The Down Syndrome Behavioural Phenotype: Taking a Developmental Approach.

Individuals with Down syndrome are predisposed to show a specific behavioural phenotype, or a pattern of strengths and challenges in functioning across different domains of development. It is argued that a developmental approach to researching the Down syndrome behavioural phenotype, including an examination of the dynamic process of the unfolding of the phenotype, will advance science and service for this population. Related issues including the distinction between primary and secondary phenotypic features, heterotypic continuity, and methodological implications are discussed.

[1]  B. Maria,et al.  Parenting Stress and Its Relationship to the Behavior of Children with Joubert Syndrome , 2006, Journal of child neurology.

[2]  S. Landry,et al.  Joint attention and infant toy exploration: effects of Down syndrome and prematurity. , 1989, Child development.

[3]  D. E. Most,et al.  Emerging Social Strengths in Young Children With Down Syndrome , 2008 .

[4]  E. Dykens Measuring behavioral phenotypes: provocations from the "new genetics". , 1995, American journal of mental retardation : AJMR.

[5]  C. Kasari,et al.  Characteristics and qualities of the play dates of children with Down syndrome: emerging or true friendships? , 2002, American journal of mental retardation : AJMR.

[6]  Neonatal imitation and imitation among children with autism and Down syndrome , 1999 .

[7]  R S Chapman,et al.  Language skills of children and adolescents with Down syndrome: II. Production deficits. , 1998, Journal of speech, language, and hearing research : JSLHR.

[8]  M. Sigman,et al.  Continuity and change in the social competence of children with autism, Down syndrome, and developmental delays. , 1999, Monographs of the Society for Research in Child Development.

[9]  S. Pueschel,et al.  Psychiatric Disorders in Persons with Down Syndrome , 1991, The Journal of nervous and mental disease.

[10]  E. Zigler Developmental versus difference theories of mental retardation and the problem of motivation. , 1969, American journal of mental deficiency.

[11]  L. Abbeduto,et al.  Collaboration in referential communication: comparison of youth with down syndrome or fragile X syndrome. , 2006, American journal of mental retardation : AJMR.

[12]  Lynn Nadel,et al.  Education and children with Down syndrome: neuroscience, development, and intervention. , 2007, Mental retardation and developmental disabilities research reviews.

[13]  D. Fidler,et al.  The Emerging Down Syndrome Behavioral Phenotype in Early Childhood: Implications for Practice , 2005 .

[14]  R. Hodapp,et al.  Maternal Attribution of Child Noncompliance in Children with Mental Retardation: Down Syndrome Versus Other Causes , 2002, Journal of developmental and behavioral pediatrics : JDBP.

[15]  A. Baddeley,et al.  Down syndrome and the phonological loop: the evidence for, and importance of, a specific verbal short-term memory deficit. , 1999, Down's syndrome, research and practice : the journal of the Sarah Duffen Centre.

[16]  B. Pennington,et al.  A theoretical approach to the deficits in infantile autism , 1991, Development and Psychopathology.

[17]  M. W. Krauss,et al.  Adults with Down syndrome and their aging mothers: diagnostic group differences. , 1993, American journal of mental retardation : AJMR.

[18]  R. Hodapp Indirect Effects of Genetic Mental Retardation Disorders: Theoretical and Methodological Issues , 1999 .

[19]  B. Fellows,et al.  Daytime behaviour problems and maternal stress in children with Down's syndrome, their siblings, and non-intellectually disabled and other intellectually disabled peers. , 2002, Journal of intellectual disability research : JIDR.

[20]  M. Dadds,et al.  Behavioural problems in children with Down's syndrome and their siblings. , 1992, Journal of child psychology and psychiatry, and allied disciplines.

[21]  M. Mon-Williams,et al.  The preparation of reach to grasp movements in adults with Down syndrome. , 2001, Human movement science.

[22]  R. Hodapp,et al.  Less Stress, More Rewarding: Parenting Children With Down Syndrome , 2001 .

[23]  P. Rosenbaum,et al.  Gross motor function of children with down syndrome: creation of motor growth curves. , 2001, Archives of physical medicine and rehabilitation.

[24]  L. Becker,et al.  Magnetic Resonance Imaging Evaluation of Delayed Myelination in Down Syndrome: A Case Report and Review of the Literature , 1992, Journal of child neurology.

[25]  W. Briegel,et al.  22q11.2 deletion syndrome: behaviour problems of infants and parental stress. , 2007, Child: care, health and development.

[26]  T. Bower,et al.  Spatial relations and the object concept: a normative study , 1984 .

[27]  Anthony S. Bryk,et al.  Hierarchical Linear Models: Applications and Data Analysis Methods , 1992 .

[28]  N. Walz,et al.  Behavioral Phenotypes in Children with Down Syndrome, Prader-Willi Syndrome, or Angelman Syndrome , 2002 .

[29]  R. Hodapp,et al.  Special Education and Genetics , 1999 .

[30]  M. Bull,et al.  Infants with Down syndrome: a look at temperament. , 1998, Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners.

[31]  Down's syndrome and infant gaze. Gaze behavior of Down's syndrome and nondelayed infants in interactions with their mothers. , 1992, Acta paedopsychiatrica.

[32]  R S Chapman,et al.  Behavioral phenotype of individuals with Down syndrome. , 2000, Mental retardation and developmental disabilities research reviews.

[33]  Doris J Kistler,et al.  Predicting longitudinal change in language production and comprehension in individuals with Down syndrome: hierarchical linear modeling. , 2002, Journal of speech, language, and hearing research : JSLHR.

[34]  B. King,et al.  Maladaptive behaviour in children and adolescents with Down's syndrome. , 2002, Journal of intellectual disability research : JIDR.

[35]  A. McNeil,et al.  Latent Curve Models: A Structural Equation Approach , 2007 .

[36]  Peter Farrell,et al.  Object Mastery Motivation in Pre-school Children with and without Disabilities , 2000 .

[37]  J. Wishart Cognitive abilities in children with Down syndrome: developmental instability and motivational deficits. , 1995, Progress in clinical and biological research.

[38]  A. Reiss,et al.  Neuroanatomy of Down's syndrome: a high-resolution MRI study. , 2001, The American journal of psychiatry.

[39]  Stefano Vicari,et al.  Motor Development and Neuropsychological Patterns in Persons with Down Syndrome , 2006, Behavior genetics.

[40]  N. Fox,et al.  Does infancy matter? predicting social behavior from infant temperament , 1999 .

[41]  P. Mundy,et al.  Attention to people and toys during social and object mastery in children with Down syndrome. , 1994, American journal of mental retardation : AJMR.

[42]  C. Dunst,et al.  Structural characteristics of sensorimotor development among Down's syndrome infants. , 2008, Journal of mental deficiency research.

[43]  G Pearlson,et al.  Small planum temporale volume in Down's syndrome: a volumetric MRI study. , 1997, The American journal of psychiatry.

[44]  P. Mundy,et al.  Nonverbal communication skills in Down syndrome children. , 1988, Child development.

[45]  Wishart Jg Cognitive abilities in children with Down syndrome: developmental instability and motivational deficits. , 1995 .

[46]  Richard M. Lerner,et al.  Developmental Science, Developmental Systems, and Contemporary Theories of Human Development† , 2007 .

[47]  R. Hodapp,et al.  Social Competence in Persons with Prader‐Willi, Williams and Down's Syndromes , 2004 .

[48]  S. Hepburn,et al.  Nonverbal requesting and problem-solving by toddlers with down syndrome. , 2005, American journal of mental retardation : AJMR.

[49]  E. Zigler Rigidity and social reinforcement effects in the performance of institutionalized and noninstitutionalized normal and retarded children. , 1963, Journal of personality.

[50]  David Rogosa,et al.  A growth curve approach to the measurement of change. , 1982 .

[51]  C. Reynolds,et al.  Handbook of neurodevelopmental and genetic disorders in children , 2010 .

[52]  P. Mundy,et al.  Attention regulation by children with Down syndrome: coordinated joint attention and social referencing looks. , 1995, American journal of mental retardation : AJMR.

[53]  A. Karmiloff-Smith Development itself is the key to understanding developmental disorders , 1998, Trends in Cognitive Sciences.

[54]  R. Hodapp Direct and indirect behavioral effects of different genetic disorders of mental retardation. , 1997, American journal of mental retardation : AJMR.

[55]  Sally Rogers,et al.  Autism symptoms in toddlers with Down syndrome: a descriptive study. , 2007, Journal of applied research in intellectual disabilities : JARID.

[56]  R. Hodapp,et al.  The effects of the child with Down syndrome on maternal stress , 2003 .

[57]  J G Wishart,et al.  The development of learning difficulties in children with Down's syndrome. , 2008, Journal of intellectual disability research : JIDR.

[58]  S. Noh Delineating Sources of Stress in Parents of Exceptional Children. , 1989 .

[59]  C. Dunst Children with Down syndrome: Sensorimotor development of infants with Down syndrome , 1990 .

[60]  R. Hodapp,et al.  Genetic Etiologies of Mental Retardation: Issues for Interventions and Interventionists , 2002 .

[61]  R. Hodapp,et al.  Stress in Families of Young Children with Down Syndrome, Williams Syndrome, and Smith-Magenis Syndrome , 2000 .

[62]  Esther Thelen,et al.  Dynamic Systems Theories , 2007 .

[63]  K. Barrett,et al.  Age-Related Differences in Smiling and Personality in Down Syndrome , 2005 .

[64]  J. Thorpe,et al.  Personality stereotype of noninstitutionalized Down syndrome children. , 1983, American journal of mental deficiency.

[65]  J A Kelso,et al.  Analysis of "invariant characteristics" in the motor control of down's syndrome and normal subjects. , 1982, Journal of motor behavior.

[66]  J. Stansfield,et al.  Expressive pragmatic skills in pre-school children with and without Down's syndrome: parental perceptions. , 2007, Journal of intellectual disability research : JIDR.

[67]  G. Carlesimo,et al.  Long-term memory in mental retardation: Evidence for a specific impairment in subjects with Down's syndrome , 1997, Neuropsychologia.

[68]  Dorothy V M Bishop,et al.  Verbal deficits in Down's syndrome and specific language impairment: a comparison. , 2004, International journal of language & communication disorders.

[69]  R. Schultz Developmental deficits in social perception in autism: the role of the amygdala and fusiform face area , 2005, International Journal of Developmental Neuroscience.

[70]  E. Zigler,et al.  Issues in the classification of mental retardation: differentiating among organic etiologies. , 1988, Journal of child psychology and psychiatry, and allied disciplines.

[71]  J. Price,et al.  Language and communication development in Down syndrome. , 2007, Mental retardation and developmental disabilities research reviews.

[72]  C Caltagirone,et al.  Short-term memory in persons with intellectual disabilities and Down's syndrome. , 1995, Journal of intellectual disability research : JIDR.

[73]  L. Leavitt,et al.  Improving the communication of people with Down syndrome , 1999 .

[74]  M. Legerstee,et al.  People and objects affect the quality of vocalizations in infants with down syndrome , 1992 .

[75]  James W. Deutsch,et al.  The First Idea: How Symbols, Language, and Intelligence Evolved From Our Primate Ancestors to Modern Humans , 2005 .

[76]  C. Dunst Stage transitioning in the sensorimotor development of Down's syndrome infants. , 2008, Journal of mental deficiency research.

[77]  A. Jobling Motor development in school-aged children with Down Syndrome , 1998 .

[78]  T. K. Pitcairn,et al.  Reactions of young children with Down's syndrome to an impossible task , 1994 .