael D Maloney,et al.  Articular Cartilage Biology , 2003, The Journal of the American Academy of Orthopaedic Surgeons.

[717]  A. Salgado,et al.  Adult stem cells in bone and cartilage tissue engineering. , 2006, Current stem cell research & therapy.

[718]  H. Alexander,et al.  Effects of growth-factor-enhanced culture on a chondrocyte-collagen implant for cartilage repair. , 1996, Journal of biomedical materials research.

[719]  K A Athanasiou,et al.  Biochemical effects of estrogen on articular cartilage in ovariectomized sheep. , 1997, Osteoarthritis and cartilage.

[720]  M. McKee,et al.  Chitosan-glycerol phosphate/blood implants elicit hyaline cartilage repair integrated with porous subchondral bone in microdrilled rabbit defects. , 2007, Osteoarthritis and cartilage.

[721]  Nathaniel S Hwang,et al.  Application of stem cells for articular cartilage regeneration. , 2009, The journal of knee surgery.

[722]  R. Coutts,et al.  Matrices for cartilage repair. , 2001, Clinical orthopaedics and related research.

[723]  H. Helminen,et al.  Effects of cyclic hydrostatic pressure on proteoglycan synthesis in cultured chondrocytes and articular cartilage explants. , 1993, Archives of biochemistry and biophysics.

[724]  M J Yaszemski,et al.  Effects of transforming growth factor beta1 released from biodegradable polymer microparticles on marrow stromal osteoblasts cultured on poly(propylene fumarate) substrates. , 2000, Journal of biomedical materials research.

[725]  Gordana Vunjak-Novakovic,et al.  Differential effects of growth factors on tissue-engineered cartilage. , 2002, Tissue engineering.

[726]  C. M. Agrawal,et al.  Technique to control pH in vicinity of biodegrading PLA-PGA implants. , 1997, Journal of biomedical materials research.

[727]  Paul B. Lewis,et al.  Trochlear Contact Pressures after Anteromedialization of the Tibial Tubercle , 2005, The American journal of sports medicine.

[728]  H. Roos,et al.  Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age. , 1995, Osteoarthritis and cartilage.

[729]  T. Miyata,et al.  Collagen as a biomaterial. , 1974, Annual review of biophysics and bioengineering.

[730]  R Langer,et al.  Modulation of the mechanical properties of tissue engineered cartilage. , 2000, Biorheology.

[731]  Yu-Chen Hu,et al.  A Novel Rotating‐Shaft Bioreactor for Two‐Phase Cultivation of Tissue‐Engineered Cartilage , 2004, Biotechnology progress.

[732]  K. Kadler,et al.  Modification of the Composition of Articular Cartilage Collagen Fibrils with Increasing Age , 2008, Connective tissue research.

[733]  J. Richmond,et al.  Development and Validation of the International Knee Documentation Committee Subjective Knee Form * , 2001, The American journal of sports medicine.

[734]  K. Athanasiou,et al.  Effects of Initial Cell Seeding in Self Assembly of Articular Cartilage , 2008, Annals of Biomedical Engineering.

[735]  K. Athanasiou,et al.  Retaining zonal chondrocyte phenotype by means of novel growth environments. , 2005, Tissue engineering.

[736]  F Guilak,et al.  Adjacent tissues (cartilage, bone) affect the functional integration of engineered calf cartilage in vitro. , 2005, Osteoarthritis and cartilage.

[737]  Farshid Guilak,et al.  Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. , 2002, Biochemical and biophysical research communications.

[738]  C B Sledge,et al.  Canine chondrocytes seeded in type I and type II collagen implants investigated in vitro. , 1997, Journal of biomedical materials research.

[739]  T. Aigner,et al.  Autologous Chondrocyte Implantation and Osteochondral Cylinder Transplantation in Cartilage Repair of the Knee Joint: A Prospective, Comparative Trial , 2003, The Journal of bone and joint surgery. American volume.

[740]  Yang Luo,et al.  N‐cadherin is not essential for limb mesenchymal chondrogenesis , 2005, Developmental dynamics : an official publication of the American Association of Anatomists.

[741]  D. Speer,et al.  Enhancement of healing in osteochondral defects by collagen sponge implants. , 1979, Clinical orthopaedics and related research.

[742]  M. Stoddart,et al.  Transplantation of De Novo Scaffold-Free Cartilage Implants into Sheep Knee Chondral Defects , 2008, The American journal of sports medicine.

[743]  A. Reddi,et al.  Superficial zone protein (lubricin) in the different tissue compartments of the knee joint: modulation by transforming growth factor beta 1 and interleukin-1 beta. , 2008, Tissue engineering. Part A.

[744]  Frank P Barry,et al.  Mesenchymal stem cells avoid allogeneic rejection , 2005, Journal of Inflammation.

[745]  T. Spector,et al.  Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study. , 1999, Arthritis and rheumatism.

[746]  C. M. Agrawal,et al.  Protein Interactions with Polylactide-Polyglycolide Particles and Scaffolds , 1997 .

[747]  Wei Wang,et al.  The restoration of full-thickness cartilage defects with BMSCs and TGF-beta 1 loaded PLGA/fibrin gel constructs. , 2010, Biomaterials.

[748]  C. M. Agrawal,et al.  Orthopaedic applications for PLA-PGA biodegradable polymers. , 1998, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[749]  A. Schmidt,et al.  Age-related changes in the incorporation of [35S]sulfate into two proteoglycan populations from human cartilage. , 1980, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

[750]  K. Hochedlinger,et al.  Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells , 2010, Nature Biotechnology.

[751]  W. Horton,et al.  Chondrocyte apoptosis increases with age in the articular cartilage of adult animals , 1998, The Anatomical record.

[752]  J. Owen,et al.  Biomechanical and biotribological correlation of induced wear on bovine femoral condyles. , 2009, Journal of biomechanical engineering.

[753]  T. Pufe,et al.  Locally applied angiogenic factors--a new therapeutic tool for meniscal repair. , 2005, Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.

[754]  M. Ochi,et al.  Beneficial effect of basic fibroblast growth factor on the repair of full-thickness defects in rabbit articular cartilage , 1999, Archives of Orthopaedic and Trauma Surgery.

[755]  Somponnat Sampattavanich,et al.  Effects of Three‐Dimensional Culture and Growth Factors on the Chondrogenic Differentiation of Murine Embryonic Stem Cells , 2006, Stem cells.

[756]  L. Tang,et al.  Isolation and characterization of a 35,000 molecular weight subunit fetal cartilage matrix protein. , 1983, The Journal of biological chemistry.

[757]  A Ratcliffe,et al.  Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures. , 1992, Biomaterials.

[758]  C. Vacanti,et al.  Tissue Engineering of Cartilage , 1998 .

[759]  S. Abramson,et al.  F-spondin, a Neuroregulatory Protein, Is Up-regulated in Osteoarthritis and Regulates Cartilage Metabolism via Tgf-␤ Activation Oa-specific Up-regulation of F-spondin Was Also Dem- Onstrated in Rat Knee Cartilage following Surgical Meni- Sectomy. F-spondin Treatment of Oa Cartilage Explants Caused a , 2022 .

[760]  Kyriacos A. Athanasiou,et al.  The effects of porosity on in vitro degradation of polylactic acid- polyglycolic acid implants used in repair of articular cartilage , 1998 .

[761]  J. Burdick,et al.  Influence of three-dimensional hyaluronic acid microenvironments on mesenchymal stem cell chondrogenesis. , 2009, Tissue engineering. Part A.

[762]  W W Minuth,et al.  Tissue engineering and autologous transplant formation: practical approaches with resorbable biomaterials and new cell culture techniques. , 1996, Biomaterials.

[763]  Gabriela A Silva,et al.  Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. , 2007, Advanced drug delivery reviews.

[764]  P. Chesterman,et al.  Homotransplantation of articular cartilage and isolated chondrocytes. An experimental study in rabbits. , 1968, The Journal of bone and joint surgery. British volume.

[765]  J S Jurvelin,et al.  Evaluation of cartilage repair in the distal femur after autologous chondrocyte transplantation using T2 relaxation time and dGEMRIC. , 2007, Osteoarthritis and cartilage.

[766]  Shinya Yamanaka,et al.  Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors , 2008, Science.

[767]  C. Ingersoll,et al.  Arthrogenic muscle response to a simulated ankle joint effusion , 2004, British Journal of Sports Medicine.

[768]  H. Mankin,et al.  Characterization of chondrocytes from bovine articular cartilage: I. Metabolic and morphological experimental studies. , 1980, The Journal of bone and joint surgery. American volume.

[769]  M. DeRuiter,et al.  Histological evaluation of decellularised porcine aortic valves: matrix changes due to different decellularisation methods. , 2005, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[770]  G. Naughton,et al.  Evaluation of matrix scaffolds for tissue engineering of articular cartilage grafts. , 1997, Journal of biomedical materials research.

[771]  G D Smith,et al.  A clinical review of cartilage repair techniques. , 2005, The Journal of bone and joint surgery. British volume.

[772]  J. Ralphs,et al.  Development of functionally distinct fibrocartilages at two sites in the quadriceps tendon of the rat: the suprapatella and the attachment to the patella , 2004, Anatomy and Embryology.

[773]  F. C. Linn,et al.  Lubrication of animal joints. II. The mechanism. , 1968, Journal of biomechanics.

[774]  K A Athanasiou,et al.  Design, validation, and utilization of an articular cartilage impact instrument , 2006, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[775]  K W Anderson,et al.  Cell-interactive Alginate Hydrogels for Bone Tissue Engineering , 2001, Journal of dental research.

[776]  H. Kleinman,et al.  Complex Extracellular Matrices Promote Tissue‐Specific Stem Cell Differentiation , 2005, Stem cells.

[777]  Maggie Glover,et al.  Decellularization and sterilization of porcine urinary bladder matrix for tissue engineering in the lower urinary tract. , 2008, Regenerative medicine.

[778]  Yoshito Ikada,et al.  Comparison of different chondrocytes for use in tissue engineering of cartilage model structures. , 2006, Tissue engineering.

[779]  D. Schurman,et al.  Protective effects of intermittent hydrostatic pressure on osteoarthritic chondrocytes activated by bacterial endotoxin in vitro , 2003, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[780]  T. Yamamuro,et al.  Repair of osteochondral defects with grafts of cultured chondrocytes. Comparison of allografts and isografts. , 1994, Clinical orthopaedics and related research.

[781]  D. English,et al.  The Longitudinal Relationship Between Body Composition and Patella Cartilage in Healthy Adults , 2008, Obesity.

[782]  A. Goodship,et al.  The culture of articular chondrocytes in hydrogel constructs within a bioreactor enhances cell proliferation and matrix synthesis. , 2006, The Journal of bone and joint surgery. British volume.

[783]  David J Mooney,et al.  Alginate type and RGD density control myoblast phenotype. , 2002, Journal of biomedical materials research.

[784]  T. Oegema,et al.  The effects of indirect blunt trauma on adult canine articular cartilage. , 1983, The Journal of bone and joint surgery. American volume.

[785]  E B Hunziker,et al.  Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture. , 1995, Journal of cell science.

[786]  J. L. López-Lacomba,et al.  Chitosan scaffolds for osteochondral tissue regeneration. , 2010, Journal of biomedical materials research. Part A.

[787]  L. Bonassar,et al.  Biomechanical analysis of a chondrocyte-based repair model of articular cartilage. , 1999, Tissue engineering.

[788]  S. Vukicevic,et al.  Articular cartilage repair: the role of bone morphogenetic proteins , 2002, International Orthopaedics.

[789]  M. Doherty,et al.  Characterisation of size and direction of osteophyte in knee osteoarthritis: a radiographic study , 2002, Annals of the rheumatic diseases.

[790]  R. Haut,et al.  Chronic changes in rabbit retro‐patellar cartilage and subchondral bone after blunt impact loading of the patellofemoral joint , 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[791]  F. Miller,et al.  Isolation and Characterization of Multipotent Skin‐Derived Precursors from Human Skin , 2005, Stem cells.

[792]  R J Todhunter,et al.  Chondrocyte‐fibrin matrix transplants for resurfacing extensive articular cartilage defects , 1994, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[793]  P. Fricker,et al.  Injuries to Young Elite Female Basketball Players Over a Six‐Year Period , 1997, Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine.

[794]  Ching-Chuan Jiang,et al.  Evaluation of articular cartilage repair using biodegradable nanofibrous scaffolds in a swine model: a pilot study , 2009, Journal of tissue engineering and regenerative medicine.

[795]  R. Giardino,et al.  Transplantation of chondrocytes seeded on a hyaluronan derivative (hyaff-11) into cartilage defects in rabbits. , 2001, Biomaterials.

[796]  Kathryn E. Smith,et al.  Influence of hydrostatic and distortional stress on chondroinduction. , 2008, Biorheology.

[797]  Albert C. Chen,et al.  Static and dynamic compression modulate matrix metabolism in tissue engineered cartilage , 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[798]  Virgil L. Woods,et al.  Integrin expression by human articular chondrocytes. , 1994, Arthritis and rheumatism.

[799]  Robert Langer,et al.  Photopolymerizable degradable polyanhydrides with osteocompatibility , 1999, Nature Biotechnology.

[800]  J. Malejczyk.  Natural anti-chondrocyte cytotoxicity of normal human peripheral blood mononuclear cells. , 1989, Clinical immunology and immunopathology.

[801]  John Fisher,et al.  Tissue engineering small-diameter vascular grafts: preparation of a biocompatible porcine ureteric scaffold. , 2008, Tissue engineering. Part A.

[802]  R. Cancedda,et al.  Autologous chondrocyte implantation (ACI) for aged patients: development of the proper cell expansion conditions for possible therapeutic applications. , 2005, Osteoarthritis and cartilage.

[803]  W. Garrett,et al.  Chondral Delamination of the Knee in Soccer Players , 1996, The American journal of sports medicine.

[804]  Seungbum Koo,et al.  A Framework for the in Vivo Pathomechanics of Osteoarthritis at the Knee , 2004, Annals of Biomedical Engineering.

[805]  S. Waldman,et al.  Genipin Cross-Linked Fibrin Hydrogels for in vitro Human Articular Cartilage Tissue-Engineered Regeneration , 2009, Cells Tissues Organs.

[806]  Kyriacos A Athanasiou,et al.  Collagens of articular cartilage: structure, function, and importance in tissue engineering. , 2007, Critical reviews in biomedical engineering.

[807]  Antonios G. Mikos,et al.  Frontiers in tissue engineering , 1998 .

[808]  Wayne R. Gombotz,et al.  Protein release from alginate matrices. , 1998, Advanced drug delivery reviews.

[809]  G. Lyons,et al.  Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis. , 1995, Development.

[810]  R.M. Capito,et al.  Scaffold-based articular cartilage repair , 2003, IEEE Engineering in Medicine and Biology Magazine.

[811]  Ranieri Cancedda,et al.  Serum-free growth medium sustains commitment of human articular chondrocyte through maintenance of Sox9 expression. , 2004, Tissue engineering.

[812]  Abbey C. Thomas,et al.  A Neuromuscular Mechanism of Posttraumatic Osteoarthritis Associated with ACL Injury , 2009, Exercise and sport sciences reviews.

[813]  Stefano Zaffagnini,et al.  Arthroscopic Second-Generation Autologous Chondrocyte Implantation Compared with Microfracture for Chondral Lesions of the Knee , 2009, The American journal of sports medicine.

[814]  L. Grover,et al.  Cell encapsulation using biopolymer gels for regenerative medicine , 2010, Biotechnology Letters.

[815]  A I Caplan,et al.  Principles of cartilage repair and regeneration. , 1997, Clinical orthopaedics and related research.

[816]  R W Mann,et al.  Contact pressures from an instrumented hip endoprosthesis. , 1989, The Journal of bone and joint surgery. American volume.

[817]  R Langer,et al.  Long-term engraftment of hepatocytes transplanted on biodegradable polymer sponges. , 1997, Journal of biomedical materials research.

[818]  R. Salter,et al.  The biological effect of continuous passive motion on the healing of full-thickness defects in articular cartilage. An experimental investigation in the rabbit. , 1980, The Journal of bone and joint surgery. American volume.

[819]  Ick Chan Kwon,et al.  Porous chitosan scaffold containing microspheres loaded with transforming growth factor-beta1: implications for cartilage tissue engineering. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[820]  J CHARNLEY,et al.  The Lubrication of Animal Joints in Relation to Surgical Reconstruction by Arthroplasty * , 1960, Annals of the rheumatic diseases.

[821]  P. Bullough,et al.  The distribution of collagen in human articular cartilage with some of its physiological implications. , 1970, The Journal of bone and joint surgery. British volume.

[822]  H. Mankin,et al.  Growth factor stimulation of adult articular cartilage , 1989, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[823]  R Langer,et al.  Collagen in tissue‐engineered cartilage: Types, structure, and crosslinks , 1998, Journal of cellular biochemistry.

[824]  A. Reddi,et al.  Role of morphogenetic proteins in skeletal tissue engineering and regeneration , 1998, Nature Biotechnology.

[825]  S. Bryant,et al.  Cross‐linking density alters early metabolic activities in chondrocytes encapsulated in poly(ethylene glycol) hydrogels and cultured in the rotating wall vessel , 2009, Biotechnology and bioengineering.

[826]  J Glowacki,et al.  Effects of medium perfusion on matrix production by bovine chondrocytes in three-dimensional collagen sponges. , 2001, Journal of biomedical materials research.

[827]  J. Buckwalter.  Articular cartilage injuries. , 2002, Clinical orthopaedics and related research.

[828]  M. Spector,et al.  Effects of FGF-2 and IGF-1 on adult canine articular chondrocytes in type II collagen-glycosaminoglycan scaffolds in vitro. , 2005, Osteoarthritis and cartilage.

[829]  Robert Langer,et al.  Preparation and characterization of poly(l-lactic acid) foams , 1994 .

[830]  Young Ha Kim,et al.  Cartilaginous tissue formation using a mechano-active scaffold and dynamic compressive stimulation , 2008, Journal of biomaterials science. Polymer edition.

[831]  J. E. Jeffrey,et al.  Impact loading of articular cartilage. , 2002, Osteoarthritis and cartilage.

[832]  A Ratcliffe,et al.  The effects of matrix compression on proteoglycan metabolism in articular cartilage explants. , 1994, Osteoarthritis and cartilage.

[833]  V. Mow,et al.  Mechanical behavior of articular cartilage in shear is altered by transection of the anterior cruciate ligament , 1995, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[834]  J. Hassenpflug,et al.  Combination of reduced oxygen tension and intermittent hydrostatic pressure: a useful tool in articular cartilage tissue engineering. , 2001, Journal of biomechanics.

[835]  G. Vunjak‐Novakovic,et al.  Gas exchange is essential for bioreactor cultivation of tissue engineered cartilage. , 1999, Biotechnology and bioengineering.

[836]  G A Ateshian,et al.  Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. , 2000, Journal of biomechanical engineering.

[837]  Antonios G. Mikos,et al.  Synthetic Biodegradable Polymers for Medical Applications , 2007 .

[838]  D Breitig,et al.  Adsorption and release properties of growth factors from biodegradable implants. , 2002, Journal of biomedical materials research.

[839]  E. Lance.  Immunological reactivity towards chondrocytes in rat and man: relevance to autoimmune arthritis. , 1989, Immunology letters.

[840]  M J Yaszemski,et al.  Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds. , 1997, Journal of biomedical materials research.

[841]  R L Juliano,et al.  Integrin signaling and cell growth control. , 1998, Current opinion in cell biology.

[842]  C. Hidaka,et al.  Interaction between zonal populations of articular chondrocytes suppresses chondrocyte mineralization and this process is mediated by PTHrP. , 2008, Osteoarthritis and cartilage.

[843]  Stuart B Goodman,et al.  Effects of hydrostatic pressure and transforming growth factor-beta 3 on adult human mesenchymal stem cell chondrogenesis in vitro. , 2006, Tissue engineering.

[844]  Jeffrey D. Gordon,et al.  Comparison of Fresh Osteochondral Autografts and Allografts: a Canine Model on Behalf Of: American Orthopaedic Society for Sports Medicine Comparison of Fresh Osteochondral Autografts and Allografts a Canine Model , 2006 .

[845]  Ramprasad Papannagari,et al.  Anterior cruciate ligament deficiency alters the in vivo motion of the tibiofemoral cartilage contact points in both the anteroposterior and mediolateral directions. , 2006, The Journal of bone and joint surgery. American volume.

[846]  Gordana Vunjak-Novakovic,et al.  Engineering cartilage‐like tissue using human mesenchymal stem cells and silk protein scaffolds , 2004, Biotechnology and bioengineering.

[847]  A. Maroudas,et al.  Influence of cyclic loading on the nutrition of articular cartilage. , 1990, Annals of the rheumatic diseases.

[848]  Chun-hsien Wu,et al.  Effects of exogenous glycosaminoglycans on human chondrocytes cultivated on type II collagen scaffolds , 2010, Journal of materials science. Materials in medicine.

[849]  C E Farnum,et al.  Volume increase in growth plate chondrocytes during hypertrophy: the contribution of organic osmolytes. , 2002, Bone.

[850]  H. Kurz,et al.  Cell-laden and cell-free biopolymer hydrogel for the treatment of osteochondral defects in a sheep model. , 2009, Tissue engineering. Part A.

[851]  R. Rajotte,et al.  Decellularization reduces the immune response to aortic valve allografts in the rat. , 2005, The Journal of thoracic and cardiovascular surgery.

[852]  Christopher G Williams,et al.  In vitro chondrogenesis of bone marrow-derived mesenchymal stem cells in a photopolymerizing hydrogel. , 2003, Tissue engineering.

[853]  Simon C Watkins,et al.  Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis. , 1996, Human gene therapy.

[854]  R. Haut,et al.  The use of a non‐ionic surfactant (P188) to save chondrocytes from necrosis following impact loading of chondral explants , 2004, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[855]  Farshid Guilak,et al.  Zonal changes in the three-dimensional morphology of the chondron under compression: the relationship among cellular, pericellular, and extracellular deformation in articular cartilage. , 2007, Journal of biomechanics.

[856]  A. Dalmasso,et al.  Transgenic pigs designed to express human CD59 and H‐transferase to avoid humoral xenograft rejection , 2002, Xenotransplantation.

[857]  Mauro Alini,et al.  The use of biodegradable polyurethane scaffolds for cartilage tissue engineering: potential and limitations. , 2003, Biomaterials.

[858]  R. Sah,et al.  Biomechanics of integrative cartilage repair. , 1999, Osteoarthritis and cartilage.

[859]  E Ruoslahti,et al.  Variants of the cell recognition site of fibronectin that retain attachment-promoting activity. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[860]  J. Suh,et al.  Dynamic unconfined compression of articular cartilage under a cyclic compressive load. , 1996, Biorheology.

[861]  E. Ruoslahti,et al.  Peptides in cell adhesion research. , 1994, Methods in enzymology.

[862]  K. Wilk,et al.  Current concepts in the rehabilitation following articular cartilage repair procedures in the knee. , 2006, The Journal of orthopaedic and sports physical therapy.

[863]  Jerry C. Hu,et al.  Zonal and topographical differences in articular cartilage gene expression , 2004, Journal of Orthopaedic Research.

[864]  Miya Ishihara,et al.  Tissue engineering of articular cartilage using an allograft of cultured chondrocytes in a membrane-sealed atelocollagen honeycomb-shaped scaffold (ACHMS scaffold). , 2005, Journal of biomedical materials research. Part B, Applied biomaterials.

[865]  W. Akeson,et al.  Articular cartilage transplantation. Clinical results in the knee. , 1999, Clinical orthopaedics and related research.

[866]  M. Lotz.  Cytokines in cartilage injury and repair. , 2001, Clinical orthopaedics and related research.

[867]  Ivan Martin,et al.  Method for Quantitative Analysis of Glycosaminoglycan Distribution in Cultured Natural and Engineered Cartilage , 1999, Annals of Biomedical Engineering.

[868]  Richard Tuli,et al.  Multilineage differentiation of human mesenchymal stem cells in a three-dimensional nanofibrous scaffold. , 2005, Biomaterials.

[869]  S. Bryant,et al.  The role of hydrogel structure and dynamic loading on chondrocyte gene expression and matrix formation. , 2008, Journal of biomechanics.

[870]  Vivian H. Fan,et al.  Tethered Epidermal Growth Factor Provides a Survival Advantage to Mesenchymal Stem Cells , 2007, Stem cells.

[871]  W. Simon.  Wear properties of articular cartilage in vitro. , 1971, Journal of biomechanics.

[872]  C. S. Chen,et al.  Geometric control of cell life and death. , 1997, Science.

[873]  J Töyräs,et al.  Estimation of the Young's modulus of articular cartilage using an arthroscopic indentation instrument and ultrasonic measurement of tissue thickness. , 2001, Journal of biomechanics.

[874]  K. Briggs,et al.  Microfracture to treat full-thickness chondral defects: surgical technique, rehabilitation, and outcomes. , 2002, The journal of knee surgery.

[875]  Eric W McFarland,et al.  Microengineering neocartilage scaffolds. , 2002, Biotechnology and bioengineering.

[876]  H. Jasin,et al.  Interactions between anticollagen antibodies and chondrocytes. , 1992, Arthritis and rheumatism.

[877]  Anders Lindahl,et al.  Autologous Chondrocyte Transplantation , 2002, The American journal of sports medicine.

[878]  A. Eskelinen,et al.  Primary Cartilage Lesions of the Knee Joint in Young Male Adults. Overweight as a Predisposing Factor. An Arthroscopic Study , 2004, Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society.

[879]  R. Salter,et al.  Periosteal neochondrogenesis for biologically resurfacing joints: its cellular origin. , 1989, Canadian journal of surgery. Journal canadien de chirurgie.

[880]  R M Aspden,et al.  Matrix loss and synthesis following a single impact load on articular cartilage in vitro. , 1997, Biochimica et biophysica acta.

[881]  N. Lee,et al.  Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[882]  I. Bellantuono,et al.  Study of Telomere Length Reveals Rapid Aging of Human Marrow Stromal Cells following In Vitro Expansion , 2004, Stem cells.

[883]  J. Steadman,et al.  Chondral Resurfacing and High Tibial Osteotomy in the Varus Knee , 2004, The American journal of sports medicine.

[884]  D. Wilson,et al.  Intramembranous osteogenesis and angiogenesis in the chick embryo. , 1989, Journal of anatomy.

[885]  K. Ono,et al.  Chondrocytes embedded in collagen gels maintain cartilage phenotype during long-term cultures. , 1984, Clinical orthopaedics and related research.

[886]  Charles A. Vacanti,et al.  Injectable cartilage. Discussion , 1995 .

[887]  L. Trümper,et al.  Mesengenic progenitor cells derived from human placenta. , 2004, Tissue engineering.

[888]  W M Lai,et al.  A triphasic theory for the swelling and deformation behaviors of articular cartilage. , 1991, Journal of biomechanical engineering.

[889]  J. Powell,et al.  Injury patterns in selected high school sports: a review of the 1995-1997 seasons. , 1999, Journal of athletic training.

[890]  E. Hay.  Extracellular matrix alters epithelial differentiation. , 1993, Current opinion in cell biology.

[891]  Dietmar W. Hutmacher,et al.  Scaffold design and fabrication technologies for engineering tissues — state of the art and future perspectives , 2001, Journal of biomaterials science. Polymer edition.

[892]  F. Guilak,et al.  In situ friction measurement on murine cartilage by atomic force microscopy. , 2008, Journal of biomechanics.

[893]  A. Grodzinsky,et al.  Catabolic Responses of Chondrocyte-Seeded Peptide Hydrogel to Dynamic Compression , 2009, Annals of Biomedical Engineering.

[894]  Jeremy J Mao,et al.  Tissue-engineered osteochondral constructs in the shape of an articular condyle. , 2005, The Journal of bone and joint surgery. American volume.

[895]  T. Cheng,et al.  Overview of Injuries in the Young Athlete , 2003, Sports medicine.

[896]  D E Cutright,et al.  The repair of fractures of the orbital floor using biodegradable polylactic acid. , 1972, Oral surgery, oral medicine, and oral pathology.

[897]  D. Wendt,et al.  Uniform tissues engineered by seeding and culturing cells in 3D scaffolds under perfusion at defined oxygen tensions. , 2006, Biorheology.

[898]  F Dubrana,et al.  Autologous chondrocyte implantation in a novel alginate-agarose hydrogel: outcome at two years. , 2008, The Journal of bone and joint surgery. British volume.

[899]  C. Brantsing,et al.  Human Serum for Culture of Articular Chondrocytes , 2005, Cell transplantation.

[900]  A. Rezania,et al.  The detachment strength and morphology of bone cells contacting materials modified with a peptide sequence found within bone sialoprotein. , 1997, Journal of biomedical materials research.

[901]  M. Buschmann,et al.  Fibroblast Growth Factor (FGF) 18 Signals through FGF Receptor 3 to Promote Chondrogenesis* , 2005, Journal of Biological Chemistry.

[902]  E. Buzás,et al.  Critical roles of glycosaminoglycan side chains of cartilage proteoglycan (aggrecan) in antigen recognition and presentation. , 1998, Journal of immunology.

[903]  A. Robins,et al.  The alpha-1,3-galactosyltransferase knockout mouse. Implications for xenotransplantation. , 1996, Transplantation.

[904]  Mauro Alini,et al.  Tribology approach to the engineering and study of articular cartilage. , 2004, Tissue engineering.

[905]  Seonghun Park,et al.  Cartilage interstitial fluid load support in unconfined compression. , 2003, Journal of biomechanics.

[906]  Yan Huang,et al.  In vitro characterization of chitosan-gelatin scaffolds for tissue engineering. , 2005, Biomaterials.

[907]  Martin J. Aryee,et al.  Epigenetic memory in induced pluripotent stem cells , 2010, Nature.

[908]  R. Bank,et al.  Ageing and zonal variation in post-translational modification of collagen in normal human articular cartilage. The age-related increase in non-enzymatic glycation affects biomechanical properties of cartilage. , 1998, The Biochemical journal.

[909]  F. Luyten,et al.  Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo. , 2001, Arthritis and rheumatism.

[910]  T. Brümmendorf,et al.  Telomere length and telomerase activity during expansion and differentiation of human mesenchymal stem cells and chondrocytes , 2003, Journal of Molecular Medicine.

[911]  J. Fisher,et al.  Soft and hard tissue response to photocrosslinked poly(propylene fumarate) scaffolds in a rabbit model. , 2002, Journal of biomedical materials research.

[912]  M. Freeman,et al.  Tensile Properties of Articular Cartilage , 1968, Nature.

[913]  F. Mallein-Gerin,et al.  Molecular analysis of chondrocytes cultured in agarose in response to dynamic compression , 2008 .

[914]  J. S. Park,et al.  Chondrogenesis of human mesenchymal stem cells in fibrin constructs evaluated in vitro and in nude mouse and rabbit defects models. , 2011, Biomaterials.

[915]  Stockwell Ra.  The interrelationship of cell density and cartilage thickness in mammalian articular cartilage. , 1971 .

[916]  Chin-Yu Lin,et al.  The repair of osteochondral defects using baculovirus-mediated gene transfer with de-differentiated chondrocytes in bioreactor culture. , 2009, Biomaterials.

[917]  T. Ochi,et al.  Articular cartilage repair. Rabbit experiments with a collagen gel-biomatrix and chondrocytes cultured in it. , 1998, Acta orthopaedica Scandinavica.

[918]  Stephen Mann,et al.  Strategies to promote chondrogenesis and osteogenesis from human bone marrow cells and articular chondrocytes encapsulated in polysaccharide templates. , 2006, Tissue engineering.

[919]  F. Luyten,et al.  Cartilage Defects of the Knee : Early Treatment Matters Five-Year Outcome of Characterized Chondrocyte Implantation Versus Microfracture for Symptomatic , 2011 .

[920]  Y. Lee,et al.  Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis , 2009, Rheumatology International.

[921]  Doris A Taylor,et al.  Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart , 2008, Nature Medicine.

[922]  D Dowson,et al.  Lubrication and cartilage. , 1976, Journal of anatomy.

[923]  D E Ingber,et al.  Cellular control lies in the balance of forces. , 1998, Current opinion in cell biology.

[924]  V. Kish,et al.  Repair of full-thickness femoral condyle cartilage defects using allogeneic synovial cell-engineered tissue constructs. , 2009, Osteoarthritis and cartilage.

[925]  M. Brittberg,et al.  Two- to 9-Year Outcome After Autologous Chondrocyte Transplantation of the Knee , 2000, Clinical orthopaedics and related research.

[926]  J. Canseco,et al.  Chondrogenic Differentiation of Adult Dermal Fibroblasts , 2004, Annals of Biomedical Engineering.

[927]  F. C. Linn,et al.  MOVEMENT AND COMPOSITION OF INTERSTITIAL FLUID OF CARTILAGE. , 1965, Arthritis and rheumatism.

[928]  K. Miyazono,et al.  Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia , 2004, The Journal of cell biology.

[929]  L. de Smet,et al.  Debridement arthroplasty for osteoarthritis of the elbow (Outerbridge-Kashiwagi procedure). , 2004, Acta orthopaedica Belgica.

[930]  K. Furukawa,et al.  Scaffold-free cartilage by rotational culture for tissue engineering. , 2008, Journal of biotechnology.

[931]  G. Vunjak‐Novakovic,et al.  Frontiers in tissue engineering. In vitro modulation of chondrogenesis. , 1999, Clinical orthopaedics and related research.

[932]  B. Oakes,et al.  Effects of growth factors on cell proliferation and matrix synthesis of low‐density, primary bovine chondrocytes cultured in collagen I gels , 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[933]  Mirela Ionescu,et al.  The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis. , 2003, Arthritis and rheumatism.

[934]  A. Astrup,et al.  Weight loss: the treatment of choice for knee osteoarthritis? A randomized trial. , 2005, Osteoarthritis and cartilage.

[935]  F. Greco,et al.  N,N-dicarboxymethyl chitosan as delivery agent for bone morphogenetic protein in the repair of articular cartilage , 2006, Medical and Biological Engineering and Computing.

[936]  A. Grodzinsky,et al.  Evaluation of adult equine bone marrow‐ and adipose‐derived progenitor cell chondrogenesis in hydrogel cultures , 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[937]  K. Athanasiou,et al.  Development of serum-free, chemically defined conditions for human embryonic stem cell-derived fibrochondrogenesis. , 2009, Tissue engineering. Part A.

[938]  A I Caplan,et al.  Tissue engineering designs for the future: new logics, old molecules. , 2000, Tissue engineering.

[939]  T. Quinn,et al.  Cartilage injury by ramp compression near the gel diffusion rate , 2004, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[940]  Junzo Tanaka,et al.  Rapid and Large-Scale Formation of Chondrocyte Aggregates by Rotational Culture , 2003, Cell transplantation.

[941]  Hagen Schmal,et al.  Characteristic Complications after Autologous Chondrocyte Implantation for Cartilage Defects of the Knee Joint , 2008, The American journal of sports medicine.

[942]  R L Spilker,et al.  An evaluation of three-dimensional diarthrodial joint contact using penetration data and the finite element method. , 2001, Journal of biomechanical engineering.

[943]  M. Spector,et al.  Collagen scaffolds for nonviral IGF-1 gene delivery in articular cartilage tissue engineering , 2007, Gene Therapy.

[944]  Naoki Ishiguro,et al.  Chondrogenesis enhanced by overexpression of sox9 gene in mouse bone marrow-derived mesenchymal stem cells. , 2003, Biochemical and biophysical research communications.

[945]  T. Nakamura,et al.  Role of uppermost superficial surface layer of articular cartilage in the lubrication mechanism of joints , 2001, Journal of anatomy.

[946]  Stuart B Goodman,et al.  Dose- and time-dependent effects of cyclic hydrostatic pressure on transforming growth factor-beta3-induced chondrogenesis by adult human mesenchymal stem cells in vitro. , 2006, Tissue engineering.

[947]  R. Kandel,et al.  In vitro formation of mineralized cartilagenous tissue by articular chondrocytes , 1997, In Vitro Cellular & Developmental Biology - Animal.

[948]  D R Carter,et al.  Time-dependent effects of intermittent hydrostatic pressure on articular chondrocyte type II collagen and aggrecan mRNA expression. , 2000, Journal of rehabilitation research and development.

[949]  Chuan‐Mu Chen,et al.  Surgical Débridement and Parenteral Antibiotics in Infected Revision Total Knee Arthroplasty , 2007, Clinical orthopaedics and related research.

[950]  K. Athanasiou,et al.  Tissue Engineering with Chondrogenically Differentiated Human Embryonic Stem Cells , 2007, Stem cells.

[951]  R. Tuan,et al.  Expression and functional involvement of N-cadherin in embryonic limb chondrogenesis. , 1994, Development.

[952]  Junzo Tanaka,et al.  Cartilaginous tissue formation from bone marrow cells using rotating wall vessel (RWV) bioreactor. , 2006, Biotechnology and bioengineering.

[953]  D W Hutmacher,et al.  An introduction to biodegradable materials for tissue engineering applications. , 2001, Annals of the Academy of Medicine, Singapore.

[954]  T. Glant,et al.  Differentiation antigens of human articular chondrocytes and their tissue distribution as assessed by monoclonal antibodies. , 1994, Journal of autoimmunity.

[955]  M. Pittenger,et al.  Multilineage potential of adult human mesenchymal stem cells. , 1999, Science.

[956]  K. Merkel,et al.  Supracondylar fracture of the femur after total knee arthroplasty. , 1986, The Journal of bone and joint surgery. American volume.

[957]  L. Díaz de León,et al.  Expression of N-cadherin, N-CAM, fibronectin and tenascin is stimulated by TGF-beta1, beta2, beta3 and beta5 during the formation of precartilage condensations. , 1999, The International journal of developmental biology.

[958]  J Glowacki,et al.  Effect of RGD coating on osteocompatibility of PLGA-polymer disks in a rat tibial wound. , 2001, Journal of biomedical materials research.

[959]  M. Zern,et al.  Analysis of local tissue-specific gene expression in cellular micropatterns. , 2006, Analytical chemistry.

[960]  G E Kempson,et al.  The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans. , 1973, Biochimica et biophysica acta.

[961]  Antonios G Mikos,et al.  In vitro release of transforming growth factor-beta 1 from gelatin microparticles encapsulated in biodegradable, injectable oligo(poly(ethylene glycol) fumarate) hydrogels. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[962]  Kyriacos A Athanasiou,et al.  Articular cartilage bioreactors and bioprocesses. , 2003, Tissue engineering.

[963]  T. Hewett,et al.  Biomechanical Measures of Neuromuscular Control and Valgus Loading of the Knee Predict Anterior Cruciate Ligament Injury Risk in Female Athletes: A Prospective Study , 2005, The American journal of sports medicine.

[964]  C. Ingersoll,et al.  Arthrogenic Muscle Inhibition in the Leg Muscles of Subjects Exhibiting Functional Ankle Instability , 2005, Foot & ankle international.

[965]  D. Bader,et al.  Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes. , 2004, Biochemical and biophysical research communications.

[966]  R. Tuan,et al.  Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture. , 2006, Osteoarthritis and cartilage.

[967]  K Remberger,et al.  Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I) , 2005, Gene Therapy.

[968]  N. Südkamp,et al.  Results after microfracture of full-thickness chondral defects in different compartments in the knee. , 2006, Osteoarthritis and cartilage.

[969]  J Fisher,et al.  The Influence of Loading Time and Lubricant on the Friction of Articular Cartilage , 1996, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[970]  H. Lorenz,et al.  Multilineage cells from human adipose tissue: implications for cell-based therapies. , 2001, Tissue engineering.

[971]  V. Goldberg,et al.  Hyaluronan‐based polymers in the treatment of osteochondral defects , 2000, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[972]  K. Arden,et al.  Expression of the human chondrocyte phenotype in vitro , 1989, In Vitro Cellular & Developmental Biology.

[973]  D. Bader,et al.  Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression. , 2003, Archives of biochemistry and biophysics.

[974]  C. McCutchen.  The frictional properties of animal joints , 1962 .

[975]  M. Hiles,et al.  Effects of sterilization on an extracellular matrix scaffold: Part II. Bioactivity and matrix interaction , 2007, Journal of materials science. Materials in medicine.

[976]  T. Hardingham,et al.  Chondrogenic Differentiation of Human Bone Marrow Stem Cells in Transwell Cultures: Generation of Scaffold‐Free Cartilage , 2007, Stem cells.

[977]  Emilia Maneiro,et al.  Xeno‐implantation of pig chondrocytes into rabbit to treat localized articular cartilage defects: an animal model , 2004, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[978]  W. B. van den Berg,et al.  Linkage of chondroitin-sulfate to type I collagen scaffolds stimulates the bioactivity of seeded chondrocytes in vitro. , 2001, Biomaterials.

[979]  M. Longaker,et al.  Transforming Growth Factor Beta Superfamily Members: Role in Cartilage Modeling , 2000, Plastic and Reconstructive Surgery.

[980]  F. Beier,et al.  Rac1/Cdc42 and RhoA GTPases Antagonistically Regulate Chondrocyte Proliferation, Hypertrophy, and Apoptosis , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[981]  A. Mak,et al.  The effect of shear fatigue on bovine articular cartilage , 1990, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[982]  A. Sadikot,et al.  Isolation of multipotent adult stem cells from the dermis of mammalian skin , 2001, Nature Cell Biology.

[983]  Jerry C. Hu,et al.  Isolation and chondroinduction of a dermis-isolated, aggrecan-sensitive subpopulation with high chondrogenic potential. , 2007, Arthritis and rheumatism.

[984]  A. Grodzinsky,et al.  Cartilage electromechanics--II. A continuum model of cartilage electrokinetics and correlation with experiments. , 1987, Journal of biomechanics.

[985]  Monika Kopacz,et al.  Experimental verification of the role of interstitial fluid pressurization in cartilage lubrication , 2004, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[986]  Thomas Pap,et al.  Cartilage biology, pathology, and repair , 2010, Cellular and Molecular Life Sciences.

[987]  H. Helminen,et al.  Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[988]  J. Elisseeff,et al.  Musculoskeletal Differentiation of Cells Derived from Human Embryonic Germ Cells , 2005, Stem cells.

[989]  W. B. van den Berg,et al.  Resurfacing potential of heterologous chondrocytes suspended in fibrin glue in large full-thickness defects of femoral articular cartilage: an experimental study in the goat. , 1999, Biomaterials.

[990]  P. M. van der Kraan,et al.  Differential effect of transforming growth factor beta on freshly isolated and cultured articular chondrocytes. , 1992, The Journal of rheumatology.

[991]  S J Bryant,et al.  Mechanical loading regimes affect the anabolic and catabolic activities by chondrocytes encapsulated in PEG hydrogels. , 2010, Osteoarthritis and cartilage.

[992]  Afshin Khalafi,et al.  Mechanotransduction of bovine articular cartilage superficial zone protein by transforming growth factor beta signaling. , 2007, Arthritis and rheumatism.

[993]  A. Nixon,et al.  Enhanced early chondrogenesis in articular defects following arthroscopic mesenchymal stem cell implantation in an equine model , 2007, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[994]  M. Dunn,et al.  Effect of chemical treatments on tendon cellularity and mechanical properties. , 2000, Journal of biomedical materials research.

[995]  R. Altman,et al.  Preliminary observations of chondral abrasion in a canine model. , 1992, Annals of the rheumatic diseases.

[996]  A. Maroudas,et al.  Balance between swelling pressure and collagen tension in normal and degenerate cartilage , 1976, Nature.

[997]  W. Eger,et al.  Hyaluronan oligosaccharides perturb cartilage matrix homeostasis and induce chondrocytic chondrolysis. , 2000, Arthritis and rheumatism.

[998]  J. Glowacki,et al.  In vitro engineering of cartilage: effects of serum substitutes, TGF-beta, and IL-1alpha. , 2005, Orthodontics & craniofacial research.

[999]  Chun Han,et al.  Macroscopic cartilage formation with embryonic stem-cell-derived mesodermal progenitor cells , 2003, Journal of Cell Science.

[1000]  J M Anderson,et al.  In vitro and in vivo degradation of poly(propylene fumarate-co-ethylene glycol) hydrogels. , 1998, Journal of biomedical materials research.

[1001]  D. Fauza,et al.  Fetal cartilage engineering from amniotic mesenchymal progenitor cells. , 2006, Stem cells and development.

[1002]  J. Mansour,et al.  Immunochemical and Mechanical Characterization of Cartilage Subtypes in Rabbit , 2002, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[1003]  Juha Töyräs,et al.  Spatial assessment of articular cartilage proteoglycans with Gd‐DTPA‐enhanced T1 imaging , 2002, Magnetic resonance in medicine.

[1004]  A. Mikos,et al.  Fibrin glue as a drug delivery system. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[1005]  T. Okano,et al.  Mechanism of cell detachment from temperature-modulated, hydrophilic-hydrophobic polymer surfaces. , 1995, Biomaterials.

[1006]  H. Helminen,et al.  Influence of short‐term hydrostatic pressure on organization of stress fibers in cultured chondrocytes , 1995, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[1007]  Margherita Cioffi,et al.  The effect of hydrodynamic shear on 3D engineered chondrocyte systems subject to direct perfusion. , 2006, Biorheology.

[1008]  P. Duke,et al.  Studies of chondrogenesis in rotating systems , 1993, Journal of cellular biochemistry.

[1009]  L. Hangody,et al.  Arthroscopic autogenous osteochondral mosaicplasty for the treatment of femoral condylar articular defects A preliminary report , 1997, Knee Surgery, Sports Traumatology, Arthroscopy.

[1010]  K. Kuettner,et al.  Biochemistry of articular cartilage in health and disease. , 1992, Clinical biochemistry.

[1011]  A. Gross,et al.  Long-Term Followup of the Use of Fresh Osteochondral Allografts for Posttraumatic Knee Defects , 2005, Clinical orthopaedics and related research.

[1012]  J. Itskovitz‐Eldor,et al.  Feeder Layer- and Serum-Free Culture of Human Embryonic Stem Cells1 , 2004, Biology of reproduction.

[1013]  E. Hunziker,et al.  Chondrogenic differentiation of bovine synovium: bone morphogenetic proteins 2 and 7 and transforming growth factor beta1 induce the formation of different types of cartilaginous tissue. , 2007, Arthritis and rheumatism.

[1014]  Adel Alhadlaq,et al.  Adult Stem Cell Driven Genesis of Human-Shaped Articular Condyle , 2004, Annals of Biomedical Engineering.

[1015]  F. Guilak,et al.  Viscoelastic properties of zonal articular chondrocytes measured by atomic force microscopy. , 2006, Osteoarthritis and cartilage.

[1016]  E. Bruscia,et al.  Plasticity of Bone Marrow–Derived Stem Cells , 2004, Stem cells.

[1017]  W. Toh,et al.  Potential of Human Embryonic Stem Cells in Cartilage Tissue Engineering and Regenerative Medicine , 2011, Stem Cell Reviews and Reports.

[1018]  Kyriacos A Athanasiou,et al.  Success rates and immunologic responses of autogenic, allogenic, and xenogenic treatments to repair articular cartilage defects. , 2009, Tissue engineering. Part B, Reviews.

[1019]  P. Eggli,et al.  Quantitation of structural features characterizing weight‐ and less‐weight‐bearing regions in articular cartilage: A stereological analysis of medical femoral condyles in young adult rabbits , 1988, The Anatomical record.

[1020]  I. Thesleff,et al.  Comparison of expression of the msx-1, msx-2, BMP-2 and BMP-4 genes in the mouse upper diastemal and molar tooth primordia. , 1995, The International journal of developmental biology.

[1021]  Stephen F Badylak,et al.  The extracellular matrix as a biologic scaffold material. , 2007, Biomaterials.

[1022]  G A Ateshian,et al.  Biomechanics of diarthrodial joints: a review of twenty years of progress. , 1993, Journal of biomechanical engineering.

[1023]  Shannon R. Magari,et al.  Mini‐review: Mechanical factors affecting cartilage regeneration in vitro , 2000, Biotechnology and bioengineering.

[1024]  A. Georgoulis,et al.  Advances in articular cartilage repair. , 2005, Injury.

[1025]  M. Hiles,et al.  Virus safety of a porcine‐derived medical device: Evaluation of a viral inactivation method , 2002, Biotechnology and bioengineering.

[1026]  David A. Wolf,et al.  Fluid dynamics within a rotating bioreactor in space and earth environments , 1994 .

[1027]  S. Jurga,et al.  Scaffold-aided repair of articular cartilage studied by MRI , 2008, Magnetic Resonance Materials in Physics, Biology and Medicine.

[1028]  Steven A. Goldstein,et al.  Chondrocyte Differentiation is Modulated by Frequency and Duration of Cyclic Compressive Loading , 2001, Annals of Biomedical Engineering.

[1029]  J J Parkkinen,et al.  Age matters: collagen birefringence of superficial articular cartilage is increased in young guinea-pigs but decreased in older animals after identical physiological type of joint loading. , 2001, Osteoarthritis and cartilage.

[1030]  Brett D Owens,et al.  Resource Utilization and Disability Outcome Assessment of Combat Casualties From Operation Iraqi Freedom and Operation Enduring Freedom , 2009, Journal of orthopaedic trauma.

[1031]  H. Alexander,et al.  Development of a novel osteochondral graft for cartilage repair. , 1998, Journal of biomedical materials research.

[1032]  G. Bentley,et al.  Repair of articular surfaces by allografts of articular and growth-plate cartilage. , 1986, The Journal of bone and joint surgery. British volume.

[1033]  F. Luyten,et al.  Presence of cartilage-derived morphogenetic proteins in articular cartilage and enhancement of matrix replacement in vitro. , 1998, Arthritis and rheumatism.

[1034]  S. Woo,et al.  Viscoelastic shear properties of the equine medial meniscus , 1991, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[1035]  J. Puzas,et al.  Transforming growth factor beta: an autocrine regulator of chondrocytes. , 1989, Connective tissue research.

[1036]  Pieter Buma,et al.  Tissue Engineering of the Meniscus , 2004 .

[1037]  T. Kubo,et al.  Hydrostatic pressure induces apoptosis of chondrocytes cultured in alginate beads , 2006, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[1038]  S. Bulstra,et al.  Repair of sheep articular cartilage defects with a rabbit costal perichondrial graft. , 1991, Acta orthopaedica Scandinavica.

[1039]  N. Südkamp,et al.  Autologous chondrocyte implantation for the treatment of retropatellar cartilage defects: clinical results referred to defect localisation , 2008, Archives of Orthopaedic and Trauma Surgery.

[1040]  Kozo Nakamura,et al.  Redifferentiation of dedifferentiated bovine articular chondrocytes enhanced by cyclic hydrostatic pressure under a gas-controlled system. , 2007, Tissue engineering.

[1041]  N. Hutchinson,et al.  Effects of fluid‐induced shear on articular chondrocyte morphology and metabolism in vitro , 1995, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[1042]  F. Noyes,et al.  A system for grading articular cartilage lesions at arthroscopy , 1989, The American journal of sports medicine.

[1043]  K A Athanasiou,et al.  Hypoxic chondrogenic differentiation of human embryonic stem cells enhances cartilage protein synthesis and biomechanical functionality. , 2008, Osteoarthritis and cartilage.

[1044]  S. Moskalewski,et al.  Rejection of cartilage formed by transplanted allogeneic chondrocytes: evaluation with monoclonal antibodies. , 1995, Transplant immunology.

[1045]  J. S. Park,et al.  Heparin-Bound Transforming Growth Factor-&bgr;3 Enhances Neocartilage Formation by Rabbit Mesenchymal Stem Cells , 2008, Transplantation.

[1046]  M B Aydelotte,et al.  Differences between sub-populations of cultured bovine articular chondrocytes. I. Morphology and cartilage matrix production. , 1988, Connective tissue research.

[1047]  H. Cheung,et al.  Cyclic compression maintains viability and induces chondrogenesis of human mesenchymal stem cells in fibrin gel scaffolds. , 2009, Stem cells and development.

[1048]  V C Mow,et al.  Tensile properties of human knee joint cartilage: I. Influence of ionic conditions, weight bearing, and fibrillation on the tensile modulus , 1986, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[1049]  F. Cicuttini,et al.  Tibial plateau size is related to grade of joint space narrowing and osteophytes in healthy women and in women with osteoarthritis , 2004, Annals of the rheumatic diseases.

[1050]  R. Haut,et al.  Treatment with the Non-ionic Surfactant Poloxamer P188 Reduces DNA Fragmentation in Cells from Bovine Chondral Explants Exposed to Injurious Unconfined Compression , 2006, Biomechanics and modeling in mechanobiology.

[1051]  Wei Liu,et al.  Tissue engineering of cartilage with the use of chitosan-gelatin complex scaffolds. , 2004, Journal of biomedical materials research. Part B, Applied biomaterials.

[1052]  S. Ayad,et al.  Chondrons from articular cartilage: I. Immunolocalization of type VI collagen in the pericellular capsule of isolated canine tibial chondrons. , 1988, Journal of cell science.

[1053]  P. Bullough,et al.  Permeability of Articular Cartilage , 1968, The Journal of bone and joint surgery. British volume.

[1054]  T. Cruz,et al.  Effects of continuous passive motion and immobilization on synovitis and cartilage degradation in antigen induced arthritis. , 1995, The Journal of rheumatology.

[1055]  R. Mülhaupt,et al.  Novel hydrogels as supports for in vitro cell growth: poly(ethylene glycol)- and gelatine-based (meth)acrylamidopeptide macromonomers. , 2002, Biomaterials.

[1056]  Jerry C. Hu,et al.  The effects of intermittent hydrostatic pressure on self-assembled articular cartilage constructs. , 2006, Tissue engineering.

[1057]  J. Stampfl,et al.  In vitro determination of biomechanical properties of human articular cartilage in osteoarthritis using multi-parametric MRI. , 2009, Journal of magnetic resonance.

[1058]  F. Luyten,et al.  Cartilage repair: past and future – lessons for regenerative medicine , 2009, Journal of cellular and molecular medicine.

[1059]  J. Bertram,et al.  Swelling and fibronectin accumulation in articular cartilage explants after cyclical impact , 1996, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[1060]  R. Kandel,et al.  Long‐term intermittent shear deformation improves the quality of cartilaginous tissue formed in vitro , 2003, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[1061]  Shuichi Mizuno,et al.  The effect of hydrostatic pressure on three-dimensional chondroinduction of human adipose-derived stem cells. , 2009, Tissue engineering. Part A.

[1062]  Lars Engebretsen,et al.  Clinical application of scaffolds for cartilage tissue engineering , 2008, Knee Surgery, Sports Traumatology, Arthroscopy.

[1063]  S. Woo,et al.  Measurements of nonhomogeneous, directional mechanical properties of articular cartilage in tension. , 1976, Journal of biomechanics.

[1064]  S J Bryant,et al.  Static and dynamic compressive strains influence nitric oxide production and chondrocyte bioactivity when encapsulated in PEG hydrogels of different crosslinking densities. , 2008, Osteoarthritis and cartilage.

[1065]  Stefan Marlovits,et al.  Autologous Chondrocyte Implantation Postoperative Care and Rehabilitation , 2006, The American journal of sports medicine.

[1066]  R. Langer,et al.  Mechanical shear properties of cell-polymer cartilage constructs. , 1999, Tissue engineering.

[1067]  Byung-Soo Kim,et al.  Control of basic fibroblast growth factor release from fibrin gel with heparin and concentrations of fibrinogen and thrombin. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[1068]  Derrick E Rancourt,et al.  Induction of chondro-, osteo- and adipogenesis in embryonic stem cells by bone morphogenetic protein-2: Effect of cofactors on differentiating lineages , 2005, BMC Developmental Biology.

[1069]  Gordana Vunjak-Novakovic,et al.  Effects of mixing on the composition and morphology of tissue‐engineered cartilage , 1996 .

[1070]  H J Mankin,et al.  Articular cartilage: tissue design and chondrocyte-matrix interactions. , 1998, Instructional course lectures.

[1071]  S. Madihally,et al.  Vascular cell responses to polysaccharide materials: in vitro and in vivo evaluations. , 2000, Biomaterials.

[1072]  M. Nimni,et al.  Isolation and characterization of cyanogen bromide peptides from the collagen of bovine articular cartilage. , 1973, The Biochemical journal.

[1073]  E. Hunziker,et al.  Ruthenium hexammine trichloride (RHT)-mediated interaction between plasmalemmal components and pericellular matrix proteoglycans is responsible for the preservation of chondrocytic plasma membranes in situ during cartilage fixation. , 1983, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[1074]  Aft Mak,et al.  Ultrasound detection of trypsin-treated articular cartilage: its association with cartilaginous proteoglycans assessed by histological and biochemical methods , 2002, Journal of Bone and Mineral Metabolism.

[1075]  K. Briggs,et al.  Reproducibility and Reliability of the Outerbridge Classification for Grading Chondral Lesions of the Knee Arthroscopically , 2003, The American journal of sports medicine.

[1076]  A. Grodzinsky,et al.  Tissue shear deformation stimulates proteoglycan and protein biosynthesis in bovine cartilage explants. , 2001, Archives of biochemistry and biophysics.

[1077]  P. Mainil-Varlet,et al.  A static, closed and scaffold-free bioreactor system that permits chondrogenesis in vitro. , 2003, Osteoarthritis and cartilage.

[1078]  B. Toole,et al.  Hyaluronan in morphogenesis , 1997, Seminars in cell & developmental biology.

[1079]  M. Spector,et al.  Articular cartilage chondrocytes in type I and type II collagen-GAG matrices exhibit contractile behavior in vitro. , 2000, Tissue engineering.

[1080]  F. Luyten,et al.  Natural bovine osteogenin and recombinant human bone morphogenetic protein-2B are equipotent in the maintenance of proteoglycans in bovine articular cartilage explant cultures. , 1992, The Journal of biological chemistry.

[1081]  H. Kagami,et al.  Differentiation of transplanted mesenchymal stem cells in a large osteochondral defect in rabbit. , 2005, Cytotherapy.

[1082]  A. Maitra,et al.  Characterization of a New NIH‐Registered Variant Human Embryonic Stem Cell Line, BG01V: A Tool for Human Embryonic Stem Cell Research , 2006, Stem cells.

[1083]  J. Hui,et al.  The potential of stem cells in orthopaedic surgery. , 2006, The Journal of bone and joint surgery. British volume.

[1084]  C. M. Agrawal,et al.  Effects of diabetes mellitus on the biomechanical properties of human ankle cartilage. , 1999, Clinical orthopaedics and related research.

[1085]  F C Newcombe.  LIMITATIONS OF THE KLINOSTAT AS AN INSTRUMENT FOR SCIENTIFIC RESEARCH. , 1904, Science.

[1086]  A. Mikos,et al.  The Importance of New Processing Techniques in Tissue Engineering , 1996, MRS bulletin.

[1087]  A. Caplan,et al.  Mesenchymal stem cells as trophic mediators , 2006, Journal of cellular biochemistry.

[1088]  Farshid Guilak.  Functional Tissue Engineering , 2001 .

[1089]  J. L. Gomez Ribelles,et al.  In Vivo Evaluation of 3-Dimensional Polycaprolactone Scaffolds for Cartilage Repair in Rabbits , 2010, The American journal of sports medicine.

[1090]  Jiang Peng,et al.  A cartilage ECM-derived 3-D porous acellular matrix scaffold for in vivo cartilage tissue engineering with PKH26-labeled chondrogenic bone marrow-derived mesenchymal stem cells. , 2008, Biomaterials.

[1091]  F. N. Ghadially,et al.  Ultrastructural observations on surgically produced partial-thickness defects in articular cartilage. , 1972, Clinical orthopaedics and related research.

[1092]  J. Kuiper,et al.  Midterm to Long-Term Longitudinal Outcome of Autologous Chondrocyte Implantation in the Knee Joint , 2009, The American journal of sports medicine.

[1093]  S. Richmond.  Magnet therapy for the relief of pain and inflammation in rheumatoid arthritis (CAMBRA): A randomised placebo-controlled crossover trial , 2008, Trials.

[1094]  A. E. Elçin,et al.  Engineering of Rat Articular Cartilage on Porous Sponges: Effects of TGF-β 1 and Microgravity Bioreactor Culture , 2008, Artificial cells, blood substitutes, and immobilization biotechnology.

[1095]  E Wolner,et al.  Comparison of Different Decellularization Procedures of Porcine Heart Valves , 2003, The International journal of artificial organs.

[1096]  F. Luyten,et al.  Recombinant bone morphogenetic protein-4, transforming growth factor-beta 1, and activin A enhance the cartilage phenotype of articular chondrocytes in vitro. , 1994, Experimental cell research.

[1097]  F. Henson,et al.  Chondrocyte outgrowth into a gelatin scaffold in a single impact load model of damage/repair – effect of BMP-2 , 2007, BMC musculoskeletal disorders.

[1098]  B. Brüggenjürgen,et al.  Follow-up costs up to 5 years after conventional treatments in patients with cartilage lesions of the knee , 2007, Knee Surgery, Sports Traumatology, Arthroscopy.

[1099]  C. McDevitt,et al.  Interaction of intact type VI collagen with hyaluronan , 1991, FEBS letters.

[1100]  A. Ratcliffe,et al.  Repair of osteochondral defects with allogeneic tissue engineered cartilage implants. , 1999, Clinical orthopaedics and related research.