In this study, a new prediction algorithm is proposed, based on the collaborative two-dimensional forecast model (CTFM) that combines the traditional method and similarity search technique. The main idea of the algorithm is that the prediction of the change trend of the slope and the accumulated slope of the cell resistance as well as the useful knowledge obtained using the similarity search technique are used as the main criteria to calculate anode effect (AE)-prediction reliability. The accumulated mass deviation value is used as an auxiliary criterion to adjust the AE-prediction reliability. Finally, the current AE-process is marked according to the current AE-prediction reliability. The prediction model based on CTFM is tested on a real situation, in which multiple samples are extracted from the production of a 400 kA aluminum electrolysis cell. We observe that when the time advance of AE-prediction is within 20 ~ 40 min, the accuracy rate of the CTFM algorithm is greater than 95% and the applicability of the method is excellent, showing a high prediction accuracy for different aluminum electrolysis cells.